Keck School Faculty

Steven L Giannotta, MD
Steven L Giannotta, MD
Chair and Professor of Neurological Surgery, Dr. Martin Weiss Chair in Neurological Surgery
Neurological Surgery
GNH 3300 Off Campus Los Angeles
Steven L. Giannotta M.D., Chair of Neurological Surgery, joined the Department of Neurosurgery at USC in 1980.

His research interests have always been related to cerebral blood flow and cerebral protection from ischemia. Based on some preliminary studies done in primates early in his career it was discovered that cerebral blood flow could be augmented by various manipulations of the cardiovascular system. This resulted in the adaptation of such techniques in the clinical realm especially as an effective means of counteracting the ischemic effects of cerebral vasospasm. This program ultimately evolved into what has come to be recognized as "hyperdynamic therapy". Subsequently his clinical interests have related to various surgical approaches to intracranial vascular and cranial base neoplastic disease. Recently his attention has turned to looking at ethnic differences in the presentation of cerebral vascular disorders.

Dr. Giannotta has gained recognition for his work in cerebrovascular disease of the brain and spinal cord. He has surgically treated over 1000 intracranial aneurysms. In conjunction with his associates Dr. Giannotta has developed a comprehensive approach to the gamut of cerebrovascular conditions. Techniques utilized in this comprehensive program include but are not limited to microsurgical clip ligation for aneurysms, coil embolization for aneurysms, microvascular excision, embolization, stereotactic radiosurgery using the Gamma Knife for arteriovenous malformations, carotid endarterectomy and extracranial to intracranial bypass procedures for cerebrovascular occlusive disease.

Dr. Giannotta also has an interest and special expertise in surgical approaches to the cranial base. He has surgically removed more than 400 acoustic neuromas and along with several colleagues in otolaryngology has developed a team approach to complex cranial base lesions including acoustic neuromas, meningiomas of the cranial base, complex aneurysms that require cranial base approaches and other benign conditions affecting the base of the brain and skull. Complex conditions may require several modes of therapy including surgical excision, embolization, and stereotactic radiosurgery using the Gamma Knife and Cyberknife.

Dr. Giannotta earned his medical degree and did his residency at University of Michigan.

He is involved in many local, national and international committees and organizations.

Prospective clinical validation of a meningioma consistency grading scheme: association with surgical outcomes and extent of tumor resection J Neurosurg. 2018 Dec 14; 1-5. . View in PubMed

Predictors of Venous Thromboembolism After Non-Emergent Craniotomy: A Nationwide Readmission Database Analysis World Neurosurg. 2018 Nov 19. . View in PubMed

Long-Term Tumor Control Rates Following Gamma Knife Radiosurgery for Acoustic Neuroma World Neurosurg. 2018 Nov 14. . View in PubMed

Predictors of Surgical Site Infection After Non-Emergent Craniotomy: A Nationwide Readmission Database Analysis World Neurosurg. 2018 Aug 24. . View in PubMed

Safety-net hospitals have higher complication and mortality rates in the neurosurgical management of traumatic brain injuries World Neurosurg. 2018 Jul 25. . View in PubMed

Extracranial-Intracranial Bypass for Treatment of Blister Aneurysms: Efficacy and Analysis of Complications as Compared to Alternative Treatment Strategies World Neurosurg. 2018 Jun 16. . View in PubMed

Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery Neurosurgery. 2018 Jun 08. . View in PubMed

Ruptured Mycotic Aneurysm of the Distal Circulation in a Patient with Mucormycosis Without Direct Skull Base Extension: Case Report Oper Neurosurg (Hagerstown). 2018 May 24. . View in PubMed

Factors associated with burnout among US neurosurgery residents: a nationwide survey J Neurosurg. 2018 Feb 09; 1-15. . View in PubMed

In situ administration of abciximab for thrombus resolution during intracranial bypass surgery: case report J Neurosurg. 2018 Jan 19; 1-5. . View in PubMed

Development of a Perfusion-Based Cadaveric Simulation Model Integrated into Neurosurgical Training: Feasibility Based On Reconstitution of Vascular and Cerebrospinal Fluid Systems Oper Neurosurg (Hagerstown). 2018 Jan 01; 14(1):72-80. . View in PubMed

Perfusion-based human cadaveric specimen as a simulation training model in repairing cerebrospinal fluid leaks during endoscopic endonasal skull base surgery J Neurosurg. 2017 Nov 03; 1-5. . View in PubMed

Impact of the 2003 ACGME Resident Duty Hour Reform on Hospital-Acquired Conditions: A National Retrospective Analysis J Grad Med Educ. 2017 Apr; 9(2):215-221. . View in PubMed

Training Standards in Neuroendovascular Surgery: Program Accreditation and Practitioner Certification Stroke. 2017 08; 48(8):2318-2325. . View in PubMed

Solitary Plasmacytoma in the Internal Auditory Canal and Cerebellopontine Angle Mimicking Meningioma Otol Neurotol. 2016 Dec; 37(10):e400-e401. . View in PubMed

Evaluation of time to aneurysm treatment following subarachnoid hemorrhage: comparison of patients treated with clipping versus coiling J Neurointerv Surg. 2016 Apr; 8(4):373-7. . View in PubMed

Response J Neurosurg. 2016 Apr; 124(4):1142-3. . View in PubMed

Giant, calcified colloid cyst of the lateral ventricle J Clin Neurosci. 2016 Feb; 24:6-9. . View in PubMed

Cerebrospinal fluid reconstitution via a perfusion-based cadaveric model: feasibility study demonstrating surgical simulation of neuroendoscopic procedures J Neurosurg. 2015 Nov; 123(5):1316-21. . View in PubMed

Retrosigmoid Versus Translabyrinthine Approach for Acoustic Neuroma Resection: An Assessment of Complications and Payments in a Longitudinal Administrative Database Cureus. 2015 Oct 30; 7(10):e369. . View in PubMed

The importance of preoperative diagnosis of blister aneurysms J Clin Neurosci. 2015 Sep; 22(9):1408-12. . View in PubMed

Recording stereoscopic 3D neurosurgery with a head-mounted 3D camera system Br J Neurosurg. 2015 Jun; 29(3):371-3. . View in PubMed

A case report of two different skull base pathologies causing hearing loss in the same ear: vestibular schwannoma and superior semicircular canal dehiscence Am J Otolaryngol. 2015 May-Jun; 36(3):488-91. . View in PubMed

Health disparities in time to aneurysm clipping/coiling among aneurysmal subarachnoid hemorrhage patients: a national study World Neurosurg. 2014 Dec; 82(6):1071-6. . View in PubMed

Intracranial fusarium fungal abscess in an immunocompetent patient: case report and review of the literature J Neurol Surg Rep. 2014 Dec; 75(2):e241-5. . View in PubMed

A Perfusion-based Human Cadaveric Model for Management of Carotid Artery Injury during Endoscopic Endonasal Skull Base Surgery J Neurol Surg B Skull Base. 2014 Oct; 75(5):309-13. . View in PubMed

Introduction: Strategies for management and outcomes of arteriovenous malformations Neurosurg Focus. 2014 Sep; 37(3):Introduction. . View in PubMed

Endoscopic-assisted resection of intracranial epidermoid tumors World Neurosurg. 2014 Sep-Oct; 82(3-4):450-4. . View in PubMed

A persistent primitive hypoglossal artery arising from the external carotid artery associated with subarachnoid hemorrhageWorld Neurosurg. 2014 Jul-Aug; 82(1-2):239. e1-3. . View in PubMed

Argonaute-2 promotes miR-18a entry in human brain endothelial cells J Am Heart Assoc. 2014 May 16; 3(3):e000968. . View in PubMed

Resection of a cystic brainstem hemangioblastoma via a retrosigmoid approach Neurosurg Focus. 2014 Jan; 36(1 Suppl):1. . View in PubMed

MicroRNA-18a improves human cerebral arteriovenous malformation endothelial cell function Stroke. 2014 Jan; 45(1):293-7. . View in PubMed

A review of epigenetic and gene expression alterations associated with intracranial meningiomas Neurosurg Focus. 2013 Dec; 35(6):E5. . View in PubMed

A proposed grading system for standardizing tumor consistency of intracranial meningiomas Neurosurg Focus. 2013 Dec; 35(6):E1. . View in PubMed

Genomic and transcriptome analysis revealing an oncogenic functional module in meningiomas Neurosurg Focus. 2013 Dec; 35(6):E3. . View in PubMed

Meningiomas Neurosurg Focus. 2013 Dec; 35(6):Introduction. . View in PubMed

Proposed Surgical Trigeminal Neuralgia Score checklist Neurosurg Focus. 2013 Sep; 35(3):E4. . View in PubMed

DNA methylation in the malignant transformation of meningiomas PLoS One. 2013; 8(1):e54114. . View in PubMed

Simulation of a high-flow extracranial-intracranial bypass using a radial artery graft in a novel fresh tissue model Neurosurgery. 2012 Dec; 71(2 Suppl Operative):ons315-19; discussion ons 319-20. . View in PubMed

Extent of resection and early postoperative outcomes following removal of cystic vestibular schwannomas: surgical experience over a decade and review of the literature Neurosurg Focus. 2012 Sep; 33(3):E13. . View in PubMed

Incidence trends in the anatomic location of primary malignant brain tumors in the United States: 1992-2006 World Neurosurg. 2012 Mar-Apr; 77(3-4):518-24. . View in PubMed

The value of translational models for microvascular anastamosis World Neurosurg. 2012 Feb; 77(2):289-90. . View in PubMed

Cervical spine dural arteriovenous fistula with coexisting spinal radiculopial artery aneurysm presenting as subarachnoid hemorrhage: case report Neurosurgery. 2012 Jan; 70(1):E259-63; discussion E263. . View in PubMed

The putative role of pericytes in tumor angiogenesis World Neurosurg. 2011 Dec; 76(6):535-6. . View in PubMed

Molecular genetics of meningiomas: a systematic review of the current literature and potential basis for future treatment paradigms Neurosurg Focus. 2011 May; 30(5):E7. . View in PubMed

Cerebral arteriovenous malformations: issues of the interplay between stereotactic radiosurgery and endovascular surgical therapy World Neurosurg. 2011 May-Jun; 75(5-6):638-47. . View in PubMed

Thrombospondin-1 modulates the angiogenic phenotype of human cerebral arteriovenous malformation endothelial cells Neurosurgery. 2011 May; 68(5):1342-53; discussion 1353. . View in PubMed

Cavernous malformations Neurosurg Focus. 2010 Sep; 29(3):Introduction. . View in PubMed

Operative strategies for minimizing hearing loss and other major complications associated with microvascular decompression for trigeminal neuralgia World Neurosurg. 2010 Jul; 74(1):172-7. . View in PubMed

Posttraumatic human cerebral myiasis World Neurosurg. 2010 May; 73(5):557-9. . View in PubMed

Cerebral vasospasm and concurrent left ventricular outflow tract obstruction: requirement for modification of hyperdynamic therapy regimen Neurocrit Care. 2010 Apr; 12(2):265-8. . View in PubMed

Delayed toxicity from gamma knife radiosurgery to lesions in and adjacent to the brainstem J Clin Neurosci. 2009 Sep; 16(9):1139-47. . View in PubMed

Digital photography using the intraoperative microscope in neurosurgery Surg Neurol. 2009 Aug; 72(2):153-6. . View in PubMed

Fenestrated aneurysm clips in the surgical management of anterior communicating artery aneurysms: operative techniques and strategyClinical article. Neurosurg Focus. 2009 May; 26(5):E7. . View in PubMed

Endovascular management of spinal dural arteriovenous fistulasA review. Neurosurg Focus. 2009 May; 26(5):E15. . View in PubMed

Aberrant angiogenic characteristics of human brain arteriovenous malformation endothelial cells Neurosurgery. 2009 Jan; 64(1):139-46; discussion 146-8. . View in PubMed

A review of selective hypothermia in the management of traumatic brain injury Neurosurg Focus. 2008 Oct; 25(4):E9. . View in PubMed

Internal carotid artery aneurysms occurring at the origin of fetal variant posterior cerebral arteries: surgical and endovascular experience Neurosurgery. 2008 Jul; 63(1 Suppl 1):ONS55-61; discussion ONS61-2. . View in PubMed

Predictors and outcomes of intraprocedural rupture in patients treated for ruptured intracranial aneurysms: the CARAT study Stroke. 2008 May; 39(5):1501-6. . View in PubMed

Novel use of an endovascular embolectomy device for retrograde suction decompression-assisted clip ligation of a large paraclinoid aneurysm: technical case report Neurosurgery. 2008 May; 62(5 Suppl 2):ONSE412-3; discussion ONSE413-4. . View in PubMed

Microvascular decompression for intractable singultus: technical case report Neurosurgery. 2008 May; 62(5):E1180-1; discussion E1181. . View in PubMed

The extradural temporopolar approach: a review of indications and operative technique Neurosurg Focus. 2008; 25(6):E3. . View in PubMed

Spontaneous intracranial hypotension and immediate improvement following epidural blood patch placement demonstrated by intracranial pressure monitoringCase report. J Neurosurg. 2007 Jun; 106(6):1089-90. . View in PubMed

Access to emergency care Bull Am Coll Surg. 2007 Apr; 92(4):44; author reply 44-5. . View in PubMed

A review of ocular manifestations in intracranial hypotension Neurosurg Focus. 2007; 23(5):E8. . View in PubMed

Postoperative Gamma Knife surgery for benign meningiomas of the cranial base Neurosurg Focus. 2007; 23(4):E6. . View in PubMed

Aneurysms in children: review of 15 years experience J Clin Neurosci. 2006 Feb; 13(2):188-92. . View in PubMed

Vector analysis correlating bullet trajectory to outcome after civilian through-and-through gunshot wound to the head: using imaging cues to predict fatal outcome Neurosurgery. 2005 Oct; 57(4):737-47; discussion 737-47. . View in PubMed

Gamma knife radiosurgery for trigeminal neuralgia Neurosurgery. 2005 Jun; 56(6):1295-301; discussion 1301-3. . View in PubMed

The treatment of complex dural arteriovenous fistulae through cranial base techniques Neurol India. 2004 Sep; 52(3):325-31. . View in PubMed

Comparison of endovascular and surface cooling during unruptured cerebral aneurysm repair Neurosurgery. 2004 Aug; 55(2):307-14; discussion 314-5. . View in PubMed

The Leksell gamma knife Model U versus Model C: a quantitative comparison of radiosurgical treatment parameters Neurosurgery. 2004 Jul; 55(1):168-72; discussion 172-3. . View in PubMed

Gamma knife radiosurgery for benign cavernous sinus tumors: quantitative analysis of treatment outcomes Neurosurgery. 2004 Jun; 54(6):1385-93; discussion 1393-4. . View in PubMed

Study of magnetic resonance imaging-based arteriovenous malformation delineation without conventional angiography Neurosurgery. 2004 May; 54(5):1104-; discussion 1108-10. . View in PubMed

Unusual presentations of cerebral solitary fibrous tumors: report of four cases Neurosurgery. 2004 Apr; 54(4):1004-9; discussion 1009. . View in PubMed

Gamma knife radiosurgery for pituitary adenoma: early results Neurosurgery. 2003 Jul; 53(1):51-9; discussion 59-61. . View in PubMed

Survival and pattern of failure in brain metastasis treated with stereotactic gamma knife radiosurgery J Neurosurg. 2002 Dec; 97(5 Suppl):499-506. . View in PubMed

Covered stent-graft repair of the brachiocephalic arteries: technical note Neurosurgery. 2002 Jul; 51(1):247-52; discussion 252-3. . View in PubMed

Cranial base approaches for the surgical treatment of aggressive posterior fossa dural arteriovenous fistulae with leptomeningeal drainage: report of four technical cases Neurosurgery. 2002 May; 50(5):1156-60; discussion 1160-1. . View in PubMed

Metastatic melanoma to the brain: prognostic factors after gamma knife radiosurgery Int J Radiat Oncol Biol Phys. 2002 Apr 01; 52(5):1277-87. . View in PubMed

The sizer-dissector for aneurysm clip selection: technical note Neurosurgery. 2002 Mar; 50(3):669-70; discussion 670-1. . View in PubMed

Ophthalmic segment aneurysm surgery Neurosurgery. 2002 Mar; 50(3):558-62. . View in PubMed

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