Array

Assistant Professor of Pharmacology and Pharmaceutical Sciences

Image of Paul Seidler
Is this your profile? Click to edit

Publications

  • A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathway Chem Sci. 2023 Oct 18; 14(40):11022-11032. . View in PubMed
  • Selective inhibition of hsp90 paralogs: Structure and binding studies uncover the role of helix 1 in Grp94-selective ligand binding bioRxiv. 2023 Aug 01. . View in PubMed
  • A heterogeneously integrated lithium niobate-on-silicon nitride photonic platform Nat Commun. 2023 Jun 13; 14(1):3499. . View in PubMed
  • Improving the solubility of pseudo-hydrophobic Alzheimer’s Disease medicinal chemicals through co-crystal formulation bioRxiv. 2023 Apr 28. . View in PubMed
  • Ultrafast tunable lasers using lithium niobate integrated photonics Nature. 2023 03; 615(7952):411-417. . View in PubMed
  • Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils Proc Natl Acad Sci U S A. 2023 02 14; 120(7):e2217835120. . View in PubMed
  • Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient-extracted tau fibrils Proc Natl Acad Sci U S A. 2023 10 10; 120(41):e2300258120. . View in PubMed
  • Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils Nat Commun. 2023 04 25; 14(1):2379. . View in PubMed
  • Microwave-to-optical conversion with a gallium phosphide photonic crystal cavity Nat Commun. 2022 Apr 19; 13(1):2065. . View in PubMed
  • Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies Nat Struct Mol Biol. 2022 06; 29(6):529-536. . View in PubMed
  • Three-repeat and four-repeat tau isoforms form different oligomers Protein Sci. 2022 03; 31(3):613-627. . View in PubMed
  • De novo designed protein inhibitors of amyloid aggregation and seeding Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2206240119. . View in PubMed
  • Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro Nat Commun. 2022 09 16; 13(1):5451. . View in PubMed
  • Maximizing Completion of the Two-Dose COVID-19 Vaccine Series with Aid from Infographics Vaccines (Basel). 2021 Oct 22; 9(11). . View in PubMed
  • Correction to: Amyloid ß-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation Alzheimers Res Ther. 2021 Apr 19; 13(1):83. . View in PubMed
  • Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2 bioRxiv. 2021 Mar 18. . View in PubMed
  • Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer’s disease J Biol Chem. 2020 07 31; 295(31):10662-10676. . View in PubMed
  • Structure-based inhibitors of amyloid beta core suggest a common interface with tau Elife. 2019 10 15; 8. . View in PubMed
  • Amyloid ß-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation Alzheimers Res Ther. 2019 10 18; 11(1):86. . View in PubMed
  • Structure-based inhibitors halt prion-like seeding by Alzheimer’s disease-and tauopathy-derived brain tissue samples J Biol Chem. 2019 11 01; 294(44):16451-16464. . View in PubMed
  • Structure-based inhibitors of tau aggregation Nat Chem. 2018 02; 10(2):170-176. . View in PubMed
  • Common fibrillar spines of amyloid-ß and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors J Biol Chem. 2018 02 23; 293(8):2888-2902. . View in PubMed
  • Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED Nat Methods. 2017 Feb 13; 14(4):399-402. . View in PubMed
  • Characterization of the Grp94/OS-9 chaperone-lectin complex J Mol Biol. 2014 Oct 23; 426(21):3590-605. . View in PubMed
  • Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2 Nat Chem Biol. 2013 Nov; 9(11):677-84. . View in PubMed
  • Investigations of chemical modifications of amino-terminated organic films on silicon substrates and controlled protein immobilization Langmuir. 2010 Feb 16; 26(4):2599-608. . View in PubMed
  • Formation, structure, and reactivity of amino-terminated organic films on silicon substrates J Colloid Interface Sci. 2009 Jan 01; 329(1):114-9. . View in PubMed