Tin A Than, PhD, MD

Assistant Professor of Research Medicine

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Dr. Than’s major areas of research interest include mitochondria biogensis, stress response and mitophagy in liver patho-physiology and developmental biology, and regulation of gene expression by reactive oxygen species and derivative DNA adducts in liver patho-physiology and developmental biology. His current research entails mitochondrial retrograde signaling and stress response, and mitochondrial biogenesis in liver diseases.

Dr. Than earned his medical degree from University of Yangon, Institute of Medicine. He then went on to earn his PhD in Free Radical Biology & Molecular Biology from Okayama University Graduate School of Medicine and Dentistry.


  • Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer’s disease mice: Potential role in chronic heavy alcohol feeding Neurobiol Dis. 2024 Jun 15; 106570. . View in PubMed
  • Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolismCell Host Microbe. 2024 Jan 10; 32(1):48-62. e9. . View in PubMed
  • Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death Front Cell Dev Biol. 2024; 12:1359152. . View in PubMed
  • Antioxid Redox Signal. 2023 06; 38(16-18):1071-1081. . View in PubMed
  • Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis Hepatology. 2021 12; 74(6):3127-3145. . View in PubMed
  • Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense Hepatology. 2020 05; 71(5):1530-1532. . View in PubMed
  • Gut Microbiota and Liver Injury (I)-Acute Liver Injury Adv Exp Med Biol. 2020; 1238:23-37. . View in PubMed
  • Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps Hepatology. 2019 10; 70(4):1457-1469. . View in PubMed
  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury J Clin Invest. 2019 12 02; 129(12):5278-5293. . View in PubMed
  • The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects Int J Mol Sci. 2018 Nov 20; 19(11). . View in PubMed
  • New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases Hepatology. 2018 05; 67(5):2013-2024. . View in PubMed
  • The role of MAP2 kinases and p38 kinase in acute murine liver injury models Cell Death Dis. 2017 06 29; 8(6):e2903. . View in PubMed
  • Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria Antioxid Redox Signal. 2017 02 10; 26(5):207-220. . View in PubMed
  • c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src Hepatology. 2016 06; 63(6):1987-2003. . View in PubMed
  • Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity J Hepatol. 2015 Jul; 63(1):5-7. . View in PubMed
  • Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity J Hepatol. 2015 Jun; 62(6):1367-74. . View in PubMed
  • In vitro assays of mitochondrial function/dysfunction Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. . View in PubMed
  • JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death Cell Death Dis. 2014 Jan 09; 5:e989. . View in PubMed
  • Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. . View in PubMed
  • c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice J Biol Chem. 2011 Oct 07; 286(40):35071-8. . View in PubMed
  • Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells J Biol Chem. 2011 Jun 24; 286(25):22047-54. . View in PubMed
  • Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1 J Biol Chem. 2010 Mar 12; 285(11):8244-55. . View in PubMed
  • Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience Neurology. 2009 Apr 07; 72(14):1217-22. . View in PubMed
  • Taurine chloramine: a possible oxidant reservoir Adv Exp Med Biol. 2009; 643:451-61. . View in PubMed
  • Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. . View in PubMed
  • Endoplasmic reticulum stress and liver injury Semin Liver Dis. 2007 Nov; 27(4):367-77. . View in PubMed
  • Physiological oxidants induce apoptosis and cell cycle arrest in a multidrug-resistant natural killer cell line, NK-YS Leuk Lymphoma. 2003 Dec; 44(12):2109-16. . View in PubMed
  • Monochloramine inhibits the expression of E-selectin and intercellular adhesion molecule-1 induced by TNF-alpha through the suppression of NF-kappaB activation in human endothelial cells Free Radic Res. 2002 Aug; 36(8):845-52. . View in PubMed
  • Monochloramine inhibits etoposide-induced apoptosis with an increase in DNA aberration Free Radic Biol Med. 2001 Apr 15; 30(8):932-40. . View in PubMed
  • Monochloramine enhances Fas (APO-1/CD95)-induced apoptosis in Jurkat T cells J Leukoc Biol. 2000 Jan; 67(1):46-52. . View in PubMed