Timothy J. Triche, MD, PhD

My research focuses on genetic aspects of cancer biology and their biologic consequences. Current research emphasizes whole genome approaches to gene expression profiling and genomic polymorphisms using DNA microarrays and software developed by our group to analyze this data. Laboratory studies typically utilize tumor cell lines expressing transfected genes, or with silenced genes. Gene targets and biologically active small molecules are often analyzed in biologic context by these same methods. Clinical correlative studies utilize tumor tissue with linked clinical data. Recently, these methods have been applied to studies of age related macular degeneration, as part of the Beckman Macular Research Center at the Doheny Eye Institute, Keck School of Medicine.

• Tumor Antigen Targeted Nanoparticle Therapy for Glioblastoma (GBM)
  NIH · R42CA281707 · Aug 8, 2023 – Jul 31, 2026 · Role: Co-Principal Investigator
• Integrated radiomic and liquid biopsy monitoring in SWOG S1802: A phase 3 therapeutic trial for metastatic prostate cancer
  NIH · R01CA257610 · Feb 9, 2021 – Jan 31, 2026 · Role: Co-Principal Investigator
• NV103: Antibody Conjugated Nanoparticle for Ewing Sarcoma Targeted Therapy
  NIH · R44CA233128 · Sep 14, 2018 – Apr 30, 2021 · Role: Co-Principal Investigator
• Nanoparticle Delivery System for Ewing Sarcoma Treatment
  NIH · R41CA203457 · Apr 15, 2016 – Mar 31, 2018 · Role: Co-Principal Investigator
• Translation of Predictive Cancer Biomarkers into Clinical Practice
  NIH · RC2CA148216 · Sep 29, 2009 – Aug 31, 2012 · Role: Co-Principal Investigator
• Diagnostic and Prognostic Sarcoma Signatures
  NIH · U01CA114757 · Sep 27, 2005 – May 31, 2010 · Role: Principal Investigator
• GENE EXPRESSION IN SARCOMAS OF CHILDHOOD AND ADOLESCENCE
  NIH · U01CA088199 · Sep 20, 2000 – Jan 31, 2007 · Role: Principal Investigator

• Lenz, Heinz-Josef
• Alonzo, Todd
• Berry, Jesse
• Wiemels, Joseph
• Alachkar, Houda
• Peters, Anne