Sharon Helene O'Neil, PhD

Dr. O’Neil is board certified in clinical neuropsychology (ABPP-CN) and in pediatric neuropsychology (ABPdN). She is the director of the Neuropsychology Core of The Saban Research Institute at Children’s Hospital Los Angeles. Dr. O’Neil is involved in research focusing on the neuropsychological sequelae of brain cancer diagnoses and treatment, preterm birth, congenital heart disease, autism spectrum disorders, and sickle and non-sickle anemias. Additionally, she teaches and trains doctoral students in the provision of neuropsychological services.

• Effects of disease modifying therapy on cognitive proficiency in pediatric-onset multiple sclerosis (POMS). Mult Scler Relat Disord. 2026 May; 109:107104.. View in PubMed
• Decreased Gross Motor, Working Memory, and Adaptive Behavior in Children with Congenital Adrenal Hyperplasia. Horm Res Paediatr. 2026 Feb 16; 1-9.. View in PubMed
• Adaptive, social, and repetitive behaviors in children with autism spectrum disorder and comorbid amblyopia and/or strabismus. J AAPOS. 2026 Feb; 30(1):104734.. View in PubMed
• Assessment of neurocognitive functioning in sickle cell disease and thalassaemia and the association with silent cerebral infarcts, cerebral haemodynamics and oxygen metabolism. Br J Haematol. 2025 Aug; 207(2):561-570.. View in PubMed
• Adaptive functioning and relationship to visual behavior in children with cerebral/cortical visual impairment. J AAPOS. 2025 02; 29(1):104107.. View in PubMed
• Dose-dependent cranial irradiation associations with brain structures and neuropsychological outcomes in children with posterior fossa brain tumors. Brain Behav. 2024 Sep; 14(9):e70019.. View in PubMed
• Tract-specific analysis and neurocognitive functioning in sickle cell patients without history of overt stroke. Brain Behav. 2021 03; 11(3):e01978.. View in PubMed
• Brain biomarkers and neuropsychological outcomes of pediatric posterior fossa brain tumor survivors treated with surgical resection with or without adjuvant chemotherapy. Pediatr Blood Cancer. 2021 02; 68(2):e28817.. View in PubMed
• Excellent outcome of young children with nodular desmoplastic medulloblastoma treated on “Head Start” III: a multi-institutional, prospective clinical trial. Neuro Oncol. 2020 12 18; 22(12):1862-1872.. View in PubMed
• Neuropsychological outcomes on Head Start III: a prospective, multi-institutional clinical trial for young children diagnosed with malignant brain tumors. Neurooncol Pract. 2020 Jun; 7(3):329-337.. View in PubMed
• Maturation of Brain Microstructure and Metabolism Associates with Increased Capacity for Self-Regulation during the Transition from Childhood to Adolescence. J Neurosci. 2019 10 16; 39(42):8362-8375.. View in PubMed
• Anemia predicts lower white matter volume and cognitive performance in sickle and non-sickle cell anemia syndrome. Am J Hematol. 2019 10; 94(10):1055-1065.. View in PubMed
• Clinical Factors Associated with Cerebral Metabolism in Term Neonates with Congenital Heart Disease. J Pediatr. 2017 04; 183:67-73.e1.. View in PubMed
• Synchronous Aberrant Cerebellar and Opercular Development in Fetuses and Neonates with Congenital Heart Disease: Correlation with Early Communicative Neurodevelopmental Outcomes, Initial Experience. AJP Rep. 2017 Jan; 7(1):e17-e27.. View in PubMed
• Contrasting resting-state fMRI abnormalities from sickle and non-sickle anemia. PLoS One. 2017; 12(10):e0184860.. View in PubMed
• Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1. Neurology. 2016 Dec 13; 87(24):2575-2584.. View in PubMed
• Multivariate surface-based analysis of corpus callosum in patients with sickle cell disease. Proc SPIE Int Soc Opt Eng. 2016 Dec; 10160.. View in PubMed
• Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors. Pediatr Blood Cancer. 2016 Mar; 63(3):527-34.. View in PubMed
• Diffusion Tensor Imaging and Neurobehavioral Outcome in Children With Brain Tumors Treated With Chemotherapy. J Pediatr Oncol Nurs. 2016 Mar-Apr; 33(2):119-28.. View in PubMed
• Effect of Increased Immunosuppression on Developmental Outcome of Opsoclonus Myoclonus Syndrome (OMS). J Child Neurol. 2015 Jul; 30(8):976-82.. View in PubMed
• Long-term follow-up of children treated for high-grade gliomas: children’s oncology group L991 final study report. J Clin Oncol. 2012 Mar 20; 30(9):943-9.. View in PubMed
• Supratentorial ependymoma in children: to observe or to treat following gross total resection? Pediatr Blood Cancer. 2012 Mar; 58(3):380-3.. View in PubMed
• Symptoms before and after posterior fossa surgery in pediatric patients. Pediatr Neurosurg. 2012; 48(1):21-5.. View in PubMed
• Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation. Pediatr Blood Cancer. 2011 Oct; 57(4):669-73.. View in PubMed
• Neuropsychological differences between survivors of supratentorial and infratentorial brain tumours. J Intellect Disabil Res. 2011 Jan; 55(1):30-40.. View in PubMed
• Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation. Pediatr Blood Cancer. 2010 Jul 15; 55(1):42-6.. View in PubMed

• Thompson, Paul
• Wood, John
• Peterson, Bradley
• Toga, Arthur
• Lenz, Heinz-Josef
• Cohen-Gadol, Aaron
• Coates, Thomas
• Shahidi, Mahnaz