Keck School Faculty

Plasma Aß42/Aß40 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer's disease Alzheimers Dement. 2023 Nov 06. . View in PubMed

The Sporadic Early-onset Alzheimer's Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Cohort Alzheimers Dement. 2023 Oct 18. . View in PubMed

Eligibility rates among racially and ethnically diverse US participants in Phase 2 and Phase 3 placebo-controlled, double-blind, randomized trials of lecanemab and elenbecestat in early Alzheimer's disease Ann Neurol. 2023 Oct 13. . View in PubMed

Pathogenic variants in the Longitudinal Early-onset Alzheimer's Disease Study cohort Alzheimers Dement. 2023 Oct 06. . View in PubMed

Trial of Solanezumab in Preclinical Alzheimer's Disease N Engl J Med. 2023 Sep 21; 389(12):1096-1107. . View in PubMed

The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022 Alzheimers Dement. 2023 Sep 12. . View in PubMed

Amyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Alzheimers Dement. 2023 Sep 10. . View in PubMed

Influence of amyloid and diagnostic syndrome on non-traditional memory scores in early-onset Alzheimer's disease Alzheimers Dement. 2023 Aug 31. . View in PubMed

Sex and APOE e4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease Alzheimers Dement. 2023 Jul 26. . View in PubMed

Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study Alzheimers Dement. 2023 Jul 25. . View in PubMed

White matter hyperintensities are higher among early-onset Alzheimer's disease participants than their cognitively normal and early-onset nonAD peers: Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Alzheimers Dement. 2023 Jul 25. . View in PubMed

Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort Alzheimers Dement. 2023 Jun 09. . View in PubMed

Profiling baseline performance on the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort near the midpoint of data collection Alzheimers Dement. 2023 May 31. . View in PubMed

Learning slopes in early-onset Alzheimer's disease Alzheimers Dement. 2023 May 27. . View in PubMed

Natural cubic splines for the analysis of Alzheimer's clinical trials Pharm Stat. 2023 May-Jun; 22(3):508-519. . View in PubMed

Safety and tolerability of lumbar puncture for the evaluation of Alzheimer's disease Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12431. . View in PubMed

Novel CYP1B1-RMDN2 Alzheimer's disease locus identified by genome-wide association analysis of cerebral tau deposition on PET medRxiv. 2023 Mar 22. . View in PubMed

The amyloid-ß pathway in Alzheimer's disease: a plain language summary Neurodegener Dis Manag. 2023 06; 13(3):141-149. . View in PubMed

Expectations and clinical meaningfulness of randomized controlled trials Alzheimers Dement. 2023 06; 19(6):2730-2736. . View in PubMed

Detection and treatment of Alzheimer's disease in its preclinical stage Nat Aging. 2023 05; 3(5):520-531. . View in PubMed

Improving generalizability and study design of Alzheimer's disease cohort studies in the United States by including under-represented populations Alzheimers Dement. 2023 04; 19(4):1549-1557. . View in PubMed

The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer's disease Alzheimers Dement. 2023 04; 19(4):1227-1233. . View in PubMed

Recommendations to address key recruitment challenges of Alzheimer's disease clinical trials Alzheimers Dement. 2023 02; 19(2):696-707. . View in PubMed

Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community-engaged approach in the Alzheimer's Disease Neuroimaging Initiative 4 Alzheimers Dement. 2023 01; 19(1):307-317. . View in PubMed

Tau positron emission tomography in preclinical Alzheimer's disease Brain. 2023 02 13; 146(2):700-711. . View in PubMed

Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab J Prev Alzheimers Dis. 2023; 10(2):171-177. . View in PubMed

Evaluation of Blood-Based Plasma Biomarkers as Potential Markers of Amyloid Burden in Preclinical Alzheimer's Disease J Alzheimers Dis. 2023; 92(1):95-107. . View in PubMed

Centralizing prescreening data collection to inform data-driven approaches to clinical trial recruitment Alzheimers Res Ther. 2023 05 02; 15(1):88. . View in PubMed

Lecanemab in Early Alzheimer's Disease N Engl J Med. 2023 01 05; 388(1):9-21. . View in PubMed

J Prev Alzheimers Dis. 2023; 10(3):418-425. . View in PubMed

Lecanemab: Appropriate Use Recommendations J Prev Alzheimers Dis. 2023; 10(3):362-377. . View in PubMed

Randomised controlled trials for the prevention of cognitive decline or dementia: A systematic review Ageing Res Rev. 2022 Dec; 82:101777. . View in PubMed

Traumatic brain injury and post-traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers Alzheimers Dement. 2022 Jun 29. . View in PubMed

ATRI EDC: a novel cloud-native remote data capture system for large multicenter Alzheimer's disease and Alzheimer's disease-related dementias clinical trails JAMIA Open. 2022 Apr; 5(1):ooab119. . View in PubMed

Corrigendum to: ATRI EDC: a novel cloud-native remote data capture system for large multicenter Alzheimer's disease and Alzheimer's disease-related dementias clinical trials JAMIA Open. 2022 Apr; 5(1):ooac008. . View in PubMed

Screening and enrollment of underrepresented ethnocultural and educational populations in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Alzheimers Dement. 2022 Feb 25. . View in PubMed

The use of lumbar puncture and safety recommendations in Alzheimer's disease: a plain language summary Neurodegener Dis Manag. 2022 10; 12(5):221-229. . View in PubMed

Designing the next-generation clinical care pathway for Alzheimer's disease Nat Aging. 2022 08; 2(8):692-703. . View in PubMed

Early-stage Alzheimer disease: getting trial-ready Nat Rev Neurol. 2022 07; 18(7):389-399. . View in PubMed

Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum Alzheimers Dement. 2022 07; 18(7):1370-1382. . View in PubMed

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease Alzheimers Dement. 2022 04; 18(4):824-857. . View in PubMed

State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease Alzheimers Dement. 2022 01; 18(1):159-177. . View in PubMed

Aducanumab: Appropriate Use Recommendations Update J Prev Alzheimers Dis. 2022; 9(2):221-230. . View in PubMed

Sensitivity of the Preclinical Alzheimer's Cognitive Composite (PACC), PACC5, and Repeatable Battery for Neuropsychological Status (RBANS) to Amyloid Status in Preclinical Alzheimer's Disease -Atabecestat Phase 2b/3 EARLY Clinical Trial J Prev Alzheimers Dis. 2022; 9(2):255-261. . View in PubMed

Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer's disease: a randomized trial Sci Rep. 2022 01 25; 12(1):1346. . View in PubMed

Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease J Prev Alzheimers Dis. 2022; 9(2):197-210. . View in PubMed

Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study Neurology. 2022 03 29; 98(13):e1327-e1336. . View in PubMed

The Ups and Downs of Amyloid in Alzheimer's J Prev Alzheimers Dis. 2022; 9(1):92-95. . View in PubMed

Amyloid-Related Imaging Abnormalities and Other MRI Findings in a Cognitively Unimpaired Population With and Without Cerebral Amyloid J Prev Alzheimers Dis. 2022; 9(4):617-624. . View in PubMed

Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology Brain. 2022 10 21; 145(10):3594-3607. . View in PubMed

J Prev Alzheimers Dis. 2022; 9(4):569-579. . View in PubMed

Impact of sex and APOE e4 on the association of cognition and hippocampal volume in clinically normal, amyloid positive adults Alzheimers Dement (Amst). 2022; 14(1):e12271. . View in PubMed

Tackling a Major Deficiency of Diversity in Alzheimer's Disease Therapeutic Trials: An CTAD Task Force Report J Prev Alzheimers Dis. 2022; 9(3):388-392. . View in PubMed

Editorial: We Have Turned the Corner J Prev Alzheimers Dis. 2022; 9(S1):S5-S6. . View in PubMed

Non-Amyloid. Where Does Consensus Lie Today? An CTAD Task Force Report. J Prev Alzheimers Dis. 2022; 9(2):231-235. . View in PubMed

Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer's disease Alzheimers Res Ther. 2022 04 19; 14(1):54. . View in PubMed

Alzheimer's Disease Clinical Trial Research Adaptation Following COVID-19 Pandemic Onset: National Sample of Alzheimer's Clinical Trial Consortium Sites J Prev Alzheimers Dis. 2022; 9(4):665-671. . View in PubMed

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease Nat Med. 2021 Jul; 27(7):1187-1196. . View in PubMed

The Longitudinal Early-onset Alzheimer's Disease Study (LEADS): Framework and methodology Alzheimers Dement. 2021 12; 17(12):2043-2055. . View in PubMed

The case for low-level BACE1 inhibition for the prevention of Alzheimer disease Nat Rev Neurol. 2021 11; 17(11):703-714. . View in PubMed

The Amyloid-ß Pathway in Alzheimer's Disease Mol Psychiatry. 2021 10; 26(10):5481-5503. . View in PubMed

Predicting amyloid risk by machine learning algorithms based on the A4 screen data: Application to the Japanese Trial-Ready Cohort study Alzheimers Dement (N Y). 2021; 7(1):e12135. . View in PubMed

The Computerized Cognitive Composite (C3) in an Alzheimer's Disease Secondary Prevention Trial J Prev Alzheimers Dis. 2021; 8(1):59-67. . View in PubMed

Pilot Evaluation of the Unsupervised, At-Home Cogstate Brief Battery in ADNI-2 J Alzheimers Dis. 2021; 83(2):915-925. . View in PubMed

Aducanumab: Appropriate Use Recommendations J Prev Alzheimers Dis. 2021; 8(4):398-410. . View in PubMed

Brain amyloid burden, sleep, and 24-hour rest/activity rhythms: screening findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration Studies Sleep Adv. 2021; 2(1):zpab015. . View in PubMed

Using Digital Tools to Advance Alzheimer's Drug Trials During a Pandemic: The EU/US CTAD Task Force J Prev Alzheimers Dis. 2021; 8(4):513-519. . View in PubMed

Detection of ß-amyloid positivity in Alzheimer's Disease Neuroimaging Initiative participants with demographics, cognition, MRI and plasma biomarkers Brain Commun. 2021; 3(2):fcab008. . View in PubMed

Editorial: How Will Aducanumab Approval Impact AD Research? J Prev Alzheimers Dis. 2021; 8(4):391-392.. View in PubMed

Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial Alzheimers Dement (Amst). 2021; 13(1):e12199. . View in PubMed

Aducanumab produced a clinically meaningful benefit in association with amyloid lowering Alzheimers Res Ther. 2021 05 10; 13(1):98. . View in PubMed

The Impact of Amyloid Burden and APOE on Rates of Cognitive Impairment in Late Life Depression J Alzheimers Dis. 2021; 80(3):991-1002. . View in PubMed

Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project Biol Psychiatry. 2021 04 15; 89(8):757-765. . View in PubMed

The Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD): A Novel Clinical Trials Training Program J Prev Alzheimers Dis. 2021; 8(3):286-291. . View in PubMed

Platform Trials to Expedite Drug Development in Alzheimer's Disease: A Report from the EU/US CTAD Task Force J Prev Alzheimers Dis. 2021; 8(3):306-312. . View in PubMed

Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease J Prev Alzheimers Dis. 2021; 8(3):240-248. . View in PubMed

New Hope for Alzheimer's Disease J Prev Alzheimers Dis. 2021; 8(3):238-239. . View in PubMed

Item-Level Investigation of Participant and Study Partner Report on the Cognitive Function Index from the A4 Study Screening Data J Prev Alzheimers Dis. 2021; 8(3):257-262. . View in PubMed

Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease: A Truncated Randomized Phase 2b/3 Clinical Trial JAMA Neurol. 2021 03 01; 78(3):293-301. . View in PubMed

Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial JAMA Netw Open. 2021 07 01; 4(7):e2114364. . View in PubMed

The search for Alzheimer disease therapeutics - same targets, better trials? Nat Rev Neurol. 2020 11; 16(11):597-598.. View in PubMed

Cognitive outcomes in trials of two BACE inhibitors in Alzheimer's disease Alzheimers Dement. 2020 11; 16(11):1483-1492. . View in PubMed

Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials J Neurol Neurosurg Psychiatry. 2020 11; 91(11):1201-1209. . View in PubMed

Initiation of symptomatic medication in Alzheimer's disease clinical trials: Hypothetical versus treatment policy approach Alzheimers Dement. 2020 05; 16(5):797-803. . View in PubMed

Data-Driven Participant Recruitment: Findings from the Alzheimer's Disease Neuroimaging Initiative 3 J Prev Alzheimers Dis. 2020; 7(2):122-127. . View in PubMed

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial JAMA Neurol. 2020 09 01; 77(9):1099-1109. . View in PubMed

Neuroanatomical spread of amyloid ß and tau in Alzheimer's disease: implications for primary prevention Brain Commun. 2020; 2(1):fcaa007. . View in PubMed

Early Stages of Alzheimer's Disease: Evolving the Care Team for Optimal Patient Management Front Neurol. 2020; 11:592302. . View in PubMed

TRC-PAD: Accelerating Recruitment of AD Clinical Trials through Innovative Information Technology J Prev Alzheimers Dis. 2020; 7(4):226-233. . View in PubMed

BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer's disease brain Brain. 2020 12 01; 143(12):3816-3826. . View in PubMed

Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease JAMA Neurol. 2020 10 01; 77(10):1288-1298. . View in PubMed

Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals JAMA Neurol. 2020 06 01; 77(6):735-745. . View in PubMed

Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report J Prev Alzheimers Dis. 2020; 7(3):152-157. . View in PubMed

Authors response to D Umbricht, letter to the editor referring Futility Analyses in Alzheimer's Disease (AD) Clinical Trials: A Risky BusinessThe Journal of Prevention of Alzheimer's Disease, 2020. J Prev Alzheimers Dis. 2020; 7(4):300. . View in PubMed

The Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease (TRC-PAD) Project: An Overview J Prev Alzheimers Dis. 2020; 7(4):208-212. . View in PubMed

The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer's Disease (TRC-PAD): Experience from the First 3 Years J Prev Alzheimers Dis. 2020; 7(4):234-241. . View in PubMed

Short-term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment JAMA Neurol. 2020 12 01; 77(12):1504-1513. . View in PubMed

Predicting Amyloid Burden to Accelerate Recruitment of Secondary Prevention Clinical Trials J Prev Alzheimers Dis. 2020; 7(4):213-218. . View in PubMed

Recruitment into the Alzheimer Prevention Trials (APT) Webstudy for a Trial-Ready Cohort for Preclinical and Prodromal Alzheimer's Disease (TRC-PAD) J Prev Alzheimers Dis. 2020; 7(4):219-225. . View in PubMed

Viewpoint: Futility Analyses in Alzheimer's Disease (AD) Clinical Trials: A Risky Business J Prev Alzheimers Dis. 2020; 7(3):195-196. . View in PubMed

The Future of Anti-Amyloid Trials J Prev Alzheimers Dis. 2020; 7(3):146-151. . View in PubMed

Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study Alzheimers Dement (Amst). 2020; 12(1):e12118. . View in PubMed

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial JAMA Neurol. 2019 Oct 01; 76(10):1219-1229. . View in PubMed

Predicting the course of Alzheimer's progression Brain Inform. 2019 Jun 28; 6(1):6. . View in PubMed

Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease N Engl J Med. 2019 Apr 11; 380(15):1408-1420. . View in PubMed

Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults Neurobiol Aging. 2019 10; 82:110-119. . View in PubMed

Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study Alzheimers Dement. 2019 09; 15(9):1208-1217. . View in PubMed

A randomized clinical trial to evaluate home-based assessment of people over 75 years old Alzheimers Dement. 2019 05; 15(5):615-624. . View in PubMed

Alzheimer's Disease Clinical Trials: Moving Toward Successful Prevention CNS Drugs. 2019 02; 33(2):99-106. . View in PubMed

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative Alzheimers Dement. 2019 01; 15(1):106-152. . View in PubMed

The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease Alzheimers Dement (N Y). 2019; 5:308-318. . View in PubMed

What Next in AD Drug Development? J Prev Alzheimers Dis. 2019; 6(3):150.. View in PubMed

Plasma Biomarkers of AD Emerging as Essential Tools for Drug Development: An EU/US CTAD Task Force Report J Prev Alzheimers Dis. 2019; 6(3):169-173. . View in PubMed

Automated and manual hippocampal segmentation techniques: Comparison of results, reproducibility and clinical applicability Neuroimage Clin. 2019; 21:101574. . View in PubMed

Combination Therapy for Alzheimer's Disease: Perspectives of the EU/US CTAD Task Force J Prev Alzheimers Dis. 2019; 6(3):164-168. . View in PubMed

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer's Disease N Engl J Med. 2019 04 11; 380(15):1483-1485. . View in PubMed

Unsuccessful trials of therapies for Alzheimer's disease Lancet. 2019 01 05; 393(10166):29. . View in PubMed

Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force J Prev Alzheimers Dis. 2019; 6(3):157-163. . View in PubMed

Randomized, Placebo Controlled Trial of NPT088, A Phage-Derived, Amyloid-Targeted Treatment for Alzheimer's Disease J Prev Alzheimers Dis. 2019; 6(4):228-231. . View in PubMed

Further analyses of the safety of verubecestat in the phase 3 EPOCH trial of mild-to-moderate Alzheimer's disease Alzheimers Res Ther. 2019 08 07; 11(1):68. . View in PubMed

Advancing Alzheimer's Disease Treatment: Lessons from CTAD 2018 J Prev Alzheimers Dis. 2019; 6(3):198-203. . View in PubMed

Participant satisfaction with dementia prevention research: Results from Home-Based Assessment trial Alzheimers Dement. 2018 11; 14(11):1397-1405. . View in PubMed

Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial PLoS Med. 2018 09; 15(9):e1002660. . View in PubMed

Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials Alzheimers Dement. 2018 08; 14(8):1077-1087. . View in PubMed

Estimating the Evolution of Disease in the Parkinson's Progression Markers Initiative Neurodegener Dis. 2018; 18(4):173-190. . View in PubMed

Author response: A phase 3 trial of IV immunoglobulin for Alzheimer disease Neurology. 2018 01 16; 90(3):145. . View in PubMed

Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial JAMA Neurol. 2018 07 01; 75(7):834-841. . View in PubMed

Analysis of the Relationship of Cognitive Impairment and Functional Impairment in Mild Alzheimer's Disease in EXPEDITION 3 J Prev Alzheimers Dis. 2018; 5(3):184-187. . View in PubMed

Biomarker and Clinical Trial Design Support for Disease-Modifying Therapies: Report of a Survey of the EU/US: Alzheimer's Disease Task Force J Prev Alzheimers Dis. 2018; 5(2):103-109. . View in PubMed

Bayesian latent time joint mixed-effects model of progression in the Alzheimer's Disease Neuroimaging Initiative Alzheimers Dement (Amst). 2018; 10:657-668. . View in PubMed

A simulation study comparing slope model with mixed-model repeated measure to assess cognitive data in clinical trials of Alzheimer's disease Alzheimers Dement (N Y). 2018; 4:46-53. . View in PubMed

Defining the Optimal Target Population for Trials of Polyunsaturated Fatty Acid Supplementation Using the Erythrocyte Omega-3 Index: A Step Towards Personalized Prevention of Cognitive Decline? J Nutr Health Aging. 2018; 22(8):982-998.. View in PubMed

What We Learn from the CTAD (Clinical Trials Alzheimer's Disease) 2018 J Prev Alzheimers Dis. 2018; 5(4):214-215. . View in PubMed

Delayed-Start Analyses in the Phase 3 Solanezumab EXPEDITION3 Study in Mild Alzheimer's Disease J Prev Alzheimers Dis. 2018; 5(1):8-14. . View in PubMed

Identifying Better Outcome Measures to Improve Treatment of Agitation in Dementia: A Report from the EU/US/CTAD Task Force J Prev Alzheimers Dis. 2018; 5(2):98-102. . View in PubMed

J Prev Alzheimers Dis. 2018; 5(3):171-174. . View in PubMed

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease N Engl J Med. 2018 05 03; 378(18):1691-1703. . View in PubMed

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease Neurobiol Aging. 2017 Dec; 60:92-103. . View in PubMed

Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid ß Alzheimers Dement. 2017 Sep; 13(9):1004-1012. . View in PubMed

On the path to 2025: understanding the Alzheimer's disease continuum Alzheimers Res Ther. 2017 Aug 09; 9(1):60. . View in PubMed

Randomized controlled trials in mild cognitive impairment: Sources of variability Neurology. 2017 May 02; 88(18):1751-1758. . View in PubMed

A phase 3 trial of IV immunoglobulin for Alzheimer disease Neurology. 2017 May 02; 88(18):1768-1775. . View in PubMed

The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement Alzheimers Dement. 2017 May; 13(5):561-571. . View in PubMed

Association between tau deposition and antecedent amyloid-ß accumulation rates in normal and early symptomatic individuals Brain. 2017 May 01; 140(5):1499-1512. . View in PubMed

Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials Alzheimers Dement. 2017 Apr; 13(4):e1-e85. . View in PubMed

Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary Report Alzheimers Dement (N Y). 2017 06; 3(2):177-188. . View in PubMed

EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials J Prev Alzheimers Dis. 2017; 4(2):116-124. . View in PubMed

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease J Neuroinflammation. 2017 01 03; 14(1):1. . View in PubMed

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons JAMA. 2017 06 13; 317(22):2305-2316. . View in PubMed

Continuing Progress in Alzheimer's Disease Trials: Cause for Optimism J Prev Alzheimers Dis. 2017; 4(4):211-212. . View in PubMed

Editorial: Collaborative Efforts to Prevent Alzheimer's Disease J Nutr Health Aging. 2017; 21(10):1072-1074. . View in PubMed

Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment J Alzheimers Dis. 2017; 56(1):229-237. . View in PubMed

Elevated Brain Amyloid in Cognitively Normal Individuals-Reply JAMA. 2017 10 10; 318(14):1393-1394. . View in PubMed

Cross-validation of optimized composites for preclinical Alzheimer's disease Alzheimers Dement (N Y). 2017 Jan; 3(1):123-129. . View in PubMed

The Utility of the Cognitive Function Instrument (CFI) to Detect Cognitive Decline in Non-Demented Older Adults J Alzheimers Dis. 2017; 60(2):427-437. . View in PubMed

Statistical properties of continuous composite scales and implications for drug development J Biopharm Stat. 2017; 27(6):1104-1114. . View in PubMed

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease BMC Med Genomics. 2017 05 24; 10(Suppl 1):29. . View in PubMed

Re-Engineering Alzheimer Clinical Trials: Global Alzheimer's Platform Network J Prev Alzheimers Dis. 2016 Jun; 3(2):114-120. . View in PubMed

Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease Alzheimers Dement (N Y). 2016 Jun; 2(2):131-139. . View in PubMed

Vitamin E in aging persons with Down syndrome: A randomized, placebo-controlled clinical trial Neurology. 2016 May 31; 86(22):2071-6. . View in PubMed

The Feasibility of At-Home iPad Cognitive Testing For Use in Clinical Trials J Prev Alzheimers Dis. 2016 Mar; 3(1):8-12. . View in PubMed

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria Alzheimers Dement. 2016 Mar; 12(3):292-323. . View in PubMed

Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia Am J Geriatr Psychiatry. 2016 Feb; 24(2):126-35. . View in PubMed

Cognitive and functional changes associated with Aß pathology and the progression to mild cognitive impairment Neurobiol Aging. 2016 12; 48:172-181. . View in PubMed

Collaboration for Alzheimer's Prevention: Principles to guide data and sample sharing in preclinical Alzheimer's disease trials Alzheimers Dement. 2016 05; 12(5):631-2. . View in PubMed

Longitudinal decline in mild-to-moderate Alzheimer's disease: Analyses of placebo data from clinical trials Alzheimers Dement. 2016 05; 12(5):598-603. . View in PubMed

Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults JAMA Neurol. 2016 06 01; 73(6):721-32. . View in PubMed

Drug development in Alzheimer's disease: the path to 2025 Alzheimers Res Ther. 2016 09 20; 8:39. . View in PubMed

Registries and Cohorts to Accelerate Early Phase Alzheimer's TrialsA Report from the E. U. /U. S. Clinical Trials in Alzheimer's Disease Task Force. J Prev Alzheimers Dis. 2016; 3(2):68-74. . View in PubMed

Accelerating rates of cognitive decline and imaging markers associated with ß-amyloid pathology Neurology. 2016 05 17; 86(20):1887-96. . View in PubMed

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease Alzheimers Res Ther. 2016 06 30; 8:25. . View in PubMed

CAP--advancing the evaluation of preclinical Alzheimer disease treatments Nat Rev Neurol. 2016 Jan; 12(1):56-61. . View in PubMed

Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer's disease BMC Med Genomics. 2016 08 12; 9 Suppl 1:30. . View in PubMed

Global Alzheimer's Platform Trial Ready Cohorts for the Prevention of Alzheimer's Dementia J Prev Alzheimers Dis. 2016; 3(4):185-187. . View in PubMed

Correlation between Cognition and Function across the Spectrum of Alzheimer's Disease J Prev Alzheimers Dis. 2016; 3(3):138-144. . View in PubMed

JPAD Is Moving Fast J Prev Alzheimers Dis. 2016; 3(1):3-4. . View in PubMed

A Combined Measure of Cognition and Function for Clinical Trials: The Integrated Alzheimer's Disease Rating Scale (iADRS) J Prev Alzheimers Dis. 2015 Dec 01; 2(4):227-241. . View in PubMed

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern Alzheimers Dement. 2015 Dec; 11(12):1417-1429. . View in PubMed

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease Neurology. 2015 Oct 20; 85(16):1383-91. . View in PubMed

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP Brain. 2015 Oct; 138(Pt 10):3076-88. . View in PubMed

The transitional association between ß-amyloid pathology and regional brain atrophy Alzheimers Dement. 2015 Oct; 11(10):1171-9. . View in PubMed

FASTKD2 is associated with memory and hippocampal structure in older adults Mol Psychiatry. 2015 Oct; 20(10):1197-204. . View in PubMed

Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline J Alzheimers Dis. 2015 Sep 24; 48 Suppl 1:S171-91. . View in PubMed

Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease Alzheimers Dement. 2015 Sep; 11(9):1080-9. . View in PubMed

Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions Lancet Neurol. 2015 Sep; 14(9):926-944. . View in PubMed

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