Philippe Friedlich, MD

Professor of Clinical Pediatrics and Surgery

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Dr. Philippe Friedlich is a Professor of Clinical Pediatrics and Surgery at the University of Southern California and Interim Director & Division Chief for the Center for Fetal and Neonatal Medicine.

A fellow of the American Academy of Pediatrics, Dr. Friedlich holds memberships with the Society of Pediatric Research and the American Academy of Pediatrics Section on Perinatal Pediatrics. Dr. Friedlich is a member of the California Children’s Medical Services /California Children’s Services NICU Technical Advisory Committee.

Dr. Friedlich earned his medical degree from the University of Southern California and completed his pediatric residency and internship at the Children’s Hospital Los Angeles. He completed a fellowship in neonatal and perinatal medicine at the University of Southern California Women’s and Children’s Hospital before joining the faculty of the USC division of Neonatal Medicine in 1998. Dr. Friedlich completed in 2004 a Master of Science in Applied Biostatics and Epidemiology from the University of Southern California and earned a MBA in Medical Management from the University of Massachusetts at Amherst in 2006.

His areas of research interests include the epidemiology of congenital malformations and neonatal healthcare delivery and outcomes. Dr. Friedlich has published over 150 abstracts, peer review articles, book chapters and support strong research collaborations between surgical, medical and healthcare related disciplines in areas of clinical, translational and basic science.


  • Does early prostacyclin therapy decrease extracorporeal life support use in infants with congenital diaphragmatic hernia? J Perinatol. 2024 Apr; 44(4):594-597.. View in PubMed
  • Cerebrovascular responses to a 90° tilt in healthy neonates Pediatr Res. 2024 Jan 27. . View in PubMed
  • Sociodemographic profile associated with congenital heart disease among infants <1 year old J Pediatr Nurs. 2023 Nov-Dec; 73:e618-e623. . View in PubMed
  • Neonates with mild hypoxic-ischaemic encephalopathy receiving supportive care versus therapeutic hypothermia in California Arch Dis Child Fetal Neonatal Ed. 2022 May; 107(3):324-328. . View in PubMed
  • Cost-effectiveness analysis of extended extracorporeal membrane oxygenation duration in newborns with congenital diaphragmatic hernia in the United States Pediatr Neonatol. 2022 03; 63(2):139-145. . View in PubMed
  • Connecting to Early Intervention Services After Neonatal Intensive Care Unit Discharge in a Medicaid Sample Acad Pediatr. 2022 03; 22(2):253-262. . View in PubMed
  • The financial burden experienced by families of preterm infants after NICU discharge J Perinatol. 2022 02; 42(2):223-230. . View in PubMed
  • Predictors of venous thromboembolism among infants in children’s hospitals in the United States: a retrospective Pediatric Health Information Study J Perinatol. 2022 Jan; 42(1):103-109. . View in PubMed
  • The association of inborn status and resource utilization among neonates who received extracorporeal membrane oxygenation J Pediatr Surg. 2021 Dec; 56(12):2311-2317. . View in PubMed
  • Maternal post-traumatic stress and depression symptoms and outcomes after NICU discharge in a low-income sample: a cross-sectional study BMC Pregnancy Childbirth. 2021 Jan 12; 21(1):48. . View in PubMed
  • Readmissions in neonatal ECMO survivors: a pediatric health information system database analysis J Perinatol. 2021 07; 41(7):1777-1781. . View in PubMed
  • Proportion of Retinopathy of Prematurity That Was Treated across Regions in the United States Am J Perinatol. 2021 05; 38(6):581-589. . View in PubMed
  • The association of care transitions measure-15 score and outcomes after discharge from the NICU BMC Pediatr. 2021 01 04; 21(1):7. . View in PubMed
  • Impact of Confounding on Cost, Survival, and Length-of-Stay Outcomes for Neonates with Hypoplastic Left Heart Syndrome Undergoing Stage 1 Palliation Surgery Pediatr Cardiol. 2020 Jun; 41(5):996-1011. . View in PubMed
  • Postoperative Opioid Analgesia Impacts Resource Utilization in Infants Undergoing Pyloromyotomy J Surg Res. 2020 11; 255:594-601. . View in PubMed
  • Delivery timing after laser surgery for twin-twin transfusion syndrome J Perinatol. 2020 02; 40(2):248-255. . View in PubMed
  • Association of WIC Participation and Growth and Developmental Outcomes in High-Risk Infants Clin Pediatr (Phila). 2020 01; 59(1):53-61. . View in PubMed
  • The association of Trisomy 13 and 18 and hospital discharge outcomes among neonates in California: A retrospective cohort study Pediatr Neonatol. 2019 12; 60(6):617-622. . View in PubMed
  • Smartphones and Text Messaging are Associated With Higher Parent Quality of Life Scores and Enrollment in Early Intervention After NICU Discharge Clin Pediatr (Phila). 2019 07; 58(8):903-911. . View in PubMed
  • Viewpoints from families for improving transition from NICU-to-home for infants with medical complexity at a safety net hospital: a qualitative study BMC Pediatr. 2019 07 05; 19(1):223. . View in PubMed
  • Resource utilization patterns using non-invasive ventilation in neonates with respiratory distress syndrome J Perinatol. 2018 07; 38(7):850-856. . View in PubMed
  • Utilization patterns of extracorporeal membrane oxygenation in neonates in the United States 1997-2012 J Pediatr Surg. 2017 Oct; 52(10):1681-1687. . View in PubMed
  • The Role of Extracorporeal Membrane Oxygenation Simulation Training at Extracorporeal Life Support Organization Centers in the United States Simul Healthc. 2017 Aug; 12(4):233-239. . View in PubMed
  • The impact of preterm birth <37 weeks on parents and families: a cross-sectional study in the 2 years after discharge from the neonatal intensive care unit Health Qual Life Outcomes. 2017 Feb 16; 15(1):38. . View in PubMed
  • “Tele-rounding” with a remotely controlled mobile robot in the neonatal intensive care unit J Telemed Telecare. 2016 Mar; 22(2):132-8. . View in PubMed
  • Cost consciousness among physicians in the neonatal intensive care unit J Perinatol. 2016 11; 36(11):1014-1020. . View in PubMed
  • The effects of therapeutic hypothermia on cerebral metabolism in neonates with hypoxic-ischemic encephalopathy: An in vivo 1H-MR spectroscopy study J Cereb Blood Flow Metab. 2016 06; 36(6):1075-86. . View in PubMed
  • The Impact of Venoarterial and Venovenous Extracorporeal Membrane Oxygenation on Cerebral Metabolism in the Newborn Brain PLoS One. 2016; 11(12):e0168578. . View in PubMed
  • Sexual Dimorphism in Newborn Vertebrae and Its Potential Implications J Pediatr. 2015 Aug; 167(2):416-21. . View in PubMed
  • Complication risks associated with lower versus upper extremity peripherally inserted central venous catheters in neonates with gastroschisis J Pediatr Surg. 2015 Apr; 50(4):556-8. . View in PubMed
  • Changes in mean arterial blood pressure during sildenafil use in neonates with meconium aspiration syndrome or sepsis Am J Ther. 2015 Mar-Apr; 22(2):125-31. . View in PubMed
  • Brain temperature in neonates with hypoxic-ischemic encephalopathy during therapeutic hypothermia J Pediatr. 2014 Dec; 165(6):1129-34. . View in PubMed
  • Acetazolamide for the management of chronic metabolic alkalosis in neonates and infants Am J Ther. 2014 Nov-Dec; 21(6):477-81. . View in PubMed
  • Maintenance of whole-body therapeutic hypothermia during patient transport and magnetic resonance imaging Pediatr Radiol. 2014 May; 44(5):613-7. . View in PubMed
  • Antithrombin III administration in neonates with congenital diaphragmatic hernia during the first three days of extracorporeal membrane oxygenation J Pediatr Surg. 2013 Sep; 48(9):1837-42. . View in PubMed
  • Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain Hum Mutat. 2013 Jun; 34(6):801-11. . View in PubMed
  • The use of mobile robotic telemedicine technology in the neonatal intensive care unit J Perinatol. 2012 Jan; 32(1):55-63. . View in PubMed
  • Dose-dependent hemodynamic and metabolic effects of vasoactive medications in normotensive, anesthetized neonatal piglets Pediatr Res. 2011 Nov; 70(5):473-9. . View in PubMed
  • A meta-analysis of dopamine use in hypotensive preterm infants: blood pressure and cerebral hemodynamics J Perinatol. 2011 Oct; 31(10):647-55. . View in PubMed
  • Sensorineural hearing loss at 9-13 years of age in children with a history of neonatal extracorporeal membrane oxygenation Arch Dis Child Fetal Neonatal Ed. 2011 Mar; 96(2):F128-32. . View in PubMed
  • Should patients be screened for 12S rRNA mutations before treatment with aminoglycosides? Mitochondrion. 2010 Jun; 10(4):391-2.. View in PubMed
  • Hydrocortisone for hypotension and vasopressor dependence in preterm neonates: a meta-analysis J Perinatol. 2010 Jun; 30(6):373-8. . View in PubMed
  • Recovery of multipotent progenitors from the peripheral blood of patients requiring extracorporeal membrane oxygenation support Am J Respir Crit Care Med. 2010 Feb 01; 181(3):226-37. . View in PubMed
  • State-based analysis of necrotizing enterocolitis outcomes J Surg Res. 2009 Nov; 157(1):21-9. . View in PubMed
  • Outcome analysis of neonates with congenital diaphragmatic hernia treated with venovenous vs venoarterial extracorporeal membrane oxygenation J Pediatr Surg. 2009 Sep; 44(9):1691-701. . View in PubMed
  • Effects of low oxygen saturation limits on the ductus arteriosus in extremely low birth weight infants J Perinatol. 2009 Aug; 29(8):553-7. . View in PubMed
  • Failure of ductus arteriosus closure is associated with increased mortality in preterm infants Pediatrics. 2009 Jan; 123(1):e138-44. . View in PubMed
  • Increased carotid artery intima-media thickness following venoarterial extracorporeal membrane oxygenation in the neonatal period J Perinatol. 2008 Dec; 28(12):811-4. . View in PubMed
  • Changes in myocardial function and hemodynamics after ligation of the ductus arteriosus in preterm infants J Pediatr. 2007 Jun; 150(6):597-602. . View in PubMed
  • Cardiovascular effects of sildenafil in neonates and infants with congenital diaphragmatic hernia and pulmonary hypertension Neonatology. 2007; 91(2):92-100. . View in PubMed
  • Hemodynamic changes after low-dosage hydrocortisone administration in vasopressor-treated preterm and term neonates Pediatrics. 2006 Oct; 118(4):1456-66. . View in PubMed
  • Concurrent use of indomethacin and dexamethasone increases the risk of spontaneous intestinal perforation in very low birth weight neonates J Perinatol. 2006 Aug; 26(8):486-92. . View in PubMed
  • Somatosensory lateralization in the newborn brain Neuroimage. 2006 Jan 01; 29(1):155-61. . View in PubMed
  • Hospital rates of maternal and neonatal infection in a low-risk population Matern Child Health J. 2005 Sep; 9(3):307-16. . View in PubMed
  • Predictability model of the need for extracorporeal membrane oxygenation in neonates with meconium aspiration syndrome treated with inhaled nitric oxide J Pediatr Surg. 2005 Jul; 40(7):1090-3. . View in PubMed
  • MR imaging of newborns by using an MR-compatible incubator with integrated radiofrequency coils: initial experience Radiology. 2004 May; 231(2):594-601. . View in PubMed
  • Risk of need for extracorporeal membrane oxygenation support in neonates with congenital diaphragmatic hernia treated with inhaled nitric oxide J Perinatol. 2004 Mar; 24(3):143-6. . View in PubMed
  • Functional MRI in neonates using neonatal head coil and MR compatible incubator Neuroimage. 2003 Oct; 20(2):683-92. . View in PubMed
  • Use of high-frequency jet ventilation in neonates with hypoxemia refractory to high-frequency oscillatory ventilation J Matern Fetal Neonatal Med. 2003 Jun; 13(6):398-402. . View in PubMed
  • Relationship between fetal monitoring and resuscitative needs: fetal distress versus routine cesarean deliveries J Perinatol. 2000 Mar; 20(2):101-4. . View in PubMed
  • A randomized trial of nasopharyngeal-synchronized intermittent mandatory ventilation versus nasopharyngeal continuous positive airway pressure in very low birth weight infants after extubation J Perinatol. 1999 Sep; 19(6 Pt 1):413-8. . View in PubMed
  • Renal tolerance with the use of intralipid-amphotericin B in low-birth-weight neonates Am J Perinatol. 1997 Aug; 14(7):377-83. . View in PubMed