Wei Li, PhD

Professor of Dermatology

Director, MSS Graduate Program

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Overview

Dr. Li research focuses on the following topics: 1) Identification of the “driver genes” for wound healing, 2) Identification of tumor-secreted molecules as drug targets for TNBCs (triple negative breast cancers). 3) Signal transduction to understand the cell motility signaling, which initiates at the cell surface, propagates via cytosolic signaling networks and executes by newly expressed and secreted gene products.

His experimental model systems are less manipulated primary human skin cells, whose migration is essential for both physiological processes, such as skin wound healing, and pathological occurrence, such as skin cancer, PDX models for TNBCs and pig models for wound healing.

Awards

  • USC Stevens Center for Innovation: Technology Commercialization Award, 2017
     – 2017
  • USC Stevens Center for Innovation: Technology Commercialization Award, 2018
     – 2018
  • USA: Elected Member, National Academy of Inventors, 2017
     – pre.

Education and Training

  • Xinjiang University, Urumqi, China — B.S. — 1982 — General Biology
  • CUSBEA, Guangzhou, China — English Certificate — 1984 — English
  • Albert Einstein College of Medicine, New York City, NY — Ph.D. — 1991 — Biochemistry and Molecular Biology
  • New York University Medical Center, New York City, NY — Postdoctoral Research — 1993 — Signal Transduction

Research Funding

  • Development of Extracellular Heat Shock Protein-90 as a Novel Topical Wound Healing
    NIH · R01AR059853 · Jul 1, 2011 – Apr 30, 2018 · Role: Principal Investigator
  • Mechanisms of Human Dermal Fibroblast Migration
    NIH · R01GM067100 · Jan 1, 2003 – Apr 30, 2021 · Role: Principal Investigator
  • Signal Transduction of Human Keratinocyte Migration
    NIH · R01GM066193 · Jul 1, 2002 – May 31, 2013 · Role: Principal Investigator
  • STUDIES OF A NOVEL SH2/SH3-CONTAINING CELLULAR ONCOGENE
    NIH · R01CA065567 · Aug 15, 1995 – Apr 30, 2001 · Role: Principal Investigator

Research Keywords

  • big molecule drug development, wound healing, breast cancer

Publications

  • The role of secreted heat shock protein-90 (Hsp90) in wound healing – how could it shape future therapeutics? Expert Rev Proteomics. 2017 08; 14(8):665-675. Guo J, Chang C, Li W . . View in PubMed
  • Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation. Nat Commun. 2017 05 31; 8:15654.. View in PubMed
  • Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression. Oncogene. 2017 04; 36(15):2160-2171.. View in PubMed
  • Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and Closure. Adv Wound Care (New Rochelle). 2016 Apr 01; 5(4):176-184.. View in PubMed
  • Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment. Sci Rep. 2016 Feb 05; 6:20605.. View in PubMed
  • The effect of surface modification of mesoporous silica micro-rod scaffold on immune cell activation and infiltration. Biomaterials. 2016 Mar; 83:249-56.. View in PubMed
  • Hsp90α and Hsp90β together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing. J Cell Sci. 2015 Apr 15; 128(8):1475-80.. View in PubMed
  • Identification of the critical therapeutic entity in secreted Hsp90α that promotes wound healing in newly re-standardized healthy and diabetic pig models. PLoS One. 2014; 9(12):e113956.. View in PubMed
  • Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology. Biomaterials. 2014 Oct; 35(32):8927-36.. View in PubMed
  • Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013 Dec; 33(24):4947-59.. View in PubMed