Radha Kalluri, PhD

Associate Professor of Otolaryngology - Head & Neck Surgery and Biomedical Engineering

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Overview

Dr. Radha Kalluri heads the Physiology of the Inner Ear Laboratory whose focus is to understand the physical and physiological mechanisms underlying sensory transduction in the inner ear, with the ultimate goal of understanding how disease and injury impair function. The lab. studies sensory transduction in the auditory and vestibular systems both at the cellular and system level using electrophysiology and biophysical modeling. Our work relies heavily on the interplay between quantitative analysis, theoretical modeling and experimental neuroscience.

https://keck.usc.edu/otolaryngology/

Research Funding

  • The role of ion channels in shaping the function of inner ear neurons
    NIH · R01DC015512 · Jul 1, 2017 – Nov 30, 2027 · Role: Principal Investigator
  • Biophysical properties and function of primary auditory neurons
    NIH · R03DC012652 · Mar 1, 2013 – Feb 28, 2017 · Role: Principal Investigator
  • Firing patterns in vestibular afferents
    NIH · F32DC009360 · Dec 1, 2007 – Nov 30, 2010 · Role: Principal Investigator

Publications

  • Genetic Targeting and Conductance-Based Modeling Reveal Novel Diversity within Mouse Type II Spiral Ganglion Neurons. J Neurosci. 2026 Aug 19; 46(33).. View in PubMed
  • Genetic Targeting and Conductance-Based Modeling Reveal Novel Diversity Within Mouse Type II Spiral Ganglion Neurons. bioRxiv. 2025 Dec 09.. View in PubMed
  • Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells. bioRxiv. 2025 Feb 25.. View in PubMed
  • Vestibular afferent neurons develop normally in the absence of quantal/glutamatergic input. Front Neurol. 2024; 15:1441964.. View in PubMed
  • Vestibular afferent neurons develop normally in the absence of quantal/glutamatergic input. bioRxiv. 2024 Jun 13.. View in PubMed
  • Isolating and Culturing Vestibular and Spiral Ganglion Somata from Neonatal Rodents for Patch-Clamp Recordings. J Vis Exp. 2023 04 21.. View in PubMed
  • Nuclear Translocation Triggered at the Onset of Hearing in Cochlear Inner Hair Cells of Rats and Mice. J Assoc Res Otolaryngol. 2023 06; 24(3):291-303.. View in PubMed
  • Muscarinic Acetylcholine Receptors Modulate HCN Channel Properties in Vestibular Ganglion Neurons. J Neurosci. 2023 02 08; 43(6):902-917.. View in PubMed
  • Patch-clamp Recordings and Single Fiber Labeling from Spiral Ganglion Somata in Acutely Prepared Semi-intact Cochleae from Neonatal Rats. Bio Protoc. 2022 Jan 05; 12(1):e4281.. View in PubMed
  • Similarities in the Biophysical Properties of Spiral-Ganglion and Vestibular-Ganglion Neurons in Neonatal Rats. Front Neurosci. 2021; 15:710275.. View in PubMed