Stella Tommasi, PhD

I am an Associate Professor of Research in the Department of Population and Public Health Sciences (PPHS) and a Full Member of the USC Norris Comprehensive Cancer Center (NCCC), Genomic and Epigenomic Regulation Program (GER). Research in my laboratory focuses on investigating the molecular mechanisms underlying the development of cancer and other chronic diseases. Specifically, we aim to elucidate how the genome and epigenome are affected by lifestyle (e.g., smoking, vaping, diet) and environmental exposures (e.g., air pollutants, chemical contaminants). Using a combination of novel seq-based omics technologies, classic molecular biology assays, and bioinformatics tools, my group investigates the role played by tobacco toxicants/carcinogens (and environmental pollutants) in the pathogenesis of cancer and nonalcoholic fatty liver disease (NAFLD), a primary form of liver disease and a growing global epidemic. Characterizing the interaction of genetic, epigenetic, and environmental determinants can provide insights into the complexity and heterogeneity of cancer and NAFLD. Improving our mechanistic understanding of their etiology will be instrumental in developing effective strategies for the prevention, early detection, treatment and monitoring of these diseases.

• Does secondhand smoke induce epigenetic changes?
  University of California Tobacco Related Disease Research Program (TRDRP) · Aug 1, 2020 – Jul 31, 2021 · Role: Principal Investigator
• Does secondhand smoke induce epigenetic changes?
  University of California Tobacco Related Disease Research Program (TRDRP) · Aug 1, 2017 – Jul 31, 2020 · Role: Principal Investigator
• Investigating the carcinogenicity of e-cig
  University of California Tobacco Related Disease Research Program (TRDRP) · Jul 1, 2016 – Jun 30, 2019 · Role: Principal Investigator

• Cancer Genetics and Epigenetics
• Genetic, epigenetic, and environmental determinants of chronic liver disease (NAFLD)
• Genomic, epigenomic, and transcriptomic effects of vaping versus smoking
• Environmental epigenetics
• Role of noncoding RNAs in health and disease

• Secondhand smoke may be linked to liver disease, new study finds (02/20/2020)
• Secondhand Smoke Plays Role In Fatty Liver Disease, Study Finds (02/20/2020)
• Secondhand smoke may be fueling rise of chronic liver disease in children and adults (02/20/2020)

• Leventhal, Adam
• Barrington-Trimis, Jessica
• Unger, Jennifer
• Besaratinia, Ahmad
• Sussman, Steven
• Harlow, Alyssa