Keck School Faculty

Timothy J Triche, MD, PhD
Timothy J Triche, MD, PhD
Professor of Pathology
Pediatrics
CHL Mail Stop 43 Off Campus Los Angeles
My research focuses on genetic aspects of cancer biology and their biologic consequences. Current research emphasizes whole genome approaches to gene expression profiling and genomic polymorphisms using DNA microarrays and software developed by our group to analyze this data. Laboratory studies typically utilize tumor cell lines expressing transfected genes, or with silenced genes. Gene targets and biologically active small molecules are often analyzed in biologic context by these same methods. Clinical correlative studies utilize tumor tissue with linked clinical data. Recently, these methods have been applied to studies of age related macular degeneration, as part of the Beckman Macular Research Center at the Doheny Eye Institute, Keck School of Medicine.

DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin Leuk Lymphoma. 2019 Jan 22; 1-9. . View in PubMed

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions Nat Med. 2018 Apr 10; 24(4):526. . View in PubMed

A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium Blood. 2018 Mar 08; 131(10):1145-1148. . View in PubMed

Author Correction: Suppression of Transposable Elements in Leukemic Stem Cells Sci Rep. 2018 Mar 06; 8(1):4240. . View in PubMed

A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium Blood. 2018 03 08; 131(10):1145-1148. . View in PubMed

EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT Blood Adv. 2017 Sep 12; 1(20):1635-1644. . View in PubMed

A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML Clin Epigenetics. 2017; 9:108. . View in PubMed

GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML Blood. 2017 06 29; 129(26):3465-3475. . View in PubMed

Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors Oncogene. 2016 Apr 07; 35(14):1797-810. . View in PubMed

A Rapid and Sensitive Next-Generation Sequencing Method to Detect RB1 Mutations Improves Care for Retinoblastoma Patients and Their Families J Mol Diagn. 2016 07; 18(4):480-93. . View in PubMed

Clinical Application of Prognostic Gene Expression Signature in Fusion Gene-Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group Clin Cancer Res. 2015 Oct 15; 21(20):4733-9. . View in PubMed

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas N Engl J Med. 2015 Jun 25; 372(26):2481-98. . View in PubMed

Gene Expression Profiling of Ewing Sarcoma Tumors Reveals the Prognostic Importance of Tumor-Stromal Interactions: A Report from the Children's Oncology Group J Pathol Clin Res. 2015 Apr; 1(2):83-94. . View in PubMed

Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewing's family tumor xenografts is associated with high exposure of tumor to drug and high SLFN11 expression Clin Cancer Res. 2015 Mar 01; 21(5):1139-50. . View in PubMed

Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line Front Cell Dev Biol. 2015; 3:15. . View in PubMed

Discovery and validation of novel expression signature for postcystectomy recurrence in high-risk bladder cancer J Natl Cancer Inst. 2014 Nov; 106(11). . View in PubMed

DrugPath: a database for academic investigators to match oncology molecular targets with drugs in development Cancer Chemother Pharmacol. 2014 May; 73(5):1089-93. . View in PubMed

Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue Nat Commun. 2014 Feb 27; 5:3365. . View in PubMed

A novel algorithm for simplification of complex gene classifiers in cancer Cancer Res. 2013 Sep 15; 73(18):5625-32. . View in PubMed

ERBB4 confers metastatic capacity in Ewing sarcoma EMBO Mol Med. 2013 Jul; 5(7):1087-102. . View in PubMed

Discovery and validation of a prostate cancer genomic classifier that predicts early metastasis following radical prostatectomy PLoS One. 2013; 8(6):e66855. . View in PubMed

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia N Engl J Med. 2013 05 30; 368(22):2059-74. . View in PubMed

Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines PLoS One. 2013; 8(12):e80060. . View in PubMed

FOXM1 is an oncogenic mediator in Ewing Sarcoma PLoS One. 2013; 8(1):e54556. . View in PubMed

An epigenomic mechanism in retinoblastoma: the end of the story? Genome Med. 2012 Feb 24; 4(2):15.. View in PubMed

A central role for long non-coding RNA in cancer Front Genet. 2012; 3:17. . View in PubMed

Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor Sarcoma. 2012; 2012:126906. . View in PubMed

Genomic "Dark Matter" in Prostate Cancer: Exploring the Clinical Utility of ncRNA as Biomarkers Front Genet. 2012; 3:23. . View in PubMed

Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group Clin Cancer Res. 2011 Jan 01; 17(1):56-66. . View in PubMed

Fusion-negative alveolar rhabdomyosarcoma: modification of risk stratification is premature J Clin Oncol. 2010 Oct 10; 28(29):e587-8; author reply e589-90. . View in PubMed

Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group J Clin Oncol. 2010 Apr 20; 28(12):1989-94. . View in PubMed

CD133 expression in chemo-resistant Ewing sarcoma cells BMC Cancer. 2010 Mar 26; 10:116. . View in PubMed

Gene expression profiling for survival prediction in pediatric rhabdomyosarcomas: a report from the children's oncology group J Clin Oncol. 2010 Mar 01; 28(7):1240-6. . View in PubMed

Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression BMC Genomics. 2009 Dec 23; 10:625. . View in PubMed

Functional genomic analysis of peripheral blood during early acute renal allograft rejection Transplantation. 2009 Oct 15; 88(7):942-51. . View in PubMed

Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound Eur J Clin Invest. 2009 May; 39(5):384-94. . View in PubMed

Extraosseous Ewing's sarcoma: 25 years later J Clin Oncol. 2008 Sep 10; 26(26):4230-2. . View in PubMed

BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression Cancer Res. 2008 Aug 15; 68(16):6507-15. . View in PubMed

Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation Genet Epidemiol. 2007 Dec; 31(8):871-82. . View in PubMed

Experimental comparison and evaluation of the Affymetrix exon and U133Plus2 GeneChip arrays PLoS One. 2007 Sep 19; 2(9):e913. . View in PubMed

Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide J Natl Cancer Inst. 2007 Jul 18; 99(14):1107-19. . View in PubMed

Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group Am J Surg Pathol. 2007 Jun; 31(6):895-901. . View in PubMed

E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase Cancer Res. 2007 Apr 01; 67(7):3094-105. . View in PubMed

Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas Cancer Res. 2006 Jul 15; 66(14):6936-46. . View in PubMed

Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species Mol Cell Biol. 2006 Jan; 26(1):277-92. . View in PubMed

Expression profiles of osteosarcoma that can predict response to chemotherapy Cancer Res. 2005 Sep 15; 65(18):8142-50. . View in PubMed

A nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver2. In vitro and in vivo uptake results. Bioconjug Chem. 2005 Sep-Oct; 16(5):1071-80. . View in PubMed

EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors Cancer Res. 2005 Jun 01; 65(11):4633-44. . View in PubMed

Affymetrix oligonucleotide analysis of gene expression in the injured heart Methods Mol Med. 2005; 112:305-20. . View in PubMed

Growth inhibition of breast epithelial cells by celecoxib is associated with upregulation of insulin-like growth factor binding protein-3 expression Biochem Biophys Res Commun. 2004 Apr 02; 316(2):421-8. . View in PubMed

Genetic determinants of coxsackievirus B3 pathogenesis Ann N Y Acad Sci. 2002 Dec; 975:169-79. . View in PubMed

Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions Cancer Res. 2002 Aug 15; 62(16):4704-10. . View in PubMed

cDNA microarray analysis of global gene expression in sarcomas Curr Opin Oncol. 2002 Jul; 14(4):406-11. . View in PubMed

Infectomics: genomics and proteomics of microbial infections Funct Integr Genomics. 2002 Apr; 1(6):331-44. . View in PubMed

Expression profiling of human tumors: the end of surgical pathology? J Mol Diagn. 2001 Aug; 3(3):92-7.. View in PubMed

DNA microarrays in pediatric cancer Cancer J. 2001 Jan-Feb; 7(1):2-15. . View in PubMed

Expression of protein gene product 95 and tyrosine hydroxylase in childhood small round cell tumors. Clin Cancer Res. 2000 Feb; 6(2):551-8. . View in PubMed

EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts Lab Invest. 1999 Dec; 79(12):1535-43. . View in PubMed

Documentation of EWS gene rearrangements by fluorescence in-situ hybridization (FISH) in frozen sections of Ewing's sarcoma-peripheral primitive neuroectodermal tumor Am J Surg Pathol. 1999 Mar; 23(3):309-15. . View in PubMed

Human neuroblastoma cell lines regain catecholamine fluorescence when xenografted into athymic (nude) mice Int J Dev Neurosci. 1996 Oct; 14(6):771-7. . View in PubMed

Gene fusions encoding chimaeric transcription factors in solid tumours Semin Cancer Biol. 1996 Feb; 7(1):3-14. . View in PubMed

Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene Cancer Res. 1995 Mar 15; 55(6):1385-92. . View in PubMed

Comparison of Ewing's sarcoma of bone and peripheral neuroepitheliomaAn immunocytochemical and ultrastructural analysis of two primitive neuroectodermal neoplasms. Arch Pathol Lab Med. 1994 Jun; 118(6):608-15. . View in PubMed

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG Nat Genet. 1994 Feb; 6(2):146-51. . View in PubMed

Combinatorial generation of variable fusion proteins in the Ewing family of tumours EMBO J. 1993 Dec; 12(12):4481-7. . View in PubMed

dbl oncogene expression in childhood tumors and tumor cell lines Diagn Mol Pathol. 1993 Sep; 2(3):158-62. . View in PubMed

Expression of the retinoblastoma susceptibility gene in childhood rhabdomyosarcomas J Natl Cancer Inst. 1993 Jan 20; 85(2):152-7. . View in PubMed

Cytogenetic studies in subgroups of rhabdomyosarcoma Genes Chromosomes Cancer. 1992 Nov; 5(4):299-310. . View in PubMed

Dynamic model of differentiation in Ewing's sarcoma cellsComparative analysis of morphologic, immunocytochemical, and oncogene expression parameters. Lab Invest. 1992 Feb; 66(2):143-51. . View in PubMed

Immunohistochemical analysis of neural cell adhesion moleculesDifferential expression in small round cell tumors of childhood and adolescence. Am J Pathol. 1991 Aug; 139(2):275-86. . View in PubMed

Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32MIC2 Am J Pathol. 1991 Aug; 139(2):317-25. . View in PubMed

An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue Am J Pathol. 1990 Oct; 137(4):845-53. . View in PubMed

Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis Cancer Res. 1990 Sep 01; 50(17):5488-96. . View in PubMed

Expression of the dbl proto-oncogene in Ewing's sarcomas Oncogene. 1989 Jul; 4(7):897-900. . View in PubMed

In vitro chemosensitivity of two Ewing's sarcoma cell lines: implication for autologous bone marrow transplantation Cancer Invest. 1989; 7(5):411-6. . View in PubMed

Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma Cancer Res. 1988 Aug 01; 48(15):4307-11. . View in PubMed

Detection of N-myc gene expression in neuroblastoma tumors by in situ hybridization Am J Pathol. 1988 Jun; 131(3):391-7. . View in PubMed

Homozygous hypobetalipoproteinemia: a disease distinct from abetalipoproproteinemia at the molecular level J Clin Invest. 1988 Feb; 81(2):590-5. . View in PubMed

Biological classification of cell lines derived from human extra-cranial neural tumors Prog Clin Biol Res. 1988; 271:291-306. . View in PubMed

Induction of catecholamine fluorescence in human neuroblastoma cell lines transplanted into nude mice Prog Clin Biol Res. 1988; 271:307-16. . View in PubMed

Diagnosis of small round cell tumors of childhood Bull Cancer. 1988; 75(3):297-310. . View in PubMed

Ewing's sarcoma is an undifferentiated neuroectodermal tumor Prog Clin Biol Res. 1988; 271:487-98. . View in PubMed

Extracellular matrix synthesis by undifferentiated childhood tumor cell lines Am J Pathol. 1987 Oct; 129(1):74-85. . View in PubMed

Differential protooncogene expression characterizes histopathologically indistinguishable tumors of the peripheral nervous system J Clin Invest. 1987 Sep; 80(3):804-11. . View in PubMed

Differentiation of human neuroblastoma recapitulates neural crest developmentStudy of morphology, neurotransmitter enzymes, and extracellular matrix proteins. Am J Pathol. 1987 Sep; 128(3):484-96. . View in PubMed

Ifosfamide with mesna uroprotection and etoposide: an effective regimen in the treatment of recurrent sarcomas and other tumors of children and young adults J Clin Oncol. 1987 Aug; 5(8):1191-8. . View in PubMed

Experimental evidence for a neural origin of Ewing's sarcoma of bone Am J Pathol. 1987 Jun; 127(3):507-18. . View in PubMed

Clinical staging in rhabdomyosarcoma: current limitations and future prospects J Clin Oncol. 1987 Jan; 5(1):8-9. . View in PubMed

Extraosseous Ewing's sarcoma versus primitive rhabdomyosarcoma: diagnostic criteria and clinical correlation Hum Pathol. 1986 Sep; 17(9):881-93. . View in PubMed

Differentiation of human retinoblastoma in vitro into cell types with characteristics observed in embryonal or mature retina Am J Pathol. 1986 Jun; 123(3):542-52. . View in PubMed

Cytogenetic characterization of selected small round cell tumors of childhood Cancer Genet Cytogenet. 1986 Apr 01; 21(3):185-208. . View in PubMed

Evidence for neural origin and PAS-positive variants of the malignant small cell tumor of thoracopulmonary region ("Askin tumor") Am J Surg Pathol. 1986 Feb; 10(2):124-33. . View in PubMed

[Immunohistochemical studies of Ewing's sarcomas and their differential diagnosis with other "small round blue cell" sarcomas of childhood and adolescence] Verh Dtsch Ges Pathol. 1986; 70:321-4. . View in PubMed

A panel of monoclonal antibodies which discriminate neuroblastoma from Ewing's sarcoma, rhabdomyosarcoma, neuroepithelioma, and hematopoietic malignancies Prog Clin Biol Res. 1985; 175:347-66. . View in PubMed

In vitro radiation studies on Ewing's sarcoma cell lines and human bone marrow: application to the clinical use of total body irradiation (TBI) Int J Radiat Oncol Biol Phys. 1984 Jul; 10(7):1005-11. . View in PubMed

Induction of plasmacytoid differentiation by phorbol ester in B-cell lymphoma cell lines bearing 8;14 translocations Proc Natl Acad Sci U S A. 1984 Jun; 81(11):3547-51. . View in PubMed

Extraskeletal Ewing's sarcoma: results of combined modality treatment J Clin Oncol. 1983 Aug; 1(8):489-95. . View in PubMed

Clonal variation of MCF-7 breast cancer cells in vitro and in athymic nude mice Cancer Res. 1983 May; 43(5):2223-39. . View in PubMed

Ewing's sarcomaCharacterization in established cultures and evidence of its histogenesis. Lab Invest. 1982 Oct; 47(4):375-82. . View in PubMed

Glycogen-containing neuroblastoma with clinical and histopathologic features of Ewing's sarcoma Cancer. 1978 Apr; 41(4):1425-32. . View in PubMed

Annulate in four cases of diffuse lymphocytic lymphoma J Natl Cancer Inst. 1977 Mar; 58(3):777-80. . View in PubMed

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