Keck School Faculty

Mitchell E. Gross, MD, PhD
Mitchell E. Gross, MD, PhD
Associate Professor of Clinical Medicine
Provost - Ellison Institute
CSC 240 Health Sciences Campus Los Angeles
Dr. Gross is research director of the USC Norris Westside Cancer Center and the Center for Applied Molecular Medicine. His overall research interest focuses on applying modern techniques relating to the study of genes and proteins (genomics and proteomics) on the clinical problems faced in treating patients with prostate cancer. A particular interest relates to the androgen receptor and relating proteins and pathways as key driving forces behind the development and treatment of prostate cancer. As a medical oncologist, his clinical activities are focused on therapeutic clinical trials incorporating both molecularly targeted and conventional therapies to the care of patients with prostate cancer. He serves as primary investigator on many multi-center phase 1 and 2 clinical trials

Dr. Gross has earned degrees from the University of California, San Diego (B.A.), Baylor College of Medicine in Houston (M.D.), and the University of California, Los Angeles (Ph.D. Molecular Biology). He completed a residency in internal medicine and a fellowship in hematology and medical oncology at the UCLA Center for the Health Sciences.

: Donna and Jesse Garber Award, 2006

: AACR-AFLAC Scholar in Training Award,, 2001

: Rhone Phoulenc Rorer Travel Award, 1999

: Amgen Fellowship Research Award, 1999

: Specialty Training Advanced Research Fellowship, 1997-2002

: Alpha Omega Alpha, 1994

: Hewlett Packard Award for Excellence in Internal Medicine, 1994

UCSD/Revelle College Academic: Leadership Award, 1990

: Phi Beta Kappa, 1989

Monitoring dynamic cytotoxic chemotherapy response in castration-resistant prostate cancer using plasma cell-free DNA (cfDNA) BMC Res Notes. 2019 May 15; 12(1):275. . View in PubMed

Effect of Monoamine oxidase A (MAOA) inhibitors on androgen-sensitive and castration-resistant prostate cancer cells Prostate. 2019 May; 79(6):667-677. . View in PubMed

Randomized Phase II Trial of Abiraterone Alone or With Dasatinib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC) Clin Genitourin Cancer. 2019 Mar 19. . View in PubMed

Effect of Monoamine oxidase A (MAOA) inhibitors on androgen-sensitive and castration-resistant prostate cancer cells Prostate. 2019 Jan 28. . View in PubMed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis Oncogene. 2019 04; 38(16):3003-3018. . View in PubMed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis Oncogene. 2018 Dec 21. . View in PubMed

Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate Oncogene. 2018 Sep; 37(38):5175-5190. . View in PubMed

Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2) Oncotarget. 2018 Jun 08; 9(44):27363-27379. . View in PubMed

Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate Oncogene. 2018 May 29. . View in PubMed

Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial BMC Cancer. 2018 Apr 03; 18(1):368. . View in PubMed

Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate Oncogene. 2018 09; 37(38):5175-5190. . View in PubMed

Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial BMC Cancer. 2018 04 03; 18(1):368. . View in PubMed

Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide Amphiphile Micelles ACS Biomater Sci Eng. 2017 Dec 11; 3(12):3273-3282. . View in PubMed

Safety and Efficacy of Docetaxel, Bevacizumab, and Everolimus for Castration-resistant Prostate Cancer (CRPC) Clin Genitourin Cancer. 2017 Jul 14. . View in PubMed

A pilot randomised controlled trial of a periodised resistance training and protein supplementation intervention in prostate cancer survivors on androgen deprivation therapy BMJ Open. 2017 Jul 10; 7(7):e016910. . View in PubMed

Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells Endocr Relat Cancer. 2017 Apr; 24(4):157-170. . View in PubMed

Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells Endocr Relat Cancer. 2017 04; 24(4):157-170. . View in PubMed

Automated analysis of co-localized protein expression in histologic sections of prostate cancer PLoS One. 2017; 12(5):e0178362. . View in PubMed

A review of clinical effects associated with metabolic syndrome and exercise in prostate cancer patients Prostate Cancer Prostatic Dis. 2016 12; 19(4):323-332. . View in PubMed

Trans-rectal ultrasound visibility of prostate lesions identified by magnetic resonance imaging increases accuracy of image-fusion targeted biopsies World J Urol. 2015 Nov; 33(11):1669-76. . View in PubMed

Salvage ablative therapy in prostate cancer: international multidisciplinary consensus on trial designUrol Oncol. 2015 Nov; 33(11):495. e1-7. . View in PubMed

Blood-based gene expression profiling in castrate-resistant prostate cancer BMC Med. 2015 Sep 14; 13:219. . View in PubMed

A novel technique using three-dimensionally documented biopsy mapping allows precise re-visiting of prostate cancer foci with serial surveillance of cell cycle progression gene panel Prostate. 2015 Jun; 75(8):863-71. . View in PubMed

Intolerance of uncertainty, cognitive complaints, and cancer-related distress in prostate cancer survivors Psychooncology. 2015 Feb; 24(2):228-35. . View in PubMed

Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression PLoS One. 2015; 10(2):e0117758. . View in PubMed

Radium 223: how can we optimize this new tool for metastatic castration-resistant prostate cancer? Am Soc Clin Oncol Educ Book. 2015; e270-3.. View in PubMed

A Phase II trial of a combination herbal supplement for men with biochemically recurrent prostate cancer Prostate Cancer Prostatic Dis. 2014 Dec; 17(4):359-65. . View in PubMed

Phase I/II trial of orteronel (TAK-700)--an investigational 17,20-lyase inhibitor--in patients with metastatic castration-resistant prostate cancer Clin Cancer Res. 2014 Mar 01; 20(5):1335-44. . View in PubMed

Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells PLoS One. 2014; 9(8):e101777. . View in PubMed

Body image predicts quality of life in men with prostate cancer Psychooncology. 2013 Apr; 22(4):756-61. . View in PubMed

Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype Prostate. 2013 Feb 15; 73(3):306-15. . View in PubMed

Prostate cancer: Age is nothing but a number Nat Rev Urol. 2013 12; 10(12):683-4. . View in PubMed

Safety and preliminary efficacy analysis of the mTOR inhibitor ridaforolimus in patients with taxane-treated, castration-resistant prostate cancer Clin Genitourin Cancer. 2012 Dec; 10(4):232-8. . View in PubMed

Multimodality imaging in biochemical recurrence of prostate cancer: utility of (18)F-NaF PET/CT in early detection of metastasis Rev Esp Med Nucl Imagen Mol. 2012 Jul-Aug; 31(4):231-2. . View in PubMed

Prospective evaluation of 18F-NaF and 18F-FDG PET/CT in detection of occult metastatic disease in biochemical recurrence of prostate cancer Clin Nucl Med. 2012 Jul; 37(7):637-43. . View in PubMed

Focal cryotherapy for clinically unilateral, low-intermediate risk prostate cancer in 73 men with a median follow-up of 37 years. Eur Urol. 2012 Jul; 62(1):55-63. . View in PubMed

Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition Mol Cancer Ther. 2012 May; 11(5):1071-81. . View in PubMed

3-Dimensional elastic registration system of prostate biopsy location by real-time 3-dimensional transrectal ultrasound guidance with magnetic resonance/transrectal ultrasound image fusion J Urol. 2012 Mar; 187(3):1080-6. . View in PubMed

Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line Phys Biol. 2012 Feb; 9(1):016002. . View in PubMed

Safety and pharmacokinetics of high-dose gefitinib in patients with solid tumors: results of a phase I study Cancer Chemother Pharmacol. 2012 Jan; 69(1):273-80. . View in PubMed

Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: a randomized phase II trial by the prostate cancer clinical trials consortium Invest New Drugs. 2011 Dec; 29(6):1432-40. . View in PubMed

Once-daily dasatinib: expansion of phase II study evaluating safety and efficacy of dasatinib in patients with metastatic castration-resistant prostate cancer Urology. 2011 May; 77(5):1166-71. . View in PubMed

Show us a sign: the search for "game changing" prostate cancer biomarkers Lancet Oncol. 2011 Mar; 12(3):204-6. . View in PubMed

The epothilones: new therapeutic agents for castration-resistant prostate cancer Oncologist. 2011; 16(10):1349-58. . View in PubMed

Detection of androgen receptor mutations in circulating tumor cells in castration-resistant prostate cancer Clin Chem. 2010 Sep; 56(9):1492-5. . View in PubMed

Beta-2-microglobulin expression correlates with high-grade prostate cancer and specific defects in androgen signaling Prostate. 2010 Aug; 70(11):1201-10. . View in PubMed

Predictors of affect following treatment decision-making for prostate cancer: conversations, cognitive processing, and coping Psychooncology. 2009 May; 18(5):508-14. . View in PubMed

Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene Leuk Res. 2007 Jan; 31(1):27-32. . View in PubMed

Ductal adenocarcinoma of the prostate Clin Adv Hematol Oncol. 2004 Jun; 2(6):393-5; discussion 396. . View in PubMed

Targeting the HER-kinase axis in cancer Semin Oncol. 2004 Feb; 31(1 Suppl 3):9-20. . View in PubMed

Update on HER-kinase-directed therapy in prostate cancer Clin Adv Hematol Oncol. 2004 Jan; 2(1):53-6, 64. . View in PubMed

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