Keck School Faculty

Nerses Sanossian, MD
Nerses Sanossian, MD
Associate Professor of Neurology (Clinical Scholar);Director, Roxanna Todd Hodges Stroke Program
CHP 209C 1540 Alcazar Street Health Sciences Campus Los Angeles
My primary clinical research interest is in emergency evaluation and treatment of stroke focusing on the prehospital arena. Other research interests include imaging of stroke and transient ischemic attack as well as stroke prevention in the underserved. I am currently Associate Professor of Neurology (Clinical Scholar), and associate director of the Division of Neurocritical Care & Stroke at the University of Southern California. Administratively I serve as stroke fellowship director, medical director of Stroke Centers at LAC+USC Medical Center and USC Verdugo Hills Hospital and the Roxana Todd Hodges (RTH) Comprehensive Stroke Clinic. My experience in prehospital care includes serving in the leadership of the NIH-funded Field Administration of Stroke Therapy Magnesium (FAST-MAG) clinical trial as well a serving as a commissioner of Emergency Medical Services for Los Angeles County since 2012. In addition to Neurology and Vascular Neurology, I am board-certified in Neuroimaging through the United Council for Neurologic Subspecialties.

Intracerebral haemorrhage during alemtuzumab administration Lancet Neurol. 2019 Apr; 18(4):329-331. . View in PubMed

Quantification of intracranial arterial blood flow using noncontrast enhanced 4D dynamic MR angiography Magn Reson Med. 2019 Mar 07. . View in PubMed

Less Than Ideal Stroke. 2018 Dec 07; STROKEAHA118022644. . View in PubMed

Frequency, Predictors, and Outcomes of Prehospital and Early Postarrival Neurological Deterioration in Acute Stroke: Exploratory Analysis of the FAST-MAG Randomized Clinical Trial JAMA Neurol. 2018 Nov 01; 75(11):1364-1374. . View in PubMed

Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3 Int J Stroke. 2018 Oct; 13(7):759-765. . View in PubMed

Los Angeles Motor Scale to Identify Large Vessel Occlusion: Prehospital Validation and Comparison With Other Screens Stroke. 2018 03; 49(3):565-572. . View in PubMed

Association Between Hyperacute Stage Blood Pressure Variability and Outcome in Patients With Spontaneous Intracerebral Hemorrhage Stroke. 2018 02; 49(2):348-354. . View in PubMed

Letter by Chang et al Regarding Article, "Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial" Stroke. 2018 01; 49(1):e18. . View in PubMed

Hospital and demographic characteristics associated with inpatient neurological services in the United States Clin Neurol Neurosurg. 2018 01; 164:39-43. . View in PubMed

Efficacy of a Chronic Care-Based Intervention on Secondary Stroke Prevention Among Vulnerable Stroke Survivors: A Randomized Controlled Trial Circ Cardiovasc Qual Outcomes. 2018 Jan; 11(1):e003228. . View in PubMed

Hospital and demographic characteristics associated with inpatient neurological services in the United States Clin Neurol Neurosurg. 2018 Jan; 164:39-43. . View in PubMed

Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3 Int J Stroke. 2018 Jan 01; 1747493018772733. . View in PubMed

Depression Is Associated with a Higher Risk of Death among Stroke Survivors J Stroke Cerebrovasc Dis. 2017 Dec; 26(12):2870-2879. . View in PubMed

Minocycline and matrix metalloproteinase inhibition in acute intracerebral hemorrhage: a pilot study Eur J Neurol. 2017 Nov; 24(11):1384-1391. . View in PubMed

Tale of 2 Health-care Systems: Disparities in Demographic and Clinical Characteristics between 2 Ischemic Stroke Populations in Los Angeles County J Stroke Cerebrovasc Dis. 2017 Jun; 26(6):1357-1362. . View in PubMed

Age, sex, and race/ethnic temporal trends in metabolic syndrome prevalence among individuals with myocardial infarction or stroke in the United States J Neurol Sci. 2017 May 15; 376:24-28. . View in PubMed

Impact of the 2003 ACGME Resident Duty Hour Reform on Hospital-Acquired Conditions: A National Retrospective Analysis J Grad Med Educ. 2017 Apr; 9(2):215-221. . View in PubMed

Heads Up! A Novel Provocative Maneuver to Guide Acute Ischemic Stroke Management Interv Neurol. 2017 Mar; 6(1-2):8-15. . View in PubMed

Trends in Ventriculostomy-Associated Infections and Mortality in Aneurysmal Subarachnoid Hemorrhage: Data From the Nationwide Inpatient Sample World Neurosurg. 2017 Mar; 99:599-604. . View in PubMed

Randomized controlled trial of a coordinated care intervention to improve risk factor control after stroke or transient ischemic attack in the safety net: Secondary stroke prevention by Uniting Community and Chronic care model teams Early to End Disparities (SUCCEED) BMC Neurol. 2017 Feb 06; 17(1):24. . View in PubMed

Reconsidering Neuroprotection in the Reperfusion Era Stroke. 2017 12; 48(12):3413-3419. . View in PubMed

Minocycline and matrix metalloproteinase inhibition in acute intracerebral hemorrhage: a pilot study Eur J Neurol. 2017 11; 24(11):1384-1391. . View in PubMed

Paramedic Initiation of Neuroprotective Agent Infusions: Successful Achievement of Target Blood Levels and Attained Level Effect on Clinical Outcomes in the FAST-MAG Pivotal Trial (Field Administration of Stroke Therapy - Magnesium) Stroke. 2017 07; 48(7):1901-1907. . View in PubMed

A Dedicated Spanish Language Line Increases Enrollment of Hispanics Into Prehospital Clinical Research Stroke. 2017 05; 48(5):1389-1391. . View in PubMed

Field Validation of the Los Angeles Motor Scale as a Tool for Paramedic Assessment of Stroke Severity Stroke. 2017 02; 48(2):298-306. . View in PubMed

Utilization of Emergent Neuroimaging for Thrombolysis-Eligible Stroke Patients J Neuroimaging. 2017 01; 27(1):59-64. . View in PubMed

The coffee paradox in stroke: Increased consumption linked with fewer strokes Nutr Neurosci. 2016 Nov; 19(9):406-413. . View in PubMed

Trends in Transient Ischemic Attack Hospitalizations in the United States J Am Heart Assoc. 2016 Sep 24; 5(9). . View in PubMed

Trends in Acute Ischemic Stroke Hospitalizations in the United States J Am Heart Assoc. 2016 May 11; 5(5). . View in PubMed

Evaluation of time to aneurysm treatment following subarachnoid hemorrhage: comparison of patients treated with clipping versus coiling J Neurointerv Surg. 2016 Apr; 8(4):373-7. . View in PubMed

Characteristics and Outcomes of Very Elderly Enrolled in a Prehospital Stroke Research Study Stroke. 2016 11; 47(11):2737-2741. . View in PubMed

Trends in Acute Ischemic Stroke Hospitalizations in the United States J Am Heart Assoc. 2016 05 11; 5(5). . View in PubMed

Collateral flow as causative of good outcomes in endovascular stroke therapy J Neurointerv Surg. 2016 Jan; 8(1):2-7. . View in PubMed

Enrollment Yield and Reasons for Screen Failure in a Large Prehospital Stroke Trial Stroke. 2016 Jan; 47(1):232-5. . View in PubMed

Early Magnesium Treatment After Aneurysmal Subarachnoid Hemorrhage: Individual Patient Data Meta-Analysis Stroke. 2015 Nov; 46(11):3190-3. . View in PubMed

Routing Ambulances to Designated Centers Increases Access to Stroke Center Care and Enrollment in Prehospital Research Stroke. 2015 Oct; 46(10):2886-90. . View in PubMed

Variability in Criteria for Emergency Medical Services Routing of Acute Stroke Patients to Designated Stroke Center Hospitals West J Emerg Med. 2015 Sep; 16(5):743-6. . View in PubMed

Racial and socioeconomic disparities in outcomes following pediatric cerebrospinal fluid shunt procedures J Neurosurg Pediatr. 2015 Jun; 15(6):560-6. . View in PubMed

Incidence of "never events" among weekend admissions versus weekday admissions to US hospitals: national analysis BMJ. 2015 Apr 15; 350:h1460. . View in PubMed

Imaging of occlusive thrombi in acute ischemic stroke Int J Stroke. 2015 Apr; 10(3):298-305. . View in PubMed

Postischemic hyperperfusion on arterial spin labeled perfusion MRI is linked to hemorrhagic transformation in stroke J Cereb Blood Flow Metab. 2015 Mar 31; 35(4):630-7. . View in PubMed

Prehospital use of magnesium sulfate as neuroprotection in acute stroke N Engl J Med. 2015 Feb 05; 372(6):528-36. . View in PubMed

Reperfusion therapy in the acute management of ischemic stroke Cardiol Clin. 2015 Feb; 33(1):99-109. . View in PubMed

Imaging of prehospital stroke therapeutics Expert Rev Cardiovasc Ther. 2015; 13(9):1001-15. . View in PubMed

Basilar artery territory stroke secondary to invasive fungal sphenoid sinusitis: a case report and review of the literature Case Rep Neurol. 2015 Jan-Apr; 7(1):51-8. . View in PubMed

Health disparities in time to aneurysm clipping/coiling among aneurysmal subarachnoid hemorrhage patients: a national study World Neurosurg. 2014 Dec; 82(6):1071-6. . View in PubMed

Hospital and demographic characteristics associated with advanced primary stroke center designation Stroke. 2014 Dec; 45(12):3717-9. . View in PubMed

The impact of patient age and comorbidities on the occurrence of "never events" in cerebrovascular surgery: an analysis of the Nationwide Inpatient Sample J Neurosurg. 2014 Sep; 121(3):580-6. . View in PubMed

Expansion of US. emergency medical service routing for stroke care: 2000-2010. West J Emerg Med. 2014 Jul; 15(4):499-503. . View in PubMed

Racial and socioeconomic disparities in incidence of hospital-acquired complications following cerebrovascular procedures Neurosurgery. 2014 Jul; 75(1):43-50. . View in PubMed

Racial and socioeconomic disparities in access to mechanical revascularization procedures for acute ischemic stroke J Stroke Cerebrovasc Dis. 2014 Feb; 23(2):327-34. . View in PubMed

Methodology of the Field Administration of Stroke Therapy - Magnesium (FAST-MAG) phase 3 trial: Part 2 - prehospital study methods Int J Stroke. 2014 Feb; 9(2):220-5. . View in PubMed

Methodology of the Field Administration of Stroke Therapy - Magnesium (FAST-MAG) phase 3 trial: Part 1 - rationale and general methods Int J Stroke. 2014 Feb; 9(2):215-9. . View in PubMed

Predictive factors of neurological complications and one-month mortality after liver transplantation Front Neurol. 2014; 5:275. . View in PubMed

Bilateral Vision Loss Secondary to Pachymeningitis in a Patient with IgG4-Related Disease Front Neurol. 2014; 5:192. . View in PubMed

Magnesium: potential roles in neurovascular disease Front Neurol. 2014; 5:52. . View in PubMed

THRIVE score predicts outcomes with a third-generation endovascular stroke treatment device in the TREVO-2 trial Stroke. 2013 Dec; 44(12):3370-5. . View in PubMed

Impact of emergency medical services stroke routing protocols on Primary Stroke Center certification in California Stroke. 2013 Dec; 44(12):3584-6. . View in PubMed

Pre-Hospital Glyceryl Trinitrate: Potential for Use in Intracerebral Hemorrhage J Neurol Disord. 2013 Nov 14; 2(1). . View in PubMed

Mechanical thrombectomy in acute stroke: utilization variances and impact of procedural volume on inpatient mortality J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):1263-9. . View in PubMed

Trends in cancer diagnoses among inpatients hospitalized with stroke J Stroke Cerebrovasc Dis. 2013 Oct; 22(7):1146-50. . View in PubMed

The aging brain and cognition: contribution of vascular injury and aß to mild cognitive dysfunction JAMA Neurol. 2013 Apr; 70(4):488-95. . View in PubMed

FLAIR vascular hyperintensity preceding stroke in cryptococcal meningitis J Neuroimaging. 2013 Jan; 23(1):126-8. . View in PubMed

Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI PLoS One. 2013; 8(6):e65175. . View in PubMed

Cerebral microbleeds after use of extracorporeal membrane oxygenation in children J Neuroimaging. 2013 Jan; 23(1):75-8. . View in PubMed

Blogging about stroke: a new chapter for the journal Stroke. 2012 Dec; 43(12):3157. . View in PubMed

Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults Stroke. 2012 Nov; 43(11):2865-70. . View in PubMed

How well do blood flow imaging and collaterals on angiography predict brain at risk? Neurology. 2012 Sep 25; 79(13 Suppl 1):S105-9.. View in PubMed

Benefits of hemicraniectomy seen many years after malignant stroke in a young patient Front Neurol. 2012; 3:123. . View in PubMed

Fluid-attenuated inversion recovery vascular hyperintensities: an important imaging marker for cerebrovascular disease AJNR Am J Neuroradiol. 2011 Nov-Dec; 32(10):1771-5. . View in PubMed

The thrombus and discontinuity of FLAIR vascular hyperintensity Arch Neurol. 2011 Jul; 68(7):950-1. . View in PubMed

Leukoaraiosis and collaterals in acute ischemic stroke J Neuroimaging. 2011 Jul; 21(3):232-5. . View in PubMed

CT and MRI early vessel signs reflect clot composition in acute stroke Stroke. 2011 May; 42(5):1237-43. . View in PubMed

Subpar utilization of dental care among Americans with a history of stroke J Stroke Cerebrovasc Dis. 2011 May-Jun; 20(3):255-9. . View in PubMed

Randomized, controlled trial of an intervention to enable stroke survivors throughout the Los Angeles County safety net to "stay with the guidelines" Circ Cardiovasc Qual Outcomes. 2011 Mar; 4(2):229-34. . View in PubMed

Intercontinental elicitation of informed consent for enrollment in stroke research Cerebrovasc Dis. 2010 Aug; 30(3):323-4. . View in PubMed

Ruptured intracranial mycotic aneurysm in infective endocarditis: a natural history Case Rep Med. 2010; 2010. . View in PubMed

Prevention and management of stroke in very elderly patients Lancet Neurol. 2009 Nov; 8(11):1031-41. . View in PubMed

Angiography reveals that fluid-attenuated inversion recovery vascular hyperintensities are due to slow flow, not thrombus AJNR Am J Neuroradiol. 2009 Mar; 30(3):564-8. . View in PubMed

Indices of kidney dysfunction and discharge outcomes in hospitalized stroke patients without known renal disease Cerebrovasc Dis. 2009; 28(6):582-8. . View in PubMed

Patterns of influenza vaccination among stroke survivors Neuroepidemiology. 2009; 32(3):165-70. . View in PubMed

Simultaneous ring voice-over-Internet phone system enables rapid physician elicitation of explicit informed consent in prehospital stroke treatment trials Cerebrovasc Dis. 2009; 28(6):539-44. . View in PubMed

Prevalence and risk factors for cerebrovascular disease in community-dwelling Latinos Clin Neurol Neurosurg. 2008 Dec; 110(10):985-7. . View in PubMed

Probing racial and regional disparities in stroke mortality: same problem, different solutions? Ann Neurol. 2008 Nov; 64(5):483-4.. View in PubMed

A brief prehospital stroke severity scale identifies ischemic stroke patients harboring persisting large arterial occlusions Stroke. 2008 Aug; 39(8):2264-7. . View in PubMed

The risk of stroke within a week of minor stroke or transient ischemic attack Expert Opin Pharmacother. 2008 Aug; 9(12):2069-76. . View in PubMed

HDL-C and LDL-C: their role in stroke pathogenesis and implications for treatment Curr Treat Options Cardiovasc Med. 2008 Jun; 10(3):195-206. . View in PubMed

Cryptogenic stroke in the setting of intravaginal prostaglandin therapy for elective abortion Clin Neurol Neurosurg. 2008 May; 110(5):529-31. . View in PubMed

Niacin for stroke prevention: evidence and rationale CNS Neurosci Ther. 2008; 14(4):287-94. . View in PubMed

Drug insight: translating evidence on statin therapy into clinical benefits Nat Clin Pract Neurol. 2008 Jan; 4(1):43-9. . View in PubMed

FLAIR vascular hyperintensity may predict stroke after TIA Clin Neurol Neurosurg. 2007 Sep; 109(7):617-9. . View in PubMed

Prediction of hemorrhagic transformation after recanalization therapy using T2*-permeability magnetic resonance imaging Ann Neurol. 2007 Aug; 62(2):170-6. . View in PubMed

High-density lipoprotein cholesterol: an emerging target for stroke treatment Stroke. 2007 Mar; 38(3):1104-9. . View in PubMed

Aspirin and stroke severity Stroke. 2006 Nov; 37(11):2660; author reply 2661. . View in PubMed

Frequency and determinants of nonpublication of research in the stroke literature Stroke. 2006 Oct; 37(10):2588-92. . View in PubMed

Do high-density lipoprotein cholesterol levels influence stroke severity? J Stroke Cerebrovasc Dis. 2006 Sep-Oct; 15(5):187-9.. View in PubMed

Achieving target cholesterol goals after stroke: is in-hospital statin initiation the key? Arch Neurol. 2006 Aug; 63(8):1081-3.. View in PubMed

Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke Stroke. 2006 Aug; 37(8):2086-93. . View in PubMed

Are elevated admission calcium levels associated with better outcomes after ischemic stroke? Neurology. 2006 Jul 11; 67(1):170-3.. View in PubMed

Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke Neurology. 2006 Jun 13; 66(11):1745-6. . View in PubMed

Premorbid antiplatelet use and ischemic stroke outcomes Neurology. 2006 Feb 14; 66(3):319-23. . View in PubMed

Predictors of cerebral microbleeds in acute ischemic stroke and TIA patients Cerebrovasc Dis. 2006; 22(5-6):378-83. . View in PubMed

Multimodality stroke prevention Neurologist. 2006 Jan; 12(1):14-31. . View in PubMed

Chronic diarrhea associated with vagal nerve stimulation Neurology. 2002 Jan 22; 58(2):330. . View in PubMed

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