Nancy Liu, MD

Assistant Professor of Research Orthopaedic Surgery

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Overview

Dr. Nancy Q. Liu is an Assistant Professor of Research Orthopaedic Surgery at USC. Her research is mainly focused on understanding the mechanisms of chondrogenesis, articular chondrocytes maintenance and regeneration, and clinically relevant applications of stem cell and small molecule-based therapies for prevention of arthritis and restoration of damaged articular cartilage. She is involved in the development of various pre-clinical in vivo models for cartilage and bone repair. Dr. Liu is the author of numerous peer-reviewed research articles and presentations. She is also the reviewer for many scientific journals.

Publications

  • STAT3 promotes a youthful epigenetic state in articular chondrocytes Aging Cell. 2023 02; 22(2):e13773. . View in PubMed
  • Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis Sci Transl Med. 2023 03 22; 15(688):eabq2395. . View in PubMed
  • Author Correction: gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes Commun Biol. 2022 Feb 25; 5(1):200. . View in PubMed
  • gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes Commun Biol. 2022 01 17; 5(1):64. . View in PubMed
  • A new mouse model of post-traumatic joint injury allows to identify the contribution of Gli1+ mesenchymal progenitors in arthrofibrosis and acquired heterotopic endochondral ossification Front Cell Dev Biol. 2022; 10:954028. . View in PubMed
  • Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes NPJ Regen Med. 2021 Nov 23; 6(1):77. . View in PubMed
  • Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis Arthritis Rheumatol. 2020 08; 72(8):1278-1288. . View in PubMed
  • In vitro behavior of tendon stem/progenitor cells on bioactive electrospun nanofiber membranes for tendon-bone tissue engineering applications Int J Nanomedicine. 2019; 14:5831-5848. . View in PubMed
  • Safety and tolerability of subcutaneous sarilumab and intravenous tocilizumab in patients with rheumatoid arthritis Rheumatology (Oxford). 2019 05 01; 58(5):849-858. . View in PubMed
  • Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration J Mol Med (Berl). 2018 10; 96(10):1049-1060. . View in PubMed
  • Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair Ann Rheum Dis. 2018 05; 77(5):760-769. . View in PubMed
  • Vitamin D-deficiency and sex-specific dysregulation of placental inflammation J Steroid Biochem Mol Biol. 2018 03; 177:223-230. . View in PubMed
  • Differential Responses to Vitamin D2 and Vitamin D3 Are Associated With Variations in Free 25-Hydroxyvitamin D Endocrinology. 2016 09; 157(9):3420-30. . View in PubMed
  • Vitamin D supplementation and antibacterial immune responses in adolescents and young adults with HIV/AIDS J Steroid Biochem Mol Biol. 2015 Apr; 148:290-7. . View in PubMed
  • Dietary vitamin D restriction in pregnant female mice is associated with maternal hypertension and altered placental and fetal development Endocrinology. 2013 Jul; 154(7):2270-80. . View in PubMed
  • Vitamin D metabolism and innate immunity Mol Cell Endocrinol. 2011 Dec 05; 347(1-2):97-105. . View in PubMed
  • Vitamin D and the regulation of placental inflammation J Immunol. 2011 May 15; 186(10):5968-74. . View in PubMed
  • 1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):228-33. . View in PubMed
  • Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis Endocrinology. 2010 Jun; 151(6):2423-32. . View in PubMed
  • Influence of simultaneous targeting of the bone morphogenetic protein pathway and RANK/RANKL axis in osteolytic prostate cancer lesion in bone Bone. 2009 Jan; 44(1):160-7. . View in PubMed
  • Stem cells from human fat as cellular delivery vehicles in an athymic rat posterolateral spine fusion model J Bone Joint Surg Am. 2008 May; 90(5):1043-52. . View in PubMed
  • Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model Bone. 2008 May; 42(5):921-31. . View in PubMed
  • Mixed metastatic lung cancer lesions in bone are inhibited by noggin overexpression and Rank:Fc administration J Bone Miner Res. 2006 Oct; 21(10):1571-80. . View in PubMed
  • Lentivirus-mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo Mol Ther. 2005 Mar; 11(3):390-8. . View in PubMed
  • The effect of cyclooxygenase-2 (COX-2) inhibition on human prostate cancer induced osteoblastic and osteolytic lesions in bone Anticancer Res. 2005 Jan-Feb; 25(1A):107-15. . View in PubMed
  • Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Dec; 5(4):213-9. . View in PubMed