Keck School Faculty

Natasha Lepore, PhD
Natasha Lepore, PhD
Associate Professor of Research Radiology
Pediatrics
CHL Mail Stop 81 Off Campus Los Angeles
My current work involves the development of numerical tools for the analysis of brain structural and diffusion magnetic resonance imaging data. In particular, these include improvements to tensor-based morphometry, surface and volume registration, segmentation and statistics for group comparisons. I also work on applying these methods to different types of brain imaging data including prematurity, healthy brain development, healthy twins, blindness, deafness, HIV/AIDS, autism and Alzheimer's disease. I am currently an assistant professor in Radiology at the University of Southern California and at Children's Hospital Los Angeles. I graduated with a Bsc in physics and mathematics from the University of Montreal and then obtained a masters in applied mathematics from Cambridge University, in general relativity. My PhD is in theoretical physics (Harvard University), and deals with quantum chaos in quantum billiards living on the plane and the pseudosphere. Afterward, I switched to neuroimaging and became a postdoctoral fellow at the Laboratory of Neuro Imaging, working with Dr Paul Thompson.

Discriminating lung adenocarcinoma from lung squamous cell carcinoma using respiration-induced tumor shape changes Phys Med Biol. 2018 Nov 07; 63(21):215027. . View in PubMed

A Tetrahedron-based Heat Flux Signature for Cortical Thickness Morphometry Analysis Med Image Comput Comput Assist Interv. 2018 Sep; 11072:420-428. . View in PubMed

ORCHESTRAL FULLY CONVOLUTIONAL NETWORKS FOR SMALL LESION SEGMENTATION IN BRAIN MRI Proc IEEE Int Symp Biomed Imaging. 2018 Apr; 2018:889-892. . View in PubMed

CEREBRAL BLOOD FLOW AND PREDICTORS OF WHITE MATTER LESIONS IN ADULTS WITH TETRALOGY OF FALLOT Proc IEEE Int Symp Biomed Imaging. 2018 Apr; 2018:1309-1312. . View in PubMed

Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial CMAJ. 2017 Oct 10; 189(40):E1252-E1258. . View in PubMed

Graph Lasso-Based Test for Evaluating Functional Brain Connectivity in Sickle Cell Disease Brain Connect. 2017 Sep; 7(7):443-453. . View in PubMed

Atypical monoarthritis presentation in children with oligoarticular juvenile idiopathic arthritis: a case series Pediatr Rheumatol Online J. 2017 Jan 13; 15(1):2. . View in PubMed

Central sulcus depth and sulcal profile differences between congenitally blind and sighted individuals Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:3008-3011. . View in PubMed

Central sulcus development in early childhood Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:161-164. . View in PubMed

Contribution to speech development of the right anterior putamen revealed with multivariate tensor-based morphometry Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:3085-3087. . View in PubMed

Tractography in the clinics: Implementing a pipeline to characterize early brain development Neuroimage Clin. 2017; 14:629-640. . View in PubMed

Contrasting resting-state fMRI abnormalities from sickle and non-sickle anemia PLoS One. 2017; 12(10):e0184860. . View in PubMed

FUNCTIONAL CONNECTIVITY ANALYSIS FOR THALASSEMIA DISEASE BASED ON A GRAPHICAL LASSO MODEL Proc IEEE Int Symp Biomed Imaging. 2016 Apr; 2016:1295-1298. . View in PubMed

BOLD delay times using group delay in sickle cell disease Proc SPIE Int Soc Opt Eng. 2016 Feb-Mar; 9784. . View in PubMed

A study of brain white matter plasticity in early blinds using tract-based spatial statistics and tract statistical analysis Neuroreport. 2015 Dec 16; 26(18):1151-4. . View in PubMed

Tract specific analysis in patients with sickle cell disease Proc SPIE Int Soc Opt Eng. 2015 Nov; 9681. . View in PubMed

Low-frequency fluctuation amplitude analysis of resting-state fMRI in sickle cell disease Proc SPIE Int Soc Opt Eng. 2015 Nov; 9681. . View in PubMed

Intraurethral Lidocaine for Urethral Catheterization in Children: A Randomized Controlled Trial Pediatrics. 2015 Oct; 136(4):e879-86. . View in PubMed

Characterization of the central sulcus in the brain in early childhood Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:149-52. . View in PubMed

The Power of Hybrid/Fusion Imaging Metrics in Future PACS Systems: A Case Study into the White Matter Hyperintensity Prenumbra using FLAIR and Diffusion MR Proc SPIE Int Soc Opt Eng. 2014 Apr 09; 9039:90390I. . View in PubMed

Mapping of ApoE4 Related White Matter Damage using Diffusion MRI Proc SPIE Int Soc Opt Eng. 2014 Apr 09; 9039:90390H. . View in PubMed

Evaluating the Predictive Power of Multivariate Tensor-based Morphometry in Alzheimers Disease Progression via Convex Fused Sparse Group Lasso Proc SPIE Int Soc Opt Eng. 2014 Mar 21; 9034:90342L. . View in PubMed

Magnetic resonance image enhancement by reducing receptors' effective size and enabling multiple channel acquisition Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:2420-3. . View in PubMed

Neuroimaging changes in the brain in contact versus noncontact sport athletes using diffusion tensor imaging World Neurosurg. 2013 Dec; 80(6):824-8. . View in PubMed

Neuroimaging biomarkers of preterm brain injury: toward developing the preterm connectome Pediatr Radiol. 2012 Jan; 42 Suppl 1:S33-61. . View in PubMed

Acute and chronic changes in diffusivity measures after sports concussion J Neurotrauma. 2011 Oct; 28(10):2049-59. . View in PubMed

A nonconservative Lagrangian framework for statistical fluid registration-SAFIRA IEEE Trans Med Imaging. 2011 Feb; 30(2):184-202. . View in PubMed

REDUCING STRUCTURAL VARIATION TO DETERMINE THE GENETICS OF WHITE MATTER INTEGRITY ACROSS HEMISPHERES - A DTI STUDY OF 100 TWINS Proc IEEE Int Symp Biomed Imaging. 2009 Jun-Jul; 2009:819-822. . View in PubMed

The underlying anatomical correlates of long-term meditation: larger hippocampal and frontal volumes of gray matter Neuroimage. 2009 Apr 15; 45(3):672-8. . View in PubMed

3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry Neuroimage. 2008 May 15; 41(1):19-34. . View in PubMed

Brain Differences Visualized in the Blind using Tensor Manifold Statistics and Diffusion Tensor Imaging Proc Front Converg Biosci Inf Technol (2007). 2007 Oct; 2007:470-476. . View in PubMed

Multivariate statistics of the Jacobian matrices in tensor based morphometry and their application to HIV/AIDS Med Image Comput Comput Assist Interv. 2006; 9(Pt 1):191-8. . View in PubMed

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