Keck School Faculty

Uttam Kumar Sinha, MD
Uttam Kumar Sinha, MD
Associate Professor of Otolaryngology--Head and Neck Surgery, Medical Director of Head and Neck Surgery;Watt Family Endowed Chair for Head and Neck Cancers
CHP 204M 1540 Alcazar Street Off Campus Los Angeles
Dr. Uttam K. Sinha graduated with distinction from the Calcutta University, India in 1985. He was invited by the House Ear Institute and University of Southern California where he started his research career in molecular biology of neuroscience and cancer. He then finished residency in Otolaryngology-Head and Neck Surgery at USC. He continued to peruse academic career and completed a clinical fellowship in Microvascular and Plastic and Reconstructive Surgery in Mount Sinai Hospital, New York. He then went to Leon, France to complete a clinical fellowship in laryngology. Subsequently, he joined the faculty of the Department of Otolaryngology-Head and Neck Surgery at USC. Because of his academic achievements, leadership, teaching and research, he became Chief and Residency Program Director for the department. His major areas of research are head and neck cancer, thyroid cancer, plastic and reconstructive surgery, trauma, and speech and swallowing. By using nanotechnology, Dr. Sinha and his team are able to detect cancer cell in the saliva and serum. He is also studying the mechanism of metastasis. Dysphagia (difficulty in swallowing) is a common symptom following head and neck cancer therapy. Dr. Sinha and his team introduced a novel treatment called neuromuscular electrical stimulation (NMES) for rehabilitation of swallowing using a new “platform” technology called BION. He received multiple federal and foundation grants. His dedication to patient care and research made him world authority in head and neck diseases. To further the research endeavors, Dr. Sinha has established collaboration with multiple national and international institutes from England, France, India, China and Mexico. Three years ago Dr. Sinha launched a Patient Survivorship Program ( The Support Group is actively involved in patient education and promoting awareness about head and neck cancer.

: Alpha Omega Alpha (Gamma Chapter) as an Outstanding Resident, 1992

House Ear Institute: Rupley Fellowship, 1986

Calcutta University: Annual Scholarship for Academic Merit, 1977

Calcutta University: Gold Medal for highest marks in General Surgery, 1977

Government of India: National Scholarship for Academic Merit, 1973

Rapidly Enlarging Parapharyngeal Mass JAMA Otolaryngol Head Neck Surg. 2018 Sep 27. . View in PubMed

The molecular mechanisms of increased radiosensitivity of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC): an extensive review J Otolaryngol Head Neck Surg. 2018 Sep 21; 47(1):59. . View in PubMed

Outcomes of reconstruction after temporal bone resection for malignancy J Craniomaxillofac Surg. 2018 Aug 11. . View in PubMed

Interdisciplinary Telemedicine in the Management of Dysphagia in Head and Neck Dysphagia. 2018 Feb 05. . View in PubMed

Clin Med Insights Ear Nose Throat. 2018; 11:1179550618792248. . View in PubMed

Effects of Resonance Voice Therapy on Hormone-Related Vocal Disorders in Professional Singers: A Pilot Study Clin Med Insights Ear Nose Throat. 2018; 11:1179550618786934. . View in PubMed

Transoral surgery vs intensity-modulated radiotherapy for early supraglottic cancer: a systematic review Curr Opin Otolaryngol Head Neck Surg. 2017 Apr; 25(2):133-141. . View in PubMed

Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies Int J Otolaryngol. 2017; 2017:8362874. . View in PubMed

Overcoming radioresistance in head and neck squamous cell carcinoma Oral Oncol. 2016 Dec; 63:44-51. . View in PubMed

Erratum to "The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma" [Oral Oncol61 (2016) 27-30]. Oral Oncol. 2016 Nov; 62:e5. . View in PubMed

J Surg Oncol. 2016 Jul; 114(1):27-31. . View in PubMed

Device Life of Two Generations of Provox Voice Prostheses Ann Otol Rhinol Laryngol. 2016 Jun; 125(6):501-7. . View in PubMed

The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis Cancers (Basel). 2016 Feb 19; 8(2). . View in PubMed

The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma Oral Oncol. 2016 10; 61:27-30. . View in PubMed

ABCLOVE: Voice therapy outcomes for patients with head and neck cancer Head Neck. 2016 04; 38 Suppl 1:E1810-3. . View in PubMed

Use of Octreotide for the Management of Chyle Fistula Following Neck Dissection JAMA Otolaryngol Head Neck Surg. 2015 Aug; 141(8):723-7. . View in PubMed

Rationale for combined blockade of PD-1 and CTLA-4 in advanced head and neck squamous cell cancer—review of current data Oral Oncol. 2015 Jan; 51(1):12-5. . View in PubMed

Defining the localization and molecular characteristic of minor salivary gland label-retaining cells Stem Cells. 2014 Aug; 32(8):2267-77. . View in PubMed

Diagnosis and management of merkel cell carcinoma of the head and neck: current trends and controversies Cancers (Basel). 2014 Jun 27; 6(3):1256-66. . View in PubMed

Bacterial biofilms and increased bacterial counts are associated with airway stenosis Otolaryngol Head Neck Surg. 2014 May; 150(5):834-40. . View in PubMed

Use of the supraclavicular artery island flap for reconstruction of cervicofacial defects Otolaryngol Head Neck Surg. 2014 Feb; 150(2):222-8. . View in PubMed

Evaluation of swallow function after tongue cancer treatment using real-time magnetic resonance imaging: a pilot study JAMA Otolaryngol Head Neck Surg. 2013 Dec; 139(12):1312-9. . View in PubMed

The supraclavicular artery island flap in head and neck reconstruction: applications and limitations JAMA Otolaryngol Head Neck Surg. 2013 Nov; 139(11):1247-55. . View in PubMed

DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays Oral Oncol. 2013 Feb; 49(2):93-101. . View in PubMed

Solitary fibrous tumor of the postcricoid region: a case report and literature review Case Rep Otolaryngol. 2013; 2013:908327. . View in PubMed

Uncommon cutaneous neoplasms of the head and neck Facial Plast Surg Clin North Am. 2012 Nov; 20(4):483-91. . View in PubMed

a-Catulin marks the invasion front of squamous cell carcinoma and is important for tumor cell metastasis Mol Cancer Res. 2012 Jul; 10(7):892-903. . View in PubMed

Prevalidation of salivary biomarkers for oral cancer detection Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):664-72. . View in PubMed

Gold nanorod-sphingosine kinase siRNA nanocomplexes: a novel therapeutic tool for potent radiosensitization of head and neck cancer Integr Biol (Camb). 2012 Feb; 4(2):132-41. . View in PubMed

Recent advances in biomarkers and potential targeted therapies in head and neck squamous cell carcinoma ISRN Surg. 2012; 2012:715743. . View in PubMed

USC-HN2, a new model cell line for recurrent oral cavity squamous cell carcinoma with immunosuppressive characteristics Oral Oncol. 2011 Sep; 47(9):810-7. . View in PubMed

Osteoradionecrosis Oral Maxillofac Surg Clin North Am. 2011 Aug; 23(3):455-64. . View in PubMed

The role of salivary cytokine biomarkers in tongue cancer invasion and mortality Oral Oncol. 2011 Apr; 47(4):282-7. . View in PubMed

Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition Head Neck. 2011 Feb; 33(2):178-88. . View in PubMed

Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations J Cell Biochem. 2010 Mar 01; 109(4):818-27. . View in PubMed

Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1 Head Neck Oncol. 2010 Feb 22; 2:5. . View in PubMed

Invasion characteristics of oral tongue cancer: frequency of reporting and effect on survival in a population-based study Cancer. 2009 Sep 01; 115(17):4010-20. . View in PubMed

Use of an oral sensory feedback device in the management of jaw-opening dystonia Otolaryngol Head Neck Surg. 2009 Jul; 141(1):142-3. . View in PubMed

The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma Arch Otolaryngol Head Neck Surg. 2008 Sep; 134(9):985-91. . View in PubMed

Provider perceptions of patient psychosocial needs after orofacial injury J Oral Maxillofac Surg. 2007 Aug; 65(8):1584-9. . View in PubMed

The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma Arch Otolaryngol Head Neck Surg. 2006 Oct; 132(10):1053-9. . View in PubMed

EphB4 provides survival advantage to squamous cell carcinoma of the head and neck Int J Cancer. 2006 Sep 15; 119(6):1236-48. . View in PubMed

Circles of prominence: a new theory on facial aesthetics Arch Facial Plast Surg. 2006 Jul-Aug; 8(4):263-7. . View in PubMed

Serum circulating human mRNA profiling and its utility for oral cancer detection J Clin Oncol. 2006 Apr 10; 24(11):1754-60. . View in PubMed

p53 apoptotic response to DNA damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines Head Neck. 2006 Jan; 28(1):15-23. . View in PubMed

Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma Hum Pathol. 2005 Dec; 36(12):1289-93. . View in PubMed

Salivary transcriptome diagnostics for oral cancer detection Clin Cancer Res. 2004 Dec 15; 10(24):8442-50. . View in PubMed

Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma Arch Otolaryngol Head Neck Surg. 2004 Aug; 130(8):929-35. . View in PubMed

Functional outcomes following palatal reconstruction with a folded radial forearm free flap Ear Nose Throat J. 2004 Jan; 83(1):45-8. . View in PubMed

Expression of EphB4 in head and neck squamous cell carcinoma Ear Nose Throat J. 2003 Nov; 82(11):866, 869-70, 887. . View in PubMed

Pressure-Specifying Sensory Device: quantitative sensory measurement in the oral cavity and oropharynx of normal adults Ear Nose Throat J. 2003 Sep; 82(9):682-4, 687-90. . View in PubMed

Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas Int J Oncol. 2003 Jun; 22(6):1285-90. . View in PubMed

Effects of steel scalpel, ultrasonic scalpel, CO2 laser, and monopolar and bipolar electrosurgery on wound healing in guinea pig oral mucosa Laryngoscope. 2003 Feb; 113(2):228-36. . View in PubMed

Use of AlloDerm implant to prevent frey syndrome after parotidectomy Arch Facial Plast Surg. 2003 Jan-Feb; 5(1):109-12. . View in PubMed

Three-layer reconstruction for large defects of the anterior skull base Laryngoscope. 2002 Mar; 112(3):424-7. . View in PubMed

Use of AlloDerm for coverage of radial forearm free flap donor site Laryngoscope. 2002 Feb; 112(2):230-4. . View in PubMed

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