Keck School Faculty

Suhn Kyong Rhie
Suhn Kyong Rhie
Assistant Professor of Research Biochemistry and Molecular Medicine
Medicine
1450 Biggy Street Health Sciences Campus Los Angeles
Dr. Rhie received her B.S. in Biochemistry, magna cum laude from the University of California, Los Angeles. She earned her Ph.D. degree in Genetic, Molecular and Cellular Biology from the University of Southern California in 2013. She completed her postdoctoral training in the laboratories of Dr. Peter Laird and Dr. Peggy Farnham. Dr. Rhie participated in Genome-Wide Association Studies (GWAS) in different cancer types, unraveling mechanisms that explain how genetic variants affect disease risks. Dr. Rhie characterized heterogeneous tumor tissues as a leader of DNA methylation analysis for The Cancer Genome Atlas (TCGA) Consortium and discovered how genetic alterations such as somatic mutations, fusions, copy number variations are associated with epigenetic changes in cancer. She has also led epigenomic data analysis to investigate how transcription factors act at regulatory elements in a 3D nucleome structure in cancer and psychiatric diseases as part of the ENCODE and PsychENCODE Consortia.
Her current research interests are to characterize key transcription factor and understand roles of regulatory elements activated in different types of cancers and neurodevelopmental diseases. By using both molecular biology and bioinformatics to address how genes are regulated in 3D nucleome structure (e.g. ChIP-seq, RNA-seq, whole genome sequencing, whole genome bisulfite sequencing, NOMe-seq, DNA methylation, Hi-C, CRISPR/Cas9, dCas9-ED systems), her lab is discovering new molecular mechanisms of human diseases that can aid in the development of therapeutics to enhance quality of life for patients.

: NCI Career Development Award, 2018-2021

: Women for Change, 2007

: Ethel Terry McCoy Award for Excellence in Chemistry and Biochemistry, 2007

A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome Nat Commun. 2019 Sep 12; 10(1):4154. . View in PubMed

The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression Sci Adv. 2019 Jul; 5(7):eaaw6710. . View in PubMed

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner Epigenetics Chromatin. 2019 May 03; 12(1):26. . View in PubMed

The Enigmatic HOX Genes: Can We Crack Their Code? Cancers (Basel). 2019 Mar 07; 11(3).. View in PubMed

Revealing the brain's molecular architecture Science. 2018 Dec 14; 362(6420):1262-1263. . View in PubMed

Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation Sci Adv. 2018 Dec; 4(12):eaav8550. . View in PubMed

CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops Genome Biol. 2018 Oct 08; 19(1):160. . View in PubMed

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes Epigenomics. 2018 Sep; 10(9):1167-1187. . View in PubMed

ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters Genome Res. 2018 Feb 02. . View in PubMed

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes Epigenomics. 2018 09; 10(9):1167-1187. . View in PubMed

Comprehensive functional genomic resource and integrative model for the human brain Science. 2018 12 14; 362(6420). . View in PubMed

Integrative functional genomic analysis of human brain development and neuropsychiatric risks Science. 2018 12 14; 362(6420). . View in PubMed

CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops Genome Biol. 2018 10 08; 19(1):160. . View in PubMed

Defining Regulatory Elements in the Human Genome Using Nucleosome Occupancy and Methylome Sequencing (NOMe-Seq) Methods Mol Biol. 2018; 1766:209-229. . View in PubMed

Transcriptome and epigenome landscape of human cortical development modeled in organoids Science. 2018 12 14; 362(6420). . View in PubMed

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder Science. 2018 12 14; 362(6420). . View in PubMed

A Prostate Cancer Risk Element Functions as a Repressive Loop that Regulates HOXA13 Cell Rep. 2017 Nov 07; 21(6):1411-1417. . View in PubMed

Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev. 2017 Jul; 26(7):1016-1026. . View in PubMed

Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1016-1026. . View in PubMed

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles Cell Rep. 2017 03 14; 18(11):2780-2794. . View in PubMed

Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas JAMA Oncol. 2017 12 01; 3(12):1654-1662. . View in PubMed

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles Cell Rep. 2017 06 27; 19(13):2878-2880. . View in PubMed

Identification of activated enhancers and linked transcription factors in breast, prostate, and kidney tumors by tracing enhancer networks using epigenetic traits Epigenetics Chromatin. 2016; 9:50. . View in PubMed

The Molecular Taxonomy of Primary Prostate Cancer Cell. 2015 Nov 05; 163(4):1011-25. . View in PubMed

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer Cell. 2015 Oct 08; 163(2):506-19. . View in PubMed

Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci Hum Mol Genet. 2015 Jul 01; 24(13):3595-607. . View in PubMed

A comprehensive examination of breast cancer risk loci in African American women Hum Mol Genet. 2014 Oct 15; 23(20):5518-26. . View in PubMed

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin Cell. 2014 Aug 14; 158(4):929-944. . View in PubMed

Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells BMC Genomics. 2014 May 02; 15:331. . View in PubMed

Comprehensive functional annotation of 77 prostate cancer risk loci PLoS Genet. 2014 Jan; 10(1):e1004102. . View in PubMed

The Cancer Genome Atlas Pan-Cancer analysis project Nat Genet. 2013 Oct; 45(10):1113-20. . View in PubMed

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry Nat Genet. 2013 Jun; 45(6):690-6. . View in PubMed

Genome-wide association studies identify four ER negative-specific breast cancer risk loci Nat Genet. 2013 Apr; 45(4):392-8, 398e1-2. . View in PubMed

Comprehensive functional annotation of seventy-one breast cancer risk Loci PLoS One. 2013; 8(5):e63925. . View in PubMed

A genome-wide association study of breast cancer in women of African ancestry Hum Genet. 2013 Jan; 132(1):39-48. . View in PubMed

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11 Hum Mol Genet. 2012 Dec 15; 21(24):5373-84. . View in PubMed

FunciSNP: an R/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs Nucleic Acids Res. 2012 Oct; 40(18):e139. . View in PubMed

Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy Hum Mol Genet. 2009 Jan 15; 18(2):318-27. . View in PubMed

A case of pulmonary cysticercosis Korean J Intern Med. 1991 Jan; 6(1):38-43. . View in PubMed

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