Rima Jubran, MD

Designated Institute Official for CHLA

GEMS Working Group Co-Leader

Professor of Clinical Pediatrics (Educational Scholar)

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Overview

Rima Fuad Jubran, MD, MPH, MACM is the Designated Institutional Official and Director of Graduate Medical Education at Children’s Hospital Los Angeles, where she oversees all physician training programs. In addition, Dr. Jubran is a pediatric oncologist who cares for patients with retinoblastoma, histiocytic disorders and solid tumors. She received her medical degree from Case Western Reserve University School of Medicine, Cleveland, Ohio, and her Master of Public Health at George Washington University, Washington, D.C. Following her residency at Rainbow Babies and Children’s Hospital in Cleveland, she completed a fellowship in pediatric hematology/oncology at Children’s National Medical Center, Washington, D.C. Dr. Jubran is a member of the retinoblastoma committee of the national Children’s Oncology Group and one of the founding members of the North American Consortium for Histiocytic Disorders. Her investigations focus on retinoblastoma and Langerhans cell histiocytosis. A frequent lecturer and author, she is an active member of the international Histiocytosis Society. She serves on the Board of the Kevin Cordasco Foundation and the Histiocyte Association.

Awards

  • University of Southern California: USC Academic Senate Faculty Service Award, 2023
  • Drexel University: The Hedwig van Ameringen Executive Leadership in Academic Medicine, 2020-2021
  • Keck School of Medicine of USC: Outstanding Teaching in Professionalism in the Practice of Medicine, 2015
  • Keck School of Medicine of USC: Outstanding Teaching in Professionalism in the Practice of Medicine, 2012
  • Children’s Hospital Los Angeles: Walter Laug Distinguished Teaching Award, 2011

Publications

  • A multi-institutional feasibility study of intra-arterial chemotherapy in children with retinoblastomaA Children’s Oncology Group study (COG ARET12P1). Pediatr Blood Cancer. 2024 Jan; 71(1):e30718. . View in PubMed
  • Retinoblastoma seeds: impact on American Joint Committee on Cancer clinical staging Br J Ophthalmol. 2023 01; 107(1):127-132. . View in PubMed
  • High-risk Pathologic Features Based on Presenting Findings in Advanced Intraocular Retinoblastoma: A Multicenter, International Data-Sharing American Joint Committee on Cancer Study Ophthalmology. 2022 08; 129(8):923-932. . View in PubMed
  • Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma: A Multicenter Registry-Based Study Ophthalmology. 2022 08; 129(8):933-945. . View in PubMed
  • Intensive Multimodality Therapy for Extraocular Retinoblastoma: A Children’s Oncology Group Trial (ARET0321) J Clin Oncol. 2022 11 20; 40(33):3839-3847. . View in PubMed
  • Inter-eye genomic heterogeneity in bilateral retinoblastoma via aqueous humor liquid biopsy NPJ Precis Oncol. 2021 Jul 27; 5(1):73. . View in PubMed
  • Establishing the Clinical Utility of ctDNA Analysis for Diagnosis, Prognosis, and Treatment Monitoring of Retinoblastoma: The Aqueous Humor Liquid Biopsy Cancers (Basel). 2021 Mar 13; 13(6). . View in PubMed
  • Response criteria for intraocular retinoblastoma: RB-RECIST Pediatr Blood Cancer. 2021 05; 68(5):e28964. . View in PubMed
  • Extracellular vesicle-associated repetitive element DNAs as candidate osteosarcoma biomarkers Sci Rep. 2021 01 08; 11(1):94. . View in PubMed
  • Intravitreal Melphalan for Retinoblastoma: The Impact of Toxicity on Recurrence and Ultimate Globe Salvage Ocul Oncol Pathol. 2020 Dec; 6(6):388-394. . View in PubMed
  • Simultaneous identification of clinically relevant RB1 mutations and copy number alterations in aqueous humor of retinoblastoma eyes Ophthalmic Genet. 2020 12; 41(6):526-532. . View in PubMed
  • Variability in retinoblastoma genome stability is driven by age and not heritability Genes Chromosomes Cancer. 2020 10; 59(10):584-590. . View in PubMed
  • A single-arm study of systemic and sub-Tenon chemotherapy for Groups C and D intraocular retinoblastoma: A Children’s Oncology Group study (ARET 0231) Pediatr Blood Cancer. 2020 09; 67(9):e28502. . View in PubMed
  • Cell-Free DNA Tumor Fraction in the Aqueous Humor Is Associated With Therapeutic Response in Retinoblastoma Patients Transl Vis Sci Technol. 2020 09; 9(10):30. . View in PubMed
  • Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival Mol Cancer Res. 2020 08; 18(8):1166-1175. . View in PubMed
  • Aqueous Humor Is Superior to Blood as a Liquid Biopsy for Retinoblastoma Ophthalmology. 2020 04; 127(4):552-554. . View in PubMed
  • Posterior Vitreous Detachment and the Associated Risk of Retinal Toxicity with Intravitreal Melphalan Treatment for Retinoblastoma Ocul Oncol Pathol. 2019 Jun; 5(4):238-244. . View in PubMed
  • A Review of Recurrent Retinoblastoma: Children’s Hospital Los Angeles Classification and Treatment Guidelines Int Ophthalmol Clin. 2019; 59(2):65-75. . View in PubMed
  • An Intraocular Pressure Predictive of High-risk Histopathologic Features in Group E Retinoblastoma Eyes Int Ophthalmol Clin. 2019; 59(2):77-86. . View in PubMed
  • Integrated Treatment during the Intravitreal Melphalan Era: Concurrent Intravitreal Melphalan and Systemic Chemoreduction Ocul Oncol Pathol. 2018 Nov; 4(6):335-340. . View in PubMed
  • Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Mol Cancer Res. 2018 11; 16(11):1701-1712. . View in PubMed
  • Lurking below: massive choroidal invasion under a calcified tumor after attempted conservative therapy for retinoblastoma Ophthalmic Genet. 2018 10; 39(5):653-657. . View in PubMed
  • Lack of correlation between age at diagnosis and RB1 mutations for unilateral retinoblastoma: the importance of genetic testing Ophthalmic Genet. 2018 06; 39(3):407-409. . View in PubMed
  • Loss of fundus view as an indication for secondary enucleation in retinoblastoma Pediatr Blood Cancer. 2018 04; 65(4). . View in PubMed
  • Three presentations of CNS disease in patients with intraocular retinoblastoma at a tertiary medical center in the United States Ophthalmic Genet. 2018 Jan-Feb; 39(1):115-119. . View in PubMed
  • Long-term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era Pediatr Blood Cancer. 2017 Dec; 64(12). . View in PubMed
  • Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion? Ocul Oncol Pathol. 2017 Nov; 3(4):283-291.. View in PubMed
  • Clinical Significance of Optic Nerve Enhancement on Magnetic Resonance Imaging in Enucleated Retinoblastoma Patients Ophthalmol Retina. 2017 Sep – Oct; 1(5):369-374. . View in PubMed
  • Treatment Outcomes of Focal Laser Consolidation during Chemoreduction for Group B Retinoblastoma Ophthalmol Retina. 2017 Sep – Oct; 1(5):361-368. . View in PubMed
  • Systemic neoadjuvant chemotherapy for Group B intraocular retinoblastoma (ARET0331): A report from the Children’s Oncology Group Pediatr Blood Cancer. 2017 Jul; 64(7). . View in PubMed
  • Not All Seeds Are Created Equal: Seed Classification Is Predictive of Outcomes in Retinoblastoma Ophthalmology. 2017 12; 124(12):1817-1825. . View in PubMed
  • Measuring pediatric hematology-oncology fellows’ skills in humanism and professionalism: A novel assessment instrument Pediatr Blood Cancer. 2017 05; 64(5). . View in PubMed
  • Risk of metastasis and orbital recurrence in advanced retinoblastoma eyes treated with systemic chemoreduction versus primary enucleation Pediatr Blood Cancer. 2017 04; 64(4). . View in PubMed
  • Patterns of subretinal fluid resolution in Group D eyes treated with chemoreduction: Experience from the Children’s Hospital Los Angeles/University of Southern California Ophthalmic Genet. 2016 12; 37(4):400-403. . View in PubMed
  • Navigating your career path in pediatric hematology/oncology: On and off the beaten track Pediatr Blood Cancer. 2016 10; 63(10):1723-30. . View in PubMed
  • Long-Term Outcomes of Group B Eyes in Patients with Retinoblastoma Treated with Short-Course Chemoreduction: Experience from Children’s Hospital Los Angeles/University of Southern California Ocul Oncol Pathol. 2015 Dec; 2(2):105-11. . View in PubMed
  • Orbital Recurrence following Aggressive Laser Treatment for Recurrent Retinoblastoma Ocul Oncol Pathol. 2015 Dec; 2(2):76-9. . View in PubMed
  • Management and Outcome of Patients With Langerhans Cell Histiocytosis and Single-Bone CNS-Risk Lesions: A Multi-Institutional Retrospective Study Pediatr Blood Cancer. 2015 Dec; 62(12):2162-6. . View in PubMed
  • Oxaliplatin and Doxorubicin for relapsed or refractory high-risk neuroblastoma Pediatr Hematol Oncol. 2015 Feb; 32(1):26-31. . View in PubMed
  • Low-Dose Chemoreduction for Infants Diagnosed with Retinoblastoma before 6 Months of Age Ocul Oncol Pathol. 2015 Feb; 1(2):103-10. . View in PubMed
  • Clinical outcomes of radiation therapy in the management of Langerhans cell histiocytosis Am J Clin Oncol. 2014 Dec; 37(6):592-6. . View in PubMed
  • Outcomes of children younger than 24 months with langerhans cell histiocytosis and bone involvement: a report from a single institution J Pediatr Orthop. 2014 Dec; 34(8):825-30. . View in PubMed
  • Factors predictive of long-term visual outcomes of Group D eyes treated with chemoreduction and low-dose IMRT salvage: the Children’s Hospital Los Angeles experience Br J Ophthalmol. 2014 Aug; 98(8):1061-5. . View in PubMed
  • Simultaneous colonic adenocarcinoma and medulloblastoma in a 12-year-old with biallelic deletions in PMS2 J Pediatr. 2013 Aug; 163(2):601-3. . View in PubMed
  • Long-term outcomes of Group D eyes in bilateral retinoblastoma patients treated with chemoreduction and low-dose IMRT salvage Pediatr Blood Cancer. 2013 Apr; 60(4):688-93. . View in PubMed
  • Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years Pediatr Blood Cancer. 2013 Feb; 60(2):175-84. . View in PubMed
  • An exploratory epidemiological study of Langerhans cell histiocytosis Pediatr Blood Cancer. 2012 Dec 15; 59(7):1324-6. . View in PubMed
  • Graduate medical education changes: yes we can or enough already? Pediatr Blood Cancer. 2012 Dec 15; 59(7):1168-72.. View in PubMed
  • Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children’s Hospital Los Angeles (CHLA) experience, 1991-2010 Pediatr Blood Cancer. 2012 Jun; 58(6):905-9. . View in PubMed
  • Symptoms before and after posterior fossa surgery in pediatric patients Pediatr Neurosurg. 2012; 48(1):21-5. . View in PubMed
  • The role of chemotherapy in pediatric clival chordomas J Neurooncol. 2011 Jul; 103(3):657-62. . View in PubMed
  • Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen J Neurooncol. 2011 Jul; 103(3):673-80. . View in PubMed
  • Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation Int J Cancer. 2011 May 15; 128(10):2393-404. . View in PubMed
  • Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation Pediatr Blood Cancer. 2010 Jul 15; 55(1):42-6. . View in PubMed
  • High-dose chemotherapy with autologous hematopoietic stem cell rescue for stage 4B retinoblastoma Pediatr Blood Cancer. 2010 Jul 15; 55(1):149-52. . View in PubMed
  • Trilateral retinoblastoma: potentially curable with intensive chemotherapy Pediatr Blood Cancer. 2010 Mar; 54(3):384-7. . View in PubMed
  • High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcome Cancer. 2009 Jul 01; 115(13):2956-63. . View in PubMed
  • Management of retinoblastoma with proximal optic nerve enhancement on MRI at diagnosis Pediatr Blood Cancer. 2008 Oct; 51(4):479-84. . View in PubMed
  • Brainstem primitive neuroectodermal tumors (bstPNET): results of treatment with intensive induction chemotherapy followed by consolidative chemotherapy with autologous hematopoietic cell rescue Pediatr Blood Cancer. 2008 Mar; 50(3):715-7. . View in PubMed
  • A case of composite neuroblastoma composed of histologically and biologically distinct clones Pediatr Dev Pathol. 2007 May-Jun; 10(3):229-32. . View in PubMed
  • Predictors of outcome in children with Langerhans cell histiocytosis Pediatr Blood Cancer. 2005 Jul; 45(1):37-42. . View in PubMed
  • Disordered respiratory control in children with partial cerebellar resections Pediatr Pulmonol. 2005 Jul; 40(1):88-91. . View in PubMed
  • Central nervous system germ cell tumors: controversies in diagnosis and treatment Oncology (Williston Park). 2005 May; 19(6):705-11; discussion 711-2715-7721. . View in PubMed
  • Approaches to treatment for extraocular retinoblastoma: Children’s Hospital Los Angeles experience J Pediatr Hematol Oncol. 2004 Jan; 26(1):31-4. . View in PubMed
  • GB virus C/Hepatitis G virus infection is frequent in American children and young adults Clin Infect Dis. 2000 Mar; 30(3):569-71. . View in PubMed
  • Successful therapy of refractory graft versus host disease with tacrolimus and Psoralen plus ultraviolet light Ther Drug Monit. 1998 Apr; 20(2):236-9. . View in PubMed