Keck School Faculty

Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 42 (Kir4. 2), Kir4. 1, and Epithelial Na+ Channel (ENaC). Hypertension. 2023 Nov 01. . View in PubMed

Abnormal lactate metabolism is linked to albuminuria and kidney injury in diabetic nephropathy Kidney Int. 2023 Oct 05. . View in PubMed

Hospital at Home meets need for new dialysis patients Clin Nephrol. 2023 Oct 02. . View in PubMed

Increased Risk of Preeclampsia with Assisted Reproductive Technologies Curr Hypertens Rep. 2023 09; 25(9):251-261. . View in PubMed

Existing Transplant Nephrology Compensation Models and Opportunities for Equitable Pay Clin J Am Soc Nephrol. 2022 09; 17(9):1407-1409. . View in PubMed

The Importance of Transplant Nephrology to a Successful Kidney Transplant Program Clin J Am Soc Nephrol. 2022 09; 17(9):1403-1406. . View in PubMed

Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice J Am Soc Nephrol. 2022 03; 33(3):584-600. . View in PubMed

Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response Glomerular Dis. 2022; 2(4):164-175. . View in PubMed

Chronic activation of vasopressin-2 receptors induces hypertension in Liddle mice by promoting Na+ and water retention Am J Physiol Renal Physiol. 2022 10 01; 323(4):F468-F478. . View in PubMed

Soluble ACE2 Is Filtered into the Urine Kidney360. 2022 12 29; 3(12):2086-2094. . View in PubMed

Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy Hypertension. 2021 02; 77(2):393-404. . View in PubMed

Advances in use of mouse models to study the renin-angiotensin system Mol Cell Endocrinol. 2021 06 01; 529:111255. . View in PubMed

Vascular control of kidney epithelial transporters Am J Physiol Renal Physiol. 2021 06 01; 320(6):F1080-F1092. . View in PubMed

Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron Am J Physiol Renal Physiol. 2021 07 01; 321(1):F69-F81. . View in PubMed

Advancing Nephrology: Division Leaders Advise ASN Clin J Am Soc Nephrol. 2021 02 08; 16(2):319-327. . View in PubMed

DNAJB9 Is Not Transcriptionally Upregulated in the Glomerulus in Fibrillary Glomerulonephritis Kidney Int Rep. 2020 Mar; 5(3):368-372. . View in PubMed

Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices Hypertension. 2020 11; 76(5):1350-1367. . View in PubMed

Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis J Am Soc Nephrol. 2020 07; 31(7):1479-1495. . View in PubMed

Electrolyte and transporter responses to angiotensin II induced hypertension in female and male rats and mice Acta Physiol (Oxf). 2020 05; 229(1):e13448. . View in PubMed

a2A-Adrenoceptors Modulate Renal Sympathetic Neurotransmission and Protect against Hypertensive Kidney Disease J Am Soc Nephrol. 2020 04; 31(4):783-798. . View in PubMed

Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults: A Living Systematic Review Ann Intern Med. 2020 08 04; 173(3):195-203. . View in PubMed

Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice Biol Sex Differ. 2019 09 04; 10(1):45. . View in PubMed

Modeling Sex Differences in the Renin Angiotensin System and the Efficacy of Antihypertensive Therapies Comput Chem Eng. 2018 Apr 06; 112:253-264. . View in PubMed

Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy Diabetes. 2018 10; 67(10):2096-2106. . View in PubMed

Blood pressure regulation by the angiotensin type 1 receptor in the proximal tubule Curr Opin Nephrol Hypertens. 2018 01; 27(1):1-7. . View in PubMed

Targeting Pim Kinases and DAPK3 to Control HypertensionCell Chem Biol. 2018 10 18; 25(10):1195-1207. e32. . View in PubMed

Modelling diabetic nephropathy in mice Nat Rev Nephrol. 2018 Jan; 14(1):48-56. . View in PubMed

Metabolic Changes with Base-Loading in CKD Clin J Am Soc Nephrol. 2018 08 07; 13(8):1244-1246. . View in PubMed

Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy Am J Physiol Renal Physiol. 2018 04 01; 314(4):F531-F542. . View in PubMed

Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells Cardiovasc Res. 2017 Nov 01; 113(13):1551-1559. . View in PubMed

Angiotensin receptor signaling and prostate tumor growth in mice J Exp Ther Oncol. 2017 Sep; 11(2):107-115. . View in PubMed

A highly efficient strategy to determine genotypes of genetically-engineered mice using genomic DNA purified from hair roots Lab Anim. 2017 Apr; 51(2):138-146. . View in PubMed

Photoacoustic imaging for in vivo quantification of placental oxygenation in mice FASEB J. 2017 12; 31(12):5520-5529. . View in PubMed

Resistance to hypertension mediated by intercalated cells of the collecting duct JCI Insight. 2017 04 06; 2(7):e92720. . View in PubMed

Incorporating Geriatric Assessment into a Nephrology Clinic: Preliminary Data from Two Models of Care J Am Geriatr Soc. 2016 10; 64(10):2154-2158. . View in PubMed

Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male miceEffects on renin-angiotensin system. J Hypertens. 2016 09; 34(9):1752-65. . View in PubMed

Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI J Am Soc Nephrol. 2016 08; 27(8):2257-64. . View in PubMed

Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension Hypertension. 2016 06; 67(6):1291-7. . View in PubMed

Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney Sci Rep. 2016 09 21; 6:33678. . View in PubMed

Angiotensin converting enzyme 2 and the kidney Curr Opin Nephrol Hypertens. 2016 Jan; 25(1):59-66. . View in PubMed

Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion J Am Soc Nephrol. 2015 Dec; 26(12):2953-62. . View in PubMed

Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity Am J Physiol Endocrinol Metab. 2015 Jul 01; 309(1):E84-94. . View in PubMed

Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis Mol Metab. 2015 Apr; 4(4):337-43. . View in PubMed

The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice Neurourol Urodyn. 2015 Jan; 34(1):72-8. . View in PubMed

Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2617-23. . View in PubMed

Classical Renin-Angiotensin system in kidney physiology Compr Physiol. 2014 Jul; 4(3):1201-28. . View in PubMed

Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells PLoS One. 2014; 9(1):e85958. . View in PubMed

ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney Physiol Rep. 2014; 2(3):e00264. . View in PubMed

Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC) J Biol Chem. 2013 Aug 23; 288(34):24834-47. . View in PubMed

Enhanced angiotensin II-induced cardiac and aortic remodeling in ACE2 knockout mice J Cardiovasc Pharmacol Ther. 2013 Mar; 18(2):138-51. . View in PubMed

Targeting eNOS in pancreatic cancer Cancer Res. 2012 Sep 01; 72(17):4472-82. . View in PubMed

Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress J Neurosci. 2012 Feb 08; 32(6):2051-61. . View in PubMed

Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion PLoS One. 2012; 7(4):e33942. . View in PubMed

Assessment of diabetic nephropathy in the Akita mouse Methods Mol Biol. 2012; 933:17-29. . View in PubMed

AT1 receptors in the collecting duct directly modulate the concentration of urine J Am Soc Nephrol. 2011 Dec; 22(12):2237-46. . View in PubMed

Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction Hypertension. 2011 Nov; 58(5):852-8. . View in PubMed

Minding the gap: connexin 40 at the heart of renin release J Am Soc Nephrol. 2011 Jun; 22(6):985-6. . View in PubMed

AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure Cell Metab. 2011 Apr 06; 13(4):469-475. . View in PubMed

Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):758-65. . View in PubMed

Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension Hypertension. 2011 Mar; 57(3):577-85. . View in PubMed

ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function PLoS One. 2011; 6(7):e22682. . View in PubMed

Renal actions of RGS2 control blood pressure J Am Soc Nephrol. 2010 Nov; 21(11):1847-51. . View in PubMed

An IRKO in the Podo: impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy Cell Metab. 2010 Oct 06; 12(4):311-312. . View in PubMed

Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice Am J Physiol Renal Physiol. 2010 Mar; 298(3):F788-95. . View in PubMed

Mouse models of diabetic nephropathy J Am Soc Nephrol. 2009 Dec; 20(12):2503-12. . View in PubMed

Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages Exp Physiol. 2008 May; 93(5):538-42. . View in PubMed

The renin-angiotensin system and diabetic nephropathy Semin Nephrol. 2007 Mar; 27(2):144-52. . View in PubMed

AT(1) receptors and control of blood pressure: the kidney and more. . Trends Cardiovasc Med. 2007 Jan; 17(1):30-4. . View in PubMed

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17985-90. . View in PubMed

Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice J Clin Invest. 2006 Aug; 116(8):2218-25. . View in PubMed

ACE and ACE2 activity in diabetic mice Diabetes. 2006 Jul; 55(7):2132-9. . View in PubMed

New mass spectrometric assay for angiotensin-converting enzyme 2 activity Hypertension. 2006 May; 47(5):1010-7. . View in PubMed

Impact of genetic background on nephropathy in diabetic mice Am J Physiol Renal Physiol. 2006 Jan; 290(1):F214-22. . View in PubMed

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system J Clin Invest. 2005 Apr; 115(4):1092-9. . View in PubMed

Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease Cold Spring Harb Symp Quant Biol. 2002; 67:451-7. . View in PubMed