Keck School Faculty

Wendy Jean Mack, PhD
Wendy Jean Mack, PhD
Professor of Preventive Medicine
Preventive Medicine
SSB 202Y 2001 N. Soto Street Health Sciences Campus Los Angeles
Wendy Mack, PhD, is a professor of biostatistics in the Department of Preventive Medicine at the Keck School of Medicine of USC. She co-directs the department’s Division of Biostatistics graduate programs and directs Biostatistics Resources at the Southern California Clinical and Translational Science Institute (SC CTSI).

Professor Mack has more than 20 years of experience directing biostatistical and data coordination activities, primarily funded by the National Institutes of Health (NIH). Her expertise includes design, conduct and analysis of multiple single-centered and multi-centered clinical trials and observational studies. She also directs biostatistical activities for the USC Alzheimer’s Disease Research Center and for other basic and clinical research programs.

She has served on numerous NIH study sections for biostatistical expertise and has recently completed a term on the NHLBI Clinical Trials Review study section. Professor Mack received her doctorate from the University of Southern California. Her home is open to needy animals wandering by, and she dabbles in competitive dog obedience in her minimal spare time.

Effect of ApoE4 Genotype on the Association Between Metabolic Phenotype and Subclinical Atherosclerosis in Postmenopausal Women Am J Cardiol. 2019 Oct 01; 124(7):1031-1037. . View in PubMed

Expanding Access to Home-Based Palliative Care: A Randomized Controlled Trial Protocol J Palliat Med. 2019 Sep; 22(S1):58-65. . View in PubMed

Effects of high-intensity interval training on vascular endothelial function and vascular wall thickness in breast cancer patients receiving anthracycline-based chemotherapy: a randomized pilot study Breast Cancer Res Treat. 2019 Sep; 177(2):477-485. . View in PubMed

Elevated Microparticle Tissue Factor Activity Is Associated With Carotid Artery Plaque in HIV-Infected Women J Acquir Immune Defic Syndr. 2019 May 01; 81(1):36-43. . View in PubMed

Differential Effect of Plasma Estradiol on Subclinical Atherosclerosis Progression in Early vs Late Postmenopause J Clin Endocrinol Metab. 2019 Feb 01; 104(2):293-300. . View in PubMed

Drug-Induced Sleep Endoscopy Findings in Supine vs Nonsupine Body Positions in Positional and Nonpositional Obstructive Sleep Apnea JAMA Otolaryngol Head Neck Surg. 2019 Feb 01; 145(2):159-165. . View in PubMed

J Alzheimers Dis. 2019; 71(2):647-658. . View in PubMed

Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer's disease Menopause. 2019 Jan; 26(1):7-15. . View in PubMed

Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention Breast Cancer Res Treat. 2018 Feb; 168(1):147-157. . View in PubMed

Cardiovascular risk after withdrawal of hormone therapy Menopause. 2018 04; 25(4):365-367. . View in PubMed

Effects of high-intensity interval training on vascular function in breast cancer survivors undergoing anthracycline chemotherapy: design of a pilot study BMJ Open. 2018 06 30; 8(6):e022622. . View in PubMed

Electrical risk score beyond the left ventricular ejection fraction: prediction of sudden cardiac death in the Oregon Sudden Unexpected Death Study and the Atherosclerosis Risk in Communities Study Eur Heart J. 2017 Oct 21; 38(40):3017-3025. . View in PubMed

A Critical Appraisal of Vascularized Bone Grafting for Scaphoid Nonunion J Wrist Surg. 2017 Aug; 6(3):251-257. . View in PubMed

Evaluation of Hemodynamic Performance of Aortic Valve Bioprostheses in a Model of Oversizing Ann Thorac Surg. 2017 Jun; 103(6):1866-1876. . View in PubMed

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review JAMA Neurol. 2017 Mar 01; 74(3):339-347. . View in PubMed

Care Variations and Outcomes for Children Hospitalized With Bacterial Tracheostomy-Associated Respiratory Infections Hosp Pediatr. 2017 01; 7(1):16-23. . View in PubMed

Effects of Antiretroviral Therapy and Depressive Symptoms on All-Cause Mortality Among HIV-Infected Women Am J Epidemiol. 2017 05 15; 185(10):869-878. . View in PubMed

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease Sci Transl Med. 2017 02 15; 9(377). . View in PubMed

Association of Macrophage Inflammation Biomarkers With Progression of Subclinical Carotid Artery Atherosclerosis in HIV-Infected Women and Men J Infect Dis. 2017 05 01; 215(9):1352-1361. . View in PubMed

Estradiol Therapy After Menopause Mitigates Effects of Stress on Cortisol and Working Memory J Clin Endocrinol Metab. 2017 12 01; 102(12):4457-4466. . View in PubMed

Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis Neurology. 2016 Aug 16; 87(7):699-708. . View in PubMed

A Dysregulated Balance of Proinflammatory and Anti-Inflammatory Host Cytokine Response Early During Therapy Predicts Persistence and Mortality in Staphylococcus aureus Bacteremia Crit Care Med. 2016 Apr; 44(4):671-9. . View in PubMed

A comparison of aortic valve replacement via an anterior right minithoracotomy with standard sternotomy: a propensity score analysis of 492 patients Eur J Cardiothorac Surg. 2016 Feb; 49(2):456-63. . View in PubMed

Effect of Reproductive History and Exogenous Hormone Use on Cognitive Function in Mid- and Late Life J Am Geriatr Soc. 2016 12; 64(12):2448-2456. . View in PubMed

Back to the future: Hormone replacement therapy as part of a prevention strategy for women at the onset of menopause Atherosclerosis. 2016 11; 254:282-290. . View in PubMed

Association of bilateral oophorectomy with cognitive function in healthy, postmenopausal womenFertil Steril. 2016 09 01; 106(3):749-756. e2. . View in PubMed

Enhancement of viral escape in HIV-1 Nef by STEP vaccination AIDS. 2016 10 23; 30(16):2449-2458. . View in PubMed

Differential effects of ischemic vascular disease and Alzheimer's disease on brain atrophy and cognition J Cereb Blood Flow Metab. 2016 Jan; 36(1):204-15. . View in PubMed

Falls among middle-aged women in the Women's Interagency HIV Study Antivir Ther. 2016; 21(8):697-706. . View in PubMed

Electrocardiographic Markers and the Left Ventricular Ejection Fraction have Cumulative Effects on Risk of Sudden Cardiac Death JACC Clin Electrophysiol. 2015 Dec 01; 1(6):542-550. . View in PubMed

Aldosterone, cognitive function, and cerebral hemodynamics in hypertension and antihypertensive therapy Am J Hypertens. 2015 Mar; 28(3):319-25. . View in PubMed

Abnormal blood rheology and chronic low grade inflammation: possible risk factors for accelerated atherosclerosis and coronary artery disease in Lewis negative subjects Atherosclerosis. 2015 Mar; 239(1):248-51. . View in PubMed

Echolucency of the carotid artery intima-media complex and intima-media thickness have different cardiovascular risk factor relationships: the Women's Interagency HIV Study J Am Heart Assoc. 2015 Feb 19; 4(2). . View in PubMed

Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women J Clin Endocrinol Metab. 2015 Feb; 100(2):508-15. . View in PubMed

Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye PLoS One. 2015; 10(9):e0138958. . View in PubMed

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study JAMA Neurol. 2014 Nov; 71(11):1394-404. . View in PubMed

Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women AIDS. 2014 Jul 31; 28(12):1815-23. . View in PubMed

Effect of prior oophorectomy on changes in bone mineral density and carotid artery intima-media thickness in postmenopausal women Fertil Steril. 2014 Apr; 101(4):1117-22. . View in PubMed

Associations between urine excretion of isoflavonoids and cognition in postmenopausal women in the Women's Isoflavone Soy Health clinical trial J Am Geriatr Soc. 2014 Apr; 62(4):629-35. . View in PubMed

Cortical thickness mediates the effect of ß-amyloid on episodic memory Neurology. 2014 Mar 04; 82(9):761-7. . View in PubMed

Associations between serum cholesterol levels and cerebral amyloidosis JAMA Neurol. 2014 Feb; 71(2):195-200. . View in PubMed

Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles Neurotoxicology. 2014 Jan; 40:1-7. . View in PubMed

Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. . View in PubMed

Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes Stroke. 2013 Oct; 44(10):2835-41. . View in PubMed

Effect of isoflavone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized controlled trial Menopause. 2013 Aug; 20(8):840-4. . View in PubMed

Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach AIDS. 2013 Jun 01; 27(9):1473-81. . View in PubMed

Birth weight and carotid artery intima-media thicknessJ Pediatr. 2013 May; 162(5):906-11. e1-2. . View in PubMed

Alzheimer pathology and angiotension receptor blockers JAMA Neurol. 2013 Mar 01; 70(3):414. . View in PubMed

Antihypertensive therapy and cerebral hemodynamics in executive mild cognitive impairment: results of a pilot randomized clinical trial J Am Geriatr Soc. 2013 Feb; 61(2):194-201. . View in PubMed

Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI PLoS One. 2013; 8(6):e65175. . View in PubMed

Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults Stroke. 2012 Nov; 43(11):2865-70. . View in PubMed

Childhood air pollutant exposure and carotid artery intima-media thickness in young adults Circulation. 2012 Sep 25; 126(13):1614-20. . View in PubMed

Coronary risk correlates with cerebral amyloid deposition Neurobiol Aging. 2012 Sep; 33(9):1979-87. . View in PubMed

Do Angiotensin receptor blockers really hold promise for the improvement of cognitive functioning? -Reply. Arch Intern Med. 2012 Aug 13; 172(15):1191-2.. View in PubMed

Equol production changes over time in postmenopausal women J Nutr Biochem. 2012 Jun; 23(6):573-9. . View in PubMed

Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial Arch Intern Med. 2012 Mar 12; 172(5):442-4. . View in PubMed

Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adults J Am Geriatr Soc. 2012 Mar; 60(3):499-504. . View in PubMed

Chronic depressive symptoms and Framingham coronary risk in HIV-infected and HIV-uninfected women AIDS Care. 2012; 24(3):394-403. . View in PubMed

Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles PLoS One. 2012; 7(2):e31267. . View in PubMed

Chinese-language montreal cognitive assessment for cantonese or mandarin speakers: age, education, and gender effects Int J Alzheimers Dis. 2012; 2012:204623. . View in PubMed

Associations of cardiovascular variables and HAART with cognition in middle-aged HIV-infected and uninfected women J Neurovirol. 2011 Oct; 17(5):469-76. . View in PubMed

Carotid artery intima-media thickness in college students: race/ethnicity matters Atherosclerosis. 2011 Aug; 217(2):441-6. . View in PubMed

Cognitive effects of atypical antipsychotic medications in patients with Alzheimer's disease: outcomes from CATIE-AD Am J Psychiatry. 2011 Aug; 168(8):831-9. . View in PubMed

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease Nat Genet. 2011 May; 43(5):436-41. . View in PubMed

A "window of opportunity:" the reduction of coronary heart disease and total mortality with menopausal therapies is age- and time-dependent Brain Res. 2011 Mar 16; 1379:244-52. . View in PubMed

Executive functions in recently postmenopausal women: absence of strong association with serum gonadal steroids Brain Res. 2011 Mar 16; 1379:199-205. . View in PubMed

Association between human immunodeficiency virus infection and stiffness of the common carotid artery Stroke. 2010 Oct; 41(10):2163-70. . View in PubMed

Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women Menopause. 2010 Jul; 17(4):785-90. . View in PubMed

Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study Am J Psychiatry. 2010 May; 167(5):589-97. . View in PubMed

Factors influencing driving status in an older Latino population J Aging Health. 2010 Apr; 22(3):332-47. . View in PubMed

Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus J Infect Dis. 2010 Mar 15; 201(6):823-34. . View in PubMed

Ambient air pollution and the progression of atherosclerosis in adults PLoS One. 2010 Feb 08; 5(2):e9096. . View in PubMed

Factors associated with prevalent hepatitis C infection among HIV-infected women with no reported history of injection drug use: the Women's Interagency HIV Study (WIHS) AIDS Patient Care STDS. 2009 Nov; 23(11):915-23. . View in PubMed

Association of hepatitis C virus and HIV infection with subclinical atherosclerosis in the women's interagency HIV study AIDS. 2009 Aug 24; 23(13):1781-4. . View in PubMed

Correlates of perinatal depression in HIV-infected women AIDS Patient Care STDS. 2009 Feb; 23(2):101-8. . View in PubMed

CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus J Infect Dis. 2008 May 15; 197(10):1402-7. . View in PubMed

Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women J Clin Virol. 2008 Apr; 41(4):255-63. . View in PubMed

Association of cells with natural killer (NK) and NKT immunophenotype with incident cancers in HIV-infected women AIDS Res Hum Retroviruses. 2008 Feb; 24(2):163-8. . View in PubMed

Brachial artery vasoreactivity is associated with cross-sectional and longitudinal anatomical measures of atherosclerosis in postmenopausal women with coronary artery disease Atherosclerosis. 2008 Feb; 196(2):674-81. . View in PubMed

Correlates of prevalent hypertension in a large cohort of HIV-infected women: Women's Interagency HIV Study AIDS. 2007 Nov 30; 21(18):2539-41. . View in PubMed

Estrogen therapy and coronary-artery calcification N Engl J Med. 2007 Sep 20; 357(12):1252-3; author reply 1254. . View in PubMed

Asthma: Effect of genotype on Response to Therapy in the Emergency Department West J Emerg Med. 2007 Aug; 8(3):73-7. . View in PubMed

Correlates of CD4+ and CD8+ lymphocyte counts in high-risk immunodeficiency virus (HIV)-seronegative women enrolled in the women's interagency HIV study (WIHS) Hum Immunol. 2007 May; 68(5):342-9. . View in PubMed

Carotid artery intima-media thickness after raloxifene treatment J Womens Health (Larchmt). 2007 Apr; 16(3):370-8. . View in PubMed

Effect of antihypertensive therapy on progression of carotid intima-media thickness in patients with type 2 diabetes mellitus Am J Cardiol. 2007 Apr 01; 99(7):956-60. . View in PubMed

Cognitive impact of subcortical vascular and Alzheimer's disease pathology Ann Neurol. 2006 Dec; 60(6):677-87. . View in PubMed

Bimodal virological response to antiretroviral therapy for HIV infection: an application using a mixture model with left censoring J Epidemiol Community Health. 2006 Sep; 60(9):811-8. . View in PubMed

Effect of peroxisome proliferator-activated receptor gamma agonist treatment on subclinical atherosclerosis in patients with insulin-requiring type 2 diabetes Diabetes Care. 2006 Jul; 29(7):1545-53. . View in PubMed

Determinants of the effect of estrogen on the progression of subclinical atherosclerosis: Estrogen in the Prevention of Atherosclerosis Trial Menopause. 2005 Jul-Aug; 12(4):366-73. . View in PubMed

Category fluency in a latino sample: associations with age, education, gender, and language J Clin Exp Neuropsychol. 2005 Jul; 27(5):591-8. . View in PubMed

Ambient air pollution and atherosclerosis in Los Angeles Environ Health Perspect. 2005 Feb; 113(2):201-6. . View in PubMed

Association between monocyte Fcgamma subclass expression and acute coronary syndrome Immun Ageing. 2004 Nov 12; 1(1):4. . View in PubMed

Early onset of subclinical atherosclerosis in young persons with type 1 diabetes J Pediatr. 2004 Oct; 145(4):452-7. . View in PubMed

Elevated subclinical atherosclerosis associated with oophorectomy is related to time since menopause rather than type of menopause Fertil Steril. 2004 Aug; 82(2):391-7. . View in PubMed

A pooled analysis of case-control studies of thyroid cancer: cigarette smoking and consumption of alcohol, coffee, and tea Cancer Causes Control. 2003 Oct; 14(8):773-85. . View in PubMed

Environmental tobacco smoke and carotid arterial stiffness Prev Med. 2003 Aug; 37(2):148-54. . View in PubMed

Does elevated body mass modify the influence of postmenopausal estrogen replacement on atherosclerosis progression: results from the estrogen in the prevention of atherosclerosis trial Atherosclerosis. 2003 May; 168(1):91-8. . View in PubMed

Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS) Circulation. 2002 Sep 17; 106(12):1453-9. . View in PubMed

Antiatherosclerosis interventions in women Am J Cardiol. 2002 Jul 03; 90(1A):17F-21F. . View in PubMed

Atherosclerosis imaging methods: assessing cardiovascular disease and evaluating the role of estrogen in the prevention of atherosclerosis Am J Cardiol. 2002 Jun 20; 89(12A):19E-27E; discussion 27E. . View in PubMed

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