Keck School Faculty

Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium Alzheimers Dement. 2022 Sep; 18(9):1677-1686. . View in PubMed

Screening and enrollment of underrepresented ethnocultural and educational populations in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Alzheimers Dement. 2022 Feb 25. . View in PubMed

Alzheimer's disease research progress in the Mediterranean region: The Alzheimer's Association International Conference Satellite Symposium Alzheimers Dement. 2022 Feb 20. . View in PubMed

Early-stage Alzheimer disease: getting trial-ready Nat Rev Neurol. 2022 07; 18(7):389-399. . View in PubMed

Tackling a Major Deficiency of Diversity in Alzheimer's Disease Therapeutic Trials: An CTAD Task Force Report J Prev Alzheimers Dis. 2022; 9(3):388-392. . View in PubMed

Enhanced Association of Tau Pathology and Cognitive Impairment in Mild Cognitive Impairment Subjects with Behavior Symptoms J Alzheimers Dis. 2022; 87(2):557-568. . View in PubMed

Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer's disease: a randomized trial Sci Rep. 2022 01 25; 12(1):1346. . View in PubMed

Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease: A Truncated Randomized Phase 2b/3 Clinical Trial JAMA Neurol. 2021 03 01; 78(3):293-301. . View in PubMed

Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial JAMA Netw Open. 2021 07 01; 4(7):e2114364. . View in PubMed

Predicting amyloid risk by machine learning algorithms based on the A4 screen data: Application to the Japanese Trial-Ready Cohort study Alzheimers Dement (N Y). 2021; 7(1):e12135. . View in PubMed

The Impact of Amyloid Burden and APOE on Rates of Cognitive Impairment in Late Life Depression J Alzheimers Dis. 2021; 80(3):991-1002. . View in PubMed

Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project Biol Psychiatry. 2021 04 15; 89(8):757-765. . View in PubMed

Impact of the COVID-19 pandemic on statistical design and analysis plans for multidomain intervention clinical trials: Experience from World-Wide FINGERS Alzheimers Dement (N Y). 2021; 7(1):e12143. . View in PubMed

Brain amyloid burden, sleep, and 24-hour rest/activity rhythms: screening findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration Studies Sleep Adv. 2021; 2(1):zpab015. . View in PubMed

The Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD): A Novel Clinical Trials Training Program J Prev Alzheimers Dis. 2021; 8(3):286-291. . View in PubMed

Tobacco use and E-cigarette regulation: Perspectives of University Students in the Asia-Pacific Addict Behav. 2020 08; 107:106420. . View in PubMed

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia Alzheimers Dement. 2020 07; 16(7):1078-1094. . View in PubMed

Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial Pediatrics. 2020 06; 145(6). . View in PubMed

The Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease (TRC-PAD) Project: An Overview J Prev Alzheimers Dis. 2020; 7(4):208-212. . View in PubMed

Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study Alzheimers Dement (Amst). 2020; 12(1):e12118. . View in PubMed

Predicting Amyloid Burden to Accelerate Recruitment of Secondary Prevention Clinical Trials J Prev Alzheimers Dis. 2020; 7(4):213-218. . View in PubMed

Authors response to D Umbricht, letter to the editor referring Futility Analyses in Alzheimer's Disease (AD) Clinical Trials: A Risky BusinessThe Journal of Prevention of Alzheimer's Disease, 2020. J Prev Alzheimers Dis. 2020; 7(4):300. . View in PubMed

The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer's Disease (TRC-PAD): Experience from the First 3 Years J Prev Alzheimers Dis. 2020; 7(4):234-241. . View in PubMed

TRC-PAD: Accelerating Recruitment of AD Clinical Trials through Innovative Information Technology J Prev Alzheimers Dis. 2020; 7(4):226-233. . View in PubMed

Viewpoint: Futility Analyses in Alzheimer's Disease (AD) Clinical Trials: A Risky Business J Prev Alzheimers Dis. 2020; 7(3):195-196. . View in PubMed

Statistical methods in handling placebo effect Int Rev Neurobiol. 2020; 153:103-120. . View in PubMed

Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals JAMA Neurol. 2020 06 01; 77(6):735-745. . View in PubMed

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial JAMA Neurol. 2020 09 01; 77(9):1099-1109. . View in PubMed

Short-term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment JAMA Neurol. 2020 12 01; 77(12):1504-1513. . View in PubMed

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial JAMA Neurol. 2019 Oct 01; 76(10):1219-1229. . View in PubMed

A mixed-methods study of cultural beliefs about dementia and genetic testing among Mexicans and Mexican-Americans at-risk for autosomal dominant Alzheimer's disease J Genet Couns. 2019 10; 28(5):921-932. . View in PubMed

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer's Disease N Engl J Med. 2019 04 11; 380(15):1483-1485. . View in PubMed

International chicken trade and increased risk for introducing or reintroducing highly pathogenic avian influenza A (H5N1) to uninfected countries Infect Dis Model. 2017 Nov; 2(4):412-418. . View in PubMed

Randomized controlled trial of acceptance and commitment therapy for distress and impairment in OEF/OIF/OND veterans Psychol Trauma. 2017 Aug; 9(Suppl 1):74-84. . View in PubMed

A randomized controlled trial of ganaxolone in posttraumatic stress disorder Psychopharmacology (Berl). 2017 Aug; 234(15):2245-2257. . View in PubMed

A phase 3 trial of IV immunoglobulin for Alzheimer disease Neurology. 2017 May 02; 88(18):1768-1775. . View in PubMed

Cross-validation of optimized composites for preclinical Alzheimer's disease Alzheimers Dement (N Y). 2017 Jan; 3(1):123-129. . View in PubMed

EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials J Prev Alzheimers Dis. 2017; 4(2):116-124. . View in PubMed

Telephone Problem Solving for Service Members with Mild Traumatic Brain Injury: A Randomized, Clinical Trial J Neurotrauma. 2017 01 15; 34(2):313-321. . View in PubMed

Accuracy of Stroke Diagnosis in Telestroke-Guided Tissue Plasminogen Activator Patients J Stroke Cerebrovasc Dis. 2016 Dec; 25(12):2942-2946. . View in PubMed

Visual Determination of Conjugate Eye Deviation on Computed Tomography Scan Predicts Diagnosis of Stroke Code Patients J Stroke Cerebrovasc Dis. 2016 Dec; 25(12):2809-2813. . View in PubMed

Neurocognitive Models of Medical Decision-Making Capacity in Traumatic Brain Injury Across Injury Severity J Head Trauma Rehabil. 2016 May-Jun; 31(3):E49-59. . View in PubMed

Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury Neuropsychopharmacology. 2016 Apr; 41(5):1191-8. . View in PubMed

Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2) Stroke. 2016 12; 47(12):2888-2895. . View in PubMed

Changes in Neuropsychiatric Inventory Associated with Semagacestat Treatment of Alzheimer's Disease J Alzheimers Dis. 2016 08 10; 54(1):373-81. . View in PubMed

Accuracy of First Recorded "Last Known Normal" Times of Stroke Code Patients J Stroke Cerebrovasc Dis. 2015 Nov; 24(11):2467-73. . View in PubMed

Feasibility and Safety of Using External Counterpulsation to Augment Cerebral Blood Flow in Acute Ischemic Stroke-The Counterpulsation to Upgrade Forward Flow in Stroke (CUFFS) Trial J Stroke Cerebrovasc Dis. 2015 Nov; 24(11):2596-604. . View in PubMed

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease Neurology. 2015 Oct 20; 85(16):1383-91. . View in PubMed

Mental Disorders, Comorbidity, and Pre-enlistment Suicidal Behavior Among New Soldiers in the US. Army: Results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Suicide Life Threat Behav. 2015 Oct; 45(5):588-599. . View in PubMed

Defining mild stroke: outcomes analysis of treated and untreated mild stroke patients J Stroke Cerebrovasc Dis. 2015 Jun; 24(6):1276-81. . View in PubMed

The "DeyeCOM Sign": Predictive Value in Acute Stroke Code Evaluations J Stroke Cerebrovasc Dis. 2015 Jun; 24(6):1299-304. . View in PubMed

Comparing recruitment, retention, and safety reporting among geographic regions in multinational Alzheimer's disease clinical trials Alzheimers Res Ther. 2015; 7(1):39. . View in PubMed

Alzheimers Res Ther. 2015; 7(1):36. . View in PubMed

Prevalence and correlates of suicidal behavior among new soldiers in the US. Army: results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Depress Anxiety. 2015 Jan; 32(1):3-12. . View in PubMed

Concussion treatment after combat trauma: development of a telephone based, problem solving intervention for service members Contemp Clin Trials. 2015 Jan; 40:54-62. . View in PubMed

Association of Hispanic ethnicity with acute ischemic stroke care processes and outcomes Ethn Dis. 2015; 25(1):19-23. . View in PubMed

Alzheimer's disease progression by geographical region in a clinical trial setting Alzheimers Res Ther. 2015; 7(1):43. . View in PubMed

Estimating long-term multivariate progression from short-term data Alzheimers Dement. 2014 Oct; 10(5 Suppl):S400-10. . View in PubMed

Dramatic decline of respiratory illness among US military recruits after the renewed use of adenovirus vaccines Clin Infect Dis. 2014 Oct; 59(7):962-8. . View in PubMed

The Alzheimer's disease cooperative study prevention instrument project: longitudinal outcome of behavioral measures as predictors of cognitive decline Dement Geriatr Cogn Dis Extra. 2014 Sep-Dec; 4(3):509-16. . View in PubMed

Individuals with chronic traumatic brain injury improve walking speed and mobility with intensive mobility training Arch Phys Med Rehabil. 2014 Aug; 95(8):1454-60. . View in PubMed

The preclinical Alzheimer cognitive composite: measuring amyloid-related decline JAMA Neurol. 2014 Aug; 71(8):961-70. . View in PubMed

Self-reported smoking and musculoskeletal overuse injury among male and female US. Marine Corps recruits. Mil Med. 2014 Jul; 179(7):735-43. . View in PubMed

A two-site pilot randomized 3 day trial of high dose left prefrontal repetitive transcranial magnetic stimulation (rTMS) for suicidal inpatients Brain Stimul. 2014 May-Jun; 7(3):421-31. . View in PubMed

Does symptom onset to primary stroke center time goals affect stroke outcome? J Stroke Cerebrovasc Dis. 2014 May-Jun; 23(5):993-1000.. View in PubMed

Imaging negative stroke: diagnoses and outcomes in intravenous tissue plasminogen activator-treated patients J Stroke Cerebrovasc Dis. 2014 May-Jun; 23(5):1046-50. . View in PubMed

Pooled assessment of computed tomography interpretation by vascular neurologists in the STRokE DOC telestroke network J Stroke Cerebrovasc Dis. 2014 Mar; 23(3):511-5. . View in PubMed

Accounting for functional loss in Alzheimer's disease and dementia with Lewy bodies: beyond cognition Alzheimers Dement. 2014 Mar; 10(2):171-8. . View in PubMed

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease N Engl J Med. 2014 Jan 23; 370(4):311-21. . View in PubMed

Effect of head impacts on diffusivity measures in a cohort of collegiate contact sport athletes Neurology. 2014 Jan 07; 82(1):63-9. . View in PubMed

Parametric comparisons of intracranial mechanical responses from three validated finite element models of the human head Ann Biomed Eng. 2014 Jan; 42(1):11-24. . View in PubMed

Epidemiology of pathogen-specific respiratory infections among three US populations PLoS One. 2014; 9(12):e114871. . View in PubMed

Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol Int J Stroke. 2014 Jan; 9(1):117-25. . View in PubMed

Weight patterns before and after total joint arthroplasty and characteristics associated with weight change Perm J. 2014; 18(1):25-31. . View in PubMed

Trends in antihypertensive drug prescription patterns among ambulatory stroke patients in the United States, 2000-2009 J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):e568-75. . View in PubMed

Diffusion-weighted imaging-fluid attenuated inversion recovery mismatch in nocturnal stroke patients with unknown time of onset J Stroke Cerebrovasc Dis. 2013 Oct; 22(7):972-7. . View in PubMed

A phase 3 trial of semagacestat for treatment of Alzheimer's disease N Engl J Med. 2013 Jul 25; 369(4):341-50. . View in PubMed

Determinants of Pneumonia Risk During Endovascular Hypothermia Ther Hypothermia Temp Manag. 2013 Mar; 3(1):24-27. . View in PubMed

Effect of study partner on the conduct of Alzheimer disease clinical trials Neurology. 2013 Jan 15; 80(3):282-8. . View in PubMed

Effects of varying duty cycle and pulse width on high-intensity focused ultrasound (HIFU)-induced transcranial thrombolysis J Ther Ultrasound. 2013; 1:18. . View in PubMed

The association of self-reported measures with poor training outcomes among male and female US. Navy recruits. Mil Med. 2013 Jan; 178(1):43-9. . View in PubMed

Intravenous tissue plasminogen activator for patients with minor ischemic stroke J Stroke Cerebrovasc Dis. 2012 Nov; 21(8):732-6. . View in PubMed

CT interpretation in a telestroke network: agreement among a spoke radiologist, hub vascular neurologist, and hub neuroradiologist Stroke. 2012 Nov; 43(11):3095-7. . View in PubMed

Late night activity regarding stroke codes: LuNAR strokes Int J Stroke. 2012 Aug; 7(6):473-6. . View in PubMed

Age and rate of cognitive decline in Alzheimer disease: implications for clinical trials Arch Neurol. 2012 Jul; 69(7):901-5. . View in PubMed

Determinants of effective cooling during endovascular hypothermia Neurocrit Care. 2012 Jun; 16(3):413-20. . View in PubMed

Assessment of long-term outcomes for the STRokE DOC telemedicine trial J Stroke Cerebrovasc Dis. 2012 May; 21(4):259-64. . View in PubMed

Efficacy of telemedicine for stroke: pooled analysis of the Stroke Team Remote Evaluation Using a Digital Observation Camera (STRokE DOC) and STRokE DOC Arizona telestroke trials Telemed J E Health. 2012 Apr; 18(3):230-7. . View in PubMed

Incidence of new-onset seizures in mild to moderate Alzheimer disease Arch Neurol. 2012 Mar; 69(3):368-72. . View in PubMed

Comprehensive stroke centers and the 'weekend effect': the SPOTRIAS experience Cerebrovasc Dis. 2012; 34(5-6):424-9. . View in PubMed

Evaluating transdiagnostic treatment for distress and impairment in veterans: a multi-site randomized controlled trial of Acceptance and Commitment Therapy Contemp Clin Trials. 2012 Jan; 33(1):116-23. . View in PubMed

Two-hour improvement of patients in the National Institute of Neurological Disorders and Stroke trials and prediction of final outcome Stroke. 2011 Nov; 42(11):3163-7. . View in PubMed

Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease Arch Gen Psychiatry. 2011 Aug; 68(8):853-61. . View in PubMed

Adding delayed recall to the Alzheimer Disease Assessment Scale is useful in studies of mild cognitive impairment but not Alzheimer disease Alzheimer Dis Assoc Disord. 2011 Apr-Jun; 25(2):122-7. . View in PubMed

Therapeutic hypothermia is associated with a decrease in urine output in acute stroke patients Resuscitation. 2010 Dec; 81(12):1642-7. . View in PubMed

Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial JAMA. 2010 Nov 03; 304(17):1903-11. . View in PubMed

Alberta Stroke Program Early CT Score (ASPECTS) in patients with wake-up stroke J Stroke Cerebrovasc Dis. 2010 Nov-Dec; 19(6):475-9. . View in PubMed

Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): final results Stroke. 2010 Oct; 41(10):2265-70. . View in PubMed

Influence of apolipoprotein E varepsilon4 on rates of cognitive and functional decline in mild cognitive impairment Alzheimers Dement. 2010 Sep; 6(5):412-9. . View in PubMed

Gender differences in acute stroke treatment: the University of California San Diego experience Stroke. 2010 Aug; 41(8):1755-7. . View in PubMed

Analysis of the National Institute of Neurological Disorders and Stroke tissue plasminogen activator studies following European Cooperative Acute Stroke Study III patient selection criteria J Stroke Cerebrovasc Dis. 2010 Jul-Aug; 19(4):290-3. . View in PubMed

Stroke team remote evaluation using a digital observation camera in Arizona: the initial mayo clinic experience trial Stroke. 2010 Jun; 41(6):1251-8. . View in PubMed

Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans Alzheimers Dement. 2010 May; 6(3):239-46. . View in PubMed

Prevalence and psychological correlates of traumatic brain injury in operation iraqi freedom J Head Trauma Rehabil. 2010 Jan-Feb; 25(1):1-8. . View in PubMed

MRI substudy participation in Alzheimer disease (AD) clinical trials: baseline comparability of a substudy sample to entire study population Alzheimer Dis Assoc Disord. 2009 Oct-Dec; 23(4):333-6. . View in PubMed

Injury-specific predictors of posttraumatic stress disorder Injury. 2009 Sep; 40(9):1004-10. . View in PubMed

National Institutes of Health Stroke Scale certification is reliable across multiple venues Stroke. 2009 Jul; 40(7):2507-11. . View in PubMed

Characteristics and performance of a modified version of the ADCS-CGIC CIBIC+ for mild cognitive impairment clinical trials Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):260-7. . View in PubMed

Clinical interview assessment of financial capacity in older adults with mild cognitive impairment and Alzheimer's disease J Am Geriatr Soc. 2009 May; 57(5):806-14. . View in PubMed

Psychological correlates of battle and nonbattle injury among Operation Iraqi Freedom veterans Mil Med. 2009 Mar; 174(3):224-31. . View in PubMed

Can comprehensive stroke centers erase the 'weekend effect'? Cerebrovasc Dis. 2009; 27(2):107-13.. View in PubMed

In vitro sonothrombolysis with duplex ultrasound: first results using a simplified model Cerebrovasc Dis. 2009; 28(4):365-70. . View in PubMed

Plasma urate and progression of mild cognitive impairment Neurodegener Dis. 2009; 6(1-2):23-8. . View in PubMed

Efficacy of site-independent telemedicine in the STRokE DOC trial: a randomised, blinded, prospective study Lancet Neurol. 2008 Sep; 7(9):787-95. . View in PubMed

Awareness of deficits in financial abilities in patients with mild cognitive impairment: going beyond self-informant discrepancy Am J Geriatr Psychiatry. 2008 Aug; 16(8):650-9. . View in PubMed

Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease Arch Neurol. 2008 Aug; 65(8):1031-8. . View in PubMed

Reliability of site-independent telemedicine when assessed by telemedicine-naive stroke practitioners J Stroke Cerebrovasc Dis. 2008 Jul-Aug; 17(4):181-6. . View in PubMed

The first puff: forces in smoking initiation among Californians of Korean descent Nicotine Tob Res. 2007 Dec; 9(12):1277-86. . View in PubMed

Diffusion of cancer education information through a Latino community health advisor program Prev Med. 2007 Aug-Sep; 45(2-3):135-8. . View in PubMed

Quetiapine for agitation or psychosis in patients with dementia and parkinsonism Neurology. 2007 Apr 24; 68(17):1356-63. . View in PubMed

An expedited code stroke protocol is feasible and safe Stroke. 2006 Dec; 37(12):2935-9. . View in PubMed

ADCS Prevention Instrument Project: ADCS-clinicians' global impression of change scales (ADCS-CGIC), self-rated and study partner-rated versions Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S124-38. . View in PubMed

ADCS Prevention Instrument Project: behavioral measures in primary prevention trials Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S147-51. . View in PubMed

ADCS Prevention Instrument Project: the Mail-In Cognitive Function Screening Instrument (MCFSI) Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S170-8. . View in PubMed

A mixed-effects regression model for three-level ordinal response data Stat Med. 2005 Nov 15; 24(21):3331-45. . View in PubMed

Divalproex sodium in nursing home residents with possible or probable Alzheimer Disease complicated by agitation: a randomized, controlled trial Am J Geriatr Psychiatry. 2005 Nov; 13(11):942-9. . View in PubMed

NIHSS training and certification using a new digital video disk is reliable Stroke. 2005 Nov; 36(11):2446-9. . View in PubMed

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease Science. 2005 Feb 25; 307(5713):1282-8. . View in PubMed

J Natl Med Assoc. 2003 Jun; 95(6):423-32. . View in PubMed

Tonsillar actinomycosis: a clinicopathological study Acta Trop. 2001 Oct 22; 80(2):163-8. . View in PubMed

Heterotopia of the tonsil J Laryngol Otol. 1996 Jun; 110(6):611-2. . View in PubMed