Keck School Faculty

Thomas A Buchanan

Thomas A Buchanan

Professor of Medicine
Bernard J. Hanley Chair in Medicine
Vice Dean for Research
Director of the CTSI,
Co-Director, Diabetes and Obesity Research Institute
Endocrine Division Chief in the Department of Medicine
Medicine
CSC 205 Health Sciences Campus Los Angeles

University of California, Los Angeles: Josiah Brown Award, 2014

Western Society for Clinical Investigation: Mayo Soley Award, 2014

Irish Endocrine Society: Lilly Lecture, 2011

Association of American Physicians: Elected Member, 2006

American Diabetes Association: Distinguished Clinical Scientist Award, 2004

J Clin Endocrinol Metab: Endocrine Society-Pharmacia Award for Excellence in Published Clinical Research, 2002

University of Washington: John Ensinck Lecture, 2000

American Diabetes Association: Norbert Freinkel Award, 1999

American Diabetes Association: Chair, Council on Diabetes and Pregnancy, 1995-1997

NIH: Chair, Special Emphasis Panel, Hyperglycemia and Pregnancy Outcomes, 1995-1997

NIH: Chair, Special Emphasis Panel, Hyperglycemia and Pregnancy Outcomes , 1995-1997

Canadian Diabetes Association: Novo-Nordisk International Lecture, 1995

Australian Diabetes Association: Medisense International Lecture, 1995

American Diabetes Association, Northern Illinois Affliate: Young Investigator Award, 1983

University of Iowa: Alpha Omega Alpha, 1978

Iowa State University: Phi Beta Kappa, 1974

A cautionary response to SMFM statement: pharmacological treatment of gestational diabetesAm J Obstet Gynecol. 2018 10; 219(4):367. e1-367. e7. . View in PubMed

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium HGG Adv. 2022 Apr 14; 3(2):100099. . View in PubMed

Weight loss and ß-cell responses following gastric banding or pharmacotherapy in adults with impaired glucose tolerance or type 2 diabetes: a randomized trial Obesity (Silver Spring). 2022 08; 30(8):1579-1588. . View in PubMed

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation Nat Genet. 2022 05; 54(5):560-572. . View in PubMed

Using Patient-Generated Health Data From Twitter to Identify, Engage, and Recruit Cancer Survivors in Clinical Trials in Los Angeles County: Evaluation of a Feasibility Study JMIR Form Res. 2021 Nov 26; 5(11):e29958. . View in PubMed

Effect of Medical and Surgical Interventions on a-Cell Function in Dysglycemic Youth and Adults in the RISE Study Diabetes Care. 2021 09; 44(9):1948-1960. . View in PubMed

Hyperglucagonemia Does Not Explain the ß-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study Diabetes Care. 2021 09; 44(9):1961-1969. . View in PubMed

Baseline Predictors of Glycemic Worsening in Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study Diabetes Care. 2021 09; 44(9):1938-1947. . View in PubMed

Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and ß-Cell Function Obesity (Silver Spring). 2021 07; 29(7):1155-1163. . View in PubMed

The trans-ancestral genomic architecture of glycemic traits Nat Genet. 2021 06; 53(6):840-860. . View in PubMed

Hispanic ethnicity as a moderator of the effects of aerobic and resistance exercise on physical fitness and quality-of-life in breast cancer survivors J Cancer Surviv. 2021 02; 15(1):127-139. . View in PubMed

Islet Autoimmunity in Adults With Impaired Glucose Tolerance and Recently Diagnosed, Treatment Naïve Type 2 Diabetes in the Restoring Insulin SEcretion (RISE) Study Front Immunol. 2021; 12:640251. . View in PubMed

Precision and accuracy of hyperglycemic clamps in a multicenter study Am J Physiol Endocrinol Metab. 2021 04 01; 320(4):E797-E807. . View in PubMed

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Hum Mol Genet. 2021 11 01; 30(22):2190-2204. . View in PubMed

Aerobic and resistance exercise improve patient-reported sleep quality and is associated with cardiometabolic biomarkers in Hispanic and non-Hispanic breast cancer survivors who are overweight or obese: results from a secondary analysis Sleep. 2021 10 11; 44(10). . View in PubMed

Withdrawal of medications leads to worsening of OGTT parameters in youth with impaired glucose tolerance or recently-diagnosed type 2 diabetes Pediatr Diabetes. 2020 12; 21(8):1437-1446. . View in PubMed

ß-cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults Pediatr Diabetes. 2020 12; 21(8):1421-1429. . View in PubMed

Classification of Type 2 Diabetes Genetic Variants and a Novel Genetic Risk Score Association With Insulin Clearance J Clin Endocrinol Metab. 2020 04 01; 105(4). . View in PubMed

Hemoglobin A1c Levels During Pregnancy and Risk of Autism Spectrum Disorders in Offspring JAMA. 2019 Aug 06; 322(5):460-461. . View in PubMed

Effect of Aerobic and Resistance Exercise Intervention on Cardiovascular Disease Risk in Women With Early-Stage Breast Cancer: A Randomized Clinical Trial JAMA Oncol. 2019 May 01; 5(5):710-714. . View in PubMed

Children Exposed to Maternal Obesity or Gestational Diabetes Mellitus During Early Fetal Development Have Hypothalamic Alterations That Predict Future Weight Gain Diabetes Care. 2019 08; 42(8):1473-1480. . View in PubMed

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans Obesity (Silver Spring). 2019 03; 27(3):434-443. . View in PubMed

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies Nat Commun. 2019 01 03; 10(1):29. . View in PubMed

Hispanic ethnicity as a moderator of the effects of aerobic and resistance exercise in survivors of breast cancer Cancer. 2019 03 15; 125(6):910-920. . View in PubMed

Aerobic and Resistance Exercise Improves Shoulder Function in Women Who Are Overweight or Obese and Have Breast Cancer: A Randomized Controlled Trial Phys Ther. 2019 10 28; 99(10):1334-1345. . View in PubMed

Monitoring Twitter Conversations for Targeted Recruitment in Cancer Trials in Los Angeles County: Protocol for a Mixed-Methods Pilot Study JMIR Res Protoc. 2018 Sep 25; 7(9):e177. . View in PubMed

Impact of Gastric Banding Versus Metformin on ß-Cell Function in Adults With Impaired Glucose Tolerance or Mild Type 2 Diabetes Diabetes Care. 2018 12; 41(12):2544-2551. . View in PubMed

Maternal Gestational Diabetes Mellitus, Type 1 Diabetes, and Type 2 Diabetes During Pregnancy and Risk of ADHD in Offspring Diabetes Care. 2018 12; 41(12):2502-2508. . View in PubMed

A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile Br J Nutr. 2018 12; 120(11):1230-1239. . View in PubMed

Research Gaps in Gestational Diabetes Mellitus: Executive Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop Obstet Gynecol. 2018 08; 132(2):496-505. . View in PubMed

Longitudinal Increases in Adiposity Contribute to Worsening Adipokine Profile over Time in Mexican Americans Obesity (Silver Spring). 2018 04; 26(4):703-712. . View in PubMed

Review of methods for measuring ß-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium Diabetes Obes Metab. 2018 01; 20(1):14-24. . View in PubMed

Reply to EParkin et al. J Clin Oncol. 2018 07 10; 36(20):2129-2130. . View in PubMed

Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial Breast Cancer Res. 2018 10 19; 20(1):124. . View in PubMed

Association of weight gain and fifteen adipokines with declining beta-cell function in Mexican Americans PLoS One. 2018; 13(8):e0201568. . View in PubMed

Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial J Clin Oncol. 2018 03 20; 36(9):875-883. . View in PubMed

Maternal Type 1 Diabetes and Risk of Autism in Offspring JAMA. 2018 07 03; 320(1):89-91. . View in PubMed

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants Diabetes. 2017 08; 66(8):2296-2309. . View in PubMed

Maternal obesity, gestational diabetes, breastfeeding and childhood overweight at age 2 years Pediatr Obes. 2017 04; 12(2):171-178. . View in PubMed

The Association of Estrogen Receptor-ß Gene Variation With Salt-Sensitive Blood Pressure J Clin Endocrinol Metab. 2017 11 01; 102(11):4124-4135. . View in PubMed

Pioglitazone is equally effective for diabetes prevention in older versus younger adults with impaired glucose tolerance Age (Dordr). 2016 Dec; 38(5-6):485-493. . View in PubMed

Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans Diabetes Care. 2016 Apr; 39(4):547-54. . View in PubMed

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium Diabetes. 2016 07; 65(7):2072-80. . View in PubMed

Diabetes Incidence and Glucose Tolerance after Termination of Pioglitazone Therapy: Results from ACT NOW J Clin Endocrinol Metab. 2016 05; 101(5):2056-62. . View in PubMed

A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics Metabolism. 2015 Dec; 64(12):1674-81. . View in PubMed

Living near a freeway is associated with lower bone mineral density among Mexican Americans Osteoporos Int. 2015 Jun; 26(6):1713-21. . View in PubMed

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium Diabetes. 2015 May; 64(5):1853-66. . View in PubMed

A novel insulin resistance index to monitor changes in insulin sensitivity and glucose tolerance: the ACT NOW study J Clin Endocrinol Metab. 2015 May; 100(5):1855-62. . View in PubMed

Association of maternal diabetes with autism in offspring JAMA. 2015 Apr 14; 313(14):1425-34. . View in PubMed

Variation in PPARG is associated with longitudinal change in insulin resistance in Mexican Americans at risk for type 2 diabetes J Clin Endocrinol Metab. 2015 Mar; 100(3):1187-95. . View in PubMed

Racial and ethnic disparities in extremes of fetal growth after gestational diabetes mellitus Diabetologia. 2015 Feb; 58(2):272-81. . View in PubMed

High calorie intake is associated with worsening insulin resistance and ß-cell function in Hispanic women after gestational diabetes mellitus Diabetes Care. 2014 Dec; 37(12):3294-300. . View in PubMed

Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans Diabetologia. 2014 Jul; 57(7):1391-9. . View in PubMed

Baseline adiponectin levels do not influence the response to pioglitazone in ACT NOW Diabetes Care. 2014 Jun; 37(6):1706-11. . View in PubMed

Randomized controlled trial to evaluate the effects of combined progressive exercise on metabolic syndrome in breast cancer survivors: rationale, design, and methods BMC Cancer. 2014 Apr 03; 14:238. . View in PubMed

Gestational diabetes mellitus, maternal obesity, and adiposity in offspring J Pediatr. 2014 Apr; 164(4):807-10. . View in PubMed

Insulin sensitivity and insulin clearance are heritable and have strong genetic correlation in Mexican Americans Obesity (Silver Spring). 2014 Apr; 22(4):1157-64. . View in PubMed

HOMA and Matsuda indices of insulin sensitivity: poor correlation with minimal model-based estimates of insulin sensitivity in longitudinal settings Diabetologia. 2014 Feb; 57(2):334-8. . View in PubMed

Longitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus Diabetologia. 2013 Dec; 56(12):2753-60. . View in PubMed

Prediction of diabetes based on baseline metabolic characteristics in individuals at high risk Diabetes Care. 2013 Nov; 36(11):3607-12. . View in PubMed

Prevention of diabetes with pioglitazone in ACT NOW: physiologic correlates Diabetes. 2013 Nov; 62(11):3920-6. . View in PubMed

Effect of pioglitazone on body composition and bone density in subjects with prediabetes in the ACT NOW trial Diabetes Obes Metab. 2013 Oct; 15(10):931-7. . View in PubMed

Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance Diabetologia. 2013 Jun; 56(6):1282-90. . View in PubMed

High-fat diet is associated with obesity-mediated insulin resistance and ß-cell dysfunction in Mexican Americans J Nutr. 2013 Apr; 143(4):479-85. . View in PubMed

Self-reported physical activity is associated with ß-cell function in Mexican American adults Diabetes Care. 2013 Mar; 36(3):638-44. . View in PubMed

Pioglitazone slows progression of atherosclerosis in prediabetes independent of changes in cardiovascular risk factors Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):393-9. . View in PubMed

The diagnosis of gestational diabetes mellitus: new paradigms or status quo? J Matern Fetal Neonatal Med. 2012 Dec; 25(12):2564-9.. View in PubMed

Gestational diabetes mellitus: risks and management during and after pregnancy Nat Rev Endocrinol. 2012 Nov; 8(11):639-49. . View in PubMed

Metabolic syndrome is linked to chromosome 7q21 and associated with genetic variants in CD36 and GNAT3 in Mexican Americans Obesity (Silver Spring). 2012 Oct; 20(10):2083-92. . View in PubMed

Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis Diabetologia. 2012 Aug; 55(8):2183-92. . View in PubMed

Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension Am J Hypertens. 2012 Jul; 25(7):812-7. . View in PubMed

A genome-wide association search for type 2 diabetes genes in African Americans PLoS One. 2012; 7(1):e29202. . View in PubMed

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals PLoS Genet. 2012; 8(3):e1002607. . View in PubMed

Deterioration in cardiometabolic risk markers in obese women during depot medroxyprogesterone acetate use Contraception. 2012 Jan; 85(1):36-41. . View in PubMed

Approach to the patient with gestational diabetes after delivery J Clin Endocrinol Metab. 2011 Dec; 96(12):3592-8. . View in PubMed

Racial and ethnic disparities in diabetes risk after gestational diabetes mellitus Diabetologia. 2011 Dec; 54(12):3016-21. . View in PubMed

Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension J Clin Endocrinol Metab. 2011 Aug; 96(8):E1288-92. . View in PubMed

The vicious cycle of maternal diabetes and obesity: moving from "what" to "how" and "why" J Pediatr. 2011 Jun; 158(6):872-3. . View in PubMed

A better index of body adiposity Obesity (Silver Spring). 2011 May; 19(5):1083-9. . View in PubMed

Pioglitazone for diabetes prevention in impaired glucose tolerance N Engl J Med. 2011 Mar 24; 364(12):1104-15. . View in PubMed

Limitations in surrogate measures of insulin resistance J Clin Endocrinol Metab. 2010 Nov; 95(11):4874-6. . View in PubMed

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Nat Genet. 2010 Nov; 42(11):937-48. . View in PubMed

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution Nat Genet. 2010 Nov; 42(11):949-60. . View in PubMed

Detailed physiological characterization of the development of type 2 diabetes in Hispanic women with prior gestational diabetes mellitus Diabetes. 2010 Oct; 59(10):2625-30. . View in PubMed

Preventing type 2 diabetes with low-dose combinations Lancet. 2010 Jul 10; 376(9735):72-4. . View in PubMed

Stemming the tide of type 2 diabetes: bring on the "big guns" Obesity (Silver Spring). 2010 Jun; 18(6):1065-7. . View in PubMed

Diabetes: preventing type 2 diabetes mellitus: is metformin the answer? Nat Rev Endocrinol. 2010 May; 6(5):253-4.. View in PubMed

Obese adolescents show impaired meal responses of the appetite-regulating hormones ghrelin and PYY Obesity (Silver Spring). 2010 May; 18(5):918-25. . View in PubMed

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans Diabetes. 2010 May; 59(5):1266-75. . View in PubMed

International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy Diabetes Care. 2010 Mar; 33(3):676-82. . View in PubMed

Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study Diabetologia. 2010 Mar; 53(3):435-45. . View in PubMed

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat Genet. 2010 Feb; 42(2):142-8. . View in PubMed

Declining beta-cell compensation for insulin resistance in Hispanic women with recent gestational diabetes mellitus: association with changes in weight, adiponectin, and C-reactive protein Diabetes Care. 2010 Feb; 33(2):396-401. . View in PubMed

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose Diabetes. 2009 Dec; 58(12):2946-53. . View in PubMed

Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102. . View in PubMed

Replication of calpain-10 genetic association with carotid intima-media thickness Atherosclerosis. 2009 Aug; 205(2):503-5. . View in PubMed

Actos Now for the prevention of diabetes (ACT NOW) study BMC Endocr Disord. 2009 Jul 29; 9:17. . View in PubMed

Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans Obesity (Silver Spring). 2009 Apr; 17(4):729-36. . View in PubMed

Variants in MTNR1B influence fasting glucose levels Nat Genet. 2009 Jan; 41(1):77-81. . View in PubMed

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels J Clin Invest. 2008 Jul; 118(7):2620-8. . View in PubMed

Effect of pioglitazone on progression of subclinical atherosclerosis in non-diabetic premenopausal Hispanic women with prior gestational diabetes Atherosclerosis. 2008 Jul; 199(1):207-14. . View in PubMed

Carotid intima-media thickness (cIMT) cosegregates with blood pressure and renal function in hypertensive Hispanic families Atherosclerosis. 2008 May; 198(1):160-5. . View in PubMed

Association of insulin sensitivity and glucose tolerance with the c825C>T variant of the G protein beta-3 subunit gene. J Diabetes Complications. 2008 May-Jun; 22(3):205-9. . View in PubMed

Allgrove syndrome in a Mexican American family is caused by an ancestral mutation derived from North Africa Clin Genet. 2008 Apr; 73(4):385-7. . View in PubMed

Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans Diabetes. 2008 Apr; 57(4):1048-56. . View in PubMed

A longitudinal study of lipids and blood pressure in relation to method of contraception in Latino women with prior gestational diabetes mellitus Diabetes Care. 2007 Aug; 30(8):1952-8. . View in PubMed

Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus Diabetes Care. 2007 Jul; 30 Suppl 2:S251-60. . View in PubMed

Genetics of gestational diabetes mellitus and type 2 diabetes Diabetes Care. 2007 Jul; 30 Suppl 2:S134-40. . View in PubMed

What is gestational diabetes? Diabetes Care. 2007 Jul; 30 Suppl 2:S105-11.. View in PubMed

(How) can we prevent type 2 diabetes? Diabetes. 2007 Jun; 56(6):1502-7.. View in PubMed

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science. 2007 Jun 01; 316(5829):1341-5. . View in PubMed

Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans Diabetes. 2007 May; 56(5):1481-5. . View in PubMed

Effect of antihypertensive therapy on progression of carotid intima-media thickness in patients with type 2 diabetes mellitus Am J Cardiol. 2007 Apr 01; 99(7):956-60. . View in PubMed

Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q Hum Hered. 2007; 63(1):17-25. . View in PubMed

Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes Diabetes. 2007 Jan; 56(1):256-64. . View in PubMed

Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns Diabetes. 2006 Sep; 55(9):2534-40. . View in PubMed

Effect of peroxisome proliferator-activated receptor gamma agonist treatment on subclinical atherosclerosis in patients with insulin-requiring type 2 diabetes Diabetes Care. 2006 Jul; 29(7):1545-53. . View in PubMed

Dancing hot on Ecstasy: physical activity and thermal comfort ratings are associated with the memory and other psychobiological problems reported by recreational MDMA users Hum Psychopharmacol. 2006 Jul; 21(5):285-98. . View in PubMed

Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight loss Fertil Steril. 2006 Jun; 85(6):1794-802. . View in PubMed

Coordinate changes in plasma glucose and pancreatic beta-cell function in Latino women at high risk for type 2 diabetes Diabetes. 2006 Apr; 55(4):1074-9. . View in PubMed

Long-acting injectable progestin contraception and risk of type 2 diabetes in Latino women with prior gestational diabetes mellitus Diabetes Care. 2006 Mar; 29(3):613-7. . View in PubMed

Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes Diabetes. 2006 Feb; 55(2):517-22. . View in PubMed

Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns Hum Genet. 2005 Nov; 118(2):245-54. . View in PubMed

Sequence variation in PPARG may underlie differential response to troglitazone Diabetes. 2005 Nov; 54(11):3319-25. . View in PubMed

Use of medications to prevent type 2 diabetes Curr Diab Rep. 2005 Aug; 5(4):237-9. . View in PubMed

Insulin resistance and preeclampsia in gestational diabetes mellitus Diabetes Care. 2005 Aug; 28(8):1995-2000. . View in PubMed

Effect of thiazolidinedione treatment on progression of subclinical atherosclerosis in premenopausal women at high risk for type 2 diabetes J Clin Endocrinol Metab. 2005 Apr; 90(4):1986-91. . View in PubMed

Gestational diabetes mellitus J Clin Invest. 2005 Mar; 115(3):485-91. . View in PubMed

Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function Naunyn Schmiedebergs Arch Pharmacol. 2005 Mar; 371(3):229-39. . View in PubMed

The association of smoking and subclinical atherosclerosis in Type 2 diabetes: modification by duration of diabetes Diabet Med. 2005 Jan; 22(1):81-7. . View in PubMed

Association between monocyte Fcgamma subclass expression and acute coronary syndrome Immun Ageing. 2004 Nov 12; 1(1):4. . View in PubMed

Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects Diabetologia. 2004 Oct; 47(10):1782-8. . View in PubMed

Pharmacological treatment of insulin resistance at two different stages in the evolution of type 2 diabetes: impact on glucose tolerance and beta-cell function J Clin Endocrinol Metab. 2004 Jun; 89(6):2846-51. . View in PubMed

Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of Diabetes (TRIPOD) study Diabetes Care. 2004 Jun; 27(6):1365-8. . View in PubMed

Frequency of EEG abnormalities in age-matched siblings of autistic children with abnormal sleep EEG patterns Epilepsy Behav. 2004 Apr; 5(2):159-62. . View in PubMed

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity J Biol Chem. 2004 Mar 26; 279(13):12152-62. . View in PubMed

A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14 Diabetes. 2004 Mar; 53(3):821-9. . View in PubMed

Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapy Cardiovasc Toxicol. 2004; 4(2):179-86. . View in PubMed

Time from diagnosis of type 2 diabetes to initiation of insulin therapy is related to carotid artery intima-media thickness Atherosclerosis. 2003 Oct; 170(2):293-9. . View in PubMed

Fasting plasma glucose test at the first prenatal visit as a screen for gestational diabetes Obstet Gynecol. 2003 Jun; 101(6):1197-203. . View in PubMed

C-reactive protein and glycemic control in adults with diabetes Diabetes Care. 2003 May; 26(5):1535-9. . View in PubMed

Decreased red blood cell aggregation subsequent to improved glycaemic control in Type 2 diabetes mellitus Diabet Med. 2003 Apr; 20(4):301-6. . View in PubMed

Prevention of type 2 diabetes: what is it really? Diabetes Care. 2003 Apr; 26(4):1306-8.. View in PubMed

Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus Br J Haematol. 2003 Apr; 121(1):139-42. . View in PubMed

Counterpoint: glucose monitoring in gestational diabetes: lots of heat, not much light Diabetes Care. 2003 Mar; 26(3):948-9. . View in PubMed

Pancreatic beta-cell loss and preservation in type 2 diabetes Clin Ther. 2003; 25 Suppl B:B32-46. . View in PubMed

Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women Diabetes. 2002 Sep; 51(9):2796-803. . View in PubMed

Prospective, intensive study of metabolic changes associated with 48 weeks of amprenavir-based antiretroviral therapy Clin Infect Dis. 2002 Aug 15; 35(4):475-81. . View in PubMed

The ratio of plasminogen activator inhibitor type-1 activity to the concentration of plasminogen activator inhibitor type-1 protein in diabetes: adding insult to injury Coron Artery Dis. 2002 Aug; 13(5):275-81. . View in PubMed

Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent Arterioscler Thromb Vasc Biol. 2002 May 01; 22(5):843-8. . View in PubMed

Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort Diabetes. 2002 May; 51(5):1644-8. . View in PubMed

Clinical predictors for a high risk for the development of diabetes mellitus in the early puerperium in women with recent gestational diabetes mellitus Am J Obstet Gynecol. 2002 Apr; 186(4):751-6. . View in PubMed

High-risk teen compliance with prescription contraception: an analysis of Ohio Medicaid claims J Pediatr Adolesc Gynecol. 2002 Feb; 15(1):15-21. . View in PubMed

The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men J Clin Endocrinol Metab. 2002 Jan; 87(1):136-43. . View in PubMed

A randomized controlled trial using glycemic plus fetal ultrasound parameters versus glycemic parameters to determine insulin therapy in gestational diabetes with fasting hyperglycemia Diabetes Care. 2001 Nov; 24(11):1904-10. . View in PubMed

Autoantibodies and human leucocyte antigen class II in first-degree family members of Mexican-American type 1 diabetic patients J Clin Endocrinol Metab. 2001 Oct; 86(10):4957-62. . View in PubMed

Coincident linkage of fasting plasma insulin and blood pressure to chromosome 7q in hypertensive hispanic families Circulation. 2001 Sep 11; 104(11):1255-60. . View in PubMed

Prospective evaluation of the effect of initiating indinavir-based therapy on insulin sensitivity and B-cell function in HIV-infected patients J Acquir Immune Defic Syndr. 2001 Jun 01; 27(2):130-4. . View in PubMed

The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences Diabetes. 2001 Apr; 50(4):886-90. . View in PubMed

Pancreatic B-cell defects in gestational diabetes: implications for the pathogenesis and prevention of type 2 diabetes J Clin Endocrinol Metab. 2001 Mar; 86(3):989-93. . View in PubMed

Evidence for joint genetic control of insulin sensitivity and systolic blood pressure in hispanic families with a hypertensive proband Circulation. 2001 Jan 02; 103(1):78-83. . View in PubMed

Effects of lipopolysaccharide on interleukin-6 production in perfused human placental cotyledons J Matern Fetal Med. 2000 Nov-Dec; 9(6):351-5. . View in PubMed

Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes Diabetes. 2000 May; 49(5):782-8. . View in PubMed

Patterns of congenital anomalies and relationship to initial maternal fasting glucose levels in pregnancies complicated by type 2 and gestational diabetes Am J Obstet Gynecol. 2000 Feb; 182(2):313-20. . View in PubMed

Gestational diabetes mellitus N Engl J Med. 1999 Dec 02; 341(23):1749-56. . View in PubMed

Is adrenomedullin a causal agent in some cases of type 2 diabetes? Peptides. 1999 Dec; 20(12):1471-8.. View in PubMed

Antepartum predictors of the development of type 2 diabetes in Latino women 11-26 months after pregnancies complicated by gestational diabetes Diabetes. 1999 Dec; 48(12):2430-6. . View in PubMed

Research on the Internet: validation of a World-Wide Web mediated personality scale Behav Res Methods Instrum Comput. 1999 Nov; 31(4):565-71. . View in PubMed

Am J Obstet Gynecol. 1999 Oct; 181(4):904-11. . View in PubMed

Gestational diabetes: risk or myth? J Clin Endocrinol Metab. 1999 Jun; 84(6):1854-7.. View in PubMed

Failure of acute hyperinsulinemia to alter blood pressure is not due to baroreceptor feedback Am J Hypertens. 1999 Apr; 12(4 Pt 1):405-13. . View in PubMed

Multiple metabolic defects during late pregnancy in women at high risk for type 2 diabetes Diabetes. 1999 Apr; 48(4):848-54. . View in PubMed

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2198-203. . View in PubMed

Screening low-risk women for gestational diabetes mellitusLet's not muddy the waters further. Diabetes Care. 1999 Mar; 22(3):535. . View in PubMed

Contraception and the risk of type 2 diabetes mellitus in Latina women with prior gestational diabetes mellitus JAMA. 1998 Aug 12; 280(6):533-8. . View in PubMed

Gestational diabetes: antepartum characteristics that predict postpartum glucose intolerance and type 2 diabetes in Latino women Diabetes. 1998 Aug; 47(8):1302-10. . View in PubMed

Utility of fetal measurements in the management of gestational diabetes mellitus Diabetes Care. 1998 Aug; 21 Suppl 2:B99-106. . View in PubMed

Hormonal choices after gestational diabetesSubsequent pregnancy, contraception, and hormone replacement. Diabetes Care. 1998 Aug; 21 Suppl 2:B50-7. . View in PubMed

Mapping genes for NIDDMDesign of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care. 1998 Jun; 21(6):949-58. . View in PubMed

TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus Control Clin Trials. 1998 Apr; 19(2):217-31. . View in PubMed

Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitusA randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1998 Feb 01; 128(3):176-85. . View in PubMed

Hyperinsulinism, neonatal obesity and placental immaturity in infants born to women with one abnormal glucose tolerance test value J Perinat Med. 1998; 26(1):27-36. . View in PubMed

Congenital malformations in offspring of women with hyperglycemia first detected during pregnancy Am J Obstet Gynecol. 1997 Nov; 177(5):1165-71. . View in PubMed

Insulin sensitivity and insulin secretion in lean and obese normal pregnant women Ann Ist Super Sanita. 1997; 33(3):367-70. . View in PubMed

Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM Diabetes. 1996 Nov; 45(11):1572-9. . View in PubMed

Pre-conception care of diabetes, congenital malformations, and spontaneous abortions Diabetes Care. 1996 May; 19(5):514-41. . View in PubMed

Birth defects in diabetic pregnancies: where do we go from here? Eur J Endocrinol. 1996 Apr; 134(4):395-7.. View in PubMed

Blood glucose monitoring in gestational diabetes mellitus N Engl J Med. 1996 Feb 29; 334(9):598-9. . View in PubMed

Long-term diabetogenic effect of single pregnancy in women with previous gestational diabetes mellitus Lancet. 1996 Jan 27; 347(8996):227-30. . View in PubMed

Congenital malformations in pregnancies complicated by NIDDM Diabetes Care. 1995 Nov; 18(11):1446-51. . View in PubMed

Blood pressure lowering by pioglitazoneEvidence for a direct vascular effect. J Clin Invest. 1995 Jul; 96(1):354-60. . View in PubMed

Predicting future diabetes in Latino women with gestational diabetesUtility of early postpartum glucose tolerance testing. Diabetes. 1995 May; 44(5):586-91. . View in PubMed

Repeatability of insulin sensitivity and glucose effectiveness from the minimal modelImplications for study design. Diabetes. 1994 Nov; 43(11):1365-71. . View in PubMed

Obesity and hypertension Endocrinol Metab Clin North Am. 1994 Jun; 23(2):405-27. . View in PubMed

Chronic insulin administration elevates blood pressure in rats Hypertension. 1994 Jun; 23(6 Pt 2):1012-7. . View in PubMed

Diabetic teratogenesisIn vitro evidence for a multifactorial etiology with little contribution from glucose per se. Diabetes. 1994 May; 43(5):656-60. . View in PubMed

Use of fetal ultrasound to select metabolic therapy for pregnancies complicated by mild gestational diabetes Diabetes Care. 1994 Apr; 17(4):275-83. . View in PubMed

Time courses of changes in hepatic and skeletal muscle insulin action and GLUT4 protein in skeletal muscle after STZ injection Diabetes. 1994 Apr; 43(4):564-71. . View in PubMed

Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test J Soc Gynecol Investig. 1994 Apr-Jun; 1(2):150-4. . View in PubMed

Metabolic interactions of diabetes and pregnancy Annu Rev Med. 1994; 45:245-60. . View in PubMed

Insulin and hypertension: are they related? Przegl Lek. 1994; 51(3):135-48.. View in PubMed

Diabetes and pregnancy Curr Ther Endocrinol Metab. 1994; 5:278-83. . View in PubMed

Insulin and hypertension: are they related? Steroids. 1993 Dec; 58(12):621-34.. View in PubMed

Insulin-requiring diabetes in pregnancy: a randomized trial of active induction of labor and expectant management Am J Obstet Gynecol. 1993 Sep; 169(3):611-5. . View in PubMed

The effect of lactation on glucose and lipid metabolism in women with recent gestational diabetes Obstet Gynecol. 1993 Sep; 82(3):451-5. . View in PubMed

Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism J Clin Invest. 1993 Aug; 92(2):720-6. . View in PubMed

Magnesium deficiency produces insulin resistance and increased thromboxane synthesis Hypertension. 1993 Jun; 21(6 Pt 2):1024-9. . View in PubMed

Fasting does not impair insulin-stimulated glucose uptake but alters intracellular glucose metabolism in conscious rats Diabetes. 1993 May; 42(5):757-63. . View in PubMed

Pre-pregnancy clinics for diabetic women Lancet. 1992 Oct 10; 340(8824):919-20. . View in PubMed

Whole body insulin sensitivity in Osborne-Mendel and S 5B/Pl rats eating a low- or high-fat diet Am J Physiol. 1992 Oct; 263(4 Pt 2):R785-9. . View in PubMed

Enhanced glucose tolerance in spontaneously hypertensive ratsPancreatic beta-cell hyperfunction with normal insulin sensitivity. Diabetes. 1992 Jul; 41(7):872-8. . View in PubMed

Hypertension without peripheral insulin resistance in spontaneously hypertensive rats Am J Physiol. 1992 Jan; 262(1 Pt 1):E14-9. . View in PubMed

Serum lipids within 36 mo of delivery in women with recent gestational diabetes Diabetes. 1991 Dec; 40 Suppl 2:142-6. . View in PubMed

Insulin resistance and hyperinsulinemia: implications for the pathogenesis and treatment of hypertension Semin Nephrol. 1991 Sep; 11(5):512-22. . View in PubMed

Glucose tolerance and insulin action in rats with renovascular hypertension Hypertension. 1991 Sep; 18(3):341-7. . View in PubMed

Glucose metabolism during pregnancy: normal physiology and implications for diabetes mellitus Isr J Med Sci. 1991 Aug-Sep; 27(8-9):432-41. . View in PubMed

Hypothermia is critical for survival during prolonged insulin-induced hypoglycemia in rats Metabolism. 1991 Mar; 40(3):330-4. . View in PubMed

Gestational diabetes mellitus: the prevalence of glucose intolerance and diabetes mellitus in the first two months post partum Am J Obstet Gynecol. 1990 Jul; 163(1 Pt 1):93-8. . View in PubMed

Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes Am J Obstet Gynecol. 1990 Apr; 162(4):1008-14. . View in PubMed

Accelerated starvation in late pregnancy: a comparison between obese women with and without gestational diabetes mellitus Am J Obstet Gynecol. 1990 Apr; 162(4):1015-20. . View in PubMed

Autonomic function in Holmes Adie syndrome Eye (Lond). 1990; 4 ( Pt 4):607-12. . View in PubMed

Impact of computer simulation on diabetes research and practice Diabetes Care. 1989 Nov-Dec; 12(10):748-9. . View in PubMed

Lack of teratogenic effect of brief maternal insulin-induced hypoglycemia in rats during late neurulation Diabetes. 1989 Aug; 38(8):1063-6. . View in PubMed

In vivo kinetics of a covalent growth hormone-binding protein complex Metabolism. 1989 Apr; 38(4):330-3. . View in PubMed

Access of maternal insulin to the rat conceptus prior to allantoic placentation Diabetes Res. 1989 Mar; 10(3):115-20. . View in PubMed

Fuel-mediated teratogenesis: symmetric growth retardation in the rat fetus at term after a circumscribed exposure to D-mannose during organogenesis Am J Obstet Gynecol. 1988 Mar; 158(3 Pt 1):663-9. . View in PubMed

The effect of circulating growth hormone-binding protein on metabolic clearance, distribution, and degradation of human growth hormone J Clin Endocrinol Metab. 1987 Apr; 64(4):657-60. . View in PubMed

Specificity of immunoglobulin E and immunoglobulin G against human (recombinant DNA) insulin in human insulin allergy and resistance J Lab Clin Med. 1987 Feb; 109(2):141-6. . View in PubMed

Embryotoxic effects of brief maternal insulin-hypoglycemia during organogenesis in the rat J Clin Invest. 1986 Sep; 78(3):643-9. . View in PubMed

Red cell genetic abnormalities in Peninsular Arabs: sickle haemoglobin, G6PD deficiency, and alpha and beta thalassaemia J Med Genet. 1986 Jun; 23(3):245-51. . View in PubMed

The medical management of diabetes in pregnancy Clin Perinatol. 1985 Oct; 12(3):625-50. . View in PubMed

Fuel-mediated teratogenesisUse of D-mannose to modify organogenesis in the rat embryo in vivo. J Clin Invest. 1985 Jun; 75(6):1927-34. . View in PubMed

Thalassaemia genes in Peninsular Arabs Br J Haematol. 1985 Jun; 60(2):269-78. . View in PubMed

Fatal fat embolism after spinal fusion for scoliosis JAMA. 1983 Feb 11; 249(6):779-81. . View in PubMed

Thomas A. Buchanan, M.D., is Professor of Medicine, Obstetrics and Gynecology, and Physiology and Biophysics; Vice Dean for Research; Chief of the Division of Endocrinology and Diabetes in the Department of Medicine in Keck School of Medicine at the University of Southern California (USC) in Los Angeles. He is also the founding director of the Southern California Clinical and Translational Science Institute.

Scientifically, Dr. Buchanan conducts research into the etiology, pathogenesis, genetics and prevention of gestational and type 2 diabetes with a focus on diabetes in Hispanic Americans. Buchanan and colleagues have conducted longitudinal studies of high risk individuals to define patterns of change in insulin resistance and insulin secretion that lead to type 2 diabetes. Based on their findings, they then conducted the first successful type 2 diabetes prevention study in the United States. The biological information gained from that study pointed to a specific pancreatic beta cell defect that is heritable, a finding that formed the basis for a large family based study that has helped to identify the genetic basis for the metabolic abnormalities that lead to type 2 diabetes. In aggregate studies performed by Buchanan and his colleagues have contributed to important advances in clinical care for gestational diabetes and the prevention of type 2 diabetes in Hispanic Americans

Administratively, Dr. Buchanan has championed the development of clinical and translational research at USC, first through his role as director of the General Clinical Research Center (1996-2010). In 2010, he led the team that created the Southern California Clinical and Translational Science Institute, which in turn won a prestigious $56.8 million Clinical and Translational Science Award from the National Institutes of Health (NIH) to support and promote scientific discoveries and their application in real-life settings to health and health care. He built and directed one of the nation’s largest General Clinical Research Center (GCRC) programs. Since 2010, he has been director and principal investigator of USC’s new Southern California Clinical and Translational Science Institute (SC CTSI).

During his career, Dr. Buchanan has brought more than $180 million in extramural research funding to USC and the Keck School. He has been ranked as highly 1st at USC and 50th world-wide in annual NIH funding.

Dr. Buchanan received his medical degree from the University of Iowa, Iowa City, where he completed residency training in internal medicine. He completed his fellowship training in endocrinology and metabolism at Northwestern University Medical School, Chicago, Illinois.

A native of Iowa, Dr. Buchanan is an avid cyclist on the challenging Angeles Crest Highway near Los Angeles, a downhill skier and a dedicated family man.
sc ctsi logoPowered by SC CTSI