Keck School Faculty

Paul Aisen

Paul Aisen

Professor of Neurology
Director, Alzheimer's Therapeutic Research Institute
Neurology
ATRI 9860 Mesa Rim Road Health Sciences Campus San Diego

Traumatic brain injury and post-traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers Alzheimers Dement. 2022 Jun 29. . View in PubMed

Corrigendum to: ATRI EDC: a novel cloud-native remote data capture system for large multicenter Alzheimer's disease and Alzheimer's disease-related dementias clinical trials JAMIA Open. 2022 Apr; 5(1):ooac008. . View in PubMed

ATRI EDC: a novel cloud-native remote data capture system for large multicenter Alzheimer's disease and Alzheimer's disease-related dementias clinical trails JAMIA Open. 2022 Apr; 5(1):ooab119. . View in PubMed

Screening and enrollment of underrepresented ethnocultural and educational populations in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Alzheimers Dement. 2022 Feb 25. . View in PubMed

The use of lumbar puncture and safety recommendations in Alzheimer's disease: a plain language summary Neurodegener Dis Manag. 2022 10; 12(5):221-229. . View in PubMed

Early-stage Alzheimer disease: getting trial-ready Nat Rev Neurol. 2022 07; 18(7):389-399. . View in PubMed

Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum Alzheimers Dement. 2022 07; 18(7):1370-1382. . View in PubMed

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease Alzheimers Dement. 2022 04; 18(4):824-857. . View in PubMed

State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease Alzheimers Dement. 2022 01; 18(1):159-177. . View in PubMed

Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study Neurology. 2022 03 29; 98(13):e1327-e1336. . View in PubMed

Impact of sex and APOE e4 on the association of cognition and hippocampal volume in clinically normal, amyloid positive adults Alzheimers Dement (Amst). 2022; 14(1):e12271. . View in PubMed

Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology Brain. 2022 10 21; 145(10):3594-3607. . View in PubMed

The Ups and Downs of Amyloid in Alzheimer's J Prev Alzheimers Dis. 2022; 9(1):92-95. . View in PubMed

Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer's disease: a randomized trial Sci Rep. 2022 01 25; 12(1):1346. . View in PubMed

Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease J Prev Alzheimers Dis. 2022; 9(2):197-210. . View in PubMed

Aducanumab: Appropriate Use Recommendations Update J Prev Alzheimers Dis. 2022; 9(2):221-230. . View in PubMed

Sensitivity of the Preclinical Alzheimer's Cognitive Composite (PACC), PACC5, and Repeatable Battery for Neuropsychological Status (RBANS) to Amyloid Status in Preclinical Alzheimer's Disease -Atabecestat Phase 2b/3 EARLY Clinical Trial J Prev Alzheimers Dis. 2022; 9(2):255-261. . View in PubMed

Non-Amyloid. Where Does Consensus Lie Today? An CTAD Task Force Report. J Prev Alzheimers Dis. 2022; 9(2):231-235. . View in PubMed

Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer's disease Alzheimers Res Ther. 2022 04 19; 14(1):54. . View in PubMed

Tackling a Major Deficiency of Diversity in Alzheimer's Disease Therapeutic Trials: An CTAD Task Force Report J Prev Alzheimers Dis. 2022; 9(3):388-392. . View in PubMed

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease Nat Med. 2021 Jul; 27(7):1187-1196. . View in PubMed

The Longitudinal Early-onset Alzheimer's Disease Study (LEADS): Framework and methodology Alzheimers Dement. 2021 12; 17(12):2043-2055. . View in PubMed

The case for low-level BACE1 inhibition for the prevention of Alzheimer disease Nat Rev Neurol. 2021 11; 17(11):703-714. . View in PubMed

The Amyloid-ß Pathway in Alzheimer's Disease Mol Psychiatry. 2021 10; 26(10):5481-5503. . View in PubMed

Platform Trials to Expedite Drug Development in Alzheimer's Disease: A Report from the EU/US CTAD Task Force J Prev Alzheimers Dis. 2021; 8(3):306-312. . View in PubMed

Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease J Prev Alzheimers Dis. 2021; 8(3):240-248. . View in PubMed

New Hope for Alzheimer's Disease J Prev Alzheimers Dis. 2021; 8(3):238-239. . View in PubMed

Item-Level Investigation of Participant and Study Partner Report on the Cognitive Function Index from the A4 Study Screening Data J Prev Alzheimers Dis. 2021; 8(3):257-262. . View in PubMed

Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial Alzheimers Dement (Amst). 2021; 13(1):e12199. . View in PubMed

Brain amyloid burden, sleep, and 24-hour rest/activity rhythms: screening findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration Studies Sleep Adv. 2021; 2(1):zpab015. . View in PubMed

Using Digital Tools to Advance Alzheimer's Drug Trials During a Pandemic: The EU/US CTAD Task Force J Prev Alzheimers Dis. 2021; 8(4):513-519. . View in PubMed

Aducanumab: Appropriate Use Recommendations J Prev Alzheimers Dis. 2021; 8(4):398-410. . View in PubMed

Aducanumab produced a clinically meaningful benefit in association with amyloid lowering Alzheimers Res Ther. 2021 05 10; 13(1):98. . View in PubMed

The Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD): A Novel Clinical Trials Training Program J Prev Alzheimers Dis. 2021; 8(3):286-291. . View in PubMed

Detection of ß-amyloid positivity in Alzheimer's Disease Neuroimaging Initiative participants with demographics, cognition, MRI and plasma biomarkers Brain Commun. 2021; 3(2):fcab008. . View in PubMed

Pilot Evaluation of the Unsupervised, At-Home Cogstate Brief Battery in ADNI-2 J Alzheimers Dis. 2021; 83(2):915-925. . View in PubMed

Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project Biol Psychiatry. 2021 04 15; 89(8):757-765. . View in PubMed

Editorial: How Will Aducanumab Approval Impact AD Research? J Prev Alzheimers Dis. 2021; 8(4):391-392.. View in PubMed

The Computerized Cognitive Composite (C3) in an Alzheimer's Disease Secondary Prevention Trial J Prev Alzheimers Dis. 2021; 8(1):59-67. . View in PubMed

Predicting amyloid risk by machine learning algorithms based on the A4 screen data: Application to the Japanese Trial-Ready Cohort study Alzheimers Dement (N Y). 2021; 7(1):e12135. . View in PubMed

The Impact of Amyloid Burden and APOE on Rates of Cognitive Impairment in Late Life Depression J Alzheimers Dis. 2021; 80(3):991-1002. . View in PubMed

Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease: A Truncated Randomized Phase 2b/3 Clinical Trial JAMA Neurol. 2021 03 01; 78(3):293-301. . View in PubMed

Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial JAMA Netw Open. 2021 07 01; 4(7):e2114364. . View in PubMed

Cognitive outcomes in trials of two BACE inhibitors in Alzheimer's disease Alzheimers Dement. 2020 11; 16(11):1483-1492. . View in PubMed

The search for Alzheimer disease therapeutics - same targets, better trials? Nat Rev Neurol. 2020 11; 16(11):597-598.. View in PubMed

Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials J Neurol Neurosurg Psychiatry. 2020 11; 91(11):1201-1209. . View in PubMed

Initiation of symptomatic medication in Alzheimer's disease clinical trials: Hypothetical versus treatment policy approach Alzheimers Dement. 2020 05; 16(5):797-803. . View in PubMed

Neuroanatomical spread of amyloid ß and tau in Alzheimer's disease: implications for primary prevention Brain Commun. 2020; 2(1):fcaa007. . View in PubMed

BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer's disease brain Brain. 2020 12 01; 143(12):3816-3826. . View in PubMed

Short-term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment JAMA Neurol. 2020 12 01; 77(12):1504-1513. . View in PubMed

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial JAMA Neurol. 2020 09 01; 77(9):1099-1109. . View in PubMed

Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease JAMA Neurol. 2020 10 01; 77(10):1288-1298. . View in PubMed

Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals JAMA Neurol. 2020 06 01; 77(6):735-745. . View in PubMed

Authors response to D Umbricht, letter to the editor referring Futility Analyses in Alzheimer's Disease (AD) Clinical Trials: A Risky BusinessThe Journal of Prevention of Alzheimer's Disease, 2020. J Prev Alzheimers Dis. 2020; 7(4):300. . View in PubMed

Early Stages of Alzheimer's Disease: Evolving the Care Team for Optimal Patient Management Front Neurol. 2020; 11:592302. . View in PubMed

Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study Alzheimers Dement (Amst). 2020; 12(1):e12118. . View in PubMed

The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer's Disease (TRC-PAD): Experience from the First 3 Years J Prev Alzheimers Dis. 2020; 7(4):234-241. . View in PubMed

Predicting Amyloid Burden to Accelerate Recruitment of Secondary Prevention Clinical Trials J Prev Alzheimers Dis. 2020; 7(4):213-218. . View in PubMed

Recruitment into the Alzheimer Prevention Trials (APT) Webstudy for a Trial-Ready Cohort for Preclinical and Prodromal Alzheimer's Disease (TRC-PAD) J Prev Alzheimers Dis. 2020; 7(4):219-225. . View in PubMed

TRC-PAD: Accelerating Recruitment of AD Clinical Trials through Innovative Information Technology J Prev Alzheimers Dis. 2020; 7(4):226-233. . View in PubMed

The Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease (TRC-PAD) Project: An Overview J Prev Alzheimers Dis. 2020; 7(4):208-212. . View in PubMed

Viewpoint: Futility Analyses in Alzheimer's Disease (AD) Clinical Trials: A Risky Business J Prev Alzheimers Dis. 2020; 7(3):195-196. . View in PubMed

The Future of Anti-Amyloid Trials J Prev Alzheimers Dis. 2020; 7(3):146-151. . View in PubMed

Data-Driven Participant Recruitment: Findings from the Alzheimer's Disease Neuroimaging Initiative 3 J Prev Alzheimers Dis. 2020; 7(2):122-127. . View in PubMed

Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report J Prev Alzheimers Dis. 2020; 7(3):152-157. . View in PubMed

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial JAMA Neurol. 2019 Oct 01; 76(10):1219-1229. . View in PubMed

Predicting the course of Alzheimer's progression Brain Inform. 2019 Jun 28; 6(1):6. . View in PubMed

Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease N Engl J Med. 2019 Apr 11; 380(15):1408-1420. . View in PubMed

Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults Neurobiol Aging. 2019 10; 82:110-119. . View in PubMed

Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study Alzheimers Dement. 2019 09; 15(9):1208-1217. . View in PubMed

A randomized clinical trial to evaluate home-based assessment of people over 75 years old Alzheimers Dement. 2019 05; 15(5):615-624. . View in PubMed

Alzheimer's Disease Clinical Trials: Moving Toward Successful Prevention CNS Drugs. 2019 02; 33(2):99-106. . View in PubMed

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative Alzheimers Dement. 2019 01; 15(1):106-152. . View in PubMed

Unsuccessful trials of therapies for Alzheimer's disease Lancet. 2019 01 05; 393(10166):29. . View in PubMed

The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease Alzheimers Dement (N Y). 2019; 5:308-318. . View in PubMed

What Next in AD Drug Development? J Prev Alzheimers Dis. 2019; 6(3):150.. View in PubMed

Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force J Prev Alzheimers Dis. 2019; 6(3):157-163. . View in PubMed

Randomized, Placebo Controlled Trial of NPT088, A Phage-Derived, Amyloid-Targeted Treatment for Alzheimer's Disease J Prev Alzheimers Dis. 2019; 6(4):228-231. . View in PubMed

Further analyses of the safety of verubecestat in the phase 3 EPOCH trial of mild-to-moderate Alzheimer's disease Alzheimers Res Ther. 2019 08 07; 11(1):68. . View in PubMed

Automated and manual hippocampal segmentation techniques: Comparison of results, reproducibility and clinical applicability Neuroimage Clin. 2019; 21:101574. . View in PubMed

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer's Disease N Engl J Med. 2019 04 11; 380(15):1483-1485. . View in PubMed

Plasma Biomarkers of AD Emerging as Essential Tools for Drug Development: An EU/US CTAD Task Force Report J Prev Alzheimers Dis. 2019; 6(3):169-173. . View in PubMed

Combination Therapy for Alzheimer's Disease: Perspectives of the EU/US CTAD Task Force J Prev Alzheimers Dis. 2019; 6(3):164-168. . View in PubMed

Advancing Alzheimer's Disease Treatment: Lessons from CTAD 2018 J Prev Alzheimers Dis. 2019; 6(3):198-203. . View in PubMed

Participant satisfaction with dementia prevention research: Results from Home-Based Assessment trial Alzheimers Dement. 2018 11; 14(11):1397-1405. . View in PubMed

Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial PLoS Med. 2018 09; 15(9):e1002660. . View in PubMed

Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials Alzheimers Dement. 2018 08; 14(8):1077-1087. . View in PubMed

Analysis of the Relationship of Cognitive Impairment and Functional Impairment in Mild Alzheimer's Disease in EXPEDITION 3 J Prev Alzheimers Dis. 2018; 5(3):184-187. . View in PubMed

Defining the Optimal Target Population for Trials of Polyunsaturated Fatty Acid Supplementation Using the Erythrocyte Omega-3 Index: A Step Towards Personalized Prevention of Cognitive Decline? J Nutr Health Aging. 2018; 22(8):982-998.. View in PubMed

What We Learn from the CTAD (Clinical Trials Alzheimer's Disease) 2018 J Prev Alzheimers Dis. 2018; 5(4):214-215. . View in PubMed

Delayed-Start Analyses in the Phase 3 Solanezumab EXPEDITION3 Study in Mild Alzheimer's Disease J Prev Alzheimers Dis. 2018; 5(1):8-14. . View in PubMed

Identifying Better Outcome Measures to Improve Treatment of Agitation in Dementia: A Report from the EU/US/CTAD Task Force J Prev Alzheimers Dis. 2018; 5(2):98-102. . View in PubMed

Estimating the Evolution of Disease in the Parkinson's Progression Markers Initiative Neurodegener Dis. 2018; 18(4):173-190. . View in PubMed

J Prev Alzheimers Dis. 2018; 5(3):171-174. . View in PubMed

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease N Engl J Med. 2018 05 03; 378(18):1691-1703. . View in PubMed

Bayesian latent time joint mixed-effects model of progression in the Alzheimer's Disease Neuroimaging Initiative Alzheimers Dement (Amst). 2018; 10:657-668. . View in PubMed

A simulation study comparing slope model with mixed-model repeated measure to assess cognitive data in clinical trials of Alzheimer's disease Alzheimers Dement (N Y). 2018; 4:46-53. . View in PubMed

Biomarker and Clinical Trial Design Support for Disease-Modifying Therapies: Report of a Survey of the EU/US: Alzheimer's Disease Task Force J Prev Alzheimers Dis. 2018; 5(2):103-109. . View in PubMed

Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial JAMA Neurol. 2018 07 01; 75(7):834-841. . View in PubMed

Author response: A phase 3 trial of IV immunoglobulin for Alzheimer disease Neurology. 2018 01 16; 90(3):145. . View in PubMed

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease Neurobiol Aging. 2017 Dec; 60:92-103. . View in PubMed

Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid ß Alzheimers Dement. 2017 Sep; 13(9):1004-1012. . View in PubMed

On the path to 2025: understanding the Alzheimer's disease continuum Alzheimers Res Ther. 2017 Aug 09; 9(1):60. . View in PubMed

Randomized controlled trials in mild cognitive impairment: Sources of variability Neurology. 2017 May 02; 88(18):1751-1758. . View in PubMed

A phase 3 trial of IV immunoglobulin for Alzheimer disease Neurology. 2017 May 02; 88(18):1768-1775. . View in PubMed

Association between tau deposition and antecedent amyloid-ß accumulation rates in normal and early symptomatic individuals Brain. 2017 May 01; 140(5):1499-1512. . View in PubMed

The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement Alzheimers Dement. 2017 May; 13(5):561-571. . View in PubMed

Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials Alzheimers Dement. 2017 Apr; 13(4):e1-e85. . View in PubMed

Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary Report Alzheimers Dement (N Y). 2017 06; 3(2):177-188. . View in PubMed

Elevated Brain Amyloid in Cognitively Normal Individuals-Reply JAMA. 2017 10 10; 318(14):1393-1394. . View in PubMed

Statistical properties of continuous composite scales and implications for drug development J Biopharm Stat. 2017; 27(6):1104-1114. . View in PubMed

Editorial: Collaborative Efforts to Prevent Alzheimer's Disease J Nutr Health Aging. 2017; 21(10):1072-1074. . View in PubMed

Continuing Progress in Alzheimer's Disease Trials: Cause for Optimism J Prev Alzheimers Dis. 2017; 4(4):211-212. . View in PubMed

The Utility of the Cognitive Function Instrument (CFI) to Detect Cognitive Decline in Non-Demented Older Adults J Alzheimers Dis. 2017; 60(2):427-437. . View in PubMed

Cross-validation of optimized composites for preclinical Alzheimer's disease Alzheimers Dement (N Y). 2017 Jan; 3(1):123-129. . View in PubMed

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease BMC Med Genomics. 2017 05 24; 10(Suppl 1):29. . View in PubMed

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease J Neuroinflammation. 2017 01 03; 14(1):1. . View in PubMed

Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment J Alzheimers Dis. 2017; 56(1):229-237. . View in PubMed

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons JAMA. 2017 06 13; 317(22):2305-2316. . View in PubMed

EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials J Prev Alzheimers Dis. 2017; 4(2):116-124. . View in PubMed

Re-Engineering Alzheimer Clinical Trials: Global Alzheimer's Platform Network J Prev Alzheimers Dis. 2016 Jun; 3(2):114-120. . View in PubMed

Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease Alzheimers Dement (N Y). 2016 Jun; 2(2):131-139. . View in PubMed

Vitamin E in aging persons with Down syndrome: A randomized, placebo-controlled clinical trial Neurology. 2016 May 31; 86(22):2071-6. . View in PubMed

The Feasibility of At-Home iPad Cognitive Testing For Use in Clinical Trials J Prev Alzheimers Dis. 2016 Mar; 3(1):8-12. . View in PubMed

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria Alzheimers Dement. 2016 Mar; 12(3):292-323. . View in PubMed

Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia Am J Geriatr Psychiatry. 2016 Feb; 24(2):126-35. . View in PubMed

Cognitive and functional changes associated with Aß pathology and the progression to mild cognitive impairment Neurobiol Aging. 2016 12; 48:172-181. . View in PubMed

Longitudinal decline in mild-to-moderate Alzheimer's disease: Analyses of placebo data from clinical trials Alzheimers Dement. 2016 05; 12(5):598-603. . View in PubMed

Collaboration for Alzheimer's Prevention: Principles to guide data and sample sharing in preclinical Alzheimer's disease trials Alzheimers Dement. 2016 05; 12(5):631-2. . View in PubMed

Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer's disease BMC Med Genomics. 2016 08 12; 9 Suppl 1:30. . View in PubMed

Correlation between Cognition and Function across the Spectrum of Alzheimer's Disease J Prev Alzheimers Dis. 2016; 3(3):138-144. . View in PubMed

Accelerating rates of cognitive decline and imaging markers associated with ß-amyloid pathology Neurology. 2016 05 17; 86(20):1887-96. . View in PubMed

Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults JAMA Neurol. 2016 06 01; 73(6):721-32. . View in PubMed

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease Alzheimers Res Ther. 2016 06 30; 8:25. . View in PubMed

Drug development in Alzheimer's disease: the path to 2025 Alzheimers Res Ther. 2016 09 20; 8:39. . View in PubMed

Registries and Cohorts to Accelerate Early Phase Alzheimer's TrialsA Report from the E. U. /U. S. Clinical Trials in Alzheimer's Disease Task Force. J Prev Alzheimers Dis. 2016; 3(2):68-74. . View in PubMed

CAP--advancing the evaluation of preclinical Alzheimer disease treatments Nat Rev Neurol. 2016 Jan; 12(1):56-61. . View in PubMed

Global Alzheimer's Platform Trial Ready Cohorts for the Prevention of Alzheimer's Dementia J Prev Alzheimers Dis. 2016; 3(4):185-187. . View in PubMed

JPAD Is Moving Fast J Prev Alzheimers Dis. 2016; 3(1):3-4. . View in PubMed

A Combined Measure of Cognition and Function for Clinical Trials: The Integrated Alzheimer's Disease Rating Scale (iADRS) J Prev Alzheimers Dis. 2015 Dec 01; 2(4):227-241. . View in PubMed

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern Alzheimers Dement. 2015 Dec; 11(12):1417-1429. . View in PubMed

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease Neurology. 2015 Oct 20; 85(16):1383-91. . View in PubMed

FASTKD2 is associated with memory and hippocampal structure in older adults Mol Psychiatry. 2015 Oct; 20(10):1197-204. . View in PubMed

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP Brain. 2015 Oct; 138(Pt 10):3076-88. . View in PubMed

The transitional association between ß-amyloid pathology and regional brain atrophy Alzheimers Dement. 2015 Oct; 11(10):1171-9. . View in PubMed

Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline J Alzheimers Dis. 2015 Sep 24; 48 Suppl 1:S171-91. . View in PubMed

Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease Alzheimers Dement. 2015 Sep; 11(9):1080-9. . View in PubMed

Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions Lancet Neurol. 2015 Sep; 14(9):926-944. . View in PubMed

Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials Alzheimers Dement. 2015 Sep; 11(9):1069-79. . View in PubMed

Delayed-start analysis: Mild Alzheimer's disease patients in solanezumab trials, 35 years. Alzheimers Dement (N Y). 2015 Sep; 1(2):111-121. . View in PubMed

Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014 Alzheimers Dement. 2015 Jul; 11(7):865-84. . View in PubMed

The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans Alzheimers Dement. 2015 Jul; 11(7):772-91. . View in PubMed

HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer's disease in a three cohorts study Mol Psychiatry. 2015 Jul; 20(7):867-73. . View in PubMed

Alzheimer's Disease Neuroimaging Initiative 2 Clinical Core: Progress and plans Alzheimers Dement. 2015 Jul; 11(7):734-9. . View in PubMed

The Alzheimer's Disease Neuroimaging Initiative phase 2: Increasing the length, breadth, and depth of our understanding Alzheimers Dement. 2015 Jul; 11(7):823-31. . View in PubMed

Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force J Prev Alzheimers Dis. 2015 Jun; 2(2):128-135. . View in PubMed

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception Alzheimers Dement. 2015 Jun; 11(6):e1-120. . View in PubMed

Predicting Reduction of Cerebrospinal Fluid ß-Amyloid 42 in Cognitively Healthy Controls JAMA Neurol. 2015 May; 72(5):554-60. . View in PubMed

Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease Ann Clin Transl Neurol. 2015 May; 2(5):534-47. . View in PubMed

Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument JAMA Neurol. 2015 Apr; 72(4):446-54. . View in PubMed

Advances in Alzheimer's disease drug development BMC Med. 2015 Mar 25; 13:62. . View in PubMed

Brain structure and function as mediators of the effects of amyloid on memory Neurology. 2015 Mar 17; 84(11):1136-44. . View in PubMed

Protective variant for hippocampal atrophy identified by whole exome sequencing Ann Neurol. 2015 Mar; 77(3):547-52. . View in PubMed

Alzheimer's disease progression by geographical region in a clinical trial setting Alzheimers Res Ther. 2015; 7(1):43. . View in PubMed

Cognitive and functional decline and their relationship in patients with mild Alzheimer's dementia J Alzheimers Dis. 2015; 43(3):949-55. . View in PubMed

Alzheimers Res Ther. 2015; 7(1):36. . View in PubMed

Cognitive Impairment Precedes and Predicts Functional Impairment in Mild Alzheimer's Disease J Alzheimers Dis. 2015; 47(1):205-14. . View in PubMed

The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome Front Behav Neurosci. 2015; 9:239. . View in PubMed

Comparing recruitment, retention, and safety reporting among geographic regions in multinational Alzheimer's disease clinical trials Alzheimers Res Ther. 2015; 7(1):39. . View in PubMed

Advances in the therapy of Alzheimer's disease: targeting amyloid beta and tau and perspectives for the future Expert Rev Neurother. 2015 Jan; 15(1):83-105. . View in PubMed

Cognitive/Clinical Endpoints for Pre-Dementia AD Trials J Prev Alzheimers Dis. 2015; 2(2):82-84. . View in PubMed

Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment Neurobiol Aging. 2015 Jan; 36(1):273-82. . View in PubMed

The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations J Prev Alzheimers Dis. 2014 Dec; 1(3):181-202. . View in PubMed

2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease Alzheimers Dement. 2014 Oct; 10(5 Suppl):S430-52. . View in PubMed

Estimating long-term multivariate progression from short-term data Alzheimers Dement. 2014 Oct; 10(5 Suppl):S400-10. . View in PubMed

The Alzheimer's disease cooperative study prevention instrument project: longitudinal outcome of behavioral measures as predictors of cognitive decline Dement Geriatr Cogn Dis Extra. 2014 Sep-Dec; 4(3):509-16. . View in PubMed

The preclinical Alzheimer cognitive composite: measuring amyloid-related decline JAMA Neurol. 2014 Aug; 71(8):961-70. . View in PubMed

Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis Neurology. 2014 Jul 15; 83(3):253-60. . View in PubMed

Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative Alzheimers Dement. 2014 Jun; 10(3 Suppl):S226-35. . View in PubMed

Alzheimer's Disease Cooperative Study Prevention Instrument Project assessing resource use and volunteer and paid work in healthy elders: a longitudinal study J Am Geriatr Soc. 2014 May; 62(5):985-8. . View in PubMed

Clinical trial of an inhibitor of RAGE-Aß interactions in Alzheimer disease Neurology. 2014 Apr 29; 82(17):1536-42. . View in PubMed

Serum brain-derived neurotrophic factor and the risk for dementia JAMA. 2014 Apr 23-30; 311(16):1684-5. . View in PubMed

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020 Biochem Pharmacol. 2014 Apr 15; 88(4):426-49. . View in PubMed

The A4 study: stopping AD before symptoms begin? Sci Transl Med. 2014 Mar 19; 6(228):228fs13.. View in PubMed

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Paul Aisen, M.D., has been appointed founding director of USC ATRI. Aisen has been a leading figure in Alzheimer’s disease research for more than two decades, having developed novel methodologies as well as designed and directed many large therapeutic trials. He received his B.A. in biochemistry and molecular biology from Harvard and his medical degree from Columbia. He completed his residency at Case Western Reserve University in Cleveland and Mount Sinai Medical Center in New York, and then fellowship training in rheumatology at New York University. After serving as chief medical resident at Mount Sinai, he began a solo practice in internal medicine and rheumatology in New York. Aisen joined the faculty of Mount Sinai in 1994 and was recruited to Georgetown University in 1999 as a professor of neurology and medicine. That year, he founded the Memory Disorders Program, a clinical and research program for Alzheimer’s disease and related disorders. He continued basic research studies on therapeutic targets and biomarkers and designed and directed multicenter therapeutic trials. He became vice chair of the Department of Neurology at Georgetown in 2004. From 2007 through 2015, he was professor in the Department of Neurosciences at the University of California, San Diego and director of the Alzheimer’s Disease Cooperative Study.
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