Roger F Duncan, PhD

Dr. Duncan received his Ph.D. from the University of Hawaii in 1978. He moved to the University of Colorado (Boulder) and the University of California (Davis) for post-doctoral research studies, before joining the University of Southern California School of Pharmacy in 1987, where he is currently an associate professor in the Department of Molecular Pharmacology.

• HEAT STRESS EFFECTS ON PROTEIN SYNTHESIS
  NIH · R29GM042644 · Jul 1, 1989 – Jun 30, 1994 · Role: Principal Investigator

• Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16348-53.. View in PubMed
• Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation. Cell Stress Chaperones. 2008; 13(2):143-55.. View in PubMed
• Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 2005 Oct; 272(20):5244-56.. View in PubMed
• Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress. Free Radic Biol Med. 2005 Mar 01; 38(5):631-43.. View in PubMed
• Translational regulation of Hsp90 mRNA. AUG-proximal 5′-untranslated region elements essential for preferential heat shock translation. J Biol Chem. 2004 Nov 26; 279(48):49919-30.. View in PubMed
• c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochem J. 2003 Jun 01; 372(Pt 2):359-69.. View in PubMed
• Heme and lipid peroxides in hemoglobin-modified low-density lipoprotein mediate cell survival and adaptation to oxidative stress. Blood. 2003 Sep 01; 102(5):1732-9.. View in PubMed
• Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells. Biochem J. 2003 Jan 15; 369(Pt 2):213-25.. View in PubMed
• Hepatitis C virus IRES-dependent translation is insensitive to an eIF2alpha-independent mechanism of inhibition by interferon in hepatocyte cell lines. Virology. 2002 Jun 05; 297(2):195-202.. View in PubMed

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