Uri Elkayam, MD

Dr. Uri Elkayam is a professor of Medicine and Obstetrics and Gynecology and director of the maternal cardiology program at the university of Southern California in Los Angeles. Dr. Elkayam has been a member of the faculty of the division of cardiology since 1981 and his previous positions included chief of cardiology USC university hospital and director of the heart failure program. He is a past member of the executive council of the Heart Failure Society of America.

Dr Elkayam research and clinical interests are congestive heart failure, heart disease and pregnancy, valvular heart disease, cardiomyopathies, and cardiovascular pharmacology. He has been involved in more than 100 self-initiated, NIH and industry funded research projects and has served in a leading position in numerous national and international multicenter studies.

He is an associate editor of the journal JACC Advances and an editorial consultant for the journal JACC heart failure. Dr. Elkayam is the author or co-author of over 250 publications and over 90 book chapters and the editor of 4 editions of the textbook “Cardiac Problems in Pregnancy”.

He has been the director of the annual Los Angeles heart failure symposium since 1996, the founder and chairman of the International Congress on Cardiac Problems in Pregnancy, and the director of an annual national symposium on cardio obstetrics university.

Dr. Elkayam was the recipient of the 2021 American College of Cardiology Bernadine Healy Leadership in Women’s Cardiovascular Disease Distinguished Award.

• 8th World Congress on Heart Failure: Melvin L. Marcus Memorial Award for Distinguished Contribution as a Gifted Teacher, 2002
• Department of Maternal- Fetal Medicine, USC Women’s & Children’s Hospital: Award for Education of Residents and Fellows, 2002
• International Academy of Cardiology: Distinguished Fellowship Award- Cardiology, 2007
• American College of Cardiology: Bernadine Healy Leadership in Women’s Cardiovascular Disease Distinguished Award, 2021

• Dr. Uri Elkayam to Deliver 6th HJC Swan Memorial Lecture at Opening of International Academy of Cardiology, 17th World Congress on Heart Disease, Scientific Sessions 2012 (07/24/2012)

• Long-Term Adverse Events and Cardiac Recovery Among Women With Peripartum Cardiomyopathy. JACC Heart Fail. 2026 Jul 28; 103234.. View in PubMed
• Managing a Pregnant Patient With a Mechanical Heart Valve and Subchorionic Hematomas. JACC Case Rep. 2026 Feb 18; 31(7):106549.. View in PubMed
• Second Wave: Dynamic LVOT Obstruction in a Patient With Previous Subaortic Membrane. Circ Heart Fail. 2026 Feb; 19(2):e013477.. View in PubMed
• Peripartum Cardiomyopathy: Lessons From Long-Term Outcomes in Israel. JACC Heart Fail. 2026 Mar; 14(3):102818.. View in PubMed
• Outcome of Pregnancy in Women With Congenitally Corrected Transposition of the Great Arteries: A Systematic Review. Am J Cardiol. 2025 Sep 01; 250:9-16.. View in PubMed
• Bromocriptine in the treatment of peripartum cardiomyopathy: is it ready for prime time? Eur Heart J. 2025 Mar 13; 46(11):1028-1030. Elkayam U . View in PubMed
• Cathepsin-D and outcomes in peripartum cardiomyopathy: Results from IPAC. Am Heart J Plus. 2025 Jan; 49:100489.. View in PubMed
• CMR and adverse clinical outcomes in peripartum cardiomyopathy. Am Heart J Plus. 2024 Dec; 48:100484.. View in PubMed
• Cardiovascular Adaptation in Normal Pregnancy With 2D and 3D Echocardiography, Speckle Tracking, and Radial Artery Tonometry. JACC Adv. 2024 Nov; 3(11):101360.. View in PubMed
• Management of Woman With Rheumatic Mitral Stenosis During Pregnancy: Importance of Multimodality Evaluation. JACC Case Rep. 2024 Oct 16; 29(20):102628.. View in PubMed
• Race, hypertensive disorders of pregnancy and outcomes in peripartum cardiomyopathy. Am Heart J. 2024 10; 276:60-69.. View in PubMed
• Successful Pregnancy After Left Ventricular Assist Device Explantation for Myocardial Recovery. ASAIO J. 2024 09 01; 70(9):e133-e136.. View in PubMed
• Peripartum HFpEF: Identification of a Novel Phenotype and the Need for Cardio-Obstetrics Management. JACC Adv. 2024 Feb; 3(2):100799.. View in PubMed
• Safety of Subsequent Pregnancy After Recovery From Peripartum Cardiomyopathy. J Am Coll Cardiol. 2023 07 04; 82(1):27-29.. View in PubMed
• Outcome of Pregnancy in Women With D-Transposition of the Great Arteries: A Systematic Review. J Am Heart Assoc. 2022 12 06; 11(23):e026862.. View in PubMed
• Hypertensive disorders of pregnant women with heart disease: the ESC EORP ROPAC Registry. Eur Heart J. 2022 10 11; 43(38):3749-3761.. View in PubMed
• Contemporary outcome of subsequent pregnancies in patients with previous peripartum cardiomyopathy. ESC Heart Fail. 2022 12; 9(6):4262-4270.. View in PubMed
• Catheter-Based Interventions for the Management of Valvular Heart Disease During Pregnancy. JACC Adv. 2022 Jun; 1(2):100022.. View in PubMed
• An Updated Review on the Role of Non-dihydropyridine Calcium Channel Blockers and Beta-blockers in Atrial Fibrillation and Acute Decompensated Heart Failure: Evidence and Gaps. Cardiovasc Drugs Ther. 2023 12; 37(6):1205-1223.. View in PubMed
• Society for Maternal-Fetal Medicine Consult Series #61: Anticoagulation in pregnant patients with cardiac disease. Am J Obstet Gynecol. 2022 08; 227(2):B28-B43.. View in PubMed
• Heart Failure Subtypes and Cardiomyopathies in Women. Circ Res. 2022 02 18; 130(4):436-454.. View in PubMed
• Arrhythmias in Pregnancy. JACC Clin Electrophysiol. 2022 01; 8(1):120-135.. View in PubMed
• Changing Incidence and Mechanism of Pregnancy-Associated Myocardial Infarction in the State of California. J Am Heart Assoc. 2021 11 02; 10(21):e021056.. View in PubMed
• Cardiomyopathy and Pregnancy: Considerations for Women With Severely Reduced Left Ventricular Dysfunction. Can J Cardiol. 2021 12; 37(12):2067-2075.. View in PubMed
• The Hidden Cost of Meth: Appraising the Socioeconomic Burden of Methamphetamine-Associated Cardiomyopathy. Circ Cardiovasc Qual Outcomes. 2021 07; 14(7):e008214.. View in PubMed
• Characteristics of Methamphetamine-associated Cardiomyopathy and the Impact of Methamphetamine Use on Cardiac Dysfunction. Am J Cardiol. 2021 09 01; 154:86-91.. View in PubMed
• Proinflammatory TH17 cytokine activation, disease severity and outcomes in peripartum cardiomyopathy. Int J Cardiol. 2021 Sep 15; 339:93-98.. View in PubMed
• Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy. Circulation. 2021 05 11; 143(19):1852-1862.. View in PubMed
• Acute pulmonary pressure change after transition to sacubitril/valsartan in patients with heart failure reduced ejection fraction. ESC Heart Fail. 2021 04; 8(2):1706-1710.. View in PubMed
• Peripartum cardiomyopathy: one disease with many faces. Eur Heart J. 2020 10 14; 41(39):3798-3800.. View in PubMed
• Pregnancy in women with rheumatic valve disease: how to improve the outcome? Heart. 2020 09; 106(18):1374-1375. Elkayam U , Shmueli H . View in PubMed
• Cardiovascular effects of preeclampsia. Curr Opin Cardiol. 2020 07; 35(4):357-359.. View in PubMed
• Tolvaptan vs. furosemide-based diuretic regimens in patients hospitalized for heart failure with hyponatremia (AQUA-AHF). ESC Heart Fail. 2020 08; 7(4):1927-1934.. View in PubMed
• Clinical Characteristics and Management of Methamphetamine-Associated Cardiomyopathy: State-of-the-Art Review. J Am Heart Assoc. 2020 06 02; 9(11):e016704.. View in PubMed
• Peripartum Cardiomyopathy: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 01 21; 75(2):207-221.. View in PubMed
• Acute Postpartum Heart Failure With Preserved Systolic Function. JACC Case Rep. 2020 Jan; 2(1):82-85.. View in PubMed
• Pregnancy outcomes in women with cardiovascular disease: evolving trends over 10 years in the ESC Registry Of Pregnancy And Cardiac disease (ROPAC). Eur Heart J. 2019 12 14; 40(47):3848-3855.. View in PubMed
• Use of Impella heart pump for management of women with peripartum cardiogenic shock. Clin Cardiol. 2019 Oct; 42(10):974-981.. View in PubMed
• Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy. JACC Basic Transl Sci. 2019 Jun; 4(3):291-300.. View in PubMed
• Electrocardiographic findings in peripartum cardiomyopathy. Clin Cardiol. 2019 May; 42(5):524-529.. View in PubMed
• Imbalanced Angiogenesis in Peripartum Cardiomyopathy (PPCM). Circ J. 2018 09 25; 82(10):2689.. View in PubMed
• Association of admission vs. nadir serum albumin concentration with short-term treatment outcomes in patients with acute heart failure. J Int Med Res. 2018 Sep; 46(9):3665-3674.. View in PubMed
• How to Predict Pregnancy Risk in an Individual Woman With Heart Disease. J Am Coll Cardiol. 2018 05 29; 71(21):2431-2433.. View in PubMed
• Peripartum cardiomyopathy: approach to management. Curr Opin Cardiol. 2018 05; 33(3):347-353.. View in PubMed
• Pregnancy-Associated Coronary Artery Dissection: A Therapeutic Dilemma. J Am Coll Cardiol. 2018 01 30; 71(4):469-470.. View in PubMed
• Pregnancy and Marfan syndrome. Ann Cardiothorac Surg. 2017 Nov; 6(6):642-653.. View in PubMed
• Can I get pregnant again? Eur J Heart Fail. 2017 12; 19(12):1729-1731. Elkayam U . View in PubMed
• Peripartum cardiomyopathy for the clinician: the known and the unknown. Eur J Heart Fail. 2017 09; 19(9):1142-1144.. View in PubMed
• Anticoagulation Therapy for Pregnant Women With Mechanical Prosthetic Heart Valves: How to Improve Safety? J Am Coll Cardiol. 2017 06 06; 69(22):2692-2695. Elkayam U . View in PubMed
• Myocardial Damage Detected by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Uncommon in Peripartum Cardiomyopathy. J Am Heart Assoc. 2017 Apr 03; 6(4).. View in PubMed
• Heart Failure-Induced Brain Injury. J Am Coll Cardiol. 2017 Mar 28; 69(12):1609-1616.. View in PubMed
• Pregnancy and the Risk of Spontaneous Coronary Artery Dissection: An Analysis of 120 Contemporary Cases. Circ Cardiovasc Interv. 2017 Mar; 10(3).. View in PubMed
• Angiotensin Receptor-Neprilysin Inhibition. J Cardiovasc Pharmacol Ther. 2017 07; 22(4):356-364.. View in PubMed
• Reply: CT Rather Than Invasive Angiography for Pregnant Patients With NSTEMI? More Delay and More Radiation. J Am Coll Cardiol. 2016 12 20; 68(24):2717-2718.. View in PubMed
• Echocardiography in Pregnancy: Part 1. Curr Cardiol Rep. 2016 09; 18(9):92.. View in PubMed
• Echocardiography in Pregnancy: Part 2. Curr Cardiol Rep. 2016 09; 18(9):90.. View in PubMed
• Response by Arany and Elkayam to Letter Regarding Article, “Peripartum Cardiomyopathy”. Circulation. 2016 Aug 16; 134(7):e83-4.. View in PubMed
• High-Risk Cardiac Disease in Pregnancy: Part I. J Am Coll Cardiol. 2016 07 26; 68(4):396-410.. View in PubMed
• High-Risk Cardiac Disease in Pregnancy: Part II. J Am Coll Cardiol. 2016 Aug 02; 68(5):502-516.. View in PubMed
• Relaxin for the Treatment of Acute Decompensated Heart Failure: Pharmacology, Mechanisms of Action, and Clinical Evidence. Cardiol Rev. 2016 Jul-Aug; 24(4):194-204.. View in PubMed
• The Search for a Crystal Ball to Predict Early Recovery From Peripartum Cardiomyopathy? JACC Heart Fail. 2016 05; 4(5):389-91. Elkayam U , Habakuk O . View in PubMed
• Peripartum Cardiomyopathy. Circulation. 2016 Apr 05; 133(14):1397-409.. View in PubMed
• GNB3 C825T Polymorphism and Myocardial Recovery in Peripartum Cardiomyopathy: Results of the Multicenter Investigations of Pregnancy-Associated Cardiomyopathy Study. Circ Heart Fail. 2016 Mar; 9(3):e002683.. View in PubMed
• Reply: Comparison of the American PPCM Registry Data With International Registries. J Am Coll Cardiol. 2016 Feb 16; 67(6):734-735.. View in PubMed
• Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. N Engl J Med. 2016 Jan 21; 374(3):233-41.. View in PubMed
• Clinical Outcomes for Peripartum Cardiomyopathy in North America: Results of the IPAC Study (Investigations of Pregnancy-Associated Cardiomyopathy). J Am Coll Cardiol. 2015 Aug 25; 66(8):905-14.. View in PubMed
• “Of mice and (wo)men”: The need to confirm results of animal experimentations with solid clinical data. Trends Cardiovasc Med. 2015 Aug; 25(6):505-7.. View in PubMed
• Risk of subsequent pregnancy in women with a history of peripartum cardiomyopathy. J Am Coll Cardiol. 2014 Oct 14; 64(15):1629-36.. View in PubMed
• Cardiac medication during pregnancy, data from the ROPAC. Int J Cardiol. 2014 Nov 15; 177(1):124-8.. View in PubMed
• Cardiorenal interactions in acute decompensated heart failure: contemporary concepts facing emerging controversies. J Card Fail. 2014 Dec; 20(12):1004-11.. View in PubMed
• Association of hyponatremia to diuretic response and incidence of increased serum creatinine levels in hospitalized patients with acute decompensated heart failure. Cardiology. 2014; 128(4):333-42.. View in PubMed
• Pregnancy-associated acute myocardial infarction: a review of contemporary experience in 150 cases between 2006 and 2011. Circulation. 2014 Apr 22; 129(16):1695-702.. View in PubMed
• Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial. Am J Cardiol. 2014 Jul 01; 114(1):151-9.. View in PubMed
• Monitoring of anti-Xa in pregnant patients with mechanical prosthetic valves receiving low-molecular-weight heparin: peak or trough levels? J Cardiovasc Pharmacol Ther. 2014 Sep; 19(5):451-6. Goland S . View in PubMed
• EURObservational Research Programme: a worldwide registry on peripartum cardiomyopathy (PPCM) in conjunction with the Heart Failure Association of the European Society of Cardiology Working Group on PPCM. Eur J Heart Fail. 2014 May; 16(5):583-91.. View in PubMed
• Some more on preventing congenital heart block. Autoimmun Rev. 2014 Jan; 13(1):73-4.. View in PubMed
• Effect of amlodipine on the survival of patients with severe chronic heart failure due to a nonischemic cardiomyopathy: results of the PRAISE-2 study (prospective randomized amlodipine survival evaluation 2). JACC Heart Fail. 2013 Aug; 1(4):308-314.. View in PubMed
• Mechanical heart valve thrombosis in pregnancy. J Heart Valve Dis. 2013 Jul; 22(4):603-6.. View in PubMed
• Preventing congenital neonatal heart block in offspring of mothers with anti-SSA/Ro and SSB/La antibodies: a review of published literature and registered clinical trials. Autoimmun Rev. 2013 Sep; 12(11):1039-45.. View in PubMed
• Differences in clinical profile of African-American women with peripartum cardiomyopathy in the United States. J Card Fail. 2013 Apr; 19(4):214-8.. View in PubMed
• Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failure. J Cardiovasc Pharmacol Ther. 2013 Jul; 18(4):345-53.. View in PubMed
• Cardiovascular imaging of the pregnant patient. AJR Am J Roentgenol. 2013 Mar; 200(3):515-21.. View in PubMed
• Anticoagulation in pregnancy. Cardiol Clin. 2012 Aug; 30(3):395-405.. View in PubMed
• Peripartum cardiomyopathy. Cardiol Clin. 2012 Aug; 30(3):435-40.. View in PubMed
• Physiologic changes during normal pregnancy and delivery. Cardiol Clin. 2012 Aug; 30(3):317-29.. View in PubMed
• Cardiovascular disease in pregnancy. Preface. Cardiol Clin. 2012 Aug; 30(3):xi-xii.. View in PubMed
• Cardiovascular drugs in pregnancy. Cardiol Clin. 2012 Aug; 30(3):463-91.. View in PubMed
• Clinical experience with low-dose continuous infusion of furosemide in acute heart failure: assessment of efficacy and safety. J Cardiovasc Pharmacol Ther. 2012 Dec; 17(4):373-81.. View in PubMed
• Serial echocardiographic assessment of the human heart in normal pregnancy. Circ Cardiovasc Imaging. 2012 May 01; 5(3):283-5.. View in PubMed
• The search for a safe and effective anticoagulation regimen in pregnant women with mechanical prosthetic heart valves. J Am Coll Cardiol. 2012 Mar 20; 59(12):1116-8.. View in PubMed
• Clinical characteristics of peripartum cardiomyopathy in the United States: diagnosis, prognosis, and management. J Am Coll Cardiol. 2011 Aug 09; 58(7):659-70.. View in PubMed
• Comparative effects of nesiritide and nitroglycerin on renal function, and incidence of renal injury by traditional and RIFLE criteria in acute heart failure. J Cardiovasc Pharmacol Ther. 2012 Mar; 17(1):79-85.. View in PubMed
• Evaluation of the clinical relevance of baseline left ventricular ejection fraction as a predictor of recovery or persistence of severe dysfunction in women in the United States with peripartum cardiomyopathy. J Card Fail. 2011 May; 17(5):426-30.. View in PubMed
• Rationale and design of the treatment of hyponatremia based on lixivaptan in NYHA class III/IV cardiac patient evaluation (THE BALANCE) study. Clin Transl Sci. 2010 Oct; 3(5):249-53.. View in PubMed
• Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. Eur J Heart Fail. 2010 Aug; 12(8):767-78.. View in PubMed
• Comparison of pioglitazone vs glyburide in early heart failure: insights from a randomized controlled study of patients with type 2 diabetes and mild cardiac disease. Congest Heart Fail. 2010 May-Jun; 16(3):111-7.. View in PubMed
• Bromocriptine for the treatment of peripartum cardiomyopathy. Circulation. 2010 Apr 06; 121(13):1463-4.. View in PubMed
• Favorable outcome of pregnancy with an elective use of epoprostenol and sildenafil in women with severe pulmonary hypertension. Cardiology. 2010; 115(3):205-8.. View in PubMed
• Venous thromboembolism in hospitalized patients with heart failure: incidence, prognosis, and prevention. Circ Heart Fail. 2010 Jan; 3(1):165-73.. View in PubMed
• Cardiomyopathy: the importance of recognizing the uncommon diagnosis. Prog Cardiovasc Dis. 2010 Jan-Feb; 52(4):262-3.. View in PubMed

• Kloner, Robert
• Demetriades, Demetrios
• Kantor, Paul
• Kim, Gene
• Matsuo, Koji
• Wood, John