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Unmesh Jadhav

Assistant Professor of Stem Cell Biology and Regenerative Medicine

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Phone +1 323 442 2563
Email ujadhav@usc.edu
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Publications

  • Crypt density and recruited enhancers underlie intestinal tumour initiation. Nature. 2025 Apr; 640(8057):231-239.. View in PubMed
  • Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis. Nat Commun. 2025 Jan 22; 16(1):929.. View in PubMed
  • DNA methylation-dependent and -independent binding of CDX2 directs activation of distinct developmental and homeostatic genes. bioRxiv. 2024 Mar 07.. View in PubMed
  • Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature. 2023 04; 616(7956):339-347.. View in PubMed
  • Epigenetic Regulation of Intestinal Stem Cells and Disease: A Balancing Act of DNA and Histone Methylation. Gastroenterology. 2021 06; 160(7):2267-2282.. View in PubMed
  • Creb5 establishes the competence for Prg4 expression in articular cartilage. Commun Biol. 2021 03 12; 4(1):332.. View in PubMed
  • Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Mol Cell. 2020 04 02; 78(1):141-151.e5.. View in PubMed
  • Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020 03 05; 26(3):377-390.e6.. View in PubMed
  • Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Mol Cell. 2019 05 02; 74(3):542-554.e5.. View in PubMed
  • Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development. Genes Dev. 2018 11 01; 32(21-22):1430-1442.. View in PubMed
  • Transcription factor-dependent ‘anti-repressive’ mammalian enhancers exclude H3K27me3 from extended genomic domains. Genes Dev. 2017 12 01; 31(23-24):2391-2404.. View in PubMed
  • Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell. 2017 07 06; 21(1):65-77.e5.. View in PubMed
  • Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep. 2016 08 23; 16(8):2053-2060.. View in PubMed
  • Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. 2016 Jun 02; 165(6):1389-1400.. View in PubMed

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