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Tin A. Than, PhD, MD

Assistant Professor of Research Medicine

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Phone +1 323 442 3175
Email [email protected]
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Overview

Dr. Than’s major areas of research interest include mitochondria biogensis, stress response and mitophagy in liver patho-physiology and developmental biology, and regulation of gene expression by reactive oxygen species and derivative DNA adducts in liver patho-physiology and developmental biology. His current research entails mitochondrial retrograde signaling and stress response, and mitochondrial biogenesis in liver diseases.

Dr. Than earned his medical degree from University of Yangon, Institute of Medicine. He then went on to earn his PhD in Free Radical Biology & Molecular Biology from Okayama University Graduate School of Medicine and Dentistry.

Publications

  • Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer’s disease mice: Potential role in chronic heavy alcohol feeding. Neurobiol Dis. 2024 09; 199:106570.. View in PubMed
  • Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death. Front Cell Dev Biol. 2024; 12:1359152.. View in PubMed
  • Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism. Cell Host Microbe. 2024 01 10; 32(1):48-62.e9.. View in PubMed
  • c-Jun-N Terminal Kinase-Mediated Degradation of γ-Glutamylcysteine Ligase Catalytic Subunit Inhibits GSH Recovery After Acetaminophen Treatment: Role in Sustaining JNK Activation and Liver Injury. Antioxid Redox Signal. 2023 06; 38(16-18):1071-1081.. View in PubMed
  • Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. Hepatology. 2021 12; 74(6):3127-3145.. View in PubMed
  • Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense. Hepatology. 2020 05; 71(5):1530-1532.. View in PubMed
  • Gut Microbiota and Liver Injury (I)-Acute Liver Injury. Adv Exp Med Biol. 2020; 1238:23-37.. View in PubMed
  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. J Clin Invest. 2019 12 02; 129(12):5278-5293.. View in PubMed
  • Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps. Hepatology. 2019 10; 70(4):1457-1469.. View in PubMed
  • The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects. Int J Mol Sci. 2018 Nov 20; 19(11).. View in PubMed

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