Oliver Bracko

Assistant Professor of Research Physiology and Neuroscience

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Overview

Oliver Bracko is Assistant Professor of Research in Physiology and Neuroscience at the USCEpstein Family Alzheimer’s Therapeutic Research Institute (ATRI).

Our research program aims to decipher the interplay of the brain microvasculature and the innate immune cells in chronic inflammatory neurodegenerative diseases using in vivo multiphoton imaging and state-of-the-art molecular tools.
The overarching goal is to shed light on the mechanisms underpinning the role of vascular-immune cell interactions in cognitive impairment across various aging disorders. Specifically, my research program focuses on elucidating the role of microvascular dysfunction and the innate immune system (including platelets and neutrophils) in Alzheimer’s Disease and related dementias. Specifically, we study how inflammatory processes triggered by neuroinflammation or in the periphery impact endothelial and innate immune cells, leading to brain-blood flow reductions, blood- brain barrier leakage, and immune cell-vascular interactions using in vivo imaging modalities and state-of- the-art molecular techniques.

Awards

  • McKnight Foundation & Florida Education Fund: Jones Mentor Award, 2026
  • University of Miami: Dean’s Excellence Award for Scholarly and Creative Activities, 2024
  • Cornell University: The Postdoc Achievement Award for Excellence in Teaching & Mentoring, 2018

Education and Training

  • Swiss Federal Institute of Technology Zurich , Zurich — PhD — Neuroscience
  • University of Tübingen, Tübingen — Diplom — Biology

Publications

  • Progranulin haploinsufficiency remodels the cerebral microvasculature and neurovascular unit. bioRxiv. 2026 Jul 22.. View in PubMed
  • Shared and disease-specific human brain vascular signatures in Alzheimer’s disease, frontotemporal dementia, and Huntington’s disease. bioRxiv. 2026 Jul 03.. View in PubMed
  • Systemic Piezo1 activation improves cerebrovascular function in Alzheimer’s disease. Alzheimers Dement. 2025 12; 21(12):e71016.. View in PubMed
  • Toxoplasma gondii impairs CX3CL1/fractalkine shedding from mouse cortical neurons, leading to microglia activation. Microbiol Spectr. 2025 Oct 07; 13(10):e0107425.. View in PubMed
  • Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes. Acta Neuropathol Commun. 2025 08 12; 13(1):171.. View in PubMed
  • One immune cell to bind them all: platelet contribution to neurodegenerative disease. Mol Neurodegener. 2024 09 27; 19(1):65.. View in PubMed
  • Resveratrol Mitigates Cognitive Impairments and Cholinergic Cell Loss in the Medial Septum in a Mouse Model of Gradual Cerebral Hypoperfusion. Antioxidants (Basel). 2024 Aug 14; 13(8).. View in PubMed
  • Revealing inconsistencies between Epworth scores and apnea-hypopnea index when evaluating obstructive sleep apnea severity: a clinical retrospective chart review. Front Neurol. 2024; 15:1387924.. View in PubMed
  • Circumscribing Laser Cuts Attenuate Seizure Propagation in a Mouse Model of Focal Epilepsy. Adv Sci (Weinh). 2024 08; 11(29):e2300747.. View in PubMed
  • A Brief Overview of Neutrophils in Neurological Diseases. Biomolecules. 2023 04 25; 13(5).. View in PubMed