Paul D Thomas, PhD

Professor of Population and Public Health Sciences and Quantitative and Computational Biology

Director of the Gene Sequence, Function, and Health Laboratory Initiative

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Overview

Trained in computational biology (specifically computational protein folding using statistical-mechanics based techniques with Dr. Ken Dill), Dr. Thomas turned to genomics as soon as the Human Genome Project began pilot work in 1995. The culmination of this early work was the publication of the paper describing the sequencing of the first human genome in 2001; Dr. Thomas led the work described in the 10-page section of the paper entitled “An overview of the predicted protein coding genes in the human genome.” Since that time, Dr. Thomas’s group has continued to innovate in the area of computational analysis of genomic data, with an emphasis on gene function and evolution. In addition to founding and continuing development on the PANTHER phylogenomics project, Dr. Thomas is a director of the Gene Ontology Consortium, one of the largest and best-known bioinformatics projects in the world.

Awards

  • Thomson-Reuters/Clarivate: Highly Cited Researcher (Biology and Biochemistry), 2014
     – 2020

Research Funding

  • Gene Ontology Consortium and Knowledgebase
    NIH · U24HG012212 · Jun 1, 2022 – Mar 31, 2027 · Role: Principal Investigator
  • Reactome and the Gene Ontology: Digital pathway convergence for core data resources
    NIH · U24HG011851 · Sep 24, 2021 – Jun 30, 2026 · Role: Co-Principal Investigator
  • EcoliHub2.0: A next-generation E. coli model organism resource (SRI Proposal ECU
    NIH · U24GM088849 · Aug 1, 2009 – Jul 31, 2015 · Role: Principal Investigator
  • Development and Maintenance of PANTHER Software
    NIH · R01GM081084 · Apr 1, 2008 – Mar 31, 2012 · Role: Principal Investigator
  • Gene Ontology Consortium
    NIH · U41HG002273 · Jan 19, 2001 – Feb 28, 2022 · Role: Principal Investigator

Publications

  • SNPWay: streamlined SNP-to-function and pathway over-representation analysis. bioRxiv. 2026 May 06.. View in PubMed
  • The Gene Ontology knowledgebase in 2026. Nucleic Acids Res. 2026 Jan 06; 54(D1):D1779-D1792.. View in PubMed
  • OrthoGrafter: Rapid Identification of Orthologs from Precomputed Placement in Phylogenetic Trees. J Mol Evol. 2025 12; 93(6):820-829.. View in PubMed
  • Quest for Orthologs in the era of Data Deluge and AI: Challenges and Innovations in Orthology Prediction and Data Integration. J Mol Evol. 2025 12; 93(6):702-719.. View in PubMed
  • Unveiling the functional fate of duplicated genes through expression profiling and structural analysis. Genome Res. 2025 10 01; 35(10):2273-2284.. View in PubMed
  • A compendium of human gene functions derived from evolutionary modelling. Nature. 2025 04; 640(8057):146-154.. View in PubMed
  • InterPro: the protein sequence classification resource in 2025. Nucleic Acids Res. 2025 Jan 06; 53(D1):D444-D456.. View in PubMed
  • New developments for the Quest for Orthologs benchmark service. NAR Genom Bioinform. 2024 Dec; 6(4):lqae167.. View in PubMed
  • Quest for Orthologs in the Era of Biodiversity Genomics. Genome Biol Evol. 2024 10 09; 16(10).. View in PubMed
  • Functional implications of glycans and their curation: insights from the workshop held at the 16th Annual International Biocuration Conference in Padua, Italy. Database (Oxford). 2024 08 13; 2024.. View in PubMed