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Nitin Pandey, PhD

Assistant Professor of Research Physiology and Neuroscience

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Email npandey@usc.edu
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Publications

  • TDP43 and huntingtin Exon-1 undergo a conformationally specific interaction that strongly alters the fibril formation of both proteins. J Biol Chem. 2024 Sep; 300(9):107660.. View in PubMed
  • Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1. J Biol Chem. 2024 01; 300(1):105585.. View in PubMed
  • Amplification of neurotoxic HTTex1 assemblies in human neurons. Neurobiol Dis. 2021 11; 159:105517.. View in PubMed
  • Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted. Nat Commun. 2021 07 13; 12(1):4272.. View in PubMed
  • Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells. ACS Chem Neurosci. 2020 08 05; 11(15):2286-2295.. View in PubMed
  • Structure of Membrane-Bound Huntingtin Exon 1 Reveals Membrane Interaction and Aggregation Mechanisms. Structure. 2019 10 01; 27(10):1570-1580.e4.. View in PubMed
  • Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL. Biochim Biophys Acta Proteins Proteom. 2019 Jul – Aug; 1867(7-8):691-700.. View in PubMed
  • The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract. J Biol Chem. 2018 12 21; 293(51):19613-19623.. View in PubMed
  • Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Hum Mol Genet. 2018 07 01; 27(13):2330-2343.. View in PubMed
  • The 17-residue-long N terminus in huntingtin controls stepwise aggregation in solution and on membranes via different mechanisms. J Biol Chem. 2018 02 16; 293(7):2597-2605.. View in PubMed
  • Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet. 2017 Sep 02; 390(10098):946-958.. View in PubMed
  • Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils. Biochemistry. 2017 07 18; 56(28):3579-3586.. View in PubMed
  • Effects of urea, metal ions and surfactants on the binding of baicalein with bovine serum albumin. J Pharm Anal. 2016 Aug; 6(4):256-267.. View in PubMed
  • Bisphenol A reduces fertilizing ability and motility by compromising mitochondrial function of sperm. Environ Toxicol Chem. 2015 Jul; 34(7):1617-22.. View in PubMed
  • Evidence of two oxidation states of copper during aggregation of hen egg white lysozyme (HEWL). Int J Biol Macromol. 2015 May; 76:1-9.. View in PubMed
  • Effect of temperature and solvent on fibrillation of human serum albumin. Protein Pept Lett. 2015; 22(2):112-8.. View in PubMed
  • Copper(II) directs formation of toxic amorphous aggregates resulting in inhibition of hen egg white lysozyme fibrillation under alkaline salt-mediated conditions. J Biomol Struct Dyn. 2015; 33(5):991-1007.. View in PubMed
  • An insight into the ribonucleolytic and antiangiogenic activity of buffalo lactoferrin. J Biomol Struct Dyn. 2015; 33(1):184-95.. View in PubMed
  • Crowded milieu prevents fibrillation of hen egg white lysozyme with retention of enzymatic activity. J Photochem Photobiol B. 2014 Sep 05; 138:8-16.. View in PubMed
  • Effect of (-)-epigallocatechin gallate on the fibrillation of human serum albumin. Int J Biol Macromol. 2014 Sep; 70:312-9.. View in PubMed
  • Disruption of human serum albumin fibrils by a static electric field. Journal of Physics D: Applied Physics. 2014; 47:305401.
  • Fibrillation of human serum albumin shows nonspecific coordination on stoichiometric increment of Copper(II). J Biomol Struct Dyn. 2014; 32(9):1366-78.. View in PubMed
  • Distribution of protein Ramachandran psi (ψ) angle using non-resonance visible raman scattering measurements. J Phys Chem B. 2013 Nov 14; 117(45):13993-4000.. View in PubMed
  • Binding of hen egg white lysozyme fibrils with nucleic acids. J Photochem Photobiol B. 2013 Oct 05; 127:52-60.. View in PubMed
  • Fructose restrains fibrillogenesis in human serum albumin. Int J Biol Macromol. 2013 Oct; 61:424-32.. View in PubMed
  • Effect of surfactants on preformed fibrils of human serum albumin. Int J Biol Macromol. 2013 Aug; 59:39-45.. View in PubMed
  • Preferential binding of fisetin to the native state of bovine serum albumin: spectroscopic and docking studies. Mol Biol Rep. 2013 Apr; 40(4):3239-53.. View in PubMed
  • (-)-Epicatechin gallate prevents alkali-salt mediated fibrillogenesis of hen egg white lysozyme. Int J Biol Macromol. 2013 Mar; 54:90-8.. View in PubMed
  • Prolonged glycation of hen egg white lysozyme generates non amyloidal structures. PLoS One. 2013; 8(9):e74336.. View in PubMed
  • Fibrillation of hen egg white lysozyme triggers reduction of copper(II). Int J Biol Macromol. 2012 Jul-Aug; 51(1-2):1-6.. View in PubMed
  • Fibrillation in human serum albumin is enhanced in the presence of copper(II). J Phys Chem B. 2010 Aug 12; 114(31):10228-33.. View in PubMed

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