Keck School Faculty

Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia J Clin Oncol. 2023 06 01; 41(16):2949-2962. . View in PubMed

Validation of Myc-Associated Protein X (MAX) regulation in growth hormone secreting and nonfunctional pituitary adenoma PLoS One. 2023; 18(4):e0284949. . View in PubMed

Non-Invasive Profiling of Advanced Prostate Cancer via Multi-Parametric Liquid Biopsy and Radiomic Analysis Int J Mol Sci. 2022 Feb 25; 23(5). . View in PubMed

Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia Nat Commun. 2022 09 19; 13(1):5487. . View in PubMed

Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications Emerg Microbes Infect. 2021 Dec; 10(1):885-893. . View in PubMed

Rapidly emerging SARS-CoV-2 B1. 1. 7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutations. Emerg Microbes Infect. 2021 Dec; 10(1):1293-1299. . View in PubMed

Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling Epigenetics Chromatin. 2021 01 13; 14(1):7. . View in PubMed

A B-cell developmental gene regulatory network is activated in infant AML PLoS One. 2021; 16(11):e0259197. . View in PubMed

Baseline Circulating Tumor Cell Count as a Prognostic Marker of PSA Response and Disease Progression in Metastatic Castrate-Sensitive Prostate Cancer (SWOG S1216) Clin Cancer Res. 2021 04 01; 27(7):1967-1973. . View in PubMed

Mithramycin induces promoter reprogramming and differentiation of rhabdoid tumor EMBO Mol Med. 2021 02 05; 13(2):e12640. . View in PubMed

Mathematical Oncology Comes to the Clinic: A Data-Driven Treatment for Financial Toxicity? Cancer Res. 2020 06 01; 80(11):2083-2084.. View in PubMed

Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study Clin Cancer Res. 2020 02 01; 26(3):726-737. . View in PubMed

Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions Nat Med. 2019 Mar; 25(3):530. . View in PubMed

DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin Leuk Lymphoma. 2019 06; 60(6):1429-1437. . View in PubMed

Landscape of Germline and Somatic Mitochondrial DNA Mutations in Pediatric Malignancies Cancer Res. 2019 04 01; 79(7):1318-1330. . View in PubMed

Integrated Epigenome, Exome, and Transcriptome Analyses Reveal Molecular Subtypes and Homeotic Transformation in Uterine FibroidsCell Rep. 2019 12 17; 29(12):4069-4085. e6. . View in PubMed

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions Nat Med. 2018 Apr 10; 24(4):526. . View in PubMed

Author Correction: Suppression of Transposable Elements in Leukemic Stem Cells Sci Rep. 2018 Mar 06; 8(1):4240. . View in PubMed

OncoKids: A Comprehensive Next-Generation Sequencing Panel for Pediatric Malignancies J Mol Diagn. 2018 11; 20(6):765-776. . View in PubMed

Senescent human hematopoietic progenitors show elevated expression of transposable elements and inflammatory genesExp Hematol. 2018 06; 62:33-38. e6. . View in PubMed

The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions Nat Med. 2018 01; 24(1):103-112. . View in PubMed

SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions Nucleic Acids Res. 2018 11 16; 46(20):e123. . View in PubMed

A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium Blood. 2018 03 08; 131(10):1145-1148. . View in PubMed

Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans Carcinogenesis. 2018 12 13; 39(11):1331-1341. . View in PubMed

Transposable Element Expression in Acute Myeloid Leukemia Transcriptome and Prognosis Sci Rep. 2018 11 06; 8(1):16449. . View in PubMed

Methylome of human senescent hematopoietic progenitors Exp Hematol Oncol. 2018; 7:32. . View in PubMed

EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT Blood Adv. 2017 Sep 12; 1(20):1635-1644. . View in PubMed

Response: Making "perfect" the enemy of good Blood. 2017 08 31; 130(9):1168-1169. . View in PubMed

Suppression of Transposable Elements in Leukemic Stem Cells Sci Rep. 2017 08 01; 7(1):7029. . View in PubMed

Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi Bioinformatics. 2017 02 15; 33(4):558-560. . View in PubMed

A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML Clin Epigenetics. 2017; 9:108. . View in PubMed

GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML Blood. 2017 06 29; 129(26):3465-3475. . View in PubMed

A Rapid and Sensitive Next-Generation Sequencing Method to Detect RB1 Mutations Improves Care for Retinoblastoma Patients and Their Families J Mol Diagn. 2016 07; 18(4):480-93. . View in PubMed

Insulin-like Growth Factor 2 Gene Expression Molecularly Differentiates Pleuropulmonary Blastoma and Embryonal Rhabdomyosarcoma J Pediatr Hematol Oncol. 2015 Aug; 37(6):e356-60. . View in PubMed

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas N Engl J Med. 2015 Jun 25; 372(26):2481-98. . View in PubMed

Discovery and validation of novel expression signature for postcystectomy recurrence in high-risk bladder cancer J Natl Cancer Inst. 2014 Nov; 106(11). . View in PubMed

Reprogramming of the human intestinal epigenome by surgical tissue transposition Genome Res. 2014 Apr; 24(4):545-53. . View in PubMed

T lymphocyte abnormalities in juvenile systemic sclerosis patients Clin Immunol. 2013 Oct; 149(1):146-55. . View in PubMed

A novel algorithm for simplification of complex gene classifiers in cancer Cancer Res. 2013 Sep 15; 73(18):5625-32. . View in PubMed

Low-level processing of Illumina Infinium DNA Methylation BeadArrays Nucleic Acids Res. 2013 Apr; 41(7):e90. . View in PubMed

FOXM1 is an oncogenic mediator in Ewing Sarcoma PLoS One. 2013; 8(1):e54556. . View in PubMed

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia N Engl J Med. 2013 05 30; 368(22):2059-74. . View in PubMed

Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines PLoS One. 2013; 8(12):e80060. . View in PubMed

An epigenomic mechanism in retinoblastoma: the end of the story? Genome Med. 2012 Feb 24; 4(2):15.. View in PubMed

Influence of RNA labeling on expression profiling of microRNAs J Mol Diagn. 2012 Jan; 14(1):12-21. . View in PubMed

Quantitative expression profiling in formalin-fixed paraffin-embedded samples by affymetrix microarrays J Mol Diagn. 2010 Jul; 12(4):409-17. . View in PubMed

Prediction of human functional genetic networks from heterogeneous data using RVM-based ensemble learning Bioinformatics. 2010 Mar 15; 26(6):807-13. . View in PubMed

Gene expression profiling for survival prediction in pediatric rhabdomyosarcomas: a report from the children's oncology group J Clin Oncol. 2010 Mar 01; 28(7):1240-6. . View in PubMed

Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation FASEB J. 2010 Mar; 24(3):833-43. . View in PubMed

Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group Am J Pathol. 2009 Feb; 174(2):550-64. . View in PubMed

Sparse representation and Bayesian detection of genome copy number alterations from microarray data Bioinformatics. 2008 Feb 01; 24(3):309-18. . View in PubMed

Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation Genet Epidemiol. 2007 Dec; 31(8):871-82. . View in PubMed

Experimental comparison and evaluation of the Affymetrix exon and U133Plus2 GeneChip arrays PLoS One. 2007 Sep 19; 2(9):e913. . View in PubMed

Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide J Natl Cancer Inst. 2007 Jul 18; 99(14):1107-19. . View in PubMed

E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase Cancer Res. 2007 Apr 01; 67(7):3094-105. . View in PubMed

Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease Ophthalmology. 2007 Jan; 114(1):99-103. . View in PubMed

Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas Cancer Res. 2006 Jul 15; 66(14):6936-46. . View in PubMed

EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors Cancer Res. 2005 Jun 01; 65(11):4633-44. . View in PubMed

Retinoid-modulated MAT1 ubiquitination and CAK activity FASEB J. 2004 Nov; 18(14):1734-6. . View in PubMed

Selective usage of D-Type cyclins by Ewing's tumors and rhabdomyosarcomas Cancer Res. 2004 Sep 01; 64(17):6026-34. . View in PubMed

MAT1-modulated cyclin-dependent kinase-activating kinase activity cross-regulates neuroblastoma cell G1 arrest and neurite outgrowth Cancer Res. 2004 May 01; 64(9):2977-83. . View in PubMed

Presence of well-differentiated rhabdomyoblasts at the end of therapy for pelvic rhabdomyosarcoma: implications for the outcome J Pediatr Hematol Oncol. 2000 Mar-Apr; 22(2):106-11. . View in PubMed