Keck School Faculty

Thomas D Coates
Thomas D Coates
Professor of Pediatrics;Section Head of Hematology;Director of Sickle/Hemoglobinopathy Program
CHL Mail Stop 54 Off Campus Los Angeles
I primarily work in two areas of basic and translational research: 1) the role of inflammation in the genesis of vascular disease in sickle cell disease; 2) the detection and management of transfusion related iron overload. Our research employs various engineering-intensive methodologies (MRI, laser Doppler flow, digital image analysis, signal processing) to explore the basic mechanisms of sickle cell disease and to measure the effect of various treatment modalities. We use direct measures of microvascular blood flow to monitor the process of vasoocclusion and relate it to simultaneous measures of autonomic nervous system function. These methodologies translate in measurements that can be used to follow patients clinically. In collaboration with members of the Cardiology, Pulmonology, and Radiology Departments at Children’s Hospital Los Angeles, the Departments of Biomedical Engineering and Physiology/Biophysics at the Keck School of Medicine, we devised methods to measure the sickling process in human sickle cell subjects and relate these measurements to clinical factors that modulate disease severity.

Transient Hypoxia Model Revealed Cerebrovascular Impairment in Anemia Using BOLD MRI and Near-Infrared Spectroscopy J Magn Reson Imaging. 2020 Jul 09. . View in PubMed

Progressive Vasoconstriction with Sequential Thermal Stimulation Indicates Vascular Dysautonomia in Sickle Cell Disease Blood. 2020 Jun 09. . View in PubMed

Autonomically-mediated decrease in microvascular blood flow due to mental stress and pain in sickle cell disease: A target for neuromodulatory interventions Complement Ther Med. 2020 Mar; 49:102334. . View in PubMed

Aura and mental stress are associated with reports of pain in sickle cell disease-a pilot study using a mobile application Am J Hematol. 2020 Jan 19. . View in PubMed

PrEP implementation in pregnant and post-partum women Lancet HIV. 2020 01; 7(1):e5-e6. . View in PubMed

Mental stress causes vasoconstriction in subjects with sickle cell disease and in normal controls Haematologica. 2020 01; 105(1):83-90. . View in PubMed

A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent ß-Thalassemia N Engl J Med. 2020 03 26; 382(13):1219-1231. . View in PubMed

Vaso-Occlusion in Sickle Cell Disease: Is Autonomic Dysregulation of the Microvasculature the Trigger? J Clin Med. 2019 Oct 15; 8(10).. View in PubMed

Anemia predicts lower white matter volume and cognitive performance in sickle and non-sickle cell anemia syndrome Am J Hematol. 2019 10; 94(10):1055-1065. . View in PubMed

Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents Free Radic Biol Med. 2019 09; 141:408-415. . View in PubMed

Sickle cell microvascular paradox-oxygen supply-demand mismatch Am J Hematol. 2019 06; 94(6):678-688. . View in PubMed

White matter has impaired resting oxygen delivery in sickle cell patients Am J Hematol. 2019 04; 94(4):467-474. . View in PubMed

Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt Front Physiol. 2019; 10:381. . View in PubMed

Iron overload in transfusion-dependent patients Hematology Am Soc Hematol Educ Program. 2019 12 06; 2019(1):337-344. . View in PubMed

Effectiveness of Clinical Decision Support Based Intervention in the Improvement of Care for Adult Sickle Cell Disease Patients in Primary Care J Am Board Fam Med. 2018 Sep-Oct; 31(5):812-816. . View in PubMed

You don't always get what you want: Does hypoxia cause sickle cell crisis? Am J Hematol. 2018 08; 93(4):475-477.. View in PubMed

Pseudo continuous arterial spin labeling quantification in anemic subjects with hyperemic cerebral blood flow Magn Reson Imaging. 2018 04; 47:137-146. . View in PubMed

Ultra-short echo time images quantify high liver iron Magn Reson Med. 2018 03; 79(3):1579-1585. . View in PubMed

Autonomic nervous system involvement in sickle cell disease Clin Hemorheol Microcirc. 2018; 68(2-3):251-262. . View in PubMed

A novel cross-correlation methodology for assessing biophysical responses associated with pain J Pain Res. 2018; 11:2207-2219. . View in PubMed

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain Am J Hematol. 2017 Nov; 92(11):1137-1145. . View in PubMed

Graph Lasso-Based Test for Evaluating Functional Brain Connectivity in Sickle Cell Disease Brain Connect. 2017 09; 7(7):443-453. . View in PubMed

Magn Reson Med. 2017 06; 77(6):2364-2371. . View in PubMed

Emergency department utilization by Californians with sickle cell disease, 2005-2014 Pediatr Blood Cancer. 2017 06; 64(6). . View in PubMed

How we manage iron overload in sickle cell patients Br J Haematol. 2017 06; 177(5):703-716. . View in PubMed

Contrasting resting-state fMRI abnormalities from sickle and non-sickle anemia PLoS One. 2017; 12(10):e0184860. . View in PubMed

The effect of hypnosis on pain and peripheral blood flow in sickle-cell disease: a pilot study J Pain Res. 2017; 10:1635-1644. . View in PubMed

Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease PLoS One. 2017; 12(5):e0178353. . View in PubMed

Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients Neuroimage Clin. 2017; 15:239-246. . View in PubMed

From Mosquitos to Humans: Genetic Evolution of Zika Virus Cell Host Microbe. 2016 May 11; 19(5):561-5. . View in PubMed

Management of iron overload in hemoglobinopathies: what is the appropriate target iron level? Ann N Y Acad Sci. 2016 03; 1368(1):95-106.. View in PubMed

Unchanneling cardiac iron in humans Blood. 2016 09 22; 128(12):1538-40. . View in PubMed

Iron and oxidative stress in cardiomyopathy in thalassemia Free Radic Biol Med. 2015 Nov; 88(Pt A):3-9. . View in PubMed

Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia Pediatrics. 2015 Sep; 136(3):e697-700. . View in PubMed

Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease Blood. 2015 Aug 06; 126(6):703-10. . View in PubMed

Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis Physiol Rep. 2015 Jul 14; 3(7). . View in PubMed

Iron toxicity and its possible association with treatment of Cancer: lessons from hemoglobinopathies and rare, transfusion-dependent anemias Free Radic Biol Med. 2015 Feb; 79:343-51. . View in PubMed

A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing J Pediatr Hematol Oncol. 2015 Jan; 37(1):54-9. . View in PubMed

Population based surveillance in sickle cell disease: methods, findings and implications from the California registry and surveillance system in hemoglobinopathies project (RuSH) Pediatr Blood Cancer. 2014 Dec; 61(12):2271-6. . View in PubMed

The impact of chelation therapy on survival in transfusional iron overload: a meta-analysis of myelodysplastic syndrome Br J Haematol. 2014 Dec; 167(5):720-3. . View in PubMed

Project HOPE: online social network changes in an HIV prevention randomized controlled trial for African American and Latino men who have sex with men Am J Public Health. 2014 Sep; 104(9):1707-12. . View in PubMed

Cardiac iron overload in sickle-cell disease Am J Hematol. 2014 Jul; 89(7):678-83. . View in PubMed

Physiology and pathophysiology of iron in hemoglobin-associated diseases Free Radic Biol Med. 2014 Jul; 72:23-40. . View in PubMed

Ferritin trends do not predict changes in total body iron in patients with transfusional iron overload Am J Hematol. 2014 Apr; 89(4):391-4. . View in PubMed

Transfusion complications in thalassemia patients: a report from the Centers for Disease Control and Prevention (CME) Transfusion. 2014 Apr; 54(4):972-81; quiz 971. . View in PubMed

Bad liver and a broken heart Blood. 2014 Mar 06; 123(10):1434-6. . View in PubMed

Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age Am J Hematol. 2013 Nov; 88(11):E283-5. . View in PubMed

Moderno love: sexual role-based identities and HIV/STI prevention among men who have sex with men in Lima, Peru AIDS Behav. 2013 May; 17(4):1313-28. . View in PubMed

Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion Transfusion. 2013 May; 53(5):1059-68. . View in PubMed

Pain in thalassaemia: the effects of age on pain frequency and severity Br J Haematol. 2013 Mar; 160(5):680-7. . View in PubMed

Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron Am J Hematol. 2013 Mar; 88(3):213-8. . View in PubMed

Exercise performance in thalassemia major: correlation with cardiac iron burden Am J Hematol. 2013 Mar; 88(3):193-7. . View in PubMed

Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy Transfusion. 2013 Feb; 53(2):297-305. . View in PubMed

Electrocardiographic consequences of cardiac iron overload in thalassemia major Am J Hematol. 2012 Feb; 87(2):139-44. . View in PubMed

Pancreatic iron and glucose dysregulation in thalassemia major Am J Hematol. 2012 Feb; 87(2):155-60. . View in PubMed

Pituitary iron and volume predict hypogonadism in transfusional iron overload Am J Hematol. 2012 Feb; 87(2):167-71. . View in PubMed

Sickle cell disease in California: sociodemographic predictors of emergency department utilization Pediatr Blood Cancer. 2012 Jan; 58(1):66-73. . View in PubMed

Is it time to SWiTCH to composite primary endpoints? Pediatr Blood Cancer. 2011 Dec 01; 57(6):906-7.. View in PubMed

Pulmonary function in thalassaemia major and its correlation with body iron stores Br J Haematol. 2011 Oct; 155(1):102-5. . View in PubMed

Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. . View in PubMed

Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial Haematologica. 2011 Jul; 96(7):1055-8. . View in PubMed

Effect of a community popular opinion leader HIV/STI intervention on stigma in urban, coastal Peru AIDS Behav. 2011 Jul; 15(5):930-7. . View in PubMed

Quantitative computed tomography assessment of transfusional iron overload Br J Haematol. 2011 Jun; 153(6):780-5. . View in PubMed

Sickle-cell disease in California: a population-based description of emergency department utilization Pediatr Blood Cancer. 2011 Mar; 56(3):413-9. . View in PubMed

Hemophagocytic lymphohistiocytosis in children with chronic granulomatous disease Pediatr Blood Cancer. 2011 Mar; 56(3):460-2. . View in PubMed

So what if blood is thicker than water? Blood. 2011 Jan 20; 117(3):745-6.. View in PubMed

Pancreatic iron loading in chronically transfused sickle cell disease is lower than in thalassaemia major Br J Haematol. 2011 Jan; 152(2):229-33. . View in PubMed

Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial Am J Hematol. 2010 Oct; 85(10):818-9. . View in PubMed

Predicting pituitary iron and endocrine dysfunction Ann N Y Acad Sci. 2010 Aug; 1202:123-8. . View in PubMed

The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores Blood. 2010 Jul 29; 116(4):537-43. . View in PubMed

Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:1626-9. . View in PubMed

Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury Blood. 2009 Nov 19; 114(21):4632-8. . View in PubMed

Pancreatic iron loading predicts cardiac iron loading in thalassemia major Blood. 2009 Nov 05; 114(19):4021-6. . View in PubMed

Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease Am J Hematol. 2009 Aug; 84(8):480-3. . View in PubMed

Nutritional deficiencies in iron overloaded patients with hemoglobinopathies Am J Hematol. 2009 Jun; 84(6):344-8. . View in PubMed

Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major J Magn Reson Imaging. 2009 Feb; 29(2):357-64. . View in PubMed

Longitudinal analysis of heart and liver iron in thalassemia major Blood. 2008 Oct 01; 112(7):2973-8. . View in PubMed

Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis J Magn Reson Imaging. 2008 Sep; 28(3):698-704. . View in PubMed

Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia Bone. 2008 Jul; 43(1):162-168. . View in PubMed

Onset of cardiac iron loading in pediatric patients with thalassemia major Haematologica. 2008 Jun; 93(6):917-20. . View in PubMed

Outcomes, utilization, and costs among thalassemia and sickle cell disease patients receiving deferoxamine therapy in the United States Am J Hematol. 2008 Apr; 83(4):263-70. . View in PubMed

Abnormal cardiac autonomic control in sickle cell disease following transient hypoxia Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:1996-9. . View in PubMed

Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review Transfusion. 2007 Oct; 47(10):1919-29. . View in PubMed

A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease Br J Haematol. 2007 Feb; 136(3):501-8. . View in PubMed

Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective Pharmacoeconomics. 2007; 25(4):329-42. . View in PubMed

Factors associated with self-efficacy for condom use and sexual negotiation among South african youth J Acquir Immune Defic Syndr. 2006 Oct 01; 43(2):226-33. . View in PubMed

MRI detects myocardial iron in the human heart Magn Reson Med. 2006 Sep; 56(3):681-6. . View in PubMed

Improved R2* measurements in myocardial iron overload J Magn Reson Imaging. 2006 Jan; 23(1):9-16. . View in PubMed

Cobalamin C disease presenting with hemophagocytic lymphohistiocytosis Pediatr Hematol Oncol. 2005 Dec; 22(8):717-21. . View in PubMed

Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens Magn Reson Med. 2005 Nov; 54(5):1185-93. . View in PubMed

Fetal haemoglobin augmentation in E/beta(0) thalassaemia: clinical and haematological outcome Br J Haematol. 2005 Nov; 131(3):378-88. . View in PubMed

MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients Blood. 2005 Aug 15; 106(4):1460-5. . View in PubMed

Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy Circulation. 2005 Jul 26; 112(4):535-43. . View in PubMed

Physiology and pathophysiology of iron cardiomyopathy in thalassemia Ann N Y Acad Sci. 2005; 1054:386-95. . View in PubMed

Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease Blood. 2004 Mar 01; 103(5):1934-6. . View in PubMed

Placenta growth factor activates monocytes and correlates with sickle cell disease severity Blood. 2003 Aug 15; 102(4):1506-14. . View in PubMed

A case of neutropenia with transient absence of neutrophil chemotaxis Ann Allergy Asthma Immunol. 2002 May; 88(5):445-50. . View in PubMed

Predictors of cerebral blood flow in patients with and without anemia J Appl Physiol (1985). 2016 Apr 15; 120(8):976-81. . View in PubMed

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