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Susan Bailey Gurley, MD, PhD

Professor of Medicine

Chair of the Department of Medicine

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Email Susan.Gurley@med.usc.edu
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Overview

Dr. Susan Gurley is the Kenneth T. Norris, Jr. Chair of the Department of Medicine. She is a nephrology physician scientist who studies the most common causes of kidney disease: diabetic nephropathy and hypertension. After completing her PhD in biophysical chemistry (University of Mississippi), she obtained her MD at Washington University School of Medicine in St. Louis, MO. She completed her residency in internal medicine and fellowship in nephrology at Duke University School of Medicine, where she began her faculty career. At Duke, she held several leadership roles focused on faculty development and biomedical research. Notably, she was Section Chief, Renal at the Durham VA HCS from2012-2018. In 2018 she was recruited to Oregon Health & Science University (OHSU) to lead the Division of Nephrology & Hypertension and was later named interim chair, Department of Medicine (2021-2023). On August 1, 2023, Dr. Gurley was appointed Chair, Department of Medicine at Keck School of Medicine, University of Southern California.

Dr. Gurley’s current research program utilizes mouse models of human diseases to study disease
pathogenesis. She has more than 20 years of experience studying the pathogenesis of hypertension and diabetic nephropathy using transgenic mouse models in renal physiologic studies. Dr. Gurley has extensive knowledge of the renin-angiotensin system (in particular the type 1 angiotensin II receptor and ACE2), including conditional gene targeting in mice, cardiovascular studies in mice, angiotensin peptide metabolism, and genomic and metabolomics analyses. A major focus of her laboratory is on the function of ACE2 in blood pressure regulation and kidney injury.

Publications

  • Kidney cell response to acute cardiorenal and isolated kidney ischemia-reperfusion injury Physiol Genomics. 2025 Feb 21. . View in PubMed
  • Angiotensin II Directly Increases Endothelial Calcium and Nitric Oxide in Kidney and Brain Microvessels In Vivo With Reduced Efficacy in Hypertension J Am Heart Assoc. 2024 May 21; 13(10):e033998. . View in PubMed
  • Characteristics and Outcomes of NELL1 Membranous Nephropathy in Lipoic Acid Users and Nonusers Kidney Int Rep. 2024 May; 9(5):1379-1386. . View in PubMed
  • Kidney Renin-Angiotensin System: Lost in a RAS Cascade Hypertension. 2024 Apr; 81(4):682-686. . View in PubMed
  • Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 42 (Kir4. 2), Kir4. 1, and Epithelial Na+ Channel (ENaC). Hypertension. 2024 Jan; 81(1):126-137. . View in PubMed
  • Parental recovered acute kidney injury causes prenatal renal dysfunction and fetal growth restriction with sexually dimorphic implications for adult offspring Front Physiol. 2024; 15:1357932. . View in PubMed
  • Abnormal lactate metabolism is linked to albuminuria and kidney injury in diabetic nephropathy Kidney Int. 2023 12; 104(6):1135-1149. . View in PubMed
  • Hospital at Home meets need for new dialysis patients Clin Nephrol. 2023 Nov; 100(5):231-234. . View in PubMed
  • Increased Risk of Preeclampsia with Assisted Reproductive Technologies Curr Hypertens Rep. 2023 09; 25(9):251-261. . View in PubMed
  • Soluble ACE2 Is Filtered into the Urine Kidney360. 2022 12 29; 3(12):2086-2094. . View in PubMed
  • Chronic activation of vasopressin-2 receptors induces hypertension in Liddle mice by promoting Na+ and water retention Am J Physiol Renal Physiol. 2022 10 01; 323(4):F468-F478. . View in PubMed
  • Existing Transplant Nephrology Compensation Models and Opportunities for Equitable Pay Clin J Am Soc Nephrol. 2022 09; 17(9):1407-1409. . View in PubMed
  • The Importance of Transplant Nephrology to a Successful Kidney Transplant Program Clin J Am Soc Nephrol. 2022 09; 17(9):1403-1406. . View in PubMed
  • Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice J Am Soc Nephrol. 2022 03; 33(3):584-600. . View in PubMed
  • Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response Glomerular Dis. 2022; 2(4):164-175. . View in PubMed
  • Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron Am J Physiol Renal Physiol. 2021 07 01; 321(1):F69-F81. . View in PubMed
  • Advances in use of mouse models to study the renin-angiotensin system Mol Cell Endocrinol. 2021 06 01; 529:111255. . View in PubMed
  • Vascular control of kidney epithelial transporters Am J Physiol Renal Physiol. 2021 06 01; 320(6):F1080-F1092. . View in PubMed
  • Advancing Nephrology: Division Leaders Advise ASN Clin J Am Soc Nephrol. 2021 02 08; 16(2):319-327. . View in PubMed
  • Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy Hypertension. 2021 02; 77(2):393-404. . View in PubMed
  • Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices Hypertension. 2020 11; 76(5):1350-1367. . View in PubMed
  • Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults: A Living Systematic Review Ann Intern Med. 2020 08 04; 173(3):195-203. . View in PubMed
  • Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis J Am Soc Nephrol. 2020 07; 31(7):1479-1495. . View in PubMed
  • Electrolyte and transporter responses to angiotensin II induced hypertension in female and male rats and mice Acta Physiol (Oxf). 2020 05; 229(1):e13448. . View in PubMed
  • a2A-Adrenoceptors Modulate Renal Sympathetic Neurotransmission and Protect against Hypertensive Kidney Disease J Am Soc Nephrol. 2020 04; 31(4):783-798. . View in PubMed
  • DNAJB9 Is Not Transcriptionally Upregulated in the Glomerulus in Fibrillary Glomerulonephritis Kidney Int Rep. 2020 Mar; 5(3):368-372. . View in PubMed
  • Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice Biol Sex Differ. 2019 09 04; 10(1):45. . View in PubMed
  • Targeting Pim Kinases and DAPK3 to Control HypertensionCell Chem Biol. 2018 10 18; 25(10):1195-1207. e32. . View in PubMed
  • Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy Diabetes. 2018 10; 67(10):2096-2106. . View in PubMed
  • Metabolic Changes with Base-Loading in CKD Clin J Am Soc Nephrol. 2018 08 07; 13(8):1244-1246. . View in PubMed
  • Modeling Sex Differences in the Renin Angiotensin System and the Efficacy of Antihypertensive Therapies Comput Chem Eng. 2018 Apr 06; 112:253-264. . View in PubMed
  • Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy Am J Physiol Renal Physiol. 2018 04 01; 314(4):F531-F542. . View in PubMed
  • Blood pressure regulation by the angiotensin type 1 receptor in the proximal tubule Curr Opin Nephrol Hypertens. 2018 01; 27(1):1-7. . View in PubMed
  • Modelling diabetic nephropathy in mice Nat Rev Nephrol. 2018 Jan; 14(1):48-56. . View in PubMed
  • Photoacoustic imaging for in vivo quantification of placental oxygenation in mice FASEB J. 2017 12; 31(12):5520-5529. . View in PubMed
  • Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells Cardiovasc Res. 2017 Nov 01; 113(13):1551-1559. . View in PubMed
  • Angiotensin receptor signaling and prostate tumor growth in mice J Exp Ther Oncol. 2017 Sep; 11(2):107-115. . View in PubMed
  • Resistance to hypertension mediated by intercalated cells of the collecting duct JCI Insight. 2017 04 06; 2(7):e92720. . View in PubMed
  • A highly efficient strategy to determine genotypes of genetically-engineered mice using genomic DNA purified from hair roots Lab Anim. 2017 Apr; 51(2):138-146. . View in PubMed
  • Incorporating Geriatric Assessment into a Nephrology Clinic: Preliminary Data from Two Models of Care J Am Geriatr Soc. 2016 10; 64(10):2154-2158. . View in PubMed
  • Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney Sci Rep. 2016 09 21; 6:33678. . View in PubMed
  • Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male miceEffects on renin-angiotensin system. J Hypertens. 2016 09; 34(9):1752-65. . View in PubMed
  • Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI J Am Soc Nephrol. 2016 08; 27(8):2257-64. . View in PubMed
  • Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension Hypertension. 2016 06; 67(6):1291-7. . View in PubMed
  • Angiotensin converting enzyme 2 and the kidney Curr Opin Nephrol Hypertens. 2016 Jan; 25(1):59-66. . View in PubMed
  • Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion J Am Soc Nephrol. 2015 Dec; 26(12):2953-62. . View in PubMed
  • Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity Am J Physiol Endocrinol Metab. 2015 Jul 01; 309(1):E84-94. . View in PubMed
  • Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis Mol Metab. 2015 Apr; 4(4):337-43. . View in PubMed
  • The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice Neurourol Urodyn. 2015 Jan; 34(1):72-8. . View in PubMed
  • Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2617-23. . View in PubMed
  • Classical Renin-Angiotensin system in kidney physiology Compr Physiol. 2014 Jul; 4(3):1201-28. . View in PubMed
  • ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney Physiol Rep. 2014; 2(3):e00264. . View in PubMed
  • Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells PLoS One. 2014; 9(1):e85958. . View in PubMed
  • Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC) J Biol Chem. 2013 Aug 23; 288(34):24834-47. . View in PubMed
  • Enhanced angiotensin II-induced cardiac and aortic remodeling in ACE2 knockout mice J Cardiovasc Pharmacol Ther. 2013 Mar; 18(2):138-51. . View in PubMed
  • Targeting eNOS in pancreatic cancer Cancer Res. 2012 Sep 01; 72(17):4472-82. . View in PubMed
  • Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress J Neurosci. 2012 Feb 08; 32(6):2051-61. . View in PubMed
  • Assessment of diabetic nephropathy in the Akita mouse Methods Mol Biol. 2012; 933:17-29. . View in PubMed
  • Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion PLoS One. 2012; 7(4):e33942. . View in PubMed
  • AT1 receptors in the collecting duct directly modulate the concentration of urine J Am Soc Nephrol. 2011 Dec; 22(12):2237-46. . View in PubMed
  • Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction Hypertension. 2011 Nov; 58(5):852-8. . View in PubMed
  • Minding the gap: connexin 40 at the heart of renin release J Am Soc Nephrol. 2011 Jun; 22(6):985-6. . View in PubMed
  • AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure Cell Metab. 2011 Apr 06; 13(4):469-475. . View in PubMed
  • Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):758-65. . View in PubMed
  • Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension Hypertension. 2011 Mar; 57(3):577-85. . View in PubMed
  • ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function PLoS One. 2011; 6(7):e22682. . View in PubMed
  • Renal actions of RGS2 control blood pressure J Am Soc Nephrol. 2010 Nov; 21(11):1847-51. . View in PubMed
  • An IRKO in the Podo: impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy Cell Metab. 2010 Oct 06; 12(4):311-312. . View in PubMed
  • Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice Am J Physiol Renal Physiol. 2010 Mar; 298(3):F788-95. . View in PubMed
  • Mouse models of diabetic nephropathy J Am Soc Nephrol. 2009 Dec; 20(12):2503-12. . View in PubMed
  • Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages Exp Physiol. 2008 May; 93(5):538-42. . View in PubMed
  • The renin-angiotensin system and diabetic nephropathy Semin Nephrol. 2007 Mar; 27(2):144-52. . View in PubMed
  • AT(1) receptors and control of blood pressure: the kidney and more. . Trends Cardiovasc Med. 2007 Jan; 17(1):30-4. . View in PubMed
  • Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17985-90. . View in PubMed
  • Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice J Clin Invest. 2006 Aug; 116(8):2218-25. . View in PubMed
  • ACE and ACE2 activity in diabetic mice Diabetes. 2006 Jul; 55(7):2132-9. . View in PubMed
  • New mass spectrometric assay for angiotensin-converting enzyme 2 activity Hypertension. 2006 May; 47(5):1010-7. . View in PubMed
  • Impact of genetic background on nephropathy in diabetic mice Am J Physiol Renal Physiol. 2006 Jan; 290(1):F214-22. . View in PubMed
  • Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system J Clin Invest. 2005 Apr; 115(4):1092-9. . View in PubMed
  • Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease Cold Spring Harb Symp Quant Biol. 2002; 67:451-7. . View in PubMed

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