Keck School Faculty

Wendy Jean Mack

Wendy Jean Mack

Professor of Population and Public Health Sciences
SSB 202Y 2001 N. Soto Street Health Sciences Campus Los Angeles

Malignancy Risk of Thyroid Nodules That Are Not Classifiable by the American Thyroid Association Ultrasound Risk Stratification System: A Systematic Review and Meta-Analysis Thyroid. 2023 Apr 13. . View in PubMed

Generalizability of cognitive results from clinical trial participants to an older adult population: Addressing external validity Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12417. . View in PubMed

Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations Proc Natl Acad Sci U S A. 2023 Mar 28; 120(13):e2205448120. . View in PubMed

Associations of ApoE4 status and DHA supplementation on plasma and CSF lipid profiles and entorhinal cortex thickness J Lipid Res. 2023 Mar 21; 100354. . View in PubMed

Particulate matter exposure and chronic cerebral hypoperfusion promote oxidative stress and induce neuronal and oligodendrocyte apoptosis in male mice J Neurosci Res. 2023 03; 101(3):384-402. . View in PubMed

Initial Clinical Experience with a Simple, Home System for Early Detection and Monitoring of Diabetic Foot Ulcers: The Foot Selfie J Diabetes Sci Technol. 2023 01; 17(1):79-88. . View in PubMed

Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists Alzheimers Dement. 2023 01; 19(1):44-55. . View in PubMed

Author Correction: Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells BMC Biol. 2022 Oct 20; 20(1):237. . View in PubMed

Lifetime personal cigarette smoking and risk of young-onset breast cancer by subtype among non-Hispanic Black and White women in the Young Women's Health History Study Breast Cancer Res Treat. 2022 Oct; 195(3):353-366. . View in PubMed

Concentrations of endogenous sex steroid hormones and SHBG in healthy postmenopausal women J Steroid Biochem Mol Biol. 2022 Oct; 223:106080. . View in PubMed

Menopausal Hormone Replacement Therapy and Reduction of All-Cause Mortality and Cardiovascular Disease: It Is About Time and Timing Cancer J. 2022 May-Jun 01; 28(3):208-223. . View in PubMed

Comparison of Cardiovascular Disease Risk Factors Between 2 Subclinical Atherosclerosis Measures in Healthy Postmenopausal Women: Carotid Artery Wall Thickness and Echogenicity: Carotid Artery Wall Thickness and Echogenicity J Ultrasound Med. 2022 Apr 07. . View in PubMed

Improving ABCDEF Bundle Compliance and Clinical Outcomes in the ICU: Randomized Control Trial to Assess the Impact of Performance Measurement, Feedback, and Data Literacy Training Crit Care Explor. 2022 Apr; 4(4):e0679. . View in PubMed

Evaluating an Evidence-Based Parenting Intervention Among Filipino Parents: Protocol for a Pilot Randomized Controlled Trial JMIR Res Protoc. 2022 Feb 17; 11(2):e21867. . View in PubMed

Development of shoulder pain with job-related repetitive load: mechanisms of tendon pathology and anxiety J Shoulder Elbow Surg. 2022 Feb; 31(2):225-234. . View in PubMed

Effect of menopausal hormone therapy on arterial wall echomorphology: Results from the Early versus Late Intervention Trial with Estradiol (ELITE) Maturitas. 2022 08; 162:15-22. . View in PubMed

Telemedicine in Otolaryngology During COVID-19: Patient and Physician Satisfaction Otolaryngol Head Neck Surg. 2022 07; 167(1):56-64. . View in PubMed

Parental Perspectives on Immunizations: Impact of the COVID-19 Pandemic on Childhood Vaccine Hesitancy J Community Health. 2022 02; 47(1):39-52. . View in PubMed

Resident education in congenital heart surgery does not compromise outcomes J Thorac Cardiovasc Surg. 2022 01; 163(1):251-260. . View in PubMed

Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells BMC Biol. 2022 09 01; 20(1):193. . View in PubMed

Higher baseline levels of CSF inflammation increase risk of incident mild cognitive impairment and Alzheimer's disease dementia Alzheimers Dement (Amst). 2022; 14(1):e12346. . View in PubMed

Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women Clin Epigenetics. 2022 07 18; 14(1):90. . View in PubMed

Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial J Nutr. 2022 07 06; 152(7):1655-1665. . View in PubMed

A Systematic Review and Meta-Analysis of Smoking and Circulating Sex Hormone Levels Among Premenopausal Women Nicotine Tob Res. 2022 10 26; 24(11):1705-1713. . View in PubMed

Subclinical carotid artery atherosclerosis and cognitive function in older adults Alzheimers Res Ther. 2022 05 07; 14(1):63. . View in PubMed

Speech-in-noise perception in musicians and non-musicians: A multi-level meta-analysis Hear Res. 2022 03 15; 416:108442. . View in PubMed

Effect of the ABCA1 agonist CS-6253 on amyloid-ß and lipoprotein metabolism in cynomolgus monkeys Alzheimers Res Ther. 2022 06 24; 14(1):87. . View in PubMed

Neurotoxicity of Diesel Exhaust Particles J Alzheimers Dis. 2022; 89(4):1263-1278. . View in PubMed

Using a participatory method to test a strategy supporting the implementation of a state policy on screening children for adverse childhood experiences (ACEs) in a Federally Qualified Health Center system: a stepped-wedge cluster randomized trial Implement Sci Commun. 2021 Dec 20; 2(1):143. . View in PubMed

Use of oral estradiol plus vaginal progesterone in healthy postmenopausal women Maturitas. 2021 Dec; 154:13-19. . View in PubMed

Gut microbiome in people living with HIV is associated with impaired thiamine and folate syntheses Microb Pathog. 2021 Nov; 160:105209. . View in PubMed

Equivalent outcomes with minimally invasive and sternotomy mitral valve repair for degenerative mitral valve disease J Card Surg. 2021 Aug; 36(8):2636-2643. . View in PubMed

Modeling extracurricular activity participation with physical and mental health in college students over time J Am Coll Health. 2021 Jul 09; 1-9. . View in PubMed

Patient Satisfaction and Trust in Telemedicine During the COVID-19 Pandemic: Retrospective Observational Study JMIR Hum Factors. 2021 Apr 22; 8(2):e28589. . View in PubMed

Cytokine measurements add value to clinical variables in predicting outcomes for Staphylococcus aureus bacteremia BMC Infect Dis. 2021 Apr 05; 21(1):317. . View in PubMed

Acute respiratory infections in hospitalised infants with congenital heart disease Cardiol Young. 2021 Apr; 31(4):547-555. . View in PubMed

Long-term outcomes with the pulmonary autograft inclusion technique in adults with bicuspid aortic valves undergoing the Ross procedure J Thorac Cardiovasc Surg. 2021 Feb 04. . View in PubMed

Thermal Conductance Through the Skull Base From Endoscopic Surgery Cauterization Instruments: Cadaver and Goat Model Otolaryngol Head Neck Surg. 2021 12; 165(6):899-904. . View in PubMed

Regional relationships between CSF VEGF levels and Alzheimer's disease brain biomarkers and cognition Neurobiol Aging. 2021 09; 105:241-251. . View in PubMed

Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model Environ Health Perspect. 2021 08; 129(8):87006. . View in PubMed

Trends in Race/Ethnicity of Pediatric Residents and Fellows: 2007-2019 Pediatrics. 2021 07; 148(1). . View in PubMed

Volumetric distribution of perivascular space in relation to mild cognitive impairment Neurobiol Aging. 2021 03; 99:28-43. . View in PubMed

Incidence of radiation induced sarcoma attributable to radiotherapy in adults: A retrospective cohort study in the SEER cancer registries across 17 primary tumor sites Cancer Epidemiol. 2021 02; 70:101857. . View in PubMed

A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders BMC Psychiatry. 2021 06 30; 21(1):323. . View in PubMed

The Indigenous South American Tsimane Exhibit Relatively Modest Decrease in Brain Volume With Age Despite High Systemic Inflammation J Gerontol A Biol Sci Med Sci. 2021 11 15; 76(12):2147-2155. . View in PubMed

Nattokinase atherothrombotic prevention study: A randomized controlled trial Clin Hemorheol Microcirc. 2021; 78(4):339-353. . View in PubMed

Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV Cardiovasc Res. 2021 03 21; 117(4):1166-1177. . View in PubMed

Urban Air Pollution Nanoparticles from Los Angeles: Recently Decreased Neurotoxicity J Alzheimers Dis. 2021; 82(1):307-316. . View in PubMed

Quantitative Computed Tomography Assessment of Bone Deficits in Ambulatory Children and Adolescents with Spina Bifida: Importance of Puberty JBMR Plus. 2020 Dec; 4(12):e10427. . View in PubMed

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial EBioMedicine. 2020 Sep; 59:102883. . View in PubMed

Information fraction estimation based on the number of events within the standard treatment regimen Biom J. 2020 Jul 06. . View in PubMed

Parenteral nutrition prolongs hospital stay in children with nonoperative blunt pancreatic injury: A propensity score weighted analysis J Pediatr Surg. 2020 Jul; 55(7):1249-1254. . View in PubMed

Factors associated with MRI detection of occult lesions in newly diagnosed breast cancers J Surg Oncol. 2020 Mar; 121(4):589-598. . View in PubMed

Challenges in Using Insurance Claims Data to Identify Palliative Care Patients for a Research Trial J Pain Symptom Manage. 2020 11; 60(5):1012-1018. . View in PubMed

Factors Associated With Serum Estradiol Levels Among Postmenopausal Women Using Hormone Therapy Obstet Gynecol. 2020 10; 136(4):675-684. . View in PubMed

Effects of Estradiol Dose and Serum Estradiol Levels on Metabolic Measures in Early and Late Postmenopausal Women in the REPLENISH Trial J Womens Health (Larchmt). 2020 08; 29(8):1052-1058. . View in PubMed

Serum Metabolomic Response to Low- and High-Dose Vitamin E Supplementation in Two Randomized Controlled Trials Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1329-1334. . View in PubMed

Technology-Dependent Pediatric Inpatients at Children's Versus Nonchildren's Hospitals Hosp Pediatr. 2020 06; 10(6):481-488. . View in PubMed

Association of hot flushes with ghrelin and adipokines in early versus late postmenopausal women Menopause. 2020 05; 27(5):512-518. . View in PubMed

Retrospective analysis of phytoSERM for management of menopause-associated vasomotor symptoms and cognitive decline: a pilot study on pharmacogenomic effects of mitochondrial haplogroup and APOE genotype on therapeutic efficacy Menopause. 2020 01; 27(1):57-65. . View in PubMed

Feasibility of quantifying change in immune white cells in abdominal adipose tissue in response to an immune modulator in clinical obesity PLoS One. 2020; 15(9):e0237496. . View in PubMed

Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer's Disease Cooperative Study-Sponsored DHA Clinical Trial J Alzheimers Dis. 2020; 74(3):975-990. . View in PubMed

Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial Alzheimers Dement (N Y). 2020; 6(1):e12107. . View in PubMed

Effect of High Intensity Interval Training on Matrix Metalloproteinases in Women with Breast Cancer Receiving Anthracycline-Based Chemotherapy Sci Rep. 2020 04 03; 10(1):5839. . View in PubMed

Defining the Breakpoint Duration of Staphylococcus aureus Bacteremia Predictive of Poor Outcomes Clin Infect Dis. 2020 02 03; 70(4):566-573. . View in PubMed

Effects of high-intensity interval training on vascular endothelial function and vascular wall thickness in breast cancer patients receiving anthracycline-based chemotherapy: a randomized pilot study Breast Cancer Res Treat. 2019 Sep; 177(2):477-485. . View in PubMed

VRE in cirrhotic patients BMC Infect Dis. 2019 Aug 13; 19(1):711. . View in PubMed

Feasibility of high intensity interval training in patients with breast Cancer undergoing anthracycline chemotherapy: a randomized pilot trial BMC Cancer. 2019 Jul 03; 19(1):653. . View in PubMed

Levels of oligomeric a-Synuclein in reflex tears distinguish Parkinson's disease patients from healthy controls Biomark Med. 2019 12; 13(17):1447-1457. . View in PubMed

The role of the American Society of anesthesiologists physical status classification in predicting trauma mortality and outcomes Am J Surg. 2019 12; 218(6):1143-1151. . View in PubMed

Timing of tracheostomy placement among children with severe traumatic brain injury: A propensity-matched analysis J Trauma Acute Care Surg. 2019 10; 87(4):818-826. . View in PubMed

Expanding Access to Home-Based Palliative Care: A Randomized Controlled Trial Protocol J Palliat Med. 2019 09; 22(S1):58-65. . View in PubMed

Oligomeric a-synuclein is increased in basal tears of Parkinson's patients Biomark Med. 2019 08; 13(11):941-952. . View in PubMed

Safety and feasibility of estrogen receptor-ß targeted phytoSERM formulation for menopausal symptoms: phase 1b/2a randomized clinical trial Menopause. 2019 08; 26(8):874-884. . View in PubMed

Contemp Clin Trials. 2019 05; 80:1-8. . View in PubMed

Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer's disease Menopause. 2019 01; 26(1):7-15. . View in PubMed

Drug-Induced Sleep Endoscopy Findings in Supine vs Nonsupine Body Positions in Positional and Nonpositional Obstructive Sleep Apnea JAMA Otolaryngol Head Neck Surg. 2019 02 01; 145(2):159-165. . View in PubMed

Loss of CXCR4 on non-classical monocytes in participants of the Women's Interagency HIV Study (WIHS) with subclinical atherosclerosis Cardiovasc Res. 2019 05 01; 115(6):1029-1040. . View in PubMed

Optimal design for high-throughput screening via false discovery rate control Stat Med. 2019 07 10; 38(15):2816-2827. . View in PubMed

J Alzheimers Dis. 2019; 71(2):647-658. . View in PubMed

Sonographic reference values of median nerve cross-sectional area: a protocol for a systematic review and meta-analysis Syst Rev. 2019 01 03; 8(1):2. . View in PubMed

Elevated Microparticle Tissue Factor Activity Is Associated With Carotid Artery Plaque in HIV-Infected Women J Acquir Immune Defic Syndr. 2019 05 01; 81(1):36-43. . View in PubMed

Differential Effect of Plasma Estradiol on Subclinical Atherosclerosis Progression in Early vs Late Postmenopause J Clin Endocrinol Metab. 2019 02 01; 104(2):293-300. . View in PubMed

Effect of ApoE4 Genotype on the Association Between Metabolic Phenotype and Subclinical Atherosclerosis in Postmenopausal Women Am J Cardiol. 2019 10 01; 124(7):1031-1037. . View in PubMed

Videoesophagography versus Endoscopy for Prediction of Intraoperative Hiatal Hernia Size Am Surg. 2018 Mar 01; 84(3):387-391. . View in PubMed

Selective Aortic Arch and Root Replacement in Repair of Acute Type A Aortic Dissection Ann Thorac Surg. 2018 Feb; 105(2):505-512. . View in PubMed

Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention Breast Cancer Res Treat. 2018 Feb; 168(1):147-157. . View in PubMed

The authors reply Crit Care Med. 2018 12; 46(12):e1231. . View in PubMed

The Association Between Inhaled Nitric Oxide Treatment and ICU Mortality and 28-Day Ventilator-Free Days in Pediatric Acute Respiratory Distress Syndrome Crit Care Med. 2018 11; 46(11):1803-1810. . View in PubMed

Cardiovascular risk after withdrawal of hormone therapy Menopause. 2018 04; 25(4):365-367. . View in PubMed

Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor ß-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women Menopause. 2018 02; 25(2):191-196. . View in PubMed

Regional association of pCASL-MRI with FDG-PET and PiB-PET in people at risk for autosomal dominant Alzheimer's disease Neuroimage Clin. 2018; 17:751-760. . View in PubMed

Effects of high-intensity interval training on vascular function in breast cancer survivors undergoing anthracycline chemotherapy: design of a pilot study BMJ Open. 2018 06 30; 8(6):e022622. . View in PubMed

Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients Sci Rep. 2018 07 23; 8(1):11044. . View in PubMed

Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans Sci Rep. 2018 09 21; 8(1):14212. . View in PubMed

Pilot study to examine the effects of indoor daylight exposure on depression and other neuropsychiatric symptoms in people living with dementia in long-term care communities Clin Interv Aging. 2018; 13:1071-1077. . View in PubMed

Improved fracture prediction using different fracture risk assessment tool adjustments in HIV-infected women AIDS. 2018 07 31; 32(12):1699-1706. . View in PubMed

The association of C-reactive protein with subclinical cardiovascular disease in HIV-infected and HIV-uninfected women AIDS. 2018 05 15; 32(8):999-1006. . View in PubMed

The Effect of Utilization Review on Emergency Department OperationsAnn Emerg Med. 2017 Nov; 70(5):623-631. e1. . View in PubMed

Electrical risk score beyond the left ventricular ejection fraction: prediction of sudden cardiac death in the Oregon Sudden Unexpected Death Study and the Atherosclerosis Risk in Communities Study Eur Heart J. 2017 Oct 21; 38(40):3017-3025. . View in PubMed

A Critical Appraisal of Vascularized Bone Grafting for Scaphoid Nonunion J Wrist Surg. 2017 Aug; 6(3):251-257. . View in PubMed

Evaluation of Hemodynamic Performance of Aortic Valve Bioprostheses in a Model of Oversizing Ann Thorac Surg. 2017 Jun; 103(6):1866-1876. . View in PubMed

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review JAMA Neurol. 2017 Mar 01; 74(3):339-347. . View in PubMed

Mortality under plausible interventions on antiretroviral treatment and depression in HIV-infected women: an application of the parametric g-formulaAnn Epidemiol. 2017 12; 27(12):783-789. e2. . View in PubMed

Outcomes after mitral valve repair: A single-center 16-year experienceJ Thorac Cardiovasc Surg. 2017 09; 154(3):822-830. e2. . View in PubMed

Reply To: Higher Intelligence and Later Maternal Age: Which Way Does the Causal Direction Go? J Am Geriatr Soc. 2017 08; 65(8):1885-1886.. View in PubMed

Care Variations and Outcomes for Children Hospitalized With Bacterial Tracheostomy-Associated Respiratory Infections Hosp Pediatr. 2017 01; 7(1):16-23. . View in PubMed

Effects of Antiretroviral Therapy and Depressive Symptoms on All-Cause Mortality Among HIV-Infected Women Am J Epidemiol. 2017 05 15; 185(10):869-878. . View in PubMed

Estradiol Therapy After Menopause Mitigates Effects of Stress on Cortisol and Working Memory J Clin Endocrinol Metab. 2017 12 01; 102(12):4457-4466. . View in PubMed

The HIV Genomic Incidence Assay Meets False Recency Rate and Mean Duration of Recency Infection Performance Standards Sci Rep. 2017 08 07; 7(1):7480. . View in PubMed

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease Sci Transl Med. 2017 02 15; 9(377). . View in PubMed

Association of Macrophage Inflammation Biomarkers With Progression of Subclinical Carotid Artery Atherosclerosis in HIV-Infected Women and Men J Infect Dis. 2017 05 01; 215(9):1352-1361. . View in PubMed

Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis Neurology. 2016 Aug 16; 87(7):699-708. . View in PubMed

Impaired coronary artery distensibility is an endothelium-dependent process and is associated with vulnerable plaque composition Clin Physiol Funct Imaging. 2016 Jul; 36(4):261-8. . View in PubMed

A Dysregulated Balance of Proinflammatory and Anti-Inflammatory Host Cytokine Response Early During Therapy Predicts Persistence and Mortality in Staphylococcus aureus Bacteremia Crit Care Med. 2016 Apr; 44(4):671-9. . View in PubMed

Identifying postmenopausal women at risk for cognitive decline within a healthy cohort using a panel of clinical metabolic indicators: potential for detecting an at-Alzheimer's risk metabolic phenotype Neurobiol Aging. 2016 Apr; 40:155-163. . View in PubMed

Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol N Engl J Med. 2016 Mar 31; 374(13):1221-31. . View in PubMed

Systemic Immune Activation and HIV Shedding in the Female Genital Tract J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):155-62. . View in PubMed

Racial Disparity in Cognitive and Functional Disability in Hypertension and All-Cause Mortality Am J Hypertens. 2016 Feb; 29(2):185-93. . View in PubMed

A comparison of aortic valve replacement via an anterior right minithoracotomy with standard sternotomy: a propensity score analysis of 492 patients Eur J Cardiothorac Surg. 2016 Feb; 49(2):456-63. . View in PubMed

Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):172-80. . View in PubMed

Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children's Health Study Environ Health Perspect. 2016 12; 124(12):1905-1912. . View in PubMed

Effect of Reproductive History and Exogenous Hormone Use on Cognitive Function in Mid- and Late Life J Am Geriatr Soc. 2016 12; 64(12):2448-2456. . View in PubMed

Back to the future: Hormone replacement therapy as part of a prevention strategy for women at the onset of menopause Atherosclerosis. 2016 11; 254:282-290. . View in PubMed

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease Alzheimers Res Ther. 2016 06 30; 8:25. . View in PubMed

Prenatal Air Pollution Exposure and Early Cardiovascular Phenotypes in Young Adults PLoS One. 2016; 11(3):e0150825. . View in PubMed

SPMM: estimating infection duration of multivariant HIV-1 infections Bioinformatics. 2016 05 01; 32(9):1308-15. . View in PubMed

Enhancement of viral escape in HIV-1 Nef by STEP vaccination AIDS. 2016 10 23; 30(16):2449-2458. . View in PubMed

Liver Fibrosis Linked to Cognitive Performance in HIV and Hepatitis C J Acquir Immune Defic Syndr. 2016 07 01; 72(3):266-73. . View in PubMed

Falls among middle-aged women in the Women's Interagency HIV Study Antivir Ther. 2016; 21(8):697-706. . View in PubMed

Association of bilateral oophorectomy with cognitive function in healthy, postmenopausal womenFertil Steril. 2016 09 01; 106(3):749-756. e2. . View in PubMed

Molecular clock of HIV-1 envelope genes under early immune selection Retrovirology. 2016 06 01; 13(1):38. . View in PubMed

Differential effects of ischemic vascular disease and Alzheimer's disease on brain atrophy and cognition J Cereb Blood Flow Metab. 2016 Jan; 36(1):204-15. . View in PubMed

Electrocardiographic Markers and the Left Ventricular Ejection Fraction have Cumulative Effects on Risk of Sudden Cardiac Death JACC Clin Electrophysiol. 2015 Dec 01; 1(6):542-550. . View in PubMed

HIV Infection Is Associated With Progression of Subclinical Carotid Atherosclerosis Clin Infect Dis. 2015 Aug 15; 61(4):640-50. . View in PubMed

Human immunodeficiency virus (HIV) modulates the associations between insulin resistance and cognition in the current combination antiretroviral therapy (cART) era: a study of the Women's Interagency HIV Study (WIHS) J Neurovirol. 2015 Aug; 21(4):415-21. . View in PubMed

Perimenopause as a neurological transition state Nat Rev Endocrinol. 2015 Jul; 11(7):393-405. . View in PubMed

The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity Neurobiol Aging. 2015 Jul; 36(7):2282-2295. . View in PubMed

Lymph node status in inflammatory breast cancer Breast Cancer Res Treat. 2015 May; 151(1):113-20. . View in PubMed

Hormone therapy and risk of all-cause mortality in women treated with statins Menopause. 2015 Apr; 22(4):363-4. . View in PubMed

Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis Menopause. 2015 Apr; 22(4):391-401. . View in PubMed

Aldosterone, cognitive function, and cerebral hemodynamics in hypertension and antihypertensive therapy Am J Hypertens. 2015 Mar; 28(3):319-25. . View in PubMed

Abnormal blood rheology and chronic low grade inflammation: possible risk factors for accelerated atherosclerosis and coronary artery disease in Lewis negative subjects Atherosclerosis. 2015 Mar; 239(1):248-51. . View in PubMed

Echolucency of the carotid artery intima-media complex and intima-media thickness have different cardiovascular risk factor relationships: the Women's Interagency HIV Study J Am Heart Assoc. 2015 Feb 19; 4(2). . View in PubMed

Rarity of the Alzheimer disease-protective APP A673T variant in the United States JAMA Neurol. 2015 Feb; 72(2):209-16. . View in PubMed

Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women J Clin Endocrinol Metab. 2015 Feb; 100(2):508-15. . View in PubMed

Nevirapine Concentration in Hair Samples Is a Strong Predictor of Virologic Suppression in a Prospective Cohort of HIV-Infected Patients PLoS One. 2015; 10(6):e0129100. . View in PubMed

Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye PLoS One. 2015; 10(9):e0138958. . View in PubMed

Serum amyloid a truncations in type 2 diabetes mellitus PLoS One. 2015; 10(1):e0115320. . View in PubMed

T-cell activation, both pre- and post-HAART levels, correlates with carotid artery stiffness over 65 years among HIV-infected women in the WIHS. J Acquir Immune Defic Syndr. 2014 Nov 01; 67(3):349-56. . View in PubMed

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study JAMA Neurol. 2014 Nov; 71(11):1394-404. . View in PubMed

Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women AIDS. 2014 Jul 31; 28(12):1815-23. . View in PubMed

Hormone replacement therapy and the association with coronary heart disease and overall mortality: clinical application of the timing hypothesis J Steroid Biochem Mol Biol. 2014 Jul; 142:68-75. . View in PubMed

Tear cathepsin S as a candidate biomarker for Sjögren's syndrome Arthritis Rheumatol. 2014 Jul; 66(7):1872-81. . View in PubMed

Vascular risk and Aß interact to reduce cortical thickness in AD vulnerable brain regions Neurology. 2014 Jul 01; 83(1):40-7. . View in PubMed

Effect of prior oophorectomy on changes in bone mineral density and carotid artery intima-media thickness in postmenopausal women Fertil Steril. 2014 Apr; 101(4):1117-22. . View in PubMed

Associations between urine excretion of isoflavonoids and cognition in postmenopausal women in the Women's Isoflavone Soy Health clinical trial J Am Geriatr Soc. 2014 Apr; 62(4):629-35. . View in PubMed

Cortical thickness mediates the effect of ß-amyloid on episodic memory Neurology. 2014 Mar 04; 82(9):761-7. . View in PubMed

Associations between serum cholesterol levels and cerebral amyloidosis JAMA Neurol. 2014 Feb; 71(2):195-200. . View in PubMed

The role of carotid intima-media thickness in predicting longitudinal cognitive function in an older adult cohort Cerebrovasc Dis. 2014; 38(6):441-7. . View in PubMed

Response letter to DrTimo Strandberg. J Am Geriatr Soc. 2014 Jan; 62(1):206-7. . View in PubMed

Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles Neurotoxicology. 2014 Jan; 40:1-7. . View in PubMed

Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. . View in PubMed

Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes Stroke. 2013 Oct; 44(10):2835-41. . View in PubMed

Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown JAMA Neurol. 2013 Sep 01; 70(9):1198-200. . View in PubMed

Effect of isoflavone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized controlled trial Menopause. 2013 Aug; 20(8):840-4. . View in PubMed

Response to letter regarding article, “Childhood air pollutant exposure and carotid artery intima–media thickness in young adults” Circulation. 2013 Jun 04; 127(22):e659. . View in PubMed

The timing hypothesis and hormone replacement therapy: a paradigm shift in the primary prevention of coronary heart disease in womenPart 2: comparative risks. J Am Geriatr Soc. 2013 Jun; 61(6):1011-1018. . View in PubMed

The timing hypothesis and hormone replacement therapy: a paradigm shift in the primary prevention of coronary heart disease in womenPart 1: comparison of therapeutic efficacy. J Am Geriatr Soc. 2013 Jun; 61(6):1005-1010. . View in PubMed

Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach AIDS. 2013 Jun 01; 27(9):1473-81. . View in PubMed

Birth weight and carotid artery intima-media thicknessJ Pediatr. 2013 May; 162(5):906-11. e1-2. . View in PubMed

The aging brain and cognition: contribution of vascular injury and aß to mild cognitive dysfunction JAMA Neurol. 2013 Apr; 70(4):488-95. . View in PubMed

Gonadotropin and sex steroid levels in HIV-infected premenopausal women and their association with subclinical atherosclerosis in HIV-infected and -uninfected women in the women's interagency HIV study (WIHS) J Clin Endocrinol Metab. 2013 Apr; 98(4):E610-8. . View in PubMed

Alzheimer pathology and angiotension receptor blockers JAMA Neurol. 2013 Mar 01; 70(3):414. . View in PubMed

Antihypertensive therapy and cerebral hemodynamics in executive mild cognitive impairment: results of a pilot randomized clinical trial J Am Geriatr Soc. 2013 Feb; 61(2):194-201. . View in PubMed

Pioglitazone slows progression of atherosclerosis in prediabetes independent of changes in cardiovascular risk factors Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):393-9. . View in PubMed

Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI PLoS One. 2013; 8(6):e65175. . View in PubMed

Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series Arch Neurol. 2012 Dec; 69(12):1632-8. . View in PubMed

Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults Stroke. 2012 Nov; 43(11):2865-70. . View in PubMed

Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine AIDS. 2012 Oct 23; 26(16):2097-106. . View in PubMed

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Hormone levels and cognitive function in postmenopausal midlife women Neurobiol Aging. 2012 Jul; 33(7):1138-47. . View in PubMed

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Associations of cardiovascular variables and HAART with cognition in middle-aged HIV-infected and uninfected women J Neurovirol. 2011 Oct; 17(5):469-76. . View in PubMed

Physical activity and sex hormone levels in estradiol- and placebo-treated postmenopausal women Menopause. 2011 Oct; 18(10):1079-86. . View in PubMed

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Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease J Aging Res. 2011; 2011:187219. . View in PubMed

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Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women Menopause. 2010 Jul; 17(4):785-90. . View in PubMed

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Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study Am J Psychiatry. 2010 May; 167(5):589-97. . View in PubMed

Factors influencing driving status in an older Latino population J Aging Health. 2010 Apr; 22(3):332-47. . View in PubMed

Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus J Infect Dis. 2010 Mar 15; 201(6):823-34. . View in PubMed

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Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women J Clin Endocrinol Metab. 2009 Nov; 94(11):4136-43. . View in PubMed

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Effect of antihypertensive therapy on progression of carotid intima-media thickness in patients with type 2 diabetes mellitus Am J Cardiol. 2007 Apr 01; 99(7):956-60. . View in PubMed

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Unopposed estradiol therapy in postmenopausal women: results from two randomized trials Obstet Gynecol. 2007 Mar; 109(3):581-7. . View in PubMed

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Platelet FcgammaRIIA receptor surface expression is increased in patients with ESRD and is associated with atherosclerotic cardiovascular events Am J Kidney Dis. 2007 Jan; 49(1):127-34. . View in PubMed

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The effect of education and occupational complexity on rate of cognitive decline in Alzheimer's patients J Int Neuropsychol Soc. 2006 Jan; 12(1):147-52. . View in PubMed

Postmenopausal oral estrogen therapy and blood pressure in normotensive and hypertensive subjects: the Estrogen in the Prevention of Atherosclerosis Trial Menopause. 2005 Nov-Dec; 12(6):728-33. . View in PubMed

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Determinants of the effect of estrogen on the progression of subclinical atherosclerosis: Estrogen in the Prevention of Atherosclerosis Trial Menopause. 2005 Jul-Aug; 12(4):366-73. . View in PubMed

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Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study Breast Cancer Res. 2005; 7(3):R336-44. . View in PubMed

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Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort Am J Med Sci. 2004 Nov; 328(5):266-73. . View in PubMed

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Elevated subclinical atherosclerosis associated with oophorectomy is related to time since menopause rather than type of menopause Fertil Steril. 2004 Aug; 82(2):391-7. . View in PubMed

A pooled analysis of case-control studies of thyroid cancer: cigarette smoking and consumption of alcohol, coffee, and tea Cancer Causes Control. 2003 Oct; 14(8):773-85. . View in PubMed

Time from diagnosis of type 2 diabetes to initiation of insulin therapy is related to carotid artery intima-media thickness Atherosclerosis. 2003 Oct; 170(2):293-9. . View in PubMed

Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women N Engl J Med. 2003 Aug 07; 349(6):535-45. . View in PubMed

Environmental tobacco smoke and carotid arterial stiffness Prev Med. 2003 Aug; 37(2):148-54. . View in PubMed

Randomized controlled trial evidence that estrogen replacement therapy reduces the progression of subclinical atherosclerosis in healthy postmenopausal women without preexisting cardiovascular disease Circulation. 2003 Jul 08; 108(1):e5; author reply e5. . View in PubMed

Does elevated body mass modify the influence of postmenopausal estrogen replacement on atherosclerosis progression: results from the estrogen in the prevention of atherosclerosis trial Atherosclerosis. 2003 May; 168(1):91-8. . View in PubMed

What is the cardioprotective role of hormone replacement therapy? Curr Atheroscler Rep. 2003 Jan; 5(1):56-66.. View in PubMed

Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS) Circulation. 2002 Sep 17; 106(12):1453-9. . View in PubMed

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Antiatherosclerosis interventions in women Am J Cardiol. 2002 Jul 03; 90(1A):17F-21F. . View in PubMed

Atherosclerosis imaging methods: assessing cardiovascular disease and evaluating the role of estrogen in the prevention of atherosclerosis Am J Cardiol. 2002 Jun 20; 89(12A):19E-27E; discussion 27E. . View in PubMed

Postmenopausal hormone replacement therapy as antiatherosclerotic therapy Curr Atheroscler Rep. 2002 Jan; 4(1):52-8. . View in PubMed

Wendy Mack, PhD, is a professor of biostatistics in the Department of Preventive Medicine at the Keck School of Medicine of USC. She co-directs the department’s Division of Biostatistics graduate programs and directs Biostatistics Resources at the Southern California Clinical and Translational Science Institute (SC CTSI).

Professor Mack has more than 20 years of experience directing biostatistical and data coordination activities, primarily funded by the National Institutes of Health (NIH). Her expertise includes design, conduct and analysis of multiple single-centered and multi-centered clinical trials and observational studies. She also directs biostatistical activities for the USC Alzheimer’s Disease Research Center and for other basic and clinical research programs.

She has served on numerous NIH study sections for biostatistical expertise and has recently completed a term on the NHLBI Clinical Trials Review study section. Professor Mack received her doctorate from the University of Southern California. Her home is open to needy animals wandering by, and she dabbles in competitive dog obedience in her minimal spare time.
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