Sarah Richman

Assistant Professor of Pediatrics

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Overview

The lab at Children’s Hospital Los Angeles (CHLA) is focused on developing chimeric antigen receptor (CAR) T cells targeting solid tumors.

Publications

  • Guideline for Children With Cancer Receiving General Anesthesia for Procedures and Imaging J Pediatr Hematol Oncol. 2022 05 01; 44(4):e859-e865. . View in PubMed
  • Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design Mol Ther Methods Clin Dev. 2020 Sep 11; 18:595-606. . View in PubMed
  • Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo Mol Ther. 2020 Aug 05; 28(8):1932. . View in PubMed
  • Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo Mol Ther. 2020 07 08; 28(7):1600-1613. . View in PubMed
  • Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene Mol Ther. 2020 01 08; 28(1):42-51. . View in PubMed
  • ß-synuclein at the “synapse” of encephalitis and neurodegeneration in multiple sclerosis? Immunol Cell Biol. 2019 07; 97(6):523-525.. View in PubMed
  • Neurotoxicity Associated with a High-Affinity GD2 CAR-Response Cancer Immunol Res. 2018 04; 6(4):496-497. . View in PubMed
  • High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model Cancer Immunol Res. 2018 01; 6(1):36-46. . View in PubMed
  • Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection Blood. 2013 Jul 18; 122(3):348-56. . View in PubMed
  • Single-chain VaVß T-cell receptors function without mispairing with endogenous TCR chains Gene Ther. 2012 Apr; 19(4):365-74. . View in PubMed
  • Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments Mol Immunol. 2009 Feb; 46(5):902-16. . View in PubMed
  • Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display Methods Mol Biol. 2009; 504:323-50. . View in PubMed
  • Display, engineering, and applications of antigen-specific T cell receptors Biomol Eng. 2007 Oct; 24(4):361-73. . View in PubMed
  • Development of a novel strategy for engineering high-affinity proteins by yeast display Protein Eng Des Sel. 2006 Jun; 19(6):255-64. . View in PubMed