Robert Rissman

Professor of Physiology and Neuroscience

Director of the Neuroscience Translational Research Division of ATRI

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Publications

  • Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups Acta Neuropathol. 2024 Aug 23; 148(1):27. . View in PubMed
  • The Alzheimer’s Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study medRxiv. 2024 Aug 22. . View in PubMed
  • Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins bioRxiv. 2024 Jul 26. . View in PubMed
  • Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing medRxiv. 2024 Jun 25. . View in PubMed
  • A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species Brain. 2024 May 14. . View in PubMed
  • Immunotherapy with an antibody against CD1d modulates neuroinflammation in an a-synuclein transgenic model of Lewy body like disease J Neuroinflammation. 2024 Apr 15; 21(1):93. . View in PubMed
  • From understanding to action: Exploring molecular connections of Down syndrome to Alzheimer’s disease for targeted therapeutic approach Alzheimers Dement (Amst). 2024 Apr-Jun; 16(2):e12580. . View in PubMed
  • CSF1R-mediated myeloid cell depletion shifts the ratio of motor cortical excitatory to inhibitory neurons in a multiple system atrophy model Exp Neurol. 2024 Apr; 374:114706. . View in PubMed
  • AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer’s disease bioRxiv. 2024 Mar 27. . View in PubMed
  • A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with Early Alzheimer’s Disease medRxiv. 2024 Mar 22. . View in PubMed
  • Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic Groups medRxiv. 2024 Feb 14. . View in PubMed
  • Correction: GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice J Neurovirol. 2024 Feb; 30(1):101-102. . View in PubMed
  • Corrigendum to ” Systemic peptide mediated delivery of an siRNA targeting a-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy Body Disease” [Neurobiology of Disease127 (2019) 163-177] Neurobiol Dis. 2024 Feb; 191:106397. . View in PubMed
  • Assessment of brain-derived extracellular vesicle enrichment for blood biomarker analysis in age-related neurodegenerative diseases: An international overview Alzheimers Dement. 2024 07; 20(7):4411-4422. . View in PubMed
  • Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer’s disease trial Alzheimers Dement. 2024 06; 20(6):3827-3838. . View in PubMed
  • Amyloid precursor protein induces reactive astrogliosis Acta Physiol (Oxf). 2024 06; 240(6):e14142. . View in PubMed
  • Plasma Aß42/Aß40 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer’s disease Alzheimers Dement. 2024 02; 20(2):1214-1224. . View in PubMed
  • Association between military service and Alzheimer’s disease neuropathology at autopsy Alzheimers Dement. 2024 02; 20(2):1468-1474. . View in PubMed
  • Retina pathology as a target for biomarkers for Alzheimer’s disease: Current status, ophthalmopathological background, challenges, and future directions Alzheimers Dement. 2024 01; 20(1):728-740. . View in PubMed
  • The heritability of blood-based biomarkers related to risk of Alzheimer’s disease in a population-based sample of early old-age men Alzheimers Dement. 2024 01; 20(1):356-365. . View in PubMed
  • Relationship between Plasma P-Tau217 and Amyloid PET in Racial and Ethnic Underrepresented Groups (RE-URG) Compared with Non RE-URG in LEARN and A4 J Prev Alzheimers Dis. 2024; 11(4):831-837. . View in PubMed
  • Maximizing the Utility of Alzheimer’s Disease Trial Data: Sharing of Baseline A4 and LEARN Data J Prev Alzheimers Dis. 2024; 11(4):889-894. . View in PubMed
  • Longitudinal Phospho-tau217 Predicts Amyloid Positron Emission Tomography in Asymptomatic Alzheimer’s Disease J Prev Alzheimers Dis. 2024; 11(4):823-830. . View in PubMed
  • Amyloid and Tau Prediction of Cognitive and Functional Decline in Unimpaired Older Individuals: Longitudinal Data from the A4 and LEARN Studies J Prev Alzheimers Dis. 2024; 11(4):802-813. . View in PubMed
  • A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer’s Disease Alzheimers Res Ther. 2024 07 05; 16(1):151. . View in PubMed
  • The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease Acta Neuropathol Commun. 2024 05 24; 12(1):81. . View in PubMed
  • Midlife cumulative deficit frailty predicts Alzheimer’s disease-related plasma biomarkers in older adults Age Ageing. 2024 03 01; 53(3). . View in PubMed
  • Characterization of Ptau181 Among a Diverse Community-Based Cohort: A HABS-HD Study J Alzheimers Dis. 2024; 100(s1):S63-S73. . View in PubMed
  • Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men Alzheimers Res Ther. 2024 04 25; 16(1):90. . View in PubMed
  • Amyloid precursor protein induces reactive astrogliosis bioRxiv. 2023 Dec 18. . View in PubMed
  • Assessment of brain-derived extracellular vesicle enrichment for blood biomarker analysis in age-related neurodegenerative diseases: An international overview bioRxiv. 2023 Oct 02. . View in PubMed
  • Differential involvement of hippocampal subfields in the relationship between Alzheimer’s pathology and memory interference in older adults Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12419. . View in PubMed
  • Clinical utility of an antibody-free LC-MS method to detect brain amyloid deposition in cognitively unimpaired individuals from the screening visit of the A4 Study Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12451. . View in PubMed
  • The Independent Walking for Brain Health Intervention for Older Adults: Protocol for a Pilot Randomized Controlled Trial JMIR Res Protoc. 2023 Feb 13; 12:e42980. . View in PubMed
  • Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer’s disease: Research outline and call for collaboration Alzheimers Dement. 2023 11; 19(11):5209-5231. . View in PubMed
  • GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice J Neurovirol. 2023 10; 29(5):564-576. . View in PubMed
  • Pathogenesis of Alzheimer’s disease: Involvement of the choroid plexus Alzheimers Dement. 2023 08; 19(8):3537-3554. . View in PubMed
  • Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer’s disease Alzheimers Dement. 2023 05; 19(5):2084-2094. . View in PubMed
  • The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer’s disease Alzheimers Dement. 2023 04; 19(4):1227-1233. . View in PubMed
  • Missorting of plasma miRNAs in aging and Alzheimer’s disease J Neurochem. 2023 04; 165(2):149-161. . View in PubMed
  • Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy Neurobiol Dis. 2023 03; 178:106010. . View in PubMed
  • LATE-NC staging in routine neuropathologic diagnosis: an update Acta Neuropathol. 2023 02; 145(2):159-173. . View in PubMed
  • TDP-43 Pathology in the Setting of Intermediate and High Alzheimer’s Disease Neuropathologic Changes: A Preliminary Evaluation Across Ethnoracial Groups J Alzheimers Dis. 2023; 91(4):1291-1301. . View in PubMed
  • Front Neurol. 2023; 14:1331194. . View in PubMed
  • D-685 Reverses Motor Deficits and Reduces Accumulation of Human a-Synuclein Protein in Two Different Parkinson’s Disease Animal Models ACS Chem Neurosci. 2023 03 01; 14(5):885-896. . View in PubMed
  • Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin Extracell Vesicles Circ Nucl Acids. 2023; 4(4):588-598. . View in PubMed
  • Precision Medicine for Preventing Alzheimer’s Disease: Analysis of the ADAPT Study J Alzheimers Dis. 2023; 95(4):1609-1622. . View in PubMed
  • Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce a-synuclein in a mouse model of Alzheimer’s disease Neurobiol Dis. 2023 10 01; 186:106285. . View in PubMed
  • Evaluation of Neighborhood-Level Disadvantage and Cognition in Mexican American and Non-Hispanic White Adults 50 Years and Older in the US JAMA Netw Open. 2023 08 01; 6(8):e2325325. . View in PubMed
  • Nicotine-mediated effects in neuronal and mouse models of synucleinopathy Front Neurosci. 2023; 17:1239009. . View in PubMed
  • Hippocampal Reduction of a-Synuclein via RNA Interference Improves Neuropathology in Alzheimer’s Disease Mice J Alzheimers Dis. 2023; 95(1):349-361. . View in PubMed
  • The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease Acta Neuropathol Commun. 2023 06 29; 11(1):105. . View in PubMed
  • Sci Transl Med. 2023 05 10; 15(695):eabq6089. . View in PubMed
  • Characterization of altered molecular mechanisms in Parkinson’s disease through cell type-resolved multiomics analyses Sci Adv. 2023 04 14; 9(15):eabo2467. . View in PubMed
  • Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration J Neurosci. 2023 05 24; 43(21):3970-3984. . View in PubMed
  • Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS-HD study Alzheimers Dement (Amst). 2023 Jan-Mar; 15(1):e12394. . View in PubMed
  • Evaluation of Blood-Based Plasma Biomarkers as Potential Markers of Amyloid Burden in Preclinical Alzheimer’s Disease J Alzheimers Dis. 2023; 92(1):95-107. . View in PubMed
  • SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer’s-like neuropathology bioRxiv. 2022 Sep 06. . View in PubMed
  • Plasma biomarkers for Alzheimer’s Disease in relation to neuropathology and cognitive change Acta Neuropathol. 2022 04; 143(4):487-503. . View in PubMed
  • Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study Alzheimers Dement. 2022 02; 18(2):240-250. . View in PubMed
  • A blood screening tool for detecting mild cognitive impairment and Alzheimer’s disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research Alzheimers Dement. 2022 01; 18(1):77-87. . View in PubMed
  • Genome-wide association study and functional validation implicates JADE1 in tauopathy Acta Neuropathol. 2022 01; 143(1):33-53. . View in PubMed
  • Noninvasive Antemortem Detection of Retinal Prions by a Fluorescent Tracer J Alzheimers Dis. 2022; 88(3):1137-1145. . View in PubMed
  • Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer’s Disease Brain ACS Chem Neurosci. 2022 07 06; 13(13):1992-2005. . View in PubMed
  • Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial JAMA Neurol. 2022 06 01; 79(6):565-574. . View in PubMed
  • Association of neurofilament light chain with renal function: mechanisms and clinical implications Alzheimers Res Ther. 2022 12 16; 14(1):189. . View in PubMed
  • Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels Commun Biol. 2022 04 08; 5(1):336. . View in PubMed
  • Proteomic Profiles of Neurodegeneration Among Mexican Americans and Non-Hispanic Whites in the HABS-HD Study J Alzheimers Dis. 2022; 86(3):1243-1254. . View in PubMed
  • The Link between APOE4 Presence and Neuropsychological Test Performance among Mexican Americans and Non-Hispanic Whites of the Multiethnic Health & Aging Brain Study – Health Disparities Cohort Dement Geriatr Cogn Disord. 2022; 51(1):26-31. . View in PubMed
  • Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study Alzheimers Dement (Amst). 2022; 14(1):e12267. . View in PubMed
  • Dopamine neurons exhibit emergent glutamatergic identity in Parkinson’s disease Brain. 2022 04 29; 145(3):879-886. . View in PubMed
  • Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer’s disease: a randomized trial Sci Rep. 2022 01 25; 12(1):1346. . View in PubMed
  • Association of Neighborhood-Level Disadvantage With Neurofibrillary Tangles on Neuropathological Tissue Assessment JAMA Netw Open. 2022 04 01; 5(4):e228966. . View in PubMed
  • Evaluation of blood-based, extracellular vesicles as biomarkers for aging-related TDP-43 pathology Alzheimers Dement (Amst). 2022; 14(1):e12365. . View in PubMed
  • Characterization of Mild Cognitive Impairment and Dementia among Community-Dwelling Mexican Americans and Non-Hispanic Whites J Alzheimers Dis. 2022; 90(2):905-915. . View in PubMed
  • Digital Histological Study of Neocortical Grey and White Matter Tau Burden Across Tauopathies J Neuropathol Exp Neurol. 2022 11 16; 81(12):953-964. . View in PubMed
  • CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy J Neurosci. 2022 10 05; 42(40):7673-7688. . View in PubMed
  • Novel Brain-Penetrating Single Chain Antibodies Directed Against 3RTau for the Treatment of Alzheimer’s Disease and Related Dementias Methods Mol Biol. 2022; 2383:447-457. . View in PubMed
  • Association of Neurofibrillary Tangle Distribution With Age at Onset-Related Clinical Heterogeneity in Alzheimer Disease: An Autopsy Study Neurology. 2022 02 01; 98(5):e506-e517. . View in PubMed
  • Modulation of Amyloid-ß and Tau in Alzheimer’s Disease Plasma Neuronal-Derived Extracellular Vesicles by Cerebrolysin® and Donepezil J Alzheimers Dis. 2022; 90(2):705-717. . View in PubMed
  • Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons ACS Omega. 2021 May 25; 6(20):13033-13056. . View in PubMed
  • Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer’s disease Alzheimers Dement. 2021 09; 17(9):1487-1498. . View in PubMed
  • Mutant three-repeat tau expression initiates retinal ganglion cell death through Caspase-2 Neurobiol Dis. 2021 05; 152:105277. . View in PubMed
  • Effects of innate immune receptor stimulation on extracellular a-synuclein uptake and degradation by brain resident cells Exp Mol Med. 2021 02; 53(2):281-290. . View in PubMed
  • Unbalanced Regulation of a7 nAChRs by Ly6h and NACHO Contributes to Neurotoxicity in Alzheimer’s Disease J Neurosci. 2021 10 13; 41(41):8461-8474. . View in PubMed
  • Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) trial Alzheimers Dement (Amst). 2021; 13(1):e12199. . View in PubMed
  • Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer’s disease Science. 2021 01 15; 371(6526). . View in PubMed
  • The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics Alzheimers Dement (Amst). 2021; 13(1):e12202. . View in PubMed
  • Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer’s Disease J Prev Alzheimers Dis. 2021; 8(3):240-248. . View in PubMed
  • Protein Footprinting via Covalent Protein Painting Reveals Structural Changes of the Proteome in Alzheimer’s Disease J Proteome Res. 2021 05 07; 20(5):2762-2771. . View in PubMed
  • A Precision Medicine Approach to Treating Alzheimer’s Disease Using Rosiglitazone Therapy: A Biomarker Analysis of the REFLECT Trials J Alzheimers Dis. 2021; 81(2):557-568. . View in PubMed
  • J Exp Med. 2021 04 05; 218(4). . View in PubMed
  • NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression Cells. 2021 12 13; 10(12). . View in PubMed
  • Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy J Neuropathol Exp Neurol. 2021 01 20; 80(2):102-111. . View in PubMed
  • Using Fractional Anisotropy Imaging to Detect Mild Cognitive Impairment and Alzheimer’s Disease among Mexican Americans and Non-Hispanic Whites: A HABLE Study Dement Geriatr Cogn Disord. 2021; 50(3):266-273. . View in PubMed
  • Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression PLoS One. 2021; 16(9):e0251611. . View in PubMed
  • A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes Genome Med. 2021 09 01; 13(1):141. . View in PubMed
  • Developing Biomarkers of Mild Traumatic Brain Injury: Promise and Progress of CNS-Derived Exosomes Front Neurol. 2021; 12:698206. . View in PubMed
  • Reproductive status impact on tau phosphorylation induced by chronic stress Neurobiol Stress. 2020 Nov; 13:100241. . View in PubMed
  • Neuroinflammation is associated with infiltration of T cells in Lewy body disease and a-synuclein transgenic models J Neuroinflammation. 2020 Jul 17; 17(1):214. . View in PubMed
  • Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein ß in HIV-associated neurocognitive disorder J Neuroinflammation. 2020 Apr 11; 17(1):112. . View in PubMed
  • A missense point mutation in nerve growth factor (NGFR100W) results in selective peripheral sensory neuropathy Prog Neurobiol. 2020 11; 194:101886. . View in PubMed
  • Nature. 2020 10; 586(7831):735-740. . View in PubMed
  • Cathepsin B in neurodegeneration of Alzheimer’s disease, traumatic brain injury, and related brain disorders Biochim Biophys Acta Proteins Proteom. 2020 08; 1868(8):140428. . View in PubMed
  • Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses Mol Cell Proteomics. 2020 06; 19(6):1017-1034. . View in PubMed
  • Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain Alzheimers Res Ther. 2020 06 19; 12(1):75. . View in PubMed
  • Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial JAMA Neurol. 2020 09 01; 77(9):1099-1109. . View in PubMed
  • Front Neurosci. 2020; 14:286. . View in PubMed
  • Correction to: Brain-derived exosomes from dementia with Lewy bodies propagate a-synuclein pathology Acta Neuropathol Commun. 2020 08 04; 8(1):123. . View in PubMed
  • The Trial-Ready Cohort for Preclinical/Prodromal Alzheimer’s Disease (TRC-PAD) Project: An Overview J Prev Alzheimers Dis. 2020; 7(4):208-212. . View in PubMed
  • LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies Sci Transl Med. 2020 10 14; 12(565). . View in PubMed
  • The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer’s Disease J Alzheimers Dis. 2020; 73(4):1541-1554. . View in PubMed
  • Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume JAMA Neurol. 2020 04 01; 77(4):451-460. . View in PubMed
  • Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau Brain Commun. 2020; 2(1):fcaa025. . View in PubMed
  • Plasma Levels of Neuron- and Astrocyte-Derived Exosomal Amyloid Beta1-42, Amyloid Beta1-40, and Phosphorylated Tau Levels in Schizophrenia Patients and Non-psychiatric Comparison Subjects: Relationships With Cognitive Functioning and Psychopathology Front Psychiatry. 2020; 11:532624. . View in PubMed
  • Association of Neighborhood-Level Disadvantage With Alzheimer Disease Neuropathology JAMA Netw Open. 2020 06 01; 3(6):e207559. . View in PubMed
  • The Area Deprivation Index: A novel tool for harmonizable risk assessment in Alzheimer’s disease research Alzheimers Dement (N Y). 2020; 6(1):e12039. . View in PubMed
  • Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease Transl Neurodegener. 2020 06 18; 9(1):26. . View in PubMed
  • DTI-identified microstructural changes in the gray matter of mice overexpressing CRF in the forebrain Psychiatry Res Neuroimaging. 2020 10 30; 304:111137. . View in PubMed
  • Reflections on the Utility of the Retina as a Biomarker for Alzheimer’s Disease: A Literature Review Neurol Ther. 2019 Dec; 8(Suppl 2):57-72. . View in PubMed
  • Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer’s disease dementia Alzheimers Dement (Amst). 2019 Dec; 11:61-66. . View in PubMed
  • Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial JAMA Neurol. 2019 Nov 01; 76(11):1330-1339. . View in PubMed
  • Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial JAMA Neurol. 2019 Oct 01; 76(10):1219-1229. . View in PubMed
  • High-Throughput Mass Spectrometry Assay for Quantifying ß-Amyloid 40 and 42 in Cerebrospinal Fluid Clin Chem. 2019 12; 65(12):1572-1580. . View in PubMed
  • Effects of single and combined immunotherapy approach targeting amyloid ß protein and a-synuclein in a dementia with Lewy bodies-like model Alzheimers Dement. 2019 09; 15(9):1133-1148. . View in PubMed
  • Systemic peptide mediated delivery of an siRNA targeting a-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease Neurobiol Dis. 2019 07; 127:163-177. . View in PubMed
  • Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD Acta Neuropathol. 2019 06; 137(6):879-899. . View in PubMed
  • Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer’s disease Alzheimers Dement. 2019 03; 15(3):487-496. . View in PubMed
  • Perspectives on ethnic and racial disparities in Alzheimer’s disease and related dementias: Update and areas of immediate need Alzheimers Dement. 2019 02; 15(2):292-312. . View in PubMed
  • Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease Acta Neuropathol Commun. 2019 05 17; 7(1):77. . View in PubMed
  • miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients Front Neurosci. 2019; 13:1208. . View in PubMed
  • Brain cell type-specific enhancer-promoter interactome maps and disease-risk association Science. 2019 11 29; 366(6469):1134-1139. . View in PubMed
  • Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity Front Neurosci. 2019; 13:1005. . View in PubMed
  • Extracellular Vesicles Isolated from Familial Alzheimer’s Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain J Alzheimers Dis. 2019; 72(2):575-585. . View in PubMed
  • Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer’s DiseaseCell Rep. 2019 07 23; 28(4):1103-1116. e4. . View in PubMed
  • Plasma Neurofilament Light and Alzheimer’s Disease Biomarkers in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI) J Alzheimers Dis. 2019; 70(1):131-138. . View in PubMed
  • Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report Brain. 2019 06 01; 142(6):1503-1527. . View in PubMed
  • Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo J Alzheimers Dis. 2019; 67(2):541-553. . View in PubMed
  • T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation Traffic. 2018 11; 19(11):840-853. . View in PubMed
  • Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders Acta Neuropathol. 2018 07; 136(1):69-87. . View in PubMed
  • Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study Lancet Neurol. 2018 06; 17(6):548-558. . View in PubMed
  • Clinical-Neuropathological Correlations of Alzheimer’s Disease and Related Dementias in Latino Volunteers J Alzheimers Dis. 2018; 66(4):1539-1548. . View in PubMed
  • Growth Hormone-Releasing Hormone Modulation of Neuronal Exosome Biomarkers in Mild Cognitive Impairment J Alzheimers Dis. 2018; 66(3):971-981. . View in PubMed
  • A Precision Medicine Model for Targeted NSAID Therapy in Alzheimer’s Disease J Alzheimers Dis. 2018; 66(1):97-104. . View in PubMed
  • Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating a-synuclein transmission and neuroinflammation Mol Neurodegener. 2018 08 09; 13(1):43. . View in PubMed
  • Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial JAMA Neurol. 2018 07 01; 75(7):834-841. . View in PubMed
  • Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau J Alzheimers Dis. 2018; 61(3):1201-1219. . View in PubMed
  • Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies J Neurosci. 2018 01 24; 38(4):1000-1014. . View in PubMed
  • Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System Front Aging Neurosci. 2018; 10:373. . View in PubMed
  • Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson’s disease/dementia with Lewy bodies Sci Rep. 2018 12 27; 8(1):18083. . View in PubMed
  • Nat Med. 2017 Nov; 23(11):1377-1383. . View in PubMed
  • Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation Neurobiol Dis. 2017 Oct; 106:222-234. . View in PubMed
  • Differential effects of immunotherapy with antibodies targeting a-synuclein oligomers and fibrils in a transgenic model of synucleinopathy Neurobiol Dis. 2017 Aug; 104:85-96. . View in PubMed
  • A phase 3 trial of IV immunoglobulin for Alzheimer disease Neurology. 2017 May 02; 88(18):1768-1775. . View in PubMed
  • J Pharmacol Exp Ther. 2017 07; 362(1):31-44. . View in PubMed
  • Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic Alzheimers Dement. 2017 01; 13(1):45-58. . View in PubMed
  • Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease J Neuroinflammation. 2017 01 03; 14(1):1. . View in PubMed
  • PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI) J Alzheimers Dis. 2017; 60(2):439-450. . View in PubMed
  • Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease Sci Rep. 2017 06 20; 7(1):3868. . View in PubMed
  • Brain-derived exosomes from dementia with Lewy bodies propagate a-synuclein pathology Acta Neuropathol Commun. 2017 06 09; 5(1):46. . View in PubMed
  • Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment J Alzheimers Dis. 2017; 56(1):229-237. . View in PubMed
  • Lack of Influence of Apolipoprotein E Status on Cognition or Brain Structure in Professional Fighters J Neurotrauma. 2017 01 15; 34(2):380-384. . View in PubMed
  • NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism Nat Commun. 2017 11 14; 8(1):1488. . View in PubMed
  • Corticotropin-releasing factor receptor-1 modulates biomarkers of DNA oxidation in Alzheimer’s disease mice PLoS One. 2017; 12(7):e0181367. . View in PubMed
  • Anti-a-synuclein immunotherapy reduces a-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy Acta Neuropathol Commun. 2017 01 13; 5(1):7. . View in PubMed
  • Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer’s disease Alzheimers Dement (N Y). 2016 Jun; 2(2):131-139. . View in PubMed
  • Dissociation of Down syndrome and Alzheimer’s disease effects with imaging Alzheimers Dement (N Y). 2016 Jun; 2(2):69-81. . View in PubMed
  • Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer’s disease Alzheimers Dement. 2016 05; 12(5):527-37. . View in PubMed
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