Patrick Lyden

Professor of Physiology and Neuroscience and Neurology

NINDS/Neuro Next Program Support

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Overview

Dr. Lyden is the Professor of Physiology & Neuroscience and Neurology at the Zilkha Neurogenetic Institute in the Keck School of Medicine at USC. Dr. Lyden helped lead the pivotal NINDS t-PA for Acute Stroke Trial, the first proven therapy for stroke. He is recognized globally for leadership in stroke therapy, having led large, multi-national trials for NIH and industry. Dr. Lyden is the Principal investigator of the NINDS-sponsored Stroke Preclinical Assessment Network, or SPAN, the first multi-site trial intended to identify candidate treatments likely to succeed in human clinical trials. He is the Chair of the Stroke Council of the American Heart Association/American Stroke Association. Dr. Lyden has been elected a Fellow of the American Academy of Neurology, American Neurology Association, American Heart Association, and the European Stroke Organization. In 2019 he was awarded the prestigious William M. Feinberg Award for Excellence in Clinical Stroke by the American Heart Association. Beginning in 2023 he will lead a 100-center, $20M clinical trial of a new drug for stroke treatment in the NIH funded StrokeNet network.

Awards

  • Cedars-Sinai Medical Center: Faculty Teaching Award, 2020
  • UT Houston: Gladys & George T. Abell Lecturship in Neurology, 2019
  • American Heart Association/American Stroke Association: AHA/ASA William M. Feinberg Award for Excellence in Clinical Stroke, 2019
  • UCSD: Department of Neurosciences Award for Outstanding Teaching, 2014
  • University of Iowa: Adolf L. Sahs, MD Memorial Visiting Lecturer, 2011
  • American Heart Association, San Diego Affiliate: Heart of Gold Award, 2002
  • Best Doctors in America, 2001-now

Publications

  • Adverse Effects of Post-Recanalization Hemorrhagic Transformation: Asymptomatic but Not Inconsequential Neurology. 2024 Dec 10; 103(11):e210164. . View in PubMed
  • A cautionary view on blood pressure lowering in patients with acute ischaemic stroke receiving reperfusion therapy Lancet Neurol. 2024 Nov 25. . View in PubMed
  • Differential vulnerability among cell types in the neurovascular unit: Description and mechanisms J Cereb Blood Flow Metab. 2024 Nov 09; 271678X241299960. . View in PubMed
  • Effect of post thrombolytic intracerebral hemorrhage volume on 90-day outcomes in acute ischemic stroke patients J Stroke Cerebrovasc Dis. 2024 Nov; 33(11):107962. . View in PubMed
  • Before, during, and after: An Argument for Safety and Improved Outcome of Thrombolysis in Acute Ischemic Stroke with Direct Oral Anticoagulant Treatment Ann Neurol. 2024 Nov; 96(5):871-886. . View in PubMed
  • Correlating stroke risk with non-invasive cerebrovascular perfusion dynamics using a portable speckle contrast optical spectroscopy laser device Biomed Opt Express. 2024 Oct 01; 15(10):6083-6097. . View in PubMed
  • Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial Circ Res. 2024 Aug 16; 135(5):575-592. . View in PubMed
  • Correlating Stroke Risk with Non-Invasive Tracing of Brain Blood Dynamic via a Portable Speckle Contrast Optical Spectroscopy Laser Device ArXiv. 2024 Jul 23. . View in PubMed
  • Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial Acta Neuropathol Commun. 2024 Jun 28; 12(1):109. . View in PubMed
  • Differential Vulnerability and Response to Injury among Brain Cell Types Comprising the Neurovascular Unit J Neurosci. 2024 May 29; 44(22). . View in PubMed
  • Distinctive retinal peri-arteriolar versus peri-venular amyloid plaque distribution correlates with the cognitive performance bioRxiv. 2024 Feb 29. . View in PubMed
  • Post-Traumatic Cerebral Infarction: A Narrative Review of Pathophysiology, Diagnosis, and Treatment Neurol Int. 2024 Jan 04; 16(1):95-112. . View in PubMed
  • MRI in the Evaluation of Cryptogenic Stroke and Embolic Stroke of Undetermined Source Radiology. 2024 04; 311(1):e231934. . View in PubMed
  • New Picture Stimuli for the NIH Stroke Scale: A Validation Study Stroke. 2024 02; 55(2):443-451. . View in PubMed
  • Analysis of brain edema in RHAPSODY Int J Stroke. 2024 Jan; 19(1):68-75. . View in PubMed
  • Immunonutrition with Omega-3 Fatty Acid Supplementation in Severe TBI: Retrospective Analysis of Patient Characteristics and Outcomes Neurotrauma Rep. 2024; 5(1):574-583. . View in PubMed
  • Immunonutrition with Omega-3 Fatty Acid Supplementation in Severe TBI: Retrospective Analysis of Patient Characteristics and Outcomes Res Sq. 2023 Nov 07. . View in PubMed
  • Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations Biomedicines. 2023 Sep 17; 11(9). . View in PubMed
  • Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke Stroke. 2023 12; 54(12):3190-3201. . View in PubMed
  • Most Promising Approaches to Improve Stroke Outcomes: The Stroke Treatment Academic Industry Roundtable XII Workshop Stroke. 2023 12; 54(12):3202-3213. . View in PubMed
  • Enhancing Enrollment in Acute Stroke Trials: Current State and Consensus Recommendations Stroke. 2023 10; 54(10):2698-2707. . View in PubMed
  • Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial Stroke. 2023 02; 54(2):620-631. . View in PubMed
  • The difference between concealment and blinding in clinical trials and why both are importantA reply to Garg and Mickenautsch, BMC Medical Research Methodology (2022) 22:17. BMC Med Res Methodol. 2023 11 21; 23(1):275. . View in PubMed
  • A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke Sci Transl Med. 2023 09 20; 15(714):eadg8656. . View in PubMed
  • Disparate trends of atherosclerotic plaque evolution in stroke patients under 18-month follow-up: a 3D whole-brain magnetic resonance vessel wall imaging study Neuroradiol J. 2022 Feb; 35(1):42-52. . View in PubMed
  • 2022 Update From the American Stroke Association and the Stroke Council Stroke. 2022 08; 53(8):e383-e384. . View in PubMed
  • Bias in Stroke Evaluation: Rethinking the Cookie Theft Picture Stroke. 2022 06; 53(6):2123-2125. . View in PubMed
  • Therapeutic hypothermia for intracerebral hemorrhage: Systematic review and meta-analysis of the experimental and clinical literature Int J Stroke. 2022 06; 17(5):506-516. . View in PubMed
  • The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results Stroke. 2022 05; 53(5):1802-1812. . View in PubMed
  • Temporal Profile of Pneumonia After Stroke Stroke. 2022 01; 53(1):53-60. . View in PubMed
  • Pro-resolving lipid mediators in traumatic brain injury: emerging concepts and translational approach Am J Transl Res. 2022; 14(3):1482-1494. . View in PubMed
  • Consensus recommendations on therapeutic hypothermia after minimally invasive intracerebral hemorrhage evacuation from the hypothermia for intracerebral hemorrhage (HICH) working group Front Neurol. 2022; 13:859894. . View in PubMed
  • Association of Recent Use of Non-Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase JAMA. 2022 02 22; 327(8):760-771. . View in PubMed
  • Author Correction: Differential expression of circulating exosomal microRNAs in refractory intracranial atherosclerosis associated with antiangiogenesis Sci Rep. 2021 Jul 21; 11(1):15266. . View in PubMed
  • Munchausen Syndrome by Tissue Plasminogen Activator: Patients Seeking Thrombolytic Administration Neurol Clin Pract. 2021 Feb; 11(1):64-68. . View in PubMed
  • Encephaloduroarteriosynangiosis (EDAS) revascularization for symptomatic intracranial atherosclerotic steno-occlusive (ERSIAS) Phase-II objective performance criterion trial Int J Stroke. 2021 08; 16(6):701-709. . View in PubMed
  • Top Priorities for Cerebroprotective Studies-A Paradigm Shift: Report From STAIR XI Stroke. 2021 08; 52(9):3063-3071. . View in PubMed
  • Cerebroprotection for Acute Ischemic Stroke: Looking Ahead Stroke. 2021 08; 52(9):3033-3044. . View in PubMed
  • Diagnosis and Management of Cerebral Venous Sinus Thrombosis With Vaccine-Induced Immune Thrombotic Thrombocytopenia Stroke. 2021 07; 52(7):2478-2482. . View in PubMed
  • Temperature Management in Neurological and Neurosurgical Intensive Care Unit Ther Hypothermia Temp Manag. 2021 03; 11(1):7-9. . View in PubMed
  • Acute ischemic stroke versus transient ischemic attack: Differential plaque morphological features in symptomatic intracranial atherosclerotic lesions Atherosclerosis. 2021 02; 319:72-78. . View in PubMed
  • The future of neuroprotection in stroke J Neurol Neurosurg Psychiatry. 2021 02; 92(2):129-135. . View in PubMed
  • Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study Cells. 2021 10 28; 10(11). . View in PubMed
  • Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation Front Neurol. 2021; 12:593582. . View in PubMed
  • COVID-19 Impact on Acute Ischemic Stroke Treatment at 9 Comprehensive Stroke Centers across Los Angeles Cerebrovasc Dis. 2021; 50(6):707-714. . View in PubMed
  • Amendment on the article “Missing outcome data management in acute stroke trials testing iv thrombolytics: Is there risk of bias? ” Eur Stroke J. 2020 Dec; 5(4):453-454.. View in PubMed
  • Magnetic Resonance Vessel Wall Imaging in Central Nervous System Vasculitides: A Case Series Neurologist. 2020 Nov; 25(6):174-177. . View in PubMed
  • Acute ophthalmic artery occlusion in a COVID-19 patient on apixaban J Stroke Cerebrovasc Dis. 2020 Aug; 29(8):104982. . View in PubMed
  • Hemodynamic latency is associated with reduced intelligence across the lifespan: an fMRI DCM study of aging, cerebrovascular integrity, and cognitive ability Brain Struct Funct. 2020 Jul; 225(6):1705-1717. . View in PubMed
  • Is there risk of bias? Eur Stroke J. 2020 Jun; 5(2):148-154.. View in PubMed
  • COVID-19 hypothesis: Activated protein C for therapy of virus-induced pathologic thromboinflammation Res Pract Thromb Haemost. 2020 May; 4(4):506-509. . View in PubMed
  • Stroke, Research and Science in the Time of COVID Stroke. 2020 09; 51(9):2613-2614. . View in PubMed
  • 3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase Stroke. 2020 07; 51(7):2236-2239. . View in PubMed
  • Selective cerebral cooling for acute ischemic stroke J Cereb Blood Flow Metab. 2020 07; 40(7):1365-1367. . View in PubMed
  • Temperature Management in Neurological and Neurosurgical Intensive Care Unit Ther Hypothermia Temp Manag. 2020 06; 10(2):86-90. . View in PubMed
  • Assessing Cerebrovascular Hemodynamics Using Transcranial Doppler in Patients with Mechanical Circulatory Support Devices J Neuroimaging. 2020 05; 30(3):297-302. . View in PubMed
  • Measuring Outcome After Stroke: More Lessons Learned Again Stroke. 2020 04; 51(4):1053-1054. . View in PubMed
  • Training and Certifying Users of the National Institutes of Health Stroke Scale Stroke. 2020 03; 51(3):990-993. . View in PubMed
  • Current Advances in the Use of Therapeutic Hypothermia Ther Hypothermia Temp Manag. 2020 03; 10(1):2-5. . View in PubMed
  • Neuron-generated thrombin induces a protective astrocyte response via protease activated receptors Glia. 2020 02; 68(2):246-262. . View in PubMed
  • Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline Alzheimers Dement (Amst). 2020; 12(1):e12109. . View in PubMed
  • Therapeutic hypothermia and Type II errors: Do not throw out the baby with the ice water Brain Circ. 2019 Oct-Dec; 5(4):203-210. . View in PubMed
  • Differential Expression of Vascular Endothelial Growth Factor-A165 Isoforms Between Intracranial Atherosclerosis and Moyamoya Disease J Stroke Cerebrovasc Dis. 2019 Feb; 28(2):360-368. . View in PubMed
  • Thrombolytic Therapy for Acute Ischemic Stroke Stroke. 2019 09; 50(9):2597-2603. . View in PubMed
  • Differential effects of hypothermia on neurovascular unit determine protective or toxic results: Toward optimized therapeutic hypothermia J Cereb Blood Flow Metab. 2019 09; 39(9):1693-1709. . View in PubMed
  • Studies Targeting Stroke and Acute Myocardial Infarction Ther Hypothermia Temp Manag. 2019 03; 9(1):8-12. . View in PubMed
  • Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke Ann Neurol. 2019 01; 85(1):125-136. . View in PubMed
  • Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer’s disease mice Crit Care. 2019 02 22; 23(1):63. . View in PubMed
  • Neuroprotection and vasculoprotection using genetically targeted protease-ligands Brain Res. 2019 07 15; 1715:13-20. . View in PubMed
  • Differential expression of circulating exosomal microRNAs in refractory intracranial atherosclerosis associated with antiangiogenesis Sci Rep. 2019 12 19; 9(1):19429. . View in PubMed
  • Retinal Microvascular Abnormalities as Surrogate Markers of Cerebrovascular Ischemic Disease: A Meta-Analysis J Stroke Cerebrovasc Dis. 2018 Jul; 27(7):1960-1968. . View in PubMed
  • Can an anticoagulant reduce brain hemorrhage: Invited comment on “Dabigatran reduces endothelial permeability through inhibition of thrombin-induced cytoskeleton reorganization” Thromb Res. 2018 Jun 12. . View in PubMed
  • Local to Systemic Use of Hypothermia Ther Hypothermia Temp Manag. 2018 Mar; 8(1):4-8. . View in PubMed
  • Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data Lancet Neurol. 2018 10; 17(10):885-894. . View in PubMed
  • Unique Uses of Cooling Strategies Ther Hypothermia Temp Manag. 2018 09; 8(3):126-130. . View in PubMed
  • Paradoxical cerebrovascular hemodynamic changes with nicardipine J Neurosurg. 2018 04; 128(4):1015-1019. . View in PubMed
  • Lack of Early Improvement Predicts Poor Outcome Following Acute Intracerebral Hemorrhage Crit Care Med. 2018 04; 46(4):e310-e317. . View in PubMed
  • When less is more (brain)-comment on “Rivaroxaban plasma levels in acute ischemic stroke and intracerebral hemorrhage” Ann Neurol. 2018 03; 83(3):446-448. . View in PubMed
  • Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: Individual-patient-data meta-analysis of randomized trials Int J Stroke. 2018 02; 13(2):175-189. . View in PubMed
  • Cerebral Pulsatility Index Is Elevated in Patients with Elevated Right Atrial Pressure J Neuroimaging. 2018 01; 28(1):95-98. . View in PubMed
  • Hypothermia in acute ischemic stroke therapy Handb Clin Neurol. 2018; 157:823-837. . View in PubMed
  • Treatment Modality and Quality Benchmarks of Aneurysmal Subarachnoid Hemorrhage at a Comprehensive Stroke Center Front Neurol. 2018; 9:152. . View in PubMed
  • Perspectives on Temperature Management Ther Hypothermia Temp Manag. 2017 Dec; 7(4):188-192. . View in PubMed
  • Cerebral microemboli detection for monitoring structural cardiac disease Neurol Clin Pract. 2017 Oct; 7(5):409-412. . View in PubMed
  • Optimizing Outcomes for Mechanically Ventilated Patients in an Era of Endovascular Acute Ischemic Stroke Therapy J Intensive Care Med. 2017 Sep; 32(8):467-472. . View in PubMed
  • Meta-Analysis of Pre-Clinical Trials of Therapeutic Hypothermia for Intracerebral Hemorrhage Ther Hypothermia Temp Manag. 2017 Sep; 7(3):141-146. . View in PubMed
  • Intracerebral Hemorrhagic Expansion Occurs in Patients Using Non-Vitamin K Antagonist Oral Anticoagulants Comparable with Patients Using Warfarin J Stroke Cerebrovasc Dis. 2017 Aug; 26(8):1874-1882. . View in PubMed
  • Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study Lancet. 2017 Jun 17; 389(10087):2383-2392. . View in PubMed
  • Temperature Management in Neurological and Neurosurgical Intensive Care Unit Ther Hypothermia Temp Manag. 2017 Jun; 7(2):70-74. . View in PubMed
  • In Response J Stroke Cerebrovasc Dis. 2017 Feb; 26(2):454. . View in PubMed
  • Clinical Studies Targeting Stroke and Ischemic Insults Ther Hypothermia Temp Manag. 2017 Jan 20. . View in PubMed
  • 2018: The Beginning of a New Era J Cereb Blood Flow Metab. 2017 10; 37(10):3273-3275. . View in PubMed
  • Translational Stroke Research: Vision and Opportunities Stroke. 2017 09; 48(9):2632-2637. . View in PubMed
  • Brain Transforming Growth Factor-ß Resists Hypertension Via Regulating Microglial Activation Stroke. 2017 09; 48(9):2557-2564. . View in PubMed
  • Rethinking Training and Distribution of Vascular Neurology Interventionists in the Era of Thrombectomy Stroke. 2017 08; 48(8):2313-2317. . View in PubMed
  • Clinical Studies Targeting Stroke and Ischemic Insults Ther Hypothermia Temp Manag. 2017 03; 7(1):12-15. . View in PubMed
  • Using the National Institutes of Health Stroke Scale: A Cautionary Tale Stroke. 2017 02; 48(2):513-519. . View in PubMed
  • Migraine and the Risk of Carotid Artery Dissection in the IPSYS Registry: Are They Related? JAMA Neurol. 2017 05 01; 74(5):503-504.. View in PubMed
  • Transcranial Doppler Changes in Patients Treated with Extracorporeal Membrane Oxygenation J Stroke Cerebrovasc Dis. 2016 Dec; 25(12):2882-2885. . View in PubMed
  • Temperature Management in Neurological and Neurosurgical Intensive Care Unit Ther Hypothermia Temp Manag. 2016 Dec; 6(4):164-168. . View in PubMed
  • Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis Lancet Neurol. 2016 Aug; 15(9):925-933. . View in PubMed
  • Activated protein C promotes neuroprotection: mechanisms and translation to the clinic Thromb Res. 2016 May; 141 Suppl 2:S62-4. . View in PubMed
  • Online Tool to Improve Stratification of Adverse Events in Stroke Clinical Trials Stroke. 2016 Mar; 47(3):882-5. . View in PubMed
  • Clinical Studies Targeting Stroke and In-Hospital Cardiac Arrest Ther Hypothermia Temp Manag. 2016 Mar; 6(1):6-8. . View in PubMed
  • Current Advances in the Use of Therapeutic Hypothermia Ther Hypothermia Temp Manag. 2016 Mar; 6(1):2-5. . View in PubMed
  • Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2) Stroke. 2016 12; 47(12):2888-2895. . View in PubMed
  • Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection Stroke. 2016 12; 47(12):2979-2985. . View in PubMed
  • Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes: A Pooled Analysis of 9 Trials Stroke. 2016 09; 47(9):2373-9. . View in PubMed
  • Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke J Cereb Blood Flow Metab. 2016 07; 36(7):1157-64. . View in PubMed
  • Novel method for inducing rapid, controllable therapeutic hypothermia in rats using a perivascular implanted closed-loop cooling circuit J Neurosci Methods. 2016 07 15; 267:55-61. . View in PubMed
  • Troubleshooting the NIHSS: question-and-answer session with one of the designers Int J Stroke. 2015 Dec; 10(8):1284-6. . View in PubMed
  • Letter by Lahiri et al Regarding Article, “Endovascular Thrombectomy for Anterior Circulation Stroke: Systematic Review and Meta-Analysis” Stroke. 2015 Dec; 46(12):e258. . View in PubMed
  • Seizures and Meperidine: Overstated and Underutilized Ther Hypothermia Temp Manag. 2015 Dec; 5(4):223-7. . View in PubMed
  • Arabic cross cultural adaptation and validation of the National Institutes of Health Stroke Scale J Neurol Sci. 2015 Oct 15; 357(1-2):152-6. . View in PubMed
  • Microglia participate in neurogenic regulation of hypertension Hypertension. 2015 Aug; 66(2):309-16. . View in PubMed
  • Type of admission is associated with outcome of spontaneous subarachnoid hemorrhage Int J Stroke. 2015 Jun; 10(4):529-33. . View in PubMed
  • Why don’t more patients receive intravenous rt-PA for acute stroke? Expert Rev Neurother. 2015 Jun; 15(6):571-4.. View in PubMed
  • Teaching neuroImages: short stature, imperforate anus, and polydactyly: When is a hypothalamic mass an incidentaloma? Neurology. 2015 Apr 14; 84(15):e117.. View in PubMed
  • Thrombolysis in acute stroke–authors’ reply Lancet. 2015 Apr 11; 385(9976):1396. . View in PubMed
  • Aphasia and Dysarthria in Acute Stroke: Recovery and Functional Outcome Int J Stroke. 2015 Apr; 10(3):400-406. . View in PubMed
  • Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture Microcirculation. 2015 Apr; 22(3):204-218. . View in PubMed
  • Clinical studies targeting stroke Ther Hypothermia Temp Manag. 2015 Mar; 5(1):4-8. . View in PubMed
  • Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema Int J Stroke. 2015 Feb; 10(2):143-52. . View in PubMed
  • Protease activated receptor-1 mediates cytotoxicity during ischemia using in vivo and in vitro models Neuroscience. 2014 Dec 05; 281:229-40. . View in PubMed
  • Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials Lancet. 2014 Nov 29; 384(9958):1929-35. . View in PubMed
  • Challenges of decision making regarding futility in a randomized trial: the Interventional Management of Stroke III experience Stroke. 2014 May; 45(5):1408-14. . View in PubMed
  • Pooled assessment of computed tomography interpretation by vascular neurologists in the STRokE DOC telestroke network J Stroke Cerebrovasc Dis. 2014 Mar; 23(3):511-5. . View in PubMed
  • Direct thrombin inhibitor argatroban reduces stroke damage in 2 different models Stroke. 2014 Mar; 45(3):896-9. . View in PubMed
  • Representation of people with aphasia in randomized controlled trials of acute stroke interventions Int J Stroke. 2014 Feb; 9(2):174-82. . View in PubMed
  • Clinical use of computed tomographic perfusion for the diagnosis and prediction of lesion growth in acute ischemic stroke J Stroke Cerebrovasc Dis. 2014 Jan; 23(1):114-22. . View in PubMed
  • Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol Int J Stroke. 2014 Jan; 9(1):117-25. . View in PubMed
  • Does the cognitive measure Cog-4 show improvement among patients treated with thrombolysis after acute stroke? Int J Stroke. 2013 Dec; 8(8):652-6.. View in PubMed
  • Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats Stroke. 2013 Dec; 44(12):3529-36. . View in PubMed
  • Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices Stroke. 2013 Dec; 44(12):3596-601. . View in PubMed
  • Optically induced occlusion of single blood vessels in rodent neocortex Cold Spring Harb Protoc. 2013 Dec 01; 2013(12):1153-60. . View in PubMed
  • Mild hypothermia reduces tissue plasminogen activator-related hemorrhage and blood brain barrier disruption after experimental stroke: editorial commentary on tang et Al, 2013. Ther Hypothermia Temp Manag. 2013 Dec; 3(4):171-2. . View in PubMed
  • Preclinical and clinical studies targeting stroke Ther Hypothermia Temp Manag. 2013 Sep; 3(3):114-9. . View in PubMed
  • Acute Stroke Imaging Research Roadmap II Stroke. 2013 Sep; 44(9):2628-39. . View in PubMed
  • Hemorrhagic transformation during thrombolytic therapy and reperfusion: effects of age, blood pressure, and matrix metalloproteinases J Stroke Cerebrovasc Dis. 2013 May; 22(4):532-8. . View in PubMed
  • Preclinical and clinical studies targeting therapeutic hypothermia in cerebral ischemia and stroke Ther Hypothermia Temp Manag. 2013 Mar; 3(1):3-6. . View in PubMed
  • Thrombolysis in stroke despite contraindications or warnings? Stroke. 2013 Mar; 44(3):727-33.. View in PubMed
  • Determinants of Pneumonia Risk During Endovascular Hypothermia Ther Hypothermia Temp Manag. 2013 Mar; 3(1):24-27. . View in PubMed
  • Concurrent middle cerebral artery occlusion and intra-arterial drug infusion via ipsilateral common carotid artery catheter in the rat J Neurosci Methods. 2013 Feb 15; 213(1):63-9. . View in PubMed
  • Relationship between temperature, hematoma growth, and functional outcome after intracerebral hemorrhage Neurocrit Care. 2013 Feb; 18(1):45-53. . View in PubMed
  • PHLPP1 gene deletion protects the brain from ischemic injury J Cereb Blood Flow Metab. 2013 Feb; 33(2):196-204. . View in PubMed
  • Recovery from poststroke visual impairment: evidence from a clinical trials resource Neurorehabil Neural Repair. 2013 Feb; 27(2):133-41. . View in PubMed
  • The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit Nat Neurosci. 2013 Jan; 16(1):55-63. . View in PubMed
  • Correlations among impairment, daily activities and thinking operations after stroke NeuroRehabilitation. 2013; 33(1):153-60. . View in PubMed
  • Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers Curr Pharm Des. 2013; 19(42):7479-85. . View in PubMed
  • Overview of therapeutic hypothermia Curr Treat Options Neurol. 2012 Dec; 14(6):541-8. . View in PubMed
  • The effect of transfer and hospital volume in subarachnoid hemorrhage patients Neurocrit Care. 2012 Dec; 17(3):312-23. . View in PubMed
  • Sisyphus and translational stroke research Sci Transl Med. 2012 Oct 17; 4(156):156ps20. . View in PubMed
  • ß-adrenergic receptor inhibition affects cerebral glucose metabolism, motor performance, and inflammatory response after traumatic brain injury J Trauma Acute Care Surg. 2012 Jul; 73(1):33-40. . View in PubMed
  • Eagle syndrome revisited: cerebrovascular complicationsAnn Vasc Surg. 2012 Jul; 26(5):729. e1-5. . View in PubMed
  • Determinants of effective cooling during endovascular hypothermia Neurocrit Care. 2012 Jun; 16(3):413-20. . View in PubMed
  • In anticipation of International Stroke Trial-3 (IST-3) Stroke. 2012 Jun; 43(6):1691-4. . View in PubMed
  • Ther Hypothermia Temp Manag. 2012 Jun; 2(2):51-2. . View in PubMed
  • Thrombin activity associated with neuronal damage during acute focal ischemia J Neurosci. 2012 May 30; 32(22):7622-31. . View in PubMed
  • Stroke: Haemorrhage risk after thrombolysis–the SEDAN score Nat Rev Neurol. 2012 Apr 17; 8(5):246-7. . View in PubMed
  • Editorial on “A simple, assumption-free, and clinically interpretable approach for analysis of modified Rankin outcomes” Stroke. 2012 Mar; 43(3):621-2. . View in PubMed
  • The argatroban and tissue-type plasminogen activator stroke study: final results of a pilot safety study Stroke. 2012 Mar; 43(3):770-5. . View in PubMed
  • Response of blood pressure and blood glucose to treatment with recombinant tissue-type plasminogen activator in acute ischemic stroke: evidence from the virtual international stroke trials archive Stroke. 2012 Feb; 43(2):399-404. . View in PubMed
  • Tenecteplase for acute ischemic stroke Int J Stroke. 2011 Dec; 6(6):509-10. . View in PubMed
  • The future of basic science research and stroke: hubris and translational stroke research Int J Stroke. 2011 Oct; 6(5):412-3. . View in PubMed
  • Advanced brain imaging studies should not be performed in patients with suspected stroke presenting within 45 hours of symptom onset. Stroke. 2011 Sep; 42(9):2668-9. . View in PubMed
  • Low body temperature does not compromise the treatment effect of alteplase Stroke. 2011 Sep; 42(9):2618-21. . View in PubMed
  • Commentary: The endovascular procedure-specific neurological examination scheme J Endovasc Ther. 2011 Aug; 18(4):538-9. . View in PubMed
  • Small intracerebral haemorrhages are associated with less haematoma expansion and better outcomes Int J Stroke. 2011 Jun; 6(3):201-6. . View in PubMed
  • Anti-adrenergic medications and edema development after intracerebral hemorrhage Neurocrit Care. 2011 Jun; 14(3):395-400. . View in PubMed
  • Validation assessment of risk scores to predict postthrombolysis intracerebral haemorrhage Int J Stroke. 2011 Apr; 6(2):109-11. . View in PubMed
  • Home time is extended in patients with ischemic stroke who receive thrombolytic therapy: a validation study of home time as an outcome measure Stroke. 2011 Apr; 42(4):1046-50. . View in PubMed
  • Frequent early cardiac complications contribute to worse stroke outcome in atrial fibrillation Cerebrovasc Dis. 2011; 32(5):454-60. . View in PubMed
  • Developing clinical trials in stroke Ther Hypothermia Temp Manag. 2011; 1(4):175-8. . View in PubMed
  • The correlation of independency in activities of daily living performance with cognitive status and the intensity of neurological impairment in right-handed stroke patients NeuroRehabilitation. 2011; 29(3):311-6. . View in PubMed
  • Therapeutic hypothermia is associated with a decrease in urine output in acute stroke patients Resuscitation. 2010 Dec; 81(12):1642-7. . View in PubMed
  • Influence of age on outcome from thrombolysis in acute stroke: a controlled comparison in patients from the Virtual International Stroke Trials Archive (VISTA) Stroke. 2010 Dec; 41(12):2840-8. . View in PubMed
  • Strokes with minor symptoms: an exploratory analysis of the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials Stroke. 2010 Nov; 41(11):2581-6. . View in PubMed
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