Keck School Faculty

Todd A. Alonzo, PhD
Todd A. Alonzo, PhD
Professor of Research Preventive Medicine;Group Statistician for Children's Oncology Group
Preventive Medicine
Children's Oncology Group Health Sciences Campus Monrovia
Todd Alonzo is a Professor of Research in the Department of Preventive Medicine, University of Southern California. He received his undergraduate degree at the California State Polytechnic University, San Luis Obispo, California in Statistics in 1994 and received both his MS and his PhD in Biostatistics in 1997 and 2000 from the University of Washington, Seattle. Dr. Alonzo’s main areas of research interest are the statistical methods for analysis of biomarkers and medical diagnostic and screening tests, clinical trials, and the design and analysis of pediatric acute myelogenous leukemia studies. He has published over 200 peer-reviewed articles.

Dr. Alonzo has been member of the Editorial Board for Biometrics, Pediatric Blood Cancer, and Biometrical Journal and has acted as a reviewer for 30 scientific journals. He is a member of several Data Safety and Monitoring Boards. Dr. Alonzo was the President of the International Biometric Society Western Northern America Region (WNAR) in 2009. He is a Fellow of the American Statistical Association.

: Fellow, American Statistical Association, 2018

The International Society for Magnetic Resonance in Medicine: Outstanding Teacher Award, 2017

University of Washington: Senior Biostatistics Award, Department of Biostatistics, 2000

University of Washington: • Senior Biostatistics Award, Department of Biostatistics, 2000

: • ENAR Biometrics Society Distinguished Student Paper Award, 1999

: WNAR Biometrics Society Best Student Oral Presentation, 1999

: • WNAR Biometrics Society Best Student Oral Presentation, 1999

: ENAR Biometrics Society Distinguished Student Paper Award, 1999

NIH: Predoctoral Cardiovascular Biostatistics Training Grant, 1995

Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia Leukemia. 2019 Feb 13. . View in PubMed

Comparisons of New HIV Rapid Test Kit Performance AIDS Behav. 2018 Jun 25. . View in PubMed

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions Nat Med. 2018 Apr 10; 24(4):526. . View in PubMed

Estimation of the volume under the receiver-operating characteristic surface adjusting for non-ignorable verification bias Stat Methods Med Res. 2018 Mar; 27(3):715-739. . View in PubMed

Effects of Maintenance on Quality of Performance of Cryotherapy Devices for Treatment of Precancerous Cervical Lesions J Low Genit Tract Dis. 2018 01; 22(1):47-51. . View in PubMed

Depth of Cervical Intraepithelial Neoplasia Grade 3 in Peruvian Women: Implications for Therapeutic Depth of Necrosis J Low Genit Tract Dis. 2018 Jan; 22(1):27-30. . View in PubMed

Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children's Oncology Group Pediatr Blood Cancer. 2017 Dec; 64(12). . View in PubMed

Distinct signaling events promote resistance to mitoxantrone and etoposide in pediatric AML: a Children's Oncology Group report Oncotarget. 2017 Oct 27; 8(52):90037-90049. . View in PubMed

Arsenic Trioxide Consolidation Allows Anthracycline Dose Reduction for Pediatric Patients With Acute Promyelocytic Leukemia: Report From the Children's Oncology Group Phase III Historically Controlled Trial AAML0631 J Clin Oncol. 2017 Sep 10; 35(26):3021-3029. . View in PubMed

Center-level variation in accuracy of adverse event reporting in a clinical trial for pediatric acute myeloid leukemia: a report from the Children's Oncology Group Haematologica. 2017 Sep; 102(9):e340-e343. . View in PubMed

CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children's Oncology Group Trial AAML0531 J Clin Oncol. 2017 Aug 10; 35(23):2674-2682. . View in PubMed

Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group Clin Cancer Res. 2017 Jul 15; 23(14):3649-3656. . View in PubMed

Center-level variation in accuracy of adverse event reporting in a clinical trial for pediatric acute myeloid leukemia: a report from the Children's Oncology Group Haematologica. 2017 09; 102(9):e340-e343. . View in PubMed

Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia Br J Haematol. 2017 Jan; 176(1):86-91. . View in PubMed

Improved outcomes for myeloid leukemia of Down syndrome: a report from the Children's Oncology Group AAML0431 trial Blood. 2017 06 22; 129(25):3304-3313. . View in PubMed

Gemtuzumab ozogamicin in infants with AML: results from the Children's Oncology Group trials AAML03P1 and AAML0531 Blood. 2017 08 17; 130(7):943-945. . View in PubMed

Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report Blood. 2017 06 08; 129(23):3051-3058. . View in PubMed

Association between prolonged neutropenia and reduced relapse risk in pediatric AML: A report from the children's oncology group Int J Cancer. 2016 Nov 01; 139(9):1930-5. . View in PubMed

Early discharge as a mediator of greater ICU-level care requirements in patients not enrolled on the AAML0531 clinical trial: a Children's Oncology Group report Cancer Med. 2016 Sep; 5(9):2412-6. . View in PubMed

Accuracy of Adverse Event Ascertainment in Clinical Trials for Pediatric Acute Myeloid Leukemia J Clin Oncol. 2016 May 01; 34(13):1537-43. . View in PubMed

Gemtuzumab Ozogamicin Reduces Relapse Risk in FLT3/ITD Acute Myeloid Leukemia: A Report from the Children's Oncology Group Clin Cancer Res. 2016 Apr 15; 22(8):1951-7. . View in PubMed

CD33 Expression and Its Association With Gemtuzumab Ozogamicin Response: Results From the Randomized Phase III Children's Oncology Group Trial AAML0531 J Clin Oncol. 2016 Mar 01; 34(7):747-55. . View in PubMed

Early discharge as a mediator of greater ICU-level care requirements in patients not enrolled on the AAML0531 clinical trial: a Children's Oncology Group report Cancer Med. 2016 09; 5(9):2412-6. . View in PubMed

A comparison of discharge strategies after chemotherapy completion in pediatric patients with acute myeloid leukemia: a report from the Children's Oncology Group Leuk Lymphoma. 2016 07; 57(7):1567-74. . View in PubMed

Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia Nat Genet. 2016 Jan; 48(1):101. . View in PubMed

Accuracy of Adverse Event Ascertainment in Clinical Trials for Pediatric Acute Myeloid Leukemia J Clin Oncol. 2016 05 01; 34(13):1537-43. . View in PubMed

CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML Blood. 2016 06 16; 127(24):3094-8. . View in PubMed

Comparing Analytic Methods for Longitudinal GWAS and a Case-Study Evaluating Chemotherapy Course Length in Pediatric AMLA Report from the Children's Oncology Group. Front Genet. 2016; 7:139. . View in PubMed

Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse Cancer Res. 2016 04 15; 76(8):2197-205. . View in PubMed

Erratum to: High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group J Hematol Oncol. 2016 11 30; 9(1):133. . View in PubMed

Clinical Impact of Additional Cytogenetic Aberrations, cKIT and RAS Mutations, and Treatment Elements in Pediatric t(8;21)-AML: Results From an International Retrospective Study by the International Berlin-Frankfurt-Münster Study Group J Clin Oncol. 2015 Dec 20; 33(36):4247-58. . View in PubMed

Comparison of in-patient costs for children treated on the AAML0531 clinical trial: A report from the Children's Oncology Group Pediatr Blood Cancer. 2015 Oct; 62(10):1775-81. . View in PubMed

Comparison of Rapid Point-of-Care Tests for Detection of Antibodies to Hepatitis C Virus Open Forum Infect Dis. 2015 Sep; 2(3):ofv101. . View in PubMed

Comparison of administrative/billing data to expected protocol-mandated chemotherapy exposure in children with acute myeloid leukemia: A report from the Children's Oncology Group Pediatr Blood Cancer. 2015 Jul; 62(7):1184-9. . View in PubMed

Concordance of copy number alterations using a common analytic pipeline for genome-wide analysis of Illumina and Affymetrix genotyping data: a report from the Children's Oncology Group Cancer Genet. 2015 Jul-Aug; 208(7-8):408-13. . View in PubMed

High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group J Hematol Oncol. 2015 10 20; 8:115. . View in PubMed

High expression of suppressor of cytokine signaling-2 predicts poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group Leuk Lymphoma. 2014 Dec; 55(12):2817-21. . View in PubMed

A Phase 2 study of bortezomib combined with either idarubicin/cytarabine or cytarabine/etoposide in children with relapsed, refractory or secondary acute myeloid leukemia: a report from the Children's Oncology Group Pediatr Blood Cancer. 2014 Oct; 61(10):1754-60. . View in PubMed

Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the randomized phase III Children’s Oncology Group trial AAML0531 J Clin Oncol. 2014 Sep 20; 32(27):3021-32. . View in PubMed

AAML0523: a report from the Children's Oncology Group on the efficacy of clofarabine in combination with cytarabine in pediatric patients with recurrent acute myeloid leukemia Cancer. 2014 Aug 15; 120(16):2482-9. . View in PubMed

Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: a report from the Children's Oncology Group Br J Haematol. 2014 Jul; 166(2):254-259. . View in PubMed

BIRC5 (survivin) splice variant expression correlates with refractory disease and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group Pediatr Blood Cancer. 2014 Apr; 61(4):647-52. . View in PubMed

Comparable survival for pediatric acute myeloid leukemia with poor-risk cytogenetics following chemotherapy, matched related donor, or unrelated donor transplantation Pediatr Blood Cancer. 2014 Feb; 61(2):269-75. . View in PubMed

Gene expression profiling to predict viridans group streptococcal and invasive fungal infection in pediatric acute myeloid leukemia: a brief report from the Children's Oncology Group Acta Haematol. 2014; 131(3):167-9. . View in PubMed

Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: a report from the Children's Oncology Group Cancer. 2013 Dec 01; 119(23):4162-9. . View in PubMed

Accuracy of a home-based device for giving an early estimate of pregnancy duration compared with reference methodsFertil Steril. 2013 Dec; 100(6):1635-41. e1. . View in PubMed

High EVI1 expression is associated with MLL rearrangements and predicts decreased survival in paediatric acute myeloid leukaemia: a report from the children's oncology group Br J Haematol. 2013 Sep; 162(5):670-7. . View in PubMed

Development and validation of a single-cell network profiling assay-based classifier to predict response to induction therapy in paediatric patients with de novo acute myeloid leukaemia: a report from the Children's Oncology Group Br J Haematol. 2013 Jul; 162(2):250-62. . View in PubMed

Children's Oncology Group's 2013 blueprint for research: acute myeloid leukemia Pediatr Blood Cancer. 2013 Jun; 60(6):964-71. . View in PubMed

Effectiveness of supportive care measures to reduce infections in pediatric AML: a report from the Children's Oncology Group Blood. 2013 May 02; 121(18):3573-7. . View in PubMed

Anthracyclines during induction therapy in acute myeloid leukaemia: a systematic review and meta-analysis Br J Haematol. 2013 Apr; 161(2):192-203. . View in PubMed

Clinical significance of CD33 nonsynonymous single-nucleotide polymorphisms in pediatric patients with acute myeloid leukemia treated with gemtuzumab-ozogamicin-containing chemotherapy Clin Cancer Res. 2013 Mar 15; 19(6):1620-7. . View in PubMed

Generalization of Youden index for multiple-class classification problems applied to the assessment of externally validated cognition in Parkinson disease screening Stat Med. 2013 Mar 15; 32(6):995-1003. . View in PubMed

FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report Blood. 2013 Feb 14; 121(7):1083-93. . View in PubMed

High expression of neutrophil elastase predicts improved survival in pediatric acute myeloid leukemia: a report from the Children's Oncology Group Leuk Lymphoma. 2013 Jan; 54(1):202-4. . View in PubMed

Favorable survival maintained in children who have myeloid leukemia associated with Down syndrome using reduced-dose chemotherapy on Children's Oncology Group trial A2971: a report from the Children's Oncology Group Cancer. 2012 Oct 01; 118(19):4806-14. . View in PubMed

Extending induced ROC methodology to the functional context Biostatistics. 2012 Sep; 13(4):594-608. . View in PubMed

Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML Blood. 2012 Apr 19; 119(16):3705-11. . View in PubMed

AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia: a report from the Children's Oncology Group Cancer. 2012 Feb 01; 118(3):761-9. . View in PubMed

Estimation of the prevalence of Fanconi anemia among patients with de novo acute myelogenous leukemia who have poor recovery from chemotherapy Leuk Res. 2012 Jan; 36(1):29-31. . View in PubMed

A phase II study of amifostine in children with myelodysplastic syndrome: a report from the Children's Oncology Group study (AAML0121) Pediatr Blood Cancer. 2011 Dec 15; 57(7):1230-2. . View in PubMed

Higher dose imatinib for children with de novo chronic phase chronic myelogenous leukemia: a report from the Children's Oncology Group Pediatr Blood Cancer. 2011 Jul 15; 57(1):56-62. . View in PubMed

Bias in estimating accuracy of a binary screening test with differential disease verification Stat Med. 2011 Jul 10; 30(15):1852-64. . View in PubMed

Beyond the 3+3 method: expanded algorithms for dose- escalation in Phase I oncology trials of two agents Clin Trials. 2011 Jun; 8(3):247-59. . View in PubMed

Immediate vsdelayed post-abortal copper T 380A IUD insertion in cases over 12 weeks of gestation. Contraception. 2011 Jun; 83(6):522-7. . View in PubMed

Adequacy of visual inspection with acetic acid in women of advancing age Int J Gynaecol Obstet. 2011 Apr; 113(1):68-71. . View in PubMed

Accuracy and cut-off point selection in three-class classification problems using a generalization of the Youden index Stat Med. 2010 Dec 10; 29(28):2946-55. . View in PubMed

Cytology versus visual inspection with acetic acid among women treated previously with cryotherapy in a low-resource setting Int J Gynaecol Obstet. 2010 Dec; 111(3):249-52. . View in PubMed

High expression of the very late antigen-4 integrin independently predicts reduced risk of relapse and improved outcome in pediatric acute myeloid leukemia: a report from the children's oncology group J Clin Oncol. 2010 Jun 10; 28(17):2831-8. . View in PubMed

Diagnostic reproducibility of cervical intraepithelial neoplasia 3 and atrophy in menopausal women on hematoxylin and eosin, Ki-67, and p16 stained slides J Low Genit Tract Dis. 2010 Apr; 14(2):108-12. . View in PubMed

Estimates of sensitivity and specificity can be biased when reporting the results of the second test in a screening trial conducted in series BMC Med Res Methodol. 2010 Jan 11; 10:3. . View in PubMed

Digital assessment of the reproductive tract versus colposcopy for directing biopsies in women with abnormal Pap smears J Low Genit Tract Dis. 2010 Jan; 14(1):5-10. . View in PubMed

A receiver operating characteristic analysis approach for the assessment of the separation of female Mediterranean fruit fly (Diptera: Tephritidae) oviposition distributions J Econ Entomol. 2009 Oct; 102(5):1985-91. . View in PubMed

Effect of tidal volume in children with acute hypoxemic respiratory failure Intensive Care Med. 2009 Aug; 35(8):1428-37. . View in PubMed

Comparing accuracy in an unpaired post-market device study with incomplete disease assessment Biom J. 2009 Jun; 51(3):491-503. . View in PubMed

Adolescent comprehension of emergency contraception in New York City Obstet Gynecol. 2009 Apr; 113(4):840-4. . View in PubMed

A comparison of tests for restricted orderings in the three-class case Stat Med. 2009 Mar 30; 28(7):1144-58. . View in PubMed

Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia Br J Haematol. 2009 Feb; 144(3):388-94. . View in PubMed

Disseminated intravascular coagulation score is associated with mortality for children with shock Intensive Care Med. 2009 Feb; 35(2):327-33. . View in PubMed

Bias in trials comparing paired continuous tests can cause researchers to choose the wrong screening modality BMC Med Res Methodol. 2009 Jan 20; 9:4. . View in PubMed

Impact of disease risk on efficacy of matched related bone marrow transplantation for pediatric acute myeloid leukemia: the Children's Oncology Group J Clin Oncol. 2008 Dec 10; 26(35):5797-801. . View in PubMed

FAS promoter polymorphism: outcome of childhood acute myeloid leukemiaA children's oncology group report. Clin Cancer Res. 2008 Dec 01; 14(23):7896-9. . View in PubMed

DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update Mol Cancer. 2008 Oct 23; 7:81. . View in PubMed

A modified sign test for comparing paired ROC curves Biostatistics. 2008 Apr; 9(2):364-72. . View in PubMed

Comparison of ROC umbrella volumes with an application to the assessment of lung cancer diagnostic markers Biom J. 2007 Aug; 49(5):654-64. . View in PubMed

Comparison of childhood myelodysplastic syndrome, AML FAB M6 or M7, CCG 2891: report from the Children's Oncology Group Pediatr Blood Cancer. 2007 Jul; 49(1):17-22. . View in PubMed

Criteria for optimizing prognostic risk groups in pediatric cancer: analysis of data from the Children's Oncology Group J Clin Oncol. 2007 May 20; 25(15):2070-7. . View in PubMed

Development and evaluation of classifiers Methods Mol Biol. 2007; 404:89-116. . View in PubMed

Clinical implications of FLT3 mutations in pediatric AML Blood. 2006 Dec 01; 108(12):3654-61. . View in PubMed

FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia Blood. 2006 Oct 15; 108(8):2764-9. . View in PubMed

Ethnicity and survival in childhood acute myeloid leukemia: a report from the Children's Oncology Group Blood. 2006 Jul 01; 108(1):74-80. . View in PubMed

A novel design for estimating relative accuracy of screening tests when complete disease verification is not feasible Biometrics. 2006 Jun; 62(2):605-12. . View in PubMed

Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukemia Blood. 2004 Nov 15; 104(10):3058-63. . View in PubMed

Allogeneic bone marrow transplantation for children with acute myelocytic leukemia in first remission demonstrates a role for graft versus leukemia in the maintenance of disease-free survival Blood. 2004 May 15; 103(10):3655-61. . View in PubMed

Extramedullary leukemia in children with newly diagnosed acute myeloid leukemia: a report from the Children's Cancer Group J Pediatr Hematol Oncol. 2003 Oct; 25(10):760-8. . View in PubMed

Increased age at diagnosis has a significantly negative effect on outcome in children with Down syndrome and acute myeloid leukemia: a report from the Children's Cancer Group Study 2891 J Clin Oncol. 2003 Sep 15; 21(18):3415-22. . View in PubMed

Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia Blood. 2003 Aug 15; 102(4):1474-9. . View in PubMed

Immunophenotypic evidence of leukemia after induction therapy predicts relapse: results from a prospective Children's Cancer Group study of 252 patients with acute myeloid leukemia Blood. 2003 May 01; 101(9):3398-406. . View in PubMed

Estimating disease prevalence in two-phase studies Biostatistics. 2003 Apr; 4(2):313-26. . View in PubMed

Impact of granulocyte colony-stimulating factor use during induction for acute myelogenous leukemia in children: a report from the Children's Cancer Group J Pediatr Hematol Oncol. 2002 Nov; 24(8):627-35. . View in PubMed

Distribution-free ROC analysis using binary regression techniques Biostatistics. 2002 Sep; 3(3):421-32. . View in PubMed

Current controversies: which patients with acute myeloid leukaemia should receive a bone marrow transplantation? --an American view. Br J Haematol. 2002 Aug; 118(2):378-84.. View in PubMed

Acute myeloid leukemia and myelodysplastic syndrome in children treated for cancer: comparison with primary presentation Blood. 2002 Jul 15; 100(2):427-34. . View in PubMed

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