Keck School Faculty

William Mack, MD
William Mack, MD
Professor of Neurological Surgery (Clinical Scholar); Director, Neurointerventional Program, Keck Hospital of USC; Director, Neurosurgery Ambulatory Services, Keck Medical Center of USC; Vice Chair, Academic Affairs
Neurological Surgery
GNH 3300 Health Sciences Campus Los Angeles
Dr. Mack's major areas of clinical interest are stroke, brain aneurysms, subarachnoid hemorrhage, arteriovenous malformations (AVMs), arteriovenous fistulas, cavernous malformations, carotid artery disease, intracranial stenosis, and brain tumors. Dr. Mack performs both open surgery and minimally invasive, endovascular procedures for cerebrovascular disorders.

Dr. Mack is a faculty member of the Neuroscience Graduate Program and is the Principal Investigator and Director of the Cerebrovascular Laboratory in the Zilkha Neurogenetic Institute. He receives NIH R01 funding for his laboratory research. Dr. Mack’s scientific interests are focused on translational efforts to treat ischemic and hemorrhagic stroke. Laboratory investigations concentrate on the pathophysiology of cerebral ischemia and inflammatory modulation. Using the information and experience gained in the laboratory, Dr. Mack is working to develop new technologies, techniques, and therapies to directly improve the clinical care administered to stroke patients.

William Mack, MD, received his Bachelor degree with honors from Cornell University. He then attended Columbia University, College of Physicians and Surgeons, where he graduated from medical school (Alpha Omega Alpha) and completed Neurosurgical residency training. During residency, he spent one year performing a post-doctoral cerebrovascular research fellowship under Drs. David J. Pinsky and E. Sander Connolly Jr. at Columbia University. Following residency, Dr. Mack completed an Interventional Neuroradiology/ Neuroendovascular Surgery fellowship at UCLA.

Dr. Mack is board certified by the American Board of Neurological Surgery (FAANS) and is a fellow of the American Heart Association (FAHA) and. He is a committee member on the executive council of the Congress of Neurological Surgeons/ American Association of Neurological Surgeons’ Cerebrovascular Section. Dr. Mack serves as an Associate Editor of the Journal of Neurointerventional Surgery and on the editorial board of World Neurosurgery.

Bow Hunter's Syndrome: Surgical Management (Video) and Review of the LiteratureWorld Neurosurg. 2017 Jul; 103:953. e7-953. e12. . View in PubMed

Increased complication and mortality among non-index hospital readmissions after brain tumor resection is associated with low-volume readmitting hospitals J Neurosurg. 2019 Oct 04; 1-13. . View in PubMed

Cell signaling associated with internalization of 67 kDa laminin receptor (67LR) by soluble laminin and its implication for protection against neurodegenerative diseases Neural Regen Res. 2019 Sep; 14(9):1513-1514. . View in PubMed

Neuroendovascular surgery: a modern family J Neurointerv Surg. 2019 Aug; 11(8):733-734. . View in PubMed

Frequency, predictors, and outcomes of readmission to index versus non-index hospitals after mechanical thrombectomy in patients with ischemic stroke J Neurointerv Surg. 2019 Jul 26. . View in PubMed

Acute Venous Thromboembolism Risk Highest Within 60 Days After Discharge From the Hospital in Patients With Inflammatory Bowel Diseases Clin Gastroenterol Hepatol. 2019 Jul 20. . View in PubMed

Acute Left M1 Stroke With Critical Left Internal Carotid Artery Stenosis: Video Case Neurosurgery. 2019 Jul 01; 85(suppl_1):S73. . View in PubMed

A joint statement from the Neurointerventional Societies: our position on operator experience and training for stroke thrombectomy J Neurointerv Surg. 2019 Jun; 11(6):533-534. . View in PubMed

Hypertensive Postpartum Admissions Among Women Without a History of Hypertension or Preeclampsia Obstet Gynecol. 2019 Apr; 133(4):712-719. . View in PubMed

Early Readmission After Ventricular Shunting in Adults with Hydrocephalus: A Nationwide Readmission Database Analysis World Neurosurg. 2019 Mar 28. . View in PubMed

Hypertensive Postpartum Admissions Among Women Without a History of Hypertension or Preeclampsia Obstet Gynecol. 2019 Mar 11. . View in PubMed

Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery Neurosurgery. 2019 Mar 01; 84(3):726-732. . View in PubMed

Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum J Cereb Blood Flow Metab. 2019 Feb; 39(2):240-250. . View in PubMed

Commentary: Trends in the Use of Deep Brain Stimulation for Parkinson Disease Neurosurgery. 2018 Dec 01; 83(6):E244-E256. . View in PubMed

A3-A3 Anastomosis in the Management of Complex Anterior Cerebral Artery Aneurysms: Experience With in Situ Bypass and Lessons Learned From Pseudoaneurysm Cases Oper Neurosurg (Hagerstown). 2018 Nov 21. . View in PubMed

Factors associated with burnout among US neurosurgery residents: a nationwide survey J Neurosurg. 2018 Nov 01; 129(5):1349-1363. . View in PubMed

Fusiform vertebral artery aneurysms involving the posterior inferior cerebellar artery origin associated with the sole angiographic anterior spinal artery origin: technical case report and treatment paradigm proposal J Neurosurg. 2018 Oct 01; 1-7. . View in PubMed

Efficacy and Outcomes of Posterior Inferior Cerebellar Artery (PICA) Bypass for Proximal PICA and Vertebral Artery-PICA Aneurysms: A Case Series Oper Neurosurg (Hagerstown). 2018 Oct 01; 15(4):395-403. . View in PubMed

Commentary: Trends in the Use of Deep Brain Stimulation for Parkinson Disease Neurosurgery. 2018 Sep 28. . View in PubMed

Descending Branch of the Lateral Circumflex Femoral Artery Graft for Posterior Inferior Cerebellar Artery Revascularization Oper Neurosurg (Hagerstown). 2018 Sep 01; 15(3):285-291. . View in PubMed

In the thrombectomy era, triage in the field improves care J Neurointerv Surg. 2018 Jul; 10(7):607-608. . View in PubMed

Commentary on 'Is periprocedural sedation during acute stroke therapy associated with poorer functional outcomes? ' J Neurointerv Surg. 2018 Jul; 10(Suppl 1):i39.. View in PubMed

Estradiol Protects White Matter of Male C57BL6J Mice against Experimental Chronic Cerebral Hypoperfusion J Stroke Cerebrovasc Dis. 2018 Jul; 27(7):1743-1751. . View in PubMed

Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery Neurosurgery. 2018 Jun 08. . View in PubMed

Estradiol Protects White Matter of Male C57BL6J Mice against Experimental Chronic Cerebral Hypoperfusion J Stroke Cerebrovasc Dis. 2018 Mar 27. . View in PubMed

Neuroendovascular management of emergent large vessel occlusion: update on the technical aspects and standards of practice by the Standards and Guidelines Committee of the Society of NeuroInterventional Surgery J Neurointerv Surg. 2018 Mar; 10(3):315-320. . View in PubMed

A2 Anterior Cerebral Artery-to-A3 Anterior Cerebral Artery Interpositional Bypass with Radial Artery Graft for a Ruptured Mycotic Fusiform Aneurysm: 2-Dimensional Operative Video Oper Neurosurg (Hagerstown). 2018 Feb 10. . View in PubMed

Factors associated with burnout among US neurosurgery residents: a nationwide survey J Neurosurg. 2018 Feb 09; 1-15. . View in PubMed

Commentary on 'Is periprocedural sedation during acute stroke therapy associated with poorer functional outcomes? ' J Neurointerv Surg. 2018 07; 10(Suppl 1):i39.. View in PubMed

In the thrombectomy era, triage in the field improves care J Neurointerv Surg. 2018 07; 10(7):607-608. . View in PubMed

Hospital and demographic characteristics associated with inpatient neurological services in the United States Clin Neurol Neurosurg. 2018 01; 164:39-43. . View in PubMed

Hospital and demographic characteristics associated with inpatient neurological services in the United States Clin Neurol Neurosurg. 2018 Jan; 164:39-43. . View in PubMed

Fusiform vertebral artery aneurysms involving the posterior inferior cerebellar artery origin associated with the sole angiographic anterior spinal artery origin: technical case report and treatment paradigm proposal J Neurosurg. 2018 10 01; 1-7. . View in PubMed

Laminin-1 induces endocytosis of 67KDa laminin receptor and protects Neuroscreen-1 cells against death induced by serum withdrawal Biochem Biophys Res Commun. 2018 01 01; 495(1):230-237. . View in PubMed

A survey of intracranial aneurysm treatment practices among United States physicians J Neurointerv Surg. 2018 Jan; 10(1):44-49. . View in PubMed

Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum PLoS One. 2018; 13(11):e0206934. . View in PubMed

Factors associated with burnout among US neurosurgery residents: a nationwide survey J Neurosurg. 2018 11 01; 129(5):1349-1363. . View in PubMed

Efficacy and Outcomes of Posterior Inferior Cerebellar Artery (PICA) Bypass for Proximal PICA and Vertebral Artery-PICA Aneurysms: A Case Series Oper Neurosurg (Hagerstown). 2018 10 01; 15(4):395-403. . View in PubMed

Development of a Perfusion-Based Cadaveric Simulation Model Integrated into Neurosurgical Training: Feasibility Based On Reconstitution of Vascular and Cerebrospinal Fluid Systems Oper Neurosurg (Hagerstown). 2018 Jan 01; 14(1):72-80. . View in PubMed

Development of a Perfusion-Based Cadaveric Simulation Model Integrated into Neurosurgical Training: Feasibility Based On Reconstitution of Vascular and Cerebrospinal Fluid Systems Oper Neurosurg (Hagerstown). 2018 01 01; 14(1):72-80. . View in PubMed

Chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis causes selective recognition impairment in adult mice Neurol Res. 2017 Oct; 39(10):910-917. . View in PubMed

Clinical effects of air pollution on the central nervous system; a review J Clin Neurosci. 2017 Sep; 43:16-24. . View in PubMed

ACR Appropriateness Criteria® Cerebrovascular Disease J Am Coll Radiol. 2017 May; 14(5S):S34-S61. . View in PubMed

Minimally Invasive Surgical Approaches for Chronic Subdural Hematomas Neurosurg Clin N Am. 2017 Apr; 28(2):219-227. . View in PubMed

Impact of the 2003 ACGME Resident Duty Hour Reform on Hospital-Acquired Conditions: A National Retrospective Analysis J Grad Med Educ. 2017 Apr; 9(2):215-221. . View in PubMed

Introduction: New techniques and technologies in the management of ischemic stroke Neurosurg Focus. 2017 04; 42(4):E1. . View in PubMed

Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients Neuroimage Clin. 2017; 15:239-246. . View in PubMed

J Cereb Blood Flow Metab. 2017 Jan 01; 271678X17743670. . View in PubMed

J Cereb Blood Flow Metab. 2017 Jan 01; 271678X17743670. . View in PubMed

Infection rate correlated with time to repair of open neural tube defects (myelomeningoceles): an institutional and national study Childs Nerv Syst. 2016 Sep; 32(9):1675-81. . View in PubMed

Evaluation of time to aneurysm treatment following subarachnoid hemorrhage: comparison of patients treated with clipping versus coiling J Neurointerv Surg. 2016 Apr; 8(4):373-7. . View in PubMed

Cross-Sectional Analysis on Racial and Economic Disparities Affecting Mortality in Preterm Infants with Posthemorrhagic Hydrocephalus World Neurosurg. 2016 Apr; 88:399-410. . View in PubMed

Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products Neural Regen Res. 2016 Apr; 11(4):545-6. . View in PubMed

Assessing characteristics of RNA amplification methods for single cell RNA sequencing BMC Genomics. 2016 11 24; 17(1):966. . View in PubMed

Casting a wide net: the unique diversity of neuroendovascular surgery J Neurointerv Surg. 2015 Aug; 7(8):549-50. . View in PubMed

Evaluation of weekend admission on the prevalence of hospital acquired conditions in patients receiving thoracolumbar fusions J Clin Neurosci. 2015 Aug; 22(8):1349-54. . View in PubMed

Evaluation of Effect of Weekend Admission on the Prevalence of Hospital-Acquired Conditions in Patients Receiving Cervical Fusions World Neurosurg. 2015 Jul; 84(1):58-68. . View in PubMed

Going Big to Explore the Detail World Neurosurg. 2015 Jun; 83(6):1041-3. . View in PubMed

Incidence of "never events" among weekend admissions versus weekday admissions to US hospitals: national analysis BMJ. 2015 Apr 15; 350:h1460. . View in PubMed

Endovascular therapy for acute ischemic stroke is indicated and evidence based: a position statement J Neurointerv Surg. 2015 Feb; 7(2):79-81. . View in PubMed

A research roadmap of future endovascular stroke trials J Neurointerv Surg. 2015 Feb; 7(2):82-3. . View in PubMed

Demographic factors, outcomes, and patient access to transsphenoidal surgery for Cushing's disease: analysis of the Nationwide Inpatient Sample from 2002 to 2010 Neurosurg Focus. 2015 Feb; 38(2):E2. . View in PubMed

Final results of the multicenter, prospective Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm Study (AMERICA) J Neurointerv Surg. 2015 Jan; 7(1):40-3. . View in PubMed

Balloon test occlusion in the setting of vessel sacrifice: procedural refinements and adjunct assessment measures World Neurosurg. 2015 Jan; 83(1):7-8. . View in PubMed

Hospital and demographic characteristics associated with advanced primary stroke center designation Stroke. 2014 Dec; 45(12):3717-9. . View in PubMed

Health disparities in time to aneurysm clipping/coiling among aneurysmal subarachnoid hemorrhage patients: a national study World Neurosurg. 2014 Dec; 82(6):1071-6. . View in PubMed

Matrix metalloproteinase-9: dual role and temporal profile in intracerebral hemorrhage J Stroke Cerebrovasc Dis. 2014 Nov-Dec; 23(10):2498-505. . View in PubMed

Early results of the Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm (AMERICA) study: a multicenter prospective observational registry J Neurointerv Surg. 2014 Sep; 6(7):495-9. . View in PubMed

Balloon-assisted transarterial embolization of type 1 spinal dural arteriovenous fistula Neurosurg Focus. 2014 Jul; 37(1 Suppl):1. . View in PubMed

A persistent primitive hypoglossal artery arising from the external carotid artery associated with subarachnoid hemorrhageWorld Neurosurg. 2014 Jul-Aug; 82(1-2):239. e1-3. . View in PubMed

Expansion of US. emergency medical service routing for stroke care: 2000-2010. West J Emerg Med. 2014 Jul; 15(4):499-503. . View in PubMed

Anticoagulation in the setting of intracerebral hemorrhage: controversies in resuming therapy World Neurosurg. 2014 May-Jun; 81(5-6):669-70. . View in PubMed

Effects of ionizing radiation on cerebral vasculature World Neurosurg. 2014 Mar-Apr; 81(3-4):490-1. . View in PubMed

Health-related quality of life after aneurysmal subarachnoid hemorrhage: interplay between physical, cognitive, and emotional factors World Neurosurg. 2014 Jan; 81(1):37-9. . View in PubMed

Magnesium: potential roles in neurovascular disease Front Neurol. 2014; 5:52. . View in PubMed

Considering radiation exposure during diagnostic and therapeutic procedures for arteriovenous malformations in the setting of pregnancy World Neurosurg. 2014 Jan; 81(1):22-4. . View in PubMed

A proposed grading system for standardizing tumor consistency of intracranial meningiomas Neurosurg Focus. 2013 Dec; 35(6):E1. . View in PubMed

Genomic and transcriptome analysis revealing an oncogenic functional module in meningiomas Neurosurg Focus. 2013 Dec; 35(6):E3. . View in PubMed

A review of epigenetic and gene expression alterations associated with intracranial meningiomas Neurosurg Focus. 2013 Dec; 35(6):E5. . View in PubMed

Impact of emergency medical services stroke routing protocols on Primary Stroke Center certification in California Stroke. 2013 Dec; 44(12):3584-6. . View in PubMed

Mechanical thrombectomy in acute stroke: utilization variances and impact of procedural volume on inpatient mortality J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):1263-9. . View in PubMed

Emerging experimental therapies for intracerebral hemorrhage: targeting mechanisms of secondary brain injury Neurosurg Focus. 2013 May; 34(5):E9. . View in PubMed

Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage Neurol Res Int. 2013; 2013:943761. . View in PubMed

Characterizing immunoglobulin repertoire from whole blood by a personal genome sequencer PLoS One. 2013; 8(9):e75294. . View in PubMed

Cerebral vasospasm in traumatic brain injury Neurol Res Int. 2013; 2013:415813. . View in PubMed

Invasive and noninvasive multimodal bedside monitoring in subarachnoid hemorrhage: a review of techniques and available data Neurol Res Int. 2013; 2013:987934. . View in PubMed

Advanced imaging modalities in the detection of cerebral vasospasm Neurol Res Int. 2013; 2013:415960. . View in PubMed

Medical Management of Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage: A Review of Current and Emerging Therapeutic Interventions Neurol Res Int. 2013; 2013:462491. . View in PubMed

DNA methylation in the malignant transformation of meningiomas PLoS One. 2013; 8(1):e54114. . View in PubMed

Mechanical thrombectomy for acute ischemic stroke using the MERCI retriever and penumbra aspiration systems World Neurosurg. 2011 Dec; 76(6 Suppl):S16-23. . View in PubMed

Molecular genetics of meningiomas: a systematic review of the current literature and potential basis for future treatment paradigms Neurosurg Focus. 2011 May; 30(5):E7. . View in PubMed

Endovascular management of anterior cranial fossa dural arteriovenous malformationsA technical report and anatomical discussion. Interv Neuroradiol. 2011 Mar; 17(1):93-103. . View in PubMed

Intraoperative magnesium infusion during carotid endarterectomy: a double-blind placebo-controlled trial J Neurosurg. 2009 May; 110(5):961-7. . View in PubMed

Doppler ultrasonography screening of poor-grade subarachnoid hemorrhage patients increases the diagnosis of deep venous thrombosis Neurol Res. 2008 Nov; 30(9):889-92. . View in PubMed

Deep hypothermic circulatory arrest for complex cerebral aneurysms: lessons learned Neurosurgery. 2008 Jun; 62(6 Suppl 3):1311-23. . View in PubMed

C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent J Cereb Blood Flow Metab. 2008 May; 28(5):1048-58. . View in PubMed

Congenital pterional dermal sinus in an 18-month-old child: case report Neurosurgery. 2007 Sep; 61(3):E661; discussion E661. . View in PubMed

Early plasma complement C3a levels correlate with functional outcome after aneurysmal subarachnoid hemorrhage Neurosurgery. 2007 Aug; 61(2):255-60; discussion 260-1. . View in PubMed

Deep hypothermic circulatory arrest for complex cerebral aneurysms: lessons learned Neurosurgery. 2007 May; 60(5):815-27; discussion 815-27. . View in PubMed

Clinicoradiological review: bilateral ethmoidal artery dural arteriovenous fistulas Neurosurgery. 2007 Jan; 60(1):131-5; discussion 135-6. . View in PubMed

A cerebroprotective dose of intravenous citrate/sorbitol-stabilized dehydroascorbic acid is correlated with increased cerebral ascorbic acid and inhibited lipid peroxidation after murine reperfused stroke Neurosurgery. 2006 Aug; 59(2):383-8; discussion 383-8. . View in PubMed

Complement component C3 mediates inflammatory injury following focal cerebral ischemia Circ Res. 2006 Jul 21; 99(2):209-17. . View in PubMed

Galbraith Award: evaluation of risk factors associated with neurocognitive changes after carotid endarterectomy Clin Neurosurg. 2006; 53:301-6. . View in PubMed

Elevations in preoperative monocyte count predispose to acute neurocognitive decline after carotid endarterectomy for asymptomatic carotid artery stenosis Stroke. 2006 Jan; 37(1):240-2. . View in PubMed

Co-registration of radiographic and pathologic infarct territory in a non-human primate model of stroke Neurol Res. 2005 Sep; 27(6):634-7. . View in PubMed

Herniation secondary to critical postcraniotomy cerebrospinal fluid hypovolemia Neurosurgery. 2005 Aug; 57(2):286-92; discussion 286-92. . View in PubMed

Clinicopathological review: tumefactive demyelination in a 12-year-old girl Neurosurgery. 2005 May; 56(5):1051-7; discussion 1051-7. . View in PubMed

Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurysmal subarachnoid hemorrhage: a matched controlled cohort study Neurosurgery. 2005 Mar; 56(3):476-84; discussion 476-84. . View in PubMed

An extramedullary foramen magnum cavernous malformation presenting with acute subarachnoid hemorrhage: case report and literature review Neurosurgery. 2005 Feb; 56(2):E410; discussion E410. . View in PubMed

A modified transorbital baboon model of reperfused stroke Methods Enzymol. 2004; 386:60-73. . View in PubMed

Intracranial pressure following aneurysmal subarachnoid hemorrhage: monitoring practices and outcome data Neurosurg Focus. 2003 Apr 15; 14(4):e3. . View in PubMed

An improved functional neurological examination for use in nonhuman primate studies of focal reperfused cerebral ischemia Neurol Res. 2003 Apr; 25(3):280-4. . View in PubMed

HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke Circ Res. 2002 Nov 15; 91(10):907-14. . View in PubMed

Interhemispheric intracranial pressure gradients in nonhuman primate stroke Surg Neurol. 2002 Nov; 58(5):295-301; discussion 301. . View in PubMed

A controlled prospective study of neuropsychological dysfunction following carotid endarterectomy Arch Neurol. 2002 Feb; 59(2):217-22. . View in PubMed

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