Roksana Karim, MD, PhD

Associate Professor of Clinical Population and Public Health Sciences

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Overview

Dr. Karim joined the USC faculty in 2007; soon after receiving her Doctoral degree in Epidemiology at Preventive Medicine USC. She has a medical degree from Dhaka Medical College, Bangladesh. Dr. Karim teaches Epidemiology and Research Methods for the MPH online program and the undergraduate program of Health promotions (HP) within the Department of Preventive Medicine. Her major research interest is women’s health, particularly the impact of menopause and sex hormone concentrations on atherosclerosis/cardiovascular disease and other age-related chronic inflammatory outcomes including bone density and cognition. She also has vast interest in HIV-associated endocrine and cardiovascular complications in women and children. Dr. Karim published over 60 original articles in well-respected, peer-reviewed journals from NIH-funded studies and received multiple awards and recognition for her research works.

Publications

  • Miscarriage among women in the United States Women’s Interagency HIV Study, 1994-2017Am J Obstet Gynecol. 2019 10; 221(4):347. e1-347. e13. . View in PubMed
  • Use of antimüllerian hormone to predict the menopausal transition in HIV-infected womenAm J Obstet Gynecol. 2017 Jan; 216(1):46. e1-46. e11. . View in PubMed
  • Trends of and factors associated with live-birth and abortion rates among HIV-positive and HIV-negative womenAm J Obstet Gynecol. 2017 Jan; 216(1):71. e1-71. e16. . View in PubMed
  • Feasibility and acceptability of sexually transmitted infection screening during antenatal care of women in Dhaka, Bangladesh Int J STD AIDS. 2024 May 06; 9564624241248674. . View in PubMed
  • Mediation analysis of chronic kidney disease risk factors using kidney biomarkers in women living with HIV AIDS. 2024 May 01; 38(6):813-824. . View in PubMed
  • Effect of Hormone Therapy on Lipoprotein Subfractions in Early and Late Postmenopausal Women J Clin Endocrinol Metab. 2024 Mar 28. . View in PubMed
  • The association of hysterectomy with or without ovarian conservation with subclinical atherosclerosis progression in healthy postmenopausal women Menopause. 2023 07 01; 30(7):692-702. . View in PubMed
  • Tubular Secretory Solute Clearance and HIV Infection J Acquir Immune Defic Syndr. 2023 08 01; 93(4):319-326. . View in PubMed
  • Comparison of Cardiovascular Disease Risk Factors Between 2 Subclinical Atherosclerosis Measures in Healthy Postmenopausal Women: Carotid Artery Wall Thickness and Echogenicity: Carotid Artery Wall Thickness and Echogenicity J Ultrasound Med. 2023 Jan; 42(1):35-44. . View in PubMed
  • Concentrations of endogenous sex steroid hormones and SHBG in healthy postmenopausal women J Steroid Biochem Mol Biol. 2022 Oct; 223:106080. . View in PubMed
  • Effect of menopausal hormone therapy on arterial wall echomorphology: Results from the Early versus Late Intervention Trial with Estradiol (ELITE) Maturitas. 2022 08; 162:15-22. . View in PubMed
  • Subclinical carotid artery atherosclerosis and cognitive function in older adults Alzheimers Res Ther. 2022 05 07; 14(1):63. . View in PubMed
  • Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women Clin Epigenetics. 2022 07 18; 14(1):90. . View in PubMed
  • Brief Report: Subclinical Carotid Artery Atherosclerosis Is Associated With Increased Expression of Peripheral Blood IL-32 Isoforms Among Women Living With HIV J Acquir Immune Defic Syndr. 2021 10 01; 88(2):186-191. . View in PubMed
  • Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis Front Immunol. 2021; 12:664371. . View in PubMed
  • Factors Associated With Serum Estradiol Levels Among Postmenopausal Women Using Hormone Therapy Obstet Gynecol. 2020 10; 136(4):675-684. . View in PubMed
  • Association of hot flushes with ghrelin and adipokines in early versus late postmenopausal women Menopause. 2020 05; 27(5):512-518. . View in PubMed
  • Women from afar: an observational study of demographic characteristics and mortality among foreign-born women living with HIV in the Women’s Interagency HIV Study (WIHS) in the United States 1994-2016 J Int AIDS Soc. 2020 05; 23(5):e25486. . View in PubMed
  • White Blood Cell Counts, Lymphocyte Subsets, and Incident Diabetes Mellitus in Women Living With and Without HIV AIDS Res Hum Retroviruses. 2020 02; 36(2):131-133. . View in PubMed
  • Longitudinal assessment of abnormal Papanicolaou test rates among women with HIV AIDS. 2020 01 01; 34(1):73-80. . View in PubMed
  • Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer’s disease Menopause. 2019 01; 26(1):7-15. . View in PubMed
  • Differential Effect of Plasma Estradiol on Subclinical Atherosclerosis Progression in Early vs Late Postmenopause J Clin Endocrinol Metab. 2019 02 01; 104(2):293-300. . View in PubMed
  • Effect of ApoE4 Genotype on the Association Between Metabolic Phenotype and Subclinical Atherosclerosis in Postmenopausal Women Am J Cardiol. 2019 10 01; 124(7):1031-1037. . View in PubMed
  • Room for Improvement: The HIV-Diabetes Care Continuum Over 15 Years in the Women’s Interagency HIV Study Open Forum Infect Dis. 2018 Jun 01; 5(6):ofy121. . View in PubMed
  • Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women’s Interagency HIV Study J Lipid Res. 2018 10; 59(10):1967-1976. . View in PubMed
  • Cognitive Burden of Common Non-antiretroviral Medications in HIV-Infected Women J Acquir Immune Defic Syndr. 2018 09 01; 79(1):83-91. . View in PubMed
  • Use of Nonantiretroviral Medications That May Impact Neurocognition: Patterns and Predictors in a Large, Long-Term HIV Cohort Study J Acquir Immune Defic Syndr. 2018 06 01; 78(2):202-208. . View in PubMed
  • Predicting diabetes risk among HIV-positive and HIV-negative women AIDS. 2018 11 28; 32(18):2767-2775. . View in PubMed
  • Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B Circulation. 2018 09 11; 138(11):1130-1143. . View in PubMed
  • Chronic hepatitis C virus infection and subsequent HIV viral load among women with HIV initiating antiretroviral therapy AIDS. 2018 03 13; 32(5):653-661. . View in PubMed
  • Reply To: Higher Intelligence and Later Maternal Age: Which Way Does the Causal Direction Go? J Am Geriatr Soc. 2017 08; 65(8):1885-1886.. View in PubMed
  • Lipoprotein(a) and HIV: Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima-Media Thickness in HIV-Infected Young Women in the Women’s Interagency HIV Study Arterioscler Thromb Vasc Biol. 2017 05; 37(5):997-1004. . View in PubMed
  • Association of Hepatitis C Virus Infection With CD4/CD8 Ratio in HIV-Positive Women J Acquir Immune Defic Syndr. 2016 Jun 01; 72(2):162-70. . View in PubMed
  • Enhanced liver fibrosis marker as a noninvasive predictor of mortality in HIV/hepatitis C virus-coinfected women from a multicenter study of women with or at risk for HIV AIDS. 2016 Mar 13; 30(5):723-9. . View in PubMed
  • Systemic Immune Activation and HIV Shedding in the Female Genital Tract J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):155-62. . View in PubMed
  • Effect of Reproductive History and Exogenous Hormone Use on Cognitive Function in Mid- and Late Life J Am Geriatr Soc. 2016 12; 64(12):2448-2456. . View in PubMed
  • Association of bilateral oophorectomy with cognitive function in healthy, postmenopausal womenFertil Steril. 2016 09 01; 106(3):749-756. e2. . View in PubMed
  • Menstrual cycle phase and single tablet antiretroviral medication adherence in women with HIV AIDS Care. 2016; 28(1):11-21. . View in PubMed
  • Impact of CD4+ lymphocytes and HIV infection on Anti-Müllerian Hormone levels in a large cohort of HIV-infected and HIV-uninfected women Am J Reprod Immunol. 2015 Mar; 73(3):273-84. . View in PubMed
  • Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women J Clin Endocrinol Metab. 2015 Feb; 100(2):508-15. . View in PubMed
  • The Effects of Viral Load Burden on Pregnancy Loss among HIV-Infected Women in the United States Infect Dis Obstet Gynecol. 2015; 2015:362357. . View in PubMed
  • T-cell activation, both pre- and post-HAART levels, correlates with carotid artery stiffness over 65 years among HIV-infected women in the WIHS. J Acquir Immune Defic Syndr. 2014 Nov 01; 67(3):349-56. . View in PubMed
  • Investigating the effects of metabolic dysregulation on hair follicles: a comparison of HIV-infected women with and without central lipohypertrophy Int J Dermatol. 2014 Oct; 53(10):e443-8. . View in PubMed
  • Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women AIDS. 2014 Jul 31; 28(12):1815-23. . View in PubMed
  • Macrophage inflammatory markers are associated with subclinical carotid artery disease in women with human immunodeficiency virus or hepatitis C virus infection Arterioscler Thromb Vasc Biol. 2014 May; 34(5):1085-92. . View in PubMed
  • RYR3 gene variants in subclinical atherosclerosis among HIV-infected women in the Women’s Interagency HIV Study (WIHS) Atherosclerosis. 2014 Apr; 233(2):666-672. . View in PubMed
  • Effects of highly active antiretroviral therapy and its adherence on herpes zoster incidence: a longitudinal cohort study AIDS Res Ther. 2013 Dec 27; 10(1):34. . View in PubMed
  • Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. . View in PubMed
  • Current treatment methods for combination antiretroviral therapy-induced lipoatrophy of the face Int J STD AIDS. 2013 Sep; 24(9):685-94. . View in PubMed
  • Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach AIDS. 2013 Jun 01; 27(9):1473-81. . View in PubMed
  • Gonadotropin and sex steroid levels in HIV-infected premenopausal women and their association with subclinical atherosclerosis in HIV-infected and -uninfected women in the women’s interagency HIV study (WIHS) J Clin Endocrinol Metab. 2013 Apr; 98(4):E610-8. . View in PubMed
  • The association of self-perception of body fat changes and quality of life in the Women’s Interagency HIV Study AIDS Care. 2013; 25(12):1544-50. . View in PubMed
  • Association of HIV infection with incident diabetes mellitus: impact of using hemoglobin A1C as a criterion for diabetes J Acquir Immune Defic Syndr. 2012 Nov 01; 61(3):334-40. . View in PubMed
  • Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women: Women’s Interagency HIV Study Fertil Steril. 2012 Jul; 98(1):228-34. . View in PubMed
  • Permissive and protective factors associated with presence, level, and longitudinal pattern of cervicovaginal HIV shedding J Acquir Immune Defic Syndr. 2012 May 01; 60(1):99-110. . View in PubMed
  • Hip fracture in postmenopausal women after cessation of hormone therapy: results from a prospective study in a large health management organization Menopause. 2011 Nov; 18(11):1172-7. . View in PubMed
  • Relative time to pregnancy among HIV-infected and uninfected women in the Women’s Interagency HIV Study, 2002-2009 AIDS. 2011 Mar 13; 25(5):707-11. . View in PubMed
  • T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women J Infect Dis. 2011 Feb 15; 203(4):452-63. . View in PubMed
  • Pre-existing albuminuria predicts AIDS and non-AIDS mortality in women initiating antiretroviral therapy Antivir Ther. 2011; 16(4):591-6. . View in PubMed
  • HIV, HAART, and lipoprotein particle concentrations in the Women’s Interagency HIV Study AIDS. 2010 Nov 27; 24(18):2809-17. . View in PubMed
  • Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection J Acquir Immune Defic Syndr. 2010 Sep; 55(1):73-7. . View in PubMed
  • Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women Menopause. 2010 Jul; 17(4):785-90. . View in PubMed
  • Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus J Infect Dis. 2010 Mar 15; 201(6):823-34. . View in PubMed
  • Pediatric endurance and limb strengthening (PEDALS) for children with cerebral palsy using stationary cycling: a randomized controlled trial Phys Ther. 2010 Mar; 90(3):367-81. . View in PubMed
  • Prevalence and correlates of elevated body mass index among HIV-positive and HIV-negative women in the Women’s Interagency HIV Study AIDS Patient Care STDS. 2009 Dec; 23(12):1009-16. . View in PubMed
  • Variations in serum müllerian inhibiting substance between white, black, and Hispanic women Fertil Steril. 2009 Nov; 92(5):1674-8. . View in PubMed
  • Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women J Clin Endocrinol Metab. 2009 Nov; 94(11):4136-43. . View in PubMed
  • Correlates of perinatal depression in HIV-infected women AIDS Patient Care STDS. 2009 Feb; 23(2):101-8. . View in PubMed
  • Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterial sites Am J Cardiol. 2008 Oct 01; 102(7):825-30. . View in PubMed
  • Longitudinal anthropometric patterns among HIV-infected and HIV-uninfected women J Acquir Immune Defic Syndr. 2008 Mar 01; 47(3):312-9. . View in PubMed
  • Relationship between serum levels of sex hormones and progression of subclinical atherosclerosis in postmenopausal women J Clin Endocrinol Metab. 2008 Jan; 93(1):131-8. . View in PubMed
  • Correlates of prevalent hypertension in a large cohort of HIV-infected women: Women’s Interagency HIV Study AIDS. 2007 Nov 30; 21(18):2539-41. . View in PubMed
  • Outcomes of a mind-body treatment program for chronic back pain with no distinct structural pathology–a case series of patients diagnosed and treated as tension myositis syndrome Altern Ther Health Med. 2007 Sep-Oct; 13(5):26-35. . View in PubMed
  • Hepatitis C virus quasispecies in HIV-infected women: role of injecting drug use and highly active antiretroviral therapy (HAART) Hepatology. 2007 Aug; 46(2):359-70. . View in PubMed
  • Correlates of CD4+ and CD8+ lymphocyte counts in high-risk immunodeficiency virus (HIV)-seronegative women enrolled in the women’s interagency HIV study (WIHS) Hum Immunol. 2007 May; 68(5):342-9. . View in PubMed
  • Neutropenia in human immunodeficiency virus infection: data from the women’s interagency HIV study Arch Intern Med. 2006 Feb 27; 166(4):405-10. . View in PubMed
  • Prognostic factors in HIV-related diffuse large-cell lymphoma: before versus after highly active antiretroviral therapy J Clin Oncol. 2005 Nov 20; 23(33):8477-82. . View in PubMed
  • AIDS-related Burkitt’s lymphoma versus diffuse large-cell lymphoma in the pre-highly active antiretroviral therapy (HAART) and HAART eras: significant differences in survival with standard chemotherapy J Clin Oncol. 2005 Jul 01; 23(19):4430-8. . View in PubMed
  • Determinants of the effect of estrogen on the progression of subclinical atherosclerosis: Estrogen in the Prevention of Atherosclerosis Trial Menopause. 2005 Jul-Aug; 12(4):366-73. . View in PubMed
  • The association of smoking and subclinical atherosclerosis in Type 2 diabetes: modification by duration of diabetes Diabet Med. 2005 Jan; 22(1):81-7. . View in PubMed
  • Impact of highly active antiretroviral therapy on anemia and relationship between anemia and survival in a large cohort of HIV-infected women: Women’s Interagency HIV Study J Acquir Immune Defic Syndr. 2004 Oct 01; 37(2):1245-52. . View in PubMed
  • Colpectomy after vaginoplasty in transsexuals Obstet Gynecol. 2000 Jun; 95(6 Pt 2):1006-8. . View in PubMed