Keck School Faculty

Thomas A Buchanan, MD
Thomas A Buchanan, MD
Professor of Medicine;Vice Dean for Research;Director of the CTSI,;Co-Director, Diabetes and Obesity Research Institute;Endocrine Division Chief in the Department of Medicine
Medicine
CSC 205 Health Sciences Campus Los Angeles
Thomas A. Buchanan, M.D., is Professor of Medicine, Obstetrics and Gynecology, and Physiology and Biophysics; Vice Dean for Research; Chief of the Division of Endocrinology and Diabetes in the Department of Medicine in Keck School of Medicine at the University of Southern California (USC) in Los Angeles. He is also the founding director of the Southern California Clinical and Translational Science Institute.

Scientifically, Dr. Buchanan conducts research into the etiology, pathogenesis, genetics and prevention of gestational and type 2 diabetes with a focus on diabetes in Hispanic Americans. Buchanan and colleagues have conducted longitudinal studies of high risk individuals to define patterns of change in insulin resistance and insulin secretion that lead to type 2 diabetes. Based on their findings, they then conducted the first successful type 2 diabetes prevention study in the United States. The biological information gained from that study pointed to a specific pancreatic beta cell defect that is heritable, a finding that formed the basis for a large family based study that has helped to identify the genetic basis for the metabolic abnormalities that lead to type 2 diabetes. In aggregate studies performed by Buchanan and his colleagues have contributed to important advances in clinical care for gestational diabetes and the prevention of type 2 diabetes in Hispanic Americans

Administratively, Dr. Buchanan has championed the development of clinical and translational research at USC, first through his role as director of the General Clinical Research Center (1996-2010). In 2010, he led the team that created the Southern California Clinical and Translational Science Institute, which in turn won a prestigious $56.8 million Clinical and Translational Science Award from the National Institutes of Health (NIH) to support and promote scientific discoveries and their application in real-life settings to health and health care. He built and directed one of the nation’s largest General Clinical Research Center (GCRC) programs. Since 2010, he has been director and principal investigator of USC’s new Southern California Clinical and Translational Science Institute (SC CTSI).

During his career, Dr. Buchanan has brought more than $180 million in extramural research funding to USC and the Keck School. He has been ranked as highly 1st at USC and 50th world-wide in annual NIH funding.

Dr. Buchanan received his medical degree from the University of Iowa, Iowa City, where he completed residency training in internal medicine. He completed his fellowship training in endocrinology and metabolism at Northwestern University Medical School, Chicago, Illinois.

A native of Iowa, Dr. Buchanan is an avid cyclist on the challenging Angeles Crest Highway near Los Angeles, a downhill skier and a dedicated family man.

Western Society for Clinical Investigation: Mayo Soley Award, 2014

University of California, Los Angeles: Josiah Brown Award, 2014

Irish Endocrine Society: Lilly Lecture, 2011

Association of American Physicians: Elected Member, 2006

American Diabetes Association: Distinguished Clinical Scientist Award, 2004

J Clin Endocrinol Metab: Endocrine Society-Pharmacia Award for Excellence in Published Clinical Research, 2002

University of Washington: John Ensinck Lecture, 2000

American Diabetes Association: Norbert Freinkel Award, 1999

American Diabetes Association: Chair, Council on Diabetes and Pregnancy, 1995-1997

NIH: Chair, Special Emphasis Panel, Hyperglycemia and Pregnancy Outcomes , 1995-1997

Canadian Diabetes Association: Novo-Nordisk International Lecture, 1995

Australian Diabetes Association: Medisense International Lecture, 1995

American Diabetes Association, Northern Illinois Affliate: Young Investigator Award, 1983

University of Iowa: Alpha Omega Alpha, 1978

Iowa State University: Phi Beta Kappa, 1974

A cautionary response to SMFM statement: pharmacological treatment of gestational diabetesAm J Obstet Gynecol. 2018 10; 219(4):367. e1-367. e7. . View in PubMed

Classification of Type 2 Diabetes Genetic Variants and a Novel Genetic Risk Score Association with Insulin Clearance J Clin Endocrinol Metab. 2019 Nov 12. . View in PubMed

Children Exposed to Maternal Obesity or Gestational Diabetes Mellitus During Early Fetal Development Have Hypothalamic Alterations That Predict Future Weight Gain Diabetes Care. 2019 Aug; 42(8):1473-1480. . View in PubMed

Aerobic and Resistance Exercise Improves Shoulder Function in Women Who Are Overweight or Obese and Have Breast Cancer: Randomized, Controlled Trial Phys Ther. 2019 Jul 16. . View in PubMed

Effect of Aerobic and Resistance Exercise Intervention on Cardiovascular Disease Risk in Women With Early-Stage Breast Cancer: A Randomized Clinical Trial JAMA Oncol. 2019 May 01; 5(5):710-714. . View in PubMed

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans Obesity (Silver Spring). 2019 03; 27(3):434-443. . View in PubMed

A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile Br J Nutr. 2018 12; 120(11):1230-1239. . View in PubMed

Association of weight gain and fifteen adipokines with declining beta-cell function in Mexican Americans PLoS One. 2018; 13(8):e0201568. . View in PubMed

Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial J Clin Oncol. 2018 03 20; 36(9):875-883. . View in PubMed

Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial Breast Cancer Res. 2018 10 19; 20(1):124. . View in PubMed

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants Diabetes. 2017 08; 66(8):2296-2309. . View in PubMed

Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans Diabetes Care. 2016 Apr; 39(4):547-54. . View in PubMed

Diabetes Incidence and Glucose Tolerance after Termination of Pioglitazone Therapy: Results from ACT NOW J Clin Endocrinol Metab. 2016 05; 101(5):2056-62. . View in PubMed

A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics Metabolism. 2015 Dec; 64(12):1674-81. . View in PubMed

A novel insulin resistance index to monitor changes in insulin sensitivity and glucose tolerance: the ACT NOW study J Clin Endocrinol Metab. 2015 May; 100(5):1855-62. . View in PubMed

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium Diabetes. 2015 May; 64(5):1853-66. . View in PubMed

Association of maternal diabetes with autism in offspring JAMA. 2015 Apr 14; 313(14):1425-34. . View in PubMed

Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans Diabetologia. 2014 Jul; 57(7):1391-9. . View in PubMed

Baseline adiponectin levels do not influence the response to pioglitazone in ACT NOW Diabetes Care. 2014 Jun; 37(6):1706-11. . View in PubMed

Gestational diabetes mellitus, maternal obesity, and adiposity in offspring J Pediatr. 2014 Apr; 164(4):807-10. . View in PubMed

Effect of pioglitazone on body composition and bone density in subjects with prediabetes in the ACT NOW trial Diabetes Obes Metab. 2013 Oct; 15(10):931-7. . View in PubMed

Gestational diabetes mellitus: risks and management during and after pregnancy Nat Rev Endocrinol. 2012 Nov; 8(11):639-49. . View in PubMed

Deterioration in cardiometabolic risk markers in obese women during depot medroxyprogesterone acetate use Contraception. 2012 Jan; 85(1):36-41. . View in PubMed

A genome-wide association search for type 2 diabetes genes in African Americans PLoS One. 2012; 7(1):e29202. . View in PubMed

Approach to the patient with gestational diabetes after delivery J Clin Endocrinol Metab. 2011 Dec; 96(12):3592-8. . View in PubMed

A better index of body adiposity Obesity (Silver Spring). 2011 May; 19(5):1083-9. . View in PubMed

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Nat Genet. 2010 Nov; 42(11):937-48. . View in PubMed

Detailed physiological characterization of the development of type 2 diabetes in Hispanic women with prior gestational diabetes mellitus Diabetes. 2010 Oct; 59(10):2625-30. . View in PubMed

Diabetes: preventing type 2 diabetes mellitus: is metformin the answer? Nat Rev Endocrinol. 2010 May; 6(5):253-4.. View in PubMed

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans Diabetes. 2010 May; 59(5):1266-75. . View in PubMed

Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study Diabetologia. 2010 Mar; 53(3):435-45. . View in PubMed

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat Genet. 2010 Feb; 42(2):142-8. . View in PubMed

Declining beta-cell compensation for insulin resistance in Hispanic women with recent gestational diabetes mellitus: association with changes in weight, adiponectin, and C-reactive protein Diabetes Care. 2010 Feb; 33(2):396-401. . View in PubMed

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose Diabetes. 2009 Dec; 58(12):2946-53. . View in PubMed

Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102. . View in PubMed

Actos Now for the prevention of diabetes (ACT NOW) study BMC Endocr Disord. 2009 Jul 29; 9:17. . View in PubMed

Effect of pioglitazone on progression of subclinical atherosclerosis in non-diabetic premenopausal Hispanic women with prior gestational diabetes Atherosclerosis. 2008 Jul; 199(1):207-14. . View in PubMed

Association of insulin sensitivity and glucose tolerance with the c825C>T variant of the G protein beta-3 subunit gene. J Diabetes Complications. 2008 May-Jun; 22(3):205-9. . View in PubMed

Carotid intima-media thickness (cIMT) cosegregates with blood pressure and renal function in hypertensive Hispanic families Atherosclerosis. 2008 May; 198(1):160-5. . View in PubMed

Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans Diabetes. 2008 Apr; 57(4):1048-56. . View in PubMed

Allgrove syndrome in a Mexican American family is caused by an ancestral mutation derived from North Africa Clin Genet. 2008 Apr; 73(4):385-7. . View in PubMed

A longitudinal study of lipids and blood pressure in relation to method of contraception in Latino women with prior gestational diabetes mellitus Diabetes Care. 2007 Aug; 30(8):1952-8. . View in PubMed

Genetics of gestational diabetes mellitus and type 2 diabetes Diabetes Care. 2007 Jul; 30 Suppl 2:S134-40. . View in PubMed

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science. 2007 Jun 01; 316(5829):1341-5. . View in PubMed

(How) can we prevent type 2 diabetes? Diabetes. 2007 Jun; 56(6):1502-7.. View in PubMed

Effect of antihypertensive therapy on progression of carotid intima-media thickness in patients with type 2 diabetes mellitus Am J Cardiol. 2007 Apr 01; 99(7):956-60. . View in PubMed

Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns Diabetes. 2006 Sep; 55(9):2534-40. . View in PubMed

Dancing hot on Ecstasy: physical activity and thermal comfort ratings are associated with the memory and other psychobiological problems reported by recreational MDMA users Hum Psychopharmacol. 2006 Jul; 21(5):285-98. . View in PubMed

Effect of peroxisome proliferator-activated receptor gamma agonist treatment on subclinical atherosclerosis in patients with insulin-requiring type 2 diabetes Diabetes Care. 2006 Jul; 29(7):1545-53. . View in PubMed

Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight loss Fertil Steril. 2006 Jun; 85(6):1794-802. . View in PubMed

Coordinate changes in plasma glucose and pancreatic beta-cell function in Latino women at high risk for type 2 diabetes Diabetes. 2006 Apr; 55(4):1074-9. . View in PubMed

Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes Diabetes. 2006 Feb; 55(2):517-22. . View in PubMed

Effect of thiazolidinedione treatment on progression of subclinical atherosclerosis in premenopausal women at high risk for type 2 diabetes J Clin Endocrinol Metab. 2005 Apr; 90(4):1986-91. . View in PubMed

Gestational diabetes mellitus J Clin Invest. 2005 Mar; 115(3):485-91. . View in PubMed

Association between monocyte Fcgamma subclass expression and acute coronary syndrome Immun Ageing. 2004 Nov 12; 1(1):4. . View in PubMed

Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of Diabetes (TRIPOD) study Diabetes Care. 2004 Jun; 27(6):1365-8. . View in PubMed

Frequency of EEG abnormalities in age-matched siblings of autistic children with abnormal sleep EEG patterns Epilepsy Behav. 2004 Apr; 5(2):159-62. . View in PubMed

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity J Biol Chem. 2004 Mar 26; 279(13):12152-62. . View in PubMed

A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14 Diabetes. 2004 Mar; 53(3):821-9. . View in PubMed

Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapy Cardiovasc Toxicol. 2004; 4(2):179-86. . View in PubMed

Fasting plasma glucose test at the first prenatal visit as a screen for gestational diabetes Obstet Gynecol. 2003 Jun; 101(6):1197-203. . View in PubMed

C-reactive protein and glycemic control in adults with diabetes Diabetes Care. 2003 May; 26(5):1535-9. . View in PubMed

Decreased red blood cell aggregation subsequent to improved glycaemic control in Type 2 diabetes mellitus Diabet Med. 2003 Apr; 20(4):301-6. . View in PubMed

Counterpoint: glucose monitoring in gestational diabetes: lots of heat, not much light Diabetes Care. 2003 Mar; 26(3):948-9. . View in PubMed

Clinical predictors for a high risk for the development of diabetes mellitus in the early puerperium in women with recent gestational diabetes mellitus Am J Obstet Gynecol. 2002 Apr; 186(4):751-6. . View in PubMed

A randomized controlled trial using glycemic plus fetal ultrasound parameters versus glycemic parameters to determine insulin therapy in gestational diabetes with fasting hyperglycemia Diabetes Care. 2001 Nov; 24(11):1904-10. . View in PubMed

Autoantibodies and human leucocyte antigen class II in first-degree family members of Mexican-American type 1 diabetic patients J Clin Endocrinol Metab. 2001 Oct; 86(10):4957-62. . View in PubMed

Coincident linkage of fasting plasma insulin and blood pressure to chromosome 7q in hypertensive hispanic families Circulation. 2001 Sep 11; 104(11):1255-60. . View in PubMed

Evidence for joint genetic control of insulin sensitivity and systolic blood pressure in hispanic families with a hypertensive proband Circulation. 2001 Jan 02; 103(1):78-83. . View in PubMed

Effects of lipopolysaccharide on interleukin-6 production in perfused human placental cotyledons J Matern Fetal Med. 2000 Nov-Dec; 9(6):351-5. . View in PubMed

Gestational diabetes mellitus N Engl J Med. 1999 Dec 02; 341(23):1749-56. . View in PubMed

Antepartum predictors of the development of type 2 diabetes in Latino women 11-26 months after pregnancies complicated by gestational diabetes Diabetes. 1999 Dec; 48(12):2430-6. . View in PubMed

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999 Diabetologia. 1999 Aug; 42(Suppl 1):A1-A330. . View in PubMed

Gestational diabetes: risk or myth? J Clin Endocrinol Metab. 1999 Jun; 84(6):1854-7.. View in PubMed

Failure of acute hyperinsulinemia to alter blood pressure is not due to baroreceptor feedback Am J Hypertens. 1999 Apr; 12(4 Pt 1):405-13. . View in PubMed

Contraception and the risk of type 2 diabetes mellitus in Latina women with prior gestational diabetes mellitus JAMA. 1998 Aug 12; 280(6):533-8. . View in PubMed

Gestational diabetes: antepartum characteristics that predict postpartum glucose intolerance and type 2 diabetes in Latino women Diabetes. 1998 Aug; 47(8):1302-10. . View in PubMed

Congenital malformations in offspring of women with hyperglycemia first detected during pregnancy Am J Obstet Gynecol. 1997 Nov; 177(5):1165-71. . View in PubMed

Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM Diabetes. 1996 Nov; 45(11):1572-9. . View in PubMed

Birth defects in diabetic pregnancies: where do we go from here? Eur J Endocrinol. 1996 Apr; 134(4):395-7.. View in PubMed

Blood glucose monitoring in gestational diabetes mellitus N Engl J Med. 1996 Feb 29; 334(9):598-9. . View in PubMed

Congenital malformations in pregnancies complicated by NIDDM Diabetes Care. 1995 Nov; 18(11):1446-51. . View in PubMed

Blood pressure lowering by pioglitazoneEvidence for a direct vascular effect. J Clin Invest. 1995 Jul; 96(1):354-60. . View in PubMed

Chronic insulin administration elevates blood pressure in rats Hypertension. 1994 Jun; 23(6 Pt 2):1012-7. . View in PubMed

Diabetic teratogenesisIn vitro evidence for a multifactorial etiology with little contribution from glucose per se. Diabetes. 1994 May; 43(5):656-60. . View in PubMed

Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test J Soc Gynecol Investig. 1994 Apr-Jun; 1(2):150-4. . View in PubMed

Diabetes and pregnancy Curr Ther Endocrinol Metab. 1994; 5:278-83. . View in PubMed

Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism J Clin Invest. 1993 Aug; 92(2):720-6. . View in PubMed

Fasting does not impair insulin-stimulated glucose uptake but alters intracellular glucose metabolism in conscious rats Diabetes. 1993 May; 42(5):757-63. . View in PubMed

Enhanced glucose tolerance in spontaneously hypertensive ratsPancreatic beta-cell hyperfunction with normal insulin sensitivity. Diabetes. 1992 Jul; 41(7):872-8. . View in PubMed

Glucose metabolism during pregnancy: normal physiology and implications for diabetes mellitus Isr J Med Sci. 1991 Aug-Sep; 27(8-9):432-41. . View in PubMed

Gestational diabetes mellitus: the prevalence of glucose intolerance and diabetes mellitus in the first two months post partum Am J Obstet Gynecol. 1990 Jul; 163(1 Pt 1):93-8. . View in PubMed

Accelerated starvation in late pregnancy: a comparison between obese women with and without gestational diabetes mellitus Am J Obstet Gynecol. 1990 Apr; 162(4):1015-20. . View in PubMed

Autonomic function in Holmes Adie syndrome Eye (Lond). 1990; 4 ( Pt 4):607-12. . View in PubMed

Access of maternal insulin to the rat conceptus prior to allantoic placentation Diabetes Res. 1989 Mar; 10(3):115-20. . View in PubMed

Fuel-mediated teratogenesis: symmetric growth retardation in the rat fetus at term after a circumscribed exposure to D-mannose during organogenesis Am J Obstet Gynecol. 1988 Mar; 158(3 Pt 1):663-9. . View in PubMed

Embryotoxic effects of brief maternal insulin-hypoglycemia during organogenesis in the rat J Clin Invest. 1986 Sep; 78(3):643-9. . View in PubMed

Fuel-mediated teratogenesisUse of D-mannose to modify organogenesis in the rat embryo in vivo. J Clin Invest. 1985 Jun; 75(6):1927-34. . View in PubMed

Fatal fat embolism after spinal fusion for scoliosis JAMA. 1983 Feb 11; 249(6):779-81. . View in PubMed

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