Preet M Chaudhary, MD, PhD

Professor of Medicine

Bloom Family Chair in Lymphoma Research

Chief, Nohl Division of Hematology and Center for Blood Diseases in the Department of Medicine

Director for Bone Marrow Transplant

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Overview

Preet M. Chaudhary, M.D., Ph.D. is chief of the Jane Anne Nohl Division of Hematology and Center for the study of Blood Diseases in the Department of Medicine, and coleader of the Molecular Genetics Program at the USC Norris Comprehensive Cancer Center. He is also Professor of Medicine, Ronald H. Bloom Family Chair in Lymphoma Research, and Program Director of the USC/Norris Blood and Marrow Transplant Program.

As a physician-scientist dedicated to hematologic oncology, Dr. Chaudhary has research interests in several areas of cancer, including AIDS-associated cancers, cancer drug resistance, biology of normal and leukemic hematopoietic stem cells, programmed cell death and cellular signaling. He is also interested in molecularly targeted and cellular therapies for leukemias, lymphomas, multiple myeloma and solid tumors. Current work in Dr. Chaudhary’s laboratory is focused on developing novel strategies to improve the outcome of stem cell transplantation and the use of chimeric antigen receptor modified T cells for the treatment of cancer.

Dr. Chaudhary holds six U.S. patents and has published in some of the top scientific journals, including Cell, Immunity, JNCI, PNAS and Blood. He has served as a peer-reviewer for several national and international cancer research funding agencies and has been elected to the prestigious American Society for Clinical Investigations, an honor society of the top physician-scientists in the country.

Awards

  • Leukemia Lymphoma Society: Translational Research Award, 2008-2011
  • Leukemia Lymphoma Society: Translational Research Award, 2005-2008
  • Multiple Myeloma Research Foundation: Senior Research Award, 2005-2006
  • American Society for Clinical Investigations, 2004
  • Leukemia Research Foundation: New Investigator Award, 1999-2000
  • Howard Hughes Institutes: New Faculty Start-Up Award, 1998-2001
  • Damon Runyon-Walter Winchell Foundation: Postdoctoral Fellowship, 1995-1998
  • March of Dimes Birth Defects Foundation: Pre-doctoral Fellowship, 1990-1992
  • Second Prize in Ophthalmology, 1986
  • Gold Medal in Surgery, 1986
  • Second Prize in Pathology, 1985
  • Distinctions in Anatomy, Physiology Biochemistry and Pharmacology, 1984-1985
  • Honors in First Professional M.B.B.S, 1984
  • National Talent Search Scholarship, 1981-1986
  • Pre-Medical University Merit Certificate (First Rank in the College), 1981

Publications

  • Concordance of Next-Generation Sequencing and Multiparametric Flow Cytometry Methods for Detecting Measurable Residual Disease in Adult Acute Lymphoblastic Leukemia: Optimizing Prediction of Clinical Outcomes From a Single-Center StudyClin Lymphoma Myeloma Leuk. 2024 03; 24(3):e59-e66. e2. . View in PubMed
  • Case report: Pulse cyclophosphamide for treatment of multi-agent-refractory hepatic graft-versus-host disease Front Oncol. 2024; 14:1329893. . View in PubMed
  • Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group Heliyon. 2023 Apr; 9(4):e14924. . View in PubMed
  • Unique challenges to diagnosing sweet syndrome following induction chemotherapy for relapsed Acute Myeloid Leukemia (AML): A case and brief-review Respir Med Case Rep. 2023; 46:101922. . View in PubMed
  • Real world experience: Examining outcomes using letermovir for CMV prophylaxis in high-risk allogeneic hematopoietic stem cell patients in the setting of using T-cell depletion as GVHD prophylaxis Transpl Immunol. 2022 Dec 01; 101769. . View in PubMed
  • Unique Challenges to Diagnosing Human Herpesvirus-6 (HHV-6) Encephalitis Following Post-Hematopoietic Stem Cell Transplant: A Case and Brief Review Cell Transplant. 2022 Jan-Dec; 31:9636897221119734. . View in PubMed
  • The time to offer treatments for COVID-19 Expert Opin Investig Drugs. 2021 May; 30(5):505-518. . View in PubMed
  • A novel thermostable beetle luciferase based cytotoxicity assay Sci Rep. 2021 05 11; 11(1):10002. . View in PubMed
  • Narciclasine, an isocarbostyril alkaloid, has preferential activity against primary effusion lymphoma Sci Rep. 2020 03 31; 10(1):5712. . View in PubMed
  • A Fast and Sensitive Luciferase-based Assay for Antibody Engineering and Design of Chimeric Antigen Receptors Sci Rep. 2020 02 11; 10(1):2318. . View in PubMed
  • A novel luciferase-based assay for the detection of Chimeric Antigen Receptors Sci Rep. 2019 02 13; 9(1):1957. . View in PubMed
  • Development and characterization of a novel luciferase based cytotoxicity assay Sci Rep. 2018 01 09; 8(1):199. . View in PubMed
  • Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia Leuk Res Rep. 2018; 9:18-20. . View in PubMed
  • Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors Oncogene. 2016 Apr 07; 35(14):1797-810. . View in PubMed
  • Toxicity profile of repeated doses of PEG-asparaginase incorporated into a pediatric-type regimen for adult acute lymphoblastic leukemia Eur J Haematol. 2016 Apr; 96(4):375-80. . View in PubMed
  • DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46. . View in PubMed
  • NEMO is essential for Kaposi’s sarcoma-associated herpesvirus-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death, and its N-terminal 251 residues are sufficient for this process J Virol. 2014 Jun; 88(11):6345-54. . View in PubMed
  • Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors Oncogene. 2014 May 29; 33(22):2928-37. . View in PubMed
  • A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-? B. Clin Cancer Res. 2013 Sep 15; 19(18):5016-26.. View in PubMed
  • Kaposi’s sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-? B activation. J Virol. 2013 Feb; 87(4):2242-52.. View in PubMed
  • Major non-ABO incompatibility caused by anti-Jk(a) in a patient before allogeneic hematopoietic stem cell transplantation Immunohematology. 2013; 29(1):11-4. . View in PubMed
  • A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma PLoS One. 2012; 7(5):e37498. . View in PubMed
  • PLoS One. 2012; 7(5):e36601. . View in PubMed
  • Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells J Biol Chem. 2011 Aug 12; 286(32):27988-97. . View in PubMed
  • A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner J Biol Chem. 2011 Jun 17; 286(24):21555-64. . View in PubMed
  • Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice Cancer Biol Ther. 2010 Nov 15; 10(10):1033-40. . View in PubMed
  • Immune evasion by Kaposi’s sarcoma-associated herpesvirus Future Microbiol. 2010 Sep; 5(9):1349-65. . View in PubMed
  • Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma Blood. 2010 Jul 15; 116(2):297-305. . View in PubMed
  • Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL) Blood. 2010 Jun 10; 115(23):4973-4. . View in PubMed
  • Kaposi’s sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 suppresses CXCR4 expression by upregulating miR-146a Oncogene. 2010 Mar 25; 29(12):1835-44. . View in PubMed
  • X-linked ectodermal dysplasia receptor is downregulated in breast cancer via promoter methylation Clin Cancer Res. 2010 Feb 15; 16(4):1140-8. . View in PubMed
  • KSHV-induced notch components render endothelial and mural cell characteristics and cell survival Blood. 2010 Jan 28; 115(4):887-95. . View in PubMed
  • Human Merkel cell polyomavirus infection IMCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer. 2009 Sep 15; 125(6):1243-9. . View in PubMed
  • Integrated microarray and multiplex cytokine analyses of Kaposi’s Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13 affected genes and cytokines in human blood vascular endothelial cells BMC Med Genomics. 2009 Aug 06; 2:50. . View in PubMed
  • Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-kappaB activation Blood. 2009 May 28; 113(22):5660-8. . View in PubMed
  • A nuclear role for Kaposi’s sarcoma-associated herpesvirus-encoded K13 protein in gene regulation Oncogene. 2008 Sep 04; 27(39):5243-53. . View in PubMed
  • Resolving “kinks” of chemotherapy in melanoma J Natl Cancer Inst. 2008 Jun 18; 100(12):833-5. . View in PubMed
  • Proteasome inhibitor Bortezomib induces cell cycle arrest and apoptosis in cell lines derived from Ewing’s sarcoma family of tumors and synergizes with TRAIL Cancer Biol Ther. 2008 Apr; 7(4):603-8. . View in PubMed
  • Adenoviral-mediated gene transfer of ectodysplasin-A2 results in induction of apoptosis and cell-cycle arrest in osteosarcoma cell lines Cancer Gene Ther. 2007 Nov; 14(11):927-33. . View in PubMed
  • Kaposi’s sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation J Biol Chem. 2007 Aug 24; 282(34):24858-65. . View in PubMed
  • In primary effusion lymphoma cells, MYB transcriptional repression is associated with v-FLIP expression during latent KSHV infection while both v-FLIP and v-GPCR become involved during the lytic cycle Br J Haematol. 2007 Aug; 138(4):487-501. . View in PubMed
  • Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13 Oncogene. 2007 Mar 08; 26(11):1656-60. . View in PubMed
  • Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-kappaB activation Oncogene. 2006 May 04; 25(19):2717-26. . View in PubMed
  • Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12885-90. . View in PubMed
  • Kaposi’s sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat Retrovirology. 2005 Feb 15; 2:9. . View in PubMed
  • The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells Cancer Biol Ther. 2005 Jan; 4(1):77-82. . View in PubMed
  • An evolutionary conserved pathway of nuclear factor-kappaB activation involving caspase-mediated cleavage and N-end rule pathway-mediated degradation of IkappaBalpha J Biol Chem. 2004 Sep 17; 279(38):39358-65. . View in PubMed
  • Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP) Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9399-404. . View in PubMed
  • Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types Int J Cancer. 2004 May 01; 109(5):786-92. . View in PubMed
  • The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation Biochem Biophys Res Commun. 2004 Feb 27; 315(1):73-8. . View in PubMed
  • Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory protein-induced NF-kappaB activation J Biol Chem. 2003 Dec 26; 278(52):52406-11. . View in PubMed
  • The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation J Biol Chem. 2003 Dec 26; 278(52):52437-45. . View in PubMed
  • Use of adeno-associated viral vector for delivery of small interfering RNA Oncogene. 2003 Aug 28; 22(36):5712-5. . View in PubMed
  • Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila Oncogene. 2003 Jul 31; 22(31):4860-7. . View in PubMed
  • Use of lentiviral vectors for delivery of small interfering RNA Cancer Biol Ther. 2003 Mar-Apr; 2(2):206-10. . View in PubMed
  • Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification Oncogene. 2002 Dec 05; 21(55):8510-4. . View in PubMed
  • Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor J Biol Chem. 2002 Nov 22; 277(47):44953-61. . View in PubMed
  • Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis Cancer Biol Ther. 2002 Nov-Dec; 1(6):652-60. . View in PubMed
  • Cytotoxicity of Tumor necrosis factor related apoptosis-inducing ligand towards Ewing’s sarcoma cell lines Oncogene. 2001 Feb 22; 20(8):1010-4. . View in PubMed
  • Activation of the NF-kappaB pathway by caspase 8 and its homologs Oncogene. 2000 Sep 14; 19(39):4451-60. . View in PubMed
  • TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death J Biol Chem. 2000 May 19; 275(20):15336-42. . View in PubMed
  • Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins Oncogene. 1999 Oct 14; 18(42):5738-46. . View in PubMed
  • Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans Blood. 1998 Jun 01; 91(11):4020-7. . View in PubMed
  • Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway Immunity. 1997 Dec; 7(6):821-30. . View in PubMed
  • MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11333-8. . View in PubMed
  • Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes Blood. 1992 Dec 01; 80(11):2735-9. . View in PubMed