Susan Bailey Gurley, MD, PhD

Professor of Medicine and Cancer Biology

Kenneth T. Norris, Jr., Chair in Medicine

Chair of the Department of Medicine

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Overview

Dr. Susan Gurley is the Kenneth T. Norris, Jr. Chair of the Department of Medicine. She is a nephrology physician scientist who studies the most common causes of kidney disease: diabetic nephropathy and hypertension. After completing her PhD in biophysical chemistry (University of Mississippi), she obtained her MD at Washington University School of Medicine in St. Louis, MO. She completed her residency in internal medicine and fellowship in nephrology at Duke University School of Medicine, where she began her faculty career. At Duke, she held several leadership roles focused on faculty development and biomedical research. Notably, she was Section Chief, Renal at the Durham VA HCS from2012-2018. In 2018 she was recruited to Oregon Health & Science University (OHSU) to lead the Division of Nephrology & Hypertension and was later named interim chair, Department of Medicine (2021-2023). On August 1, 2023, Dr. Gurley was appointed Chair, Department of Medicine at Keck School of Medicine, University of Southern California.

Dr. Gurley’s current research program utilizes mouse models of human diseases to study disease
pathogenesis. She has more than 20 years of experience studying the pathogenesis of hypertension and diabetic nephropathy using transgenic mouse models in renal physiologic studies. Dr. Gurley has extensive knowledge of the renin-angiotensin system (in particular the type 1 angiotensin II receptor and ACE2), including conditional gene targeting in mice, cardiovascular studies in mice, angiotensin peptide metabolism, and genomic and metabolomics analyses. A major focus of her laboratory is on the function of ACE2 in blood pressure regulation and kidney injury.

Research Funding

  • Medical Scientist Training Program of Oregon Health & Science University
    NIH · T32GM141938 · Jul 1, 2021 – Jun 30, 2026 · Role: Co-Principal Investigator
  • Actions of ACE2 along with Nephron to Regulate Blood Pressure
    NIH · R01DK098382 · Apr 1, 2014 – May 31, 2026 · Role: Principal Investigator

Publications

  • Proximal tubule ACE2 mediates early responses to hypertension by regulating intrarenal RAS and sodium homeostasis. JCI Insight. 2026 Sep 22; 11(18).. View in PubMed
  • Sex-dependent epigenomic and transcriptomic reprogramming links maternal obesity to cardiac remodeling in adult offspring. Am J Physiol Heart Circ Physiol. 2026 Oct 01; 331(4):H1307-H1328.. View in PubMed
  • Cardiac LIM Protein, Kidney Fibrosis, and Vascular Change after Acute Cardiorenal Syndrome. J Am Soc Nephrol. 2025 Dec 01; 36(12):2330-2347.. View in PubMed
  • Maternal obesity programs cardiac remodeling in offspring via epigenetic, metabolic, and immune dysregulations. bioRxiv. 2025 May 27.. View in PubMed
  • ACE2 deficiency protects against heme protein-induced acute kidney injury. Am J Physiol Renal Physiol. 2025 05 01; 328(5):F676-F683.. View in PubMed
  • Kidney cell response to acute cardiorenal and isolated kidney ischemia-reperfusion injury. Physiol Genomics. 2025 04 01; 57(4):266-278.. View in PubMed
  • Angiotensin II Directly Increases Endothelial Calcium and Nitric Oxide in Kidney and Brain Microvessels In Vivo With Reduced Efficacy in Hypertension. J Am Heart Assoc. 2024 05 21; 13(10):e033998.. View in PubMed
  • Parental recovered acute kidney injury causes prenatal renal dysfunction and fetal growth restriction with sexually dimorphic implications for adult offspring. Front Physiol. 2024; 15:1357932.. View in PubMed
  • Kidney Renin-Angiotensin System: Lost in a RAS Cascade. Hypertension. 2024 04; 81(4):682-686.. View in PubMed
  • Characteristics and Outcomes of NELL1 Membranous Nephropathy in Lipoic Acid Users and Nonusers. Kidney Int Rep. 2024 May; 9(5):1379-1386.. View in PubMed