Richard M. Watanabe, PhD

Professor of Population and Public Health Sciences

Associate Dean for Health and Population Science Programs

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Overview

I have a primary interest in the pathophysiology and genetics of type 2 diabetes mellitus. My research program focuses on genetics, pathophysiology (and the correlation with genetics), and mathematical modeling of physiologic systems.

In the area of complex disease genetics, I am focusing on both positional cloning of susceptibility genes for type 2 diabetes and diabetes-related traits and understanding the gene-phenotype relationships and how they are impacted by environmental exposures.

Research Funding

  • Summer Program in Diabetes and Obesity Research (SPIDOR)
    NIH · R25DK112738 · Aug 22, 2017 – Apr 30, 2022 · Role: Co-Principal Investigator
  • Physiologic Consequence of Genetic Variation
    NIH · R01DK105517 · Apr 10, 2015 – Mar 31, 2021 · Role: Principal Investigator
  • Genetic & Epidemiologic Predictors of Glucose Homeostasis Measures in Hispanics
    NIH · R01DK085175 · Jul 20, 2010 – Dec 31, 2015 · Role: Co-Principal Investigator
  • Pharmacogenetics of Diabetes Prevention
    NIH · R01DK069922 · Feb 1, 2007 – Jan 31, 2011 · Role: Principal Investigator
  • POSITIONAL CLONING OF GENES FOR NIDDM
    NIH · F32DK009525 · Jan 5, 1997 · Role: Principal Investigator

Publications

  • Lipidomic Profiling Reveals Differential Behaviors of Individual Free Fatty Acids During Altered Metabolic States in Rats. Mol Nutr Food Res. 2026 04; 70(8):e70473.. View in PubMed
  • Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans. J Clin Endocrinol Metab. 2026 Feb 20; 111(3):e937-e942.. View in PubMed
  • Systematic review and meta-analysis corrected for history of smoking tobacco identifies type 1 diabetes as a possible risk factor for bladder cancer. Diabetes Res Clin Pract. 2025 Dec; 230:112976.. View in PubMed
  • Polygenic prediction of body mass index and obesity through the life course and across ancestries. Nat Med. 2025 Sep; 31(9):3151-3168.. View in PubMed
  • What Is Gestational Diabetes-Really? Diabetes. 2025 Jul 01; 74(7):1037-1046. Buchanan TA , Xiang AH, Page KA , Watanabe RM . . View in PubMed
  • Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver. Diabetes. 2025 Jul 01; 74(7):1300-1309.. View in PubMed
  • Associations between perceived stress and cortisol biomarkers in predominantly Latino adolescents. Sci Rep. 2025 Apr 04; 15(1):11572.. View in PubMed
  • Associations Between Perceived Stress and Cortisol Biomarkers in Predominantly Latino Adolescents. Res Sq. 2024 Nov 15.. View in PubMed
  • Higher Genetic Risk for Type 2 Diabetes Is Associated With a Faster Decline of β-Cell Function in an East Asian Population. Diabetes Care. 2024 08 01; 47(8):1386-1394.. View in PubMed
  • A saturated map of common genetic variants associated with human height. Nature. 2022 10; 610(7933):704-712.. View in PubMed