Sook-Lei Liew

Professor of Occupational Science and Occupational Therapy

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Overview

Dr. Liew’s research focuses on mechanisms of neural plasticity in healthy individuals and individuals after neurological injury in order to improve their quality of life and engagement in meaningful activities. She directs the Neural Plastiticity and Neurorehabilitation Laboratory, whose goals are: 1) to characterize processes of neural plasticity during learning and rehabilitation using neuroimaging and cortical physiology, 2) to enhance neural plasticity and neurorehabilitation through novel techniques, such as noninvasive brain stimulation and brain computer interfaecs, and 3) to personalize the use of plasticity-inducing paradigms in order to capitalize on each individual’s unique learning or recovery potential.

Research Funding

  • Data Science and Analytics for Precision Rehabilitation (DAPR) Center
    NIH · P50HD118603 · Sep 8, 2025 – Aug 31, 2030 · Role: Principal Investigator
  • Building a data science workforce to improve the reproducibility of rehabilitation research
    NIH · R25HD105583 · Mar 1, 2022 – Feb 28, 2027 · Role: Principal Investigator
  • Global Brain Health Predictors of Post-Stroke Sensorimotor Recovery using AI-Enhanced Clinical MRIs
    NIH · RF1NS115845 · Apr 1, 2020 – Jun 30, 2029 · Role: Principal Investigator
  • Effects of global brain health on sensorimotor recovery after stroke
    NIH · R01NS115845 · Apr 1, 2020 – Mar 31, 2025 · Role: Principal Investigator
  • Big Data Neuroimaging to Predict Motor Behavior After Stroke
    NIH · K01HD091283 · Apr 1, 2017 – Dec 31, 2020 · Role: Principal Investigator

Publications

  • Invited Commentary: Transforming Occupational Therapy Research With Artificial Intelligence. OTJR (Thorofare N J). 2026 Jul 13; 15394492261464096.. View in PubMed
  • Exploring the Application of the Observational Medical Outcomes Partnership Common Data Model to Multi-site Stroke Rehabilitation Research Data. medRxiv. 2026 Jul 08.. View in PubMed
  • A composite measure of cerebral small vessel disease predicts cognitive change after stroke. medRxiv. 2026 Apr 24.. View in PubMed
  • Estimating white matter hyperintensities volume in individuals with stroke using T1-weighted images. Neuroimage Rep. 2026 Jun; 6(2):100344.. View in PubMed
  • Optimizing the Approach to Calculating CST Lesion Load in Ischemic Stroke Patients for Understanding Motor Outcomes. Neurorehabil Neural Repair. 2026 Jun; 40(6):448-460.. View in PubMed
  • Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study. Lancet Digit Health. 2026 Jan; 8(1):100942.. View in PubMed
  • Self-Organizing Recruitment of Compensatory Cortical Areas Post-Stroke Can Maximize Residual Motor Performance. IEEE Trans Neural Syst Rehabil Eng. 2026; 34:1557-1569.. View in PubMed
  • Asymmetry in fractional anisotropy of the corticospinal tract correlates with measures of body structure/function and activity in the chronic phase after stroke. Top Stroke Rehabil. 2026 Sep; 33(6):630-640.. View in PubMed
  • Targeted isolation and identification of isoquinoline alkaloids from Xylopia ferruginea bark with anti Aβ-induced paralysis activity. Fitoterapia. 2026 Mar; 189:107040.. View in PubMed
  • Collaborative AI for precision neurorehabilitation: a roadmap. J Neuroeng Rehabil. 2025 Nov 27; 22(1):269.. View in PubMed