Keck School Faculty

Siamak Daneshmand, MD
Siamak Daneshmand, MD
Associate Professor of Urology (Clinical Scholar);Director of Clinical Research
Urology
NOR 7416 Health Sciences Campus Los Angeles
Dr. Sia Daneshmand earned his medical degree at the University of California, Davis and completed his residency at the University of Southern California (USC) followed by a two-year fellowship in Urologic Oncology at the USC/Norris Comprehensive Cancer Center. He spent almost 6 years at Oregon Health and Science University where he established the Section of Urologic Oncology as a center of excellence for treatment of bladder and testis cancers. He was recruited to USC Institute of Urology in 2010 as Director of Urologic Oncology. He is currently an associate professor of urology with clinical scholar designation and serves as director of clinical research as well as the urologic oncology fellowship director. Dr. Daneshmand’s main interests include bladder cancer, advanced kidney cancer and testicular cancer. He has extensive experience in urinary diversion and reconstruction following surgical removal of the bladder (radical cystectomy) as well as nerve-sparing retroperitoneal lymph node dissection (RPLND) following chemotherapy for advanced testis cancer. He is one of the highest volume surgeons for this disease on the west coast. He has been selected as one of “True Experts” in the Testicular Cancer Resource Center web site. He also has extensive experience in the management of advanced kidney cancers with vena caval tumor thrombus involvement, as well as prostate cancer, retroperitoneal sarcomas and surgeries requiring replacement of the great vessels. He is a member of Alpha Omega Alpha medical honor society, and has been designated one of the “America’s Top Doctors” for several years. He is an active member of the Society of Urologic Oncology, has presented over 150 abstracts at scientific meetings and has authored over 120 peer-reviewed articles, reviews, and chapters. He is a reviewer for numerous urology journals.

Access to high-volume surgeons and the opportunity cost of performing radical prostatectomy by low-volume providersUrol Oncol. 2017 07; 35(7):459. e15-459. e24. . View in PubMed

Blue light cystoscopy for the diagnosis of bladder cancer: Results from the US prospective multicenter registryUrol Oncol. 2018 08; 36(8):361. e1-361. e6. . View in PubMed

Impact of lymph node dissection at the time of radical nephrectomy with tumor thrombectomy on oncological outcomes: Results from the International Renal Cell Carcinoma-Venous Thrombus Consortium (IRCC-VTC)Urol Oncol. 2018 02; 36(2):79. e11-79. e17. . View in PubMed

Global, Regional, and National Burden of Bladder Cancer, 1990 - 2016: Results from the Global Burden of Disease Study 2016 J Urol. 2019 Jan 25. . View in PubMed

Frailty as a predictor of complications after radical cystectomy: A prospective study of various preoperative assessments Urol Oncol. 2019 Jan; 37(1):40-47. . View in PubMed

Association between precystectomy epithelial tumor marker response to neoadjuvant chemotherapy and oncological outcomes in urothelial bladder cancer Urol Oncol. 2019 Jan; 37(1):1-11. . View in PubMed

Implications of micropapillary urothelial carcinoma variant on prognosis following radical cystectomy: A multi-institutional investigation Urol Oncol. 2019 Jan; 37(1):48-56. . View in PubMed

Growing Teratoma Syndrome of Testicular Origin Urology. 2019 Jan; 123:20-23. . View in PubMed

Factors influencing intraoperative conversion from planned orthotopic to non-orthotopic urinary diversion during radical cystectomy World J Urol. 2018 Dec 05. . View in PubMed

Gastrointestinal Complications Following Radical Cystectomy Using Enhanced Recovery Protocol Eur Urol Focus. 2018 Dec; 4(6):889-894. . View in PubMed

Assessing trends in urinary diversion after radical cystectomy for bladder cancer in the United States Urol Oncol. 2018 Nov 25. . View in PubMed

Association between precystectomy epithelial tumor marker response to neoadjuvant chemotherapy and oncological outcomes in urothelial bladder cancer Urol Oncol. 2018 Nov 20. . View in PubMed

Frailty as a predictor of complications after radical cystectomy: A prospective study of various preoperative assessments Urol Oncol. 2018 Nov 15. . View in PubMed

Implications of micropapillary urothelial carcinoma variant on prognosis following radical cystectomy: A multi-institutional investigation Urol Oncol. 2018 Nov 13. . View in PubMed

Development and validation of surgical training tool: cystectomy assessment and surgical evaluation (CASE) for robot-assisted radical cystectomy for men Surg Endosc. 2018 Nov; 32(11):4458-4464. . View in PubMed

Enhanced Endoscopy in Bladder Cancer Curr Urol Rep. 2018 Aug 17; 19(10):84. . View in PubMed

Association between race and oncologic outcome following radical prostatectomy for clinically organ-confined prostate cancer: a long-term follow-up study World J Urol. 2018 Aug; 36(8):1233-1239. . View in PubMed

Current controversies on the role of lymphadenectomy for bladder cancer Urol Oncol. 2018 Jun 14. . View in PubMed

Blue light cystoscopy for the diagnosis of bladder cancer: Results from the US prospective multicenter registry Urol Oncol. 2018 May 30. . View in PubMed

Growing Teratoma Syndrome of Testicular Origin Urology. 2018 May 25. . View in PubMed

Enhanced Recovery After Surgery Pathways: Role and Outcomes in the Management of Muscle Invasive Bladder Cancer Urol Clin North Am. 2018 May; 45(2):229-239. . View in PubMed

Efficacy and Safety of Blue Light Flexible Cystoscopy with Hexaminolevulinate in the Surveillance of Bladder Cancer: A Phase III, Comparative, Multicenter Study J Urol. 2018 May; 199(5):1158-1165. . View in PubMed

Development and validation of surgical training tool: cystectomy assessment and surgical evaluation (CASE) for robot-assisted radical cystectomy for men Surg Endosc. 2018 Apr 13. . View in PubMed

Association between race and oncologic outcome following radical prostatectomy for clinically organ-confined prostate cancer: a long-term follow-up study World J Urol. 2018 Mar 13. . View in PubMed

Continent Cutaneous Diversion Urol Clin North Am. 2018 Feb; 45(1):55-65. . View in PubMed

Clinical Lymphadenopathy in Urothelial Cancer: A Transatlantic Collaboration on Performance of Cross-sectional Imaging and Oncologic Outcomes in Patients Treated with Radical Cystectomy Without Neoadjuvant Chemotherapy Eur Urol Focus. 2018 03; 4(2):245-251. . View in PubMed

Effectiveness of extended pelvic lymphadenectomy in the survival of prostate cancer: a systematic review and meta-analysis Cent European J Urol. 2018; 71(3):262-269. . View in PubMed

Association of Distance to Treatment Facility With Survival and Quality Outcomes After Radical Cystectomy: A Multi-Institutional StudyClin Genitourin Cancer. 2017 Dec; 15(6):689-695. e2. . View in PubMed

Dose dense MVAC prior to radical cystectomy: a real-world experience World J Urol. 2017 Nov; 35(11):1729-1736. . View in PubMed

Feasibility of expert and crowd-sourced review of intraoperative video for quality improvement of intracorporeal urinary diversion during robotic radical cystectomy Can Urol Assoc J. 2017 Oct; 11(10):331-336. . View in PubMed

Baseline Glomerular Filtration Rate and Cisplatin- Induced Renal Toxicity in Urothelial Cancer Patients Clin Genitourin Cancer. 2017 Sep 06. . View in PubMed

90-Day complication rate in patients undergoing radical cystectomy with enhanced recovery protocol: a prospective cohort study World J Urol. 2017 Jun; 35(6):907-911. . View in PubMed

Gastrointestinal Complications Following Radical Cystectomy Using Enhanced Recovery Protocol Eur Urol Focus. 2017 Apr 25. . View in PubMed

Adherence to National Comprehensive Cancer Network® Guidelines for Testicular Cancer J Urol. 2017 Mar; 197(3 Pt 1):684-689. . View in PubMed

Association of Distance to Treatment Facility With Survival and Quality Outcomes After Radical Cystectomy: A Multi-Institutional StudyClin Genitourin Cancer. 2017 12; 15(6):689-695. e2. . View in PubMed

Incidence, Characteristics and Implications of Thromboembolic Events in Patients with Muscle Invasive Urothelial Carcinoma of the Bladder Undergoing Neoadjuvant Chemotherapy J Urol. 2016 Dec; 196(6):1627-1633. . View in PubMed

Clinical Lymphadenopathy in Urothelial Cancer: A Transatlantic Collaboration on Performance of Cross-sectional Imaging and Oncologic Outcomes in Patients Treated with Radical Cystectomy Without Neoadjuvant Chemotherapy Eur Urol Focus. 2016 Nov 23. . View in PubMed

Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline J Urol. 2016 Oct; 196(4):1021-9. . View in PubMed

Incisional and Parastomal Hernia following Radical Cystectomy and Urinary Diversion: The University of Southern California Experience J Urol. 2016 Sep; 196(3):777-81. . View in PubMed

Gastrointestinal Complications in Patients Who Undergo Radical Cystectomy with Enhanced Recovery Protocol Curr Urol Rep. 2016 Jul; 17(7):50. . View in PubMed

Editorial Comment J Urol. 2016 Jun; 195(6):1716. . View in PubMed

Cost Analysis of the Enhanced Recovery After Surgery Protocol in Patients Undergoing Radical Cystectomy for Bladder Cancer Eur Urol Focus. 2016 Apr; 2(1):92-96. . View in PubMed

Final Pathological Stage after Neoadjuvant Chemotherapy and Radical Cystectomy for Bladder Cancer-Does pT0 Predict Better Survival than pTa/Tis/T1? J Urol. 2016 Apr; 195(4 Pt 1):886-93.. View in PubMed

Gender and Bladder Cancer: A Collaborative Review of Etiology, Biology, and Outcomes Eur Urol. 2016 Feb; 69(2):300-10. . View in PubMed

Incidence, Characteristics and Implications of Thromboembolic Events in Patients with Muscle Invasive Urothelial Carcinoma of the Bladder Undergoing Neoadjuvant Chemotherapy J Urol. 2016 12; 196(6):1627-1633. . View in PubMed

Assessment of Urologists' Knowledge of Intraoperative Floppy Iris Syndrome Urology. 2016 11; 97:40-45. . View in PubMed

Editorial Comment J Urol. 2016 06; 195(6):1716. . View in PubMed

A Multi-Institutional Analysis of Outcomes of Patients with Clinically Node Positive Urothelial Bladder Cancer Treated with Induction Chemotherapy and Radical Cystectomy J Urol. 2016 Jan; 195(1):53-9. . View in PubMed

Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy World J Urol. 2015 Oct; 33(10):1419-28. . View in PubMed

Cardiopulmonary Bypass has No Significant Impact on Survival in Patients Undergoing Nephrectomy and Level III-IV Inferior Vena Cava Thrombectomy: Multi-Institutional Analysis J Urol. 2015 Aug; 194(2):304-308. . View in PubMed

Female reproductive organ-sparing radical cystectomy: contemporary indications, techniques and outcomes Curr Opin Urol. 2015 Mar; 25(2):105-10. . View in PubMed

Impact of synchronous metastasis distribution on cancer specific survival in renal cell carcinoma after radical nephrectomy with tumor thrombectomy J Urol. 2015 Feb; 193(2):436-42. . View in PubMed

Current and recent clinical trials for perioperative systemic therapy for muscle invasive bladder cancer: a systematic review BMC Cancer. 2014 Dec 16; 14:966. . View in PubMed

Discovery and validation of novel expression signature for postcystectomy recurrence in high-risk bladder cancer J Natl Cancer Inst. 2014 Nov; 106(11). . View in PubMed

Hexaminolevulinate blue-light cystoscopy in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on appropriate use in the USA Nat Rev Urol. 2014 Oct; 11(10):589-96. . View in PubMed

Impact of histologic subtype on cancer-specific survival in patients with renal cell carcinoma and tumor thrombus Eur Urol. 2014 Sep; 66(3):577-83. . View in PubMed

Growing teratoma syndrome: clinical and radiographic characteristics Int J Urol. 2014 Sep; 21(9):905-8. . View in PubMed

Enhanced recovery protocol after radical cystectomy for bladder cancer J Urol. 2014 Jul; 192(1):50-5. . View in PubMed

Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: a systematic review Eur Urol. 2014 Jul; 66(1):120-37. . View in PubMed

Blood- and tissue-based biomarkers for prediction of outcomes in urothelial carcinoma of the bladder Urol Oncol. 2014 Apr; 32(3):230-42. . View in PubMed

A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence Clin Cancer Res. 2014 Apr 01; 20(7):1978-89. . View in PubMed

Enhanced recovery pathway following radical cystectomy Curr Opin Urol. 2014 Mar; 24(2):135-9. . View in PubMed

Impact of micropapillary urothelial carcinoma variant histology on survival after radical cystectomy Urol Oncol. 2014 Feb; 32(2):110-6. . View in PubMed

Urol Oncol. 2014 Feb; 32(2):117-27. . View in PubMed

Effect of gender on outcomes following radical cystectomy for urothelial carcinoma of the bladder: a critical analysis of 1,994 patientsUrol Oncol. 2014 Jan; 32(1):52. e1-9. . View in PubMed

Androgen deprivation therapy for prostate cancer: long-term safety and patient outcomes Patient Relat Outcome Meas. 2014; 5:63-70. . View in PubMed

Incidence and location of lymph node metastases in patients undergoing radical cystectomy for clinical non-muscle invasive bladder cancer: results from a prospective lymph node mapping studyUrol Oncol. 2014 Jan; 32(1):24. e13-9. . View in PubMed

Editorial comment Urology. 2013 Dec; 82(6):1346. . View in PubMed

Extranodal extension is a powerful prognostic factor in bladder cancer patients with lymph node metastasis Eur Urol. 2013 Nov; 64(5):837-45. . View in PubMed

Incidental prostate cancer in patients with bladder urothelial carcinoma: comprehensive analysis of 1,476 radical cystoprostatectomy specimens J Urol. 2013 Nov; 190(5):1704-9. . View in PubMed

Active surveillance is the preferred approach to clinical stage I testicular cancer J Clin Oncol. 2013 Oct 01; 31(28):3490-3. . View in PubMed

Editorial comment J Urol. 2013 Sep; 190(3):927. . View in PubMed

Determining the role of cystectomy for high-grade T1 urothelial carcinoma Urol Clin North Am. 2013 May; 40(2):233-47. . View in PubMed

Conversion from incontinent conduit to continent cutaneous reservoir after renal transplant Urology. 2013 May; 81(5):1086-9. . View in PubMed

Editorial comment J Urol. 2013 Apr; 189(4):1318-9. . View in PubMed

Androgen deprivation therapy: evidence-based management of side effects BJU Int. 2013 Apr; 111(4):543-8. . View in PubMed

A precystectomy decision model to predict pathological upstaging and oncological outcomes in clinical stage T2 bladder cancer BJU Int. 2013 Feb; 111(2):240-8. . View in PubMed

Does increasing the nodal yield improve outcomes in patients without nodal metastasis at radical cystectomy? World J Urol. 2012 Dec; 30(6):807-14.. View in PubMed

Contemporary management of postchemotherapy testis cancer Eur Urol. 2012 Nov; 62(5):867-76. . View in PubMed

Critical evaluation of the American Joint Committee on Cancer TNM nodal staging system in patients with lymph node-positive disease after radical cystectomy Eur Urol. 2012 Oct; 62(4):671-6. . View in PubMed

Editorial comment Urology. 2012 Sep; 80(3):639; author reply 639-40. . View in PubMed

A systematic review of neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer Eur Urol. 2012 Sep; 62(3):523-33. . View in PubMed

Adjuvant surgery in testicular cancer patients undergoing postchemotherapy retroperitoneal lymph node dissection Ann Surg Oncol. 2012 Jul; 19(7):2388-93. . View in PubMed

Factors influencing post-recurrence survival in bladder cancer following radical cystectomy BJU Int. 2012 Mar; 109(6):846-54. . View in PubMed

Editorial comment Urology. 2012 Feb; 79(2):481; author reply 481-2. . View in PubMed

Clinical nodal staging scores for bladder cancer: a proposal for preoperative risk assessment Eur Urol. 2012 Feb; 61(2):237-42. . View in PubMed

Colocalycostomy for repair of ureterojejunal fistula Urology. 2012 Feb; 79(2):e12-4. . View in PubMed

Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics Front Endocrinol (Lausanne). 2012; 3:182. . View in PubMed

Chemoresponsive liver hemangioma in a patient with a metastatic germ cell tumor J Clin Oncol. 2011 Dec 10; 29(35):e842-4. . View in PubMed

Androgen-producing testicular germ cell tumors J Clin Oncol. 2011 Jul 20; 29(21):e634-5. . View in PubMed

Improving selection of appropriate urinary diversion following radical cystectomy for bladder cancer Expert Rev Anticancer Ther. 2011 Jun; 11(6):941-8. . View in PubMed

Evaluation and Preservation of Fertility in Patients with Testicular Cancer J Adolesc Young Adult Oncol. 2011 Mar; 1(1):25-9. . View in PubMed

Distinctive morphology of renal cell carcinomas in tuberous sclerosis Int J Surg Pathol. 2010 Oct; 18(5):409-18. . View in PubMed

Editorial comment Urology. 2010 Oct; 76(4):1001. . View in PubMed

Factors influencing the choice of urinary diversion in patients undergoing radical cystectomy BJU Int. 2010 Sep; 106(5):654-7. . View in PubMed

Application of the Yang-Monti channel in adult continent cutaneous urinary diversion Urology. 2008 Oct; 72(4):828-31. . View in PubMed

Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival Hum Pathol. 2007 Oct; 38(10):1547-52. . View in PubMed

Bilateral segmental testicular infarction ScientificWorldJournal. 2007 Feb 19; 7:779-83. . View in PubMed

Evolving treatment paradigms for locally advanced and metastatic prostate cancer Expert Rev Anticancer Ther. 2006 Nov; 6(11):1639-51. . View in PubMed

A critical analysis of perioperative mortality from radical cystectomy J Urol. 2006 Mar; 175(3 Pt 1):886-9; discussion 889-90. . View in PubMed

Intraoperative renal cell carcinoma tumor embolization to the right atrium: incidental diagnosis by transesophageal echocardiography Anesth Analg. 2006 Feb; 102(2):378-9. . View in PubMed

Adrenal myelolipoma: diagnosis and management Urol J. 2006; 3(2):71-4. . View in PubMed

Current clinical trials in renal cell carcinoma Urol Oncol. 2005 Jul-Aug; 23(4):289-92. . View in PubMed

EphB4 expression and biological significance in prostate cancer Cancer Res. 2005 Jun 01; 65(11):4623-32. . View in PubMed

Ethnic differences in neuroendocrine cell expression in normal human prostatic tissue Urology. 2005 May; 65(5):1008-12. . View in PubMed

Angiomyolipoma of the kidney: expanding disease spectrum demonstrated by 3 cases Appl Immunohistochem Mol Morphol. 2004 Sep; 12(3):277-83. . View in PubMed

Adenomatous polyp of the verumontanum causing bladder outlet obstruction ScientificWorldJournal. 2004 Jun 07; 4 Suppl 1:89-91. . View in PubMed

Continent right colon reservoir using a cutaneous appendicostomy Urology. 2004 Mar; 63(3):577-80; discussion 580-1. . View in PubMed

Benign retroperitoneal schwannoma: a case series and review of the literature Urology. 2003 Dec; 62(6):993-7. . View in PubMed

Colourachal fistula in an adult presenting with feculent umbilical drainage J Urol. 2003 Jul; 170(1):184. . View in PubMed

Endoscopic management of upper urinary tract transitional cell carcinoma: long-term experience Cancer. 2003 Jul 01; 98(1):55-60. . View in PubMed

Endoscopic management of renal hemangioma J Urol. 2002 Feb; 167(2 Pt 1):488-9. . View in PubMed

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