Yang Chai, DMD, PhD, DDS

University Professor and Associate Dean, Research and Director, Center for Craniofacial Molecular Biology

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Overview

Yang Chai, DMD, PhD, DDS is the chair of the National Institute of Dental and Craniofacial Research Board of Scientific Counselors.

Professor Chai, who holds the George and Mary Lou Boone Chair in Craniofacial Biology and is the associate dean of research and director of the Center for Craniofacial Molecular Biology at the Ostrow School, has been a member of the board since 2008 and will serve a one-year term as chair. A total of nine board members, including the chair, are selected from among the most accomplished and celebrated experts in biomedical, dental and craniofacial science.

Chai is internationally renowned for his research into the genetics, cellular signaling, and development of cranial and facial structures, including the causes of and potential preventive measures for facial deformities such as cleft palate. Among his many honors, he has received a National Institutes of Health MERIT Award, has been elected as an American Association for the Advancement of Sciences Fellow, has received an International Association for Dental Research Distinguished Scientist Award, and has served on the editorial boards of several scientific journals. He is also an alumnus of the Ostrow School of Dentistry and is an award-winning educator and a practicing dentist at the school.

Awards

  • NIDCR, NIH: Chair of the Board of Scientific Counselors, 2013
  • Craniofacial Biology Research Award: IADR Distinguished Scientist Award, 2011
  • Journal of Bone and Mineral Research: Editorial Board, 2010-2014
  • American Association for the Advancement of Sciences (AAAS) Elected Fellow, 2010
  • NIH: NIH MERIT Award, 2010
  • NIDCR, NIH: Member of the Board of Scientific Counselors, 2008-2012
  • JBMR: Editorial Board DEVELOPMENTAL BIOLOGY, 2007-2014
  • University of Southern California: James H. Zumberge Faculty Research and Innovation Award, 2007
  • The Chinese Journal of Dental Research: Editorial Board, 2006-2014
  • Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, 2006
  • Regular member of SBDD study section CSR NIH, 2004-2008
  • Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, 2004
  • NIH Ad hoc grant reviewer (OBM-2, ODCS) and Reviewer for the Welcome Trust, UK, 2002-2014
  • University of Southern California: Award of Excellence in Teaching, 2001-2003
  • University of Southern California: Annual Excellence in Teaching Award, 1997
  • University of Southern California: James H. Zumberge Faculty Research and Innovation Award, 1997
  • OKU Scholarship award for outstanding academic performance, 1996
  • Special Recognition by the Dean for outstanding service and contribution to the University of Southe, 1996
  • University of Southern California, School of Dentistry: Annual Teaching Award, 1995
  • University of Southern California, (GPA 4.0): PHI KAPPA PHI, All-University Honor Society, 1991
  • University of Southern California: Certificate for Outstanding Academic Achievement, 1990

Publications

  • H-151 attenuates lipopolysaccharide-induced acute kidney injury by inhibiting the STING-TBK1 pathway Ren Fail. 2024 Dec; 46(2):2363591. . View in PubMed
  • FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development Bone Res. 2024 Jun 24; 12(1):37. . View in PubMed
  • Polymerized carbon dots with high electrochemiluminescence efficiency and long wavelength ECL emission for ultrasensitive detection of MicroRNA-222 Biosens Bioelectron. 2024 Jun 15; 254:116193. . View in PubMed
  • Neural crest and periderm-specific requirements of Irf6 during neural tube and craniofacial development bioRxiv. 2024 Jun 11. . View in PubMed
  • Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisorCell Stem Cell. 2024 Jun 06; 31(6):904-920. e6. . View in PubMed
  • Exploring caspase functions in mouse models Apoptosis. 2024 Jun 02. . View in PubMed
  • ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling Nat Commun. 2024 May 30; 15(1):4614. . View in PubMed
  • FasL impacts Tgfb signaling in osteoblastic cells Cells Dev. 2024 May 27; 203929. . View in PubMed
  • Single-Atom Iron Doped Carbon Dots with Highly Efficient Electrochemiluminescence for Ultrasensitive Detection of MicroRNAs Anal Chem. 2024 May 14; 96(19):7516-7523. . View in PubMed
  • From Bedside to Bench and Back: Advancing Our Understanding of the Pathophysiology of Cleft Palate and Implications for the Future Cleft Palate Craniofac J. 2024 May; 61(5):759-773. . View in PubMed
  • Electrochromic Devices Based on 2D MoO3-x/PEDOT:PSS Composite Film with Boosted Ion Transport ACS Appl Mater Interfaces. 2024 Apr 10; 16(14):18052-18062. . View in PubMed
  • Renewable Electrochemiluminescence Biosensor Based on Eu-MOGs as a Highly Efficient Emitter and a DNAzyme-Mediated Dual-drive DNA Walker as a Signal Amplifier for Ultrasensitive Detection of miRNA-222 Anal Chem. 2024 Mar 19; 96(11):4589-4596. . View in PubMed
  • A Calvarial Defect Model to Investigate the Osteogenic Potential of Umbilical Cord Stem Cells in Bone Regeneration Plast Reconstr Surg. 2024 Mar 01; 153(3):637-646. . View in PubMed
  • Optoelectronic Synapses Based on MXene/Violet Phosphorus van der Waals Heterojunctions for Visual-Olfactory Crossmodal Perception Nanomicro Lett. 2024 Feb 01; 16(1):104. . View in PubMed
  • Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis Development. 2024 Jan 15; 151(2). . View in PubMed
  • Generation of tamoxifen-inducible Tfap2b-CreERT2 mice using CRISPR-Cas9 Genesis. 2024 02; 62(1):e23582. . View in PubMed
  • Elevated transaminases in congenital central hypoventilation syndrome ERJ Open Res. 2024 Jan; 10(1). . View in PubMed
  • A Biocompatible Supercapacitor Diode with Enhanced Rectification Capability toward Ion/Electron-Coupling Logic Operations Adv Mater. 2023 Jun; 35(25):e2301218. . View in PubMed
  • A Self-Rectifying Synaptic Memristor Array with Ultrahigh Weight Potentiation Linearity for a Self-Organizing-Map Neural Network Nano Lett. 2023 Apr 26; 23(8):3107-3115. . View in PubMed
  • Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells Chem Sci. 2023 Mar 01; 14(9):2318-2324. . View in PubMed
  • Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis Nat Commun. 2023 01 20; 14(1):344. . View in PubMed
  • Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosisCell Stem Cell. 2023 11 02; 30(11):1472-1485. e7. . View in PubMed
  • Factors affecting do-not-attempt-resuscitation (DNAR) decisions among adult patients in the emergency department of a general tertiary teaching hospital in China: a retrospective observational study BMJ Open. 2023 10 10; 13(10):e075714. . View in PubMed
  • Lineage-specific mutation of Lmx1b provides new insights into distinct regulation of suture development in different areas of the calvaria Front Physiol. 2023; 14:1225118. . View in PubMed
  • AgAuS Quantum Dots as a Highly Efficient Near-Infrared Electrochemiluminescence Emitter for the Ultrasensitive Detection of MicroRNA Anal Chem. 2023 06 20; 95(24):9314-9322. . View in PubMed
  • Nitrogen-, Sulfur-, and Fluorine-Codoped Carbon Dots with Low Excitation Potential and High Electrochemiluminescence Efficiency for Sensitive Detection of Matrix Metalloproteinase-2 Anal Chem. 2023 05 02; 95(17):7021-7029. . View in PubMed
  • Zn2+-Induced Gold Cluster Aggregation Enhanced Electrochemiluminescence for Ultrasensitive Detection of MicroRNA-21 Anal Chem. 2023 04 04; 95(13):5568-5574. . View in PubMed
  • Current Understanding of the Regulatory Mechanism of Tooth Root Development and Future Perspectives J Calif Dent Assoc. 2023; 51(1). . View in PubMed
  • Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis Development. 2023 03 01; 150(5). . View in PubMed
  • High-Efficiency 3D DNA Walker Immobilized by a DNA Tetrahedral Nanostructure for Fast and Ultrasensitive Electrochemical Detection of MiRNA Anal Chem. 2023 02 28; 95(8):4077-4085. . View in PubMed
  • Room-temperature valley transistors for low-power neuromorphic computing Nat Commun. 2022 Dec 15; 13(1):7758. . View in PubMed
  • Programmable mismatch-fueled high-efficiency DNA signal amplifier Chem Sci. 2022 Oct 19; 13(40):11926-11935. . View in PubMed
  • A 619-pixel machine vision enhancement chip based on two-dimensional semiconductors Sci Adv. 2022 Aug 05; 8(31):eabn9328. . View in PubMed
  • Topological phase change transistors based on tellurium Weyl semiconductor Sci Adv. 2022 Jun 10; 8(23):eabn3837. . View in PubMed
  • Scalable production of ultrafine polyaniline fibres for tactile organic electrochemical transistors Nat Commun. 2022 Apr 19; 13(1):2101. . View in PubMed
  • Effect of sponsor on enrollment criteria in non-small cell lung cancer clinical trials J Cancer Policy. 2022 09; 33:100336. . View in PubMed
  • TGF-ß signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development Elife. 2022 12 21; 11. . View in PubMed
  • Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis Nat Commun. 2022 08 16; 13(1):4803. . View in PubMed
  • Embryonic requirements for Tcf12 in the development of the mouse coronal suture Development. 2022 01 01; 149(1). . View in PubMed
  • KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis Elife. 2022 02 25; 11. . View in PubMed
  • Single-cell transcriptomic signatures and gene regulatory networks modulated by Wls in mammalian midline facial formation and clefts Development. 2022 07 15; 149(14). . View in PubMed
  • Construction of Fast-Walking Tetrahedral DNA Walker with Four Arms for Sensitive Detection and Intracellular Imaging of Apurinic/Apyrimidinic Endonuclease 1 Anal Chem. 2022 06 21; 94(24):8732-8739. . View in PubMed
  • Boron and Nitrogen-Codoped Carbon Dots as Highly Efficient Electrochemiluminescence Emitters for Ultrasensitive Detection of Hepatitis B Virus DNA Anal Chem. 2022 05 31; 94(21):7601-7608. . View in PubMed
  • The clinical manifestations, molecular mechanisms and treatment of craniosynostosis Dis Model Mech. 2022 04 01; 15(4). . View in PubMed
  • Transferred metal gate to 2D semiconductors for sub-1 V operation and near ideal subthreshold slope Sci Adv. 2021 Oct 29; 7(44):eabf8744. . View in PubMed
  • Mesenchymal stem cells and three-dimensional-osteoconductive scaffold regenerate calvarial bone in critical size defects in swine Stem Cells Transl Med. 2021 08; 10(8):1170-1183. . View in PubMed
  • Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning PLoS Genet. 2021 02; 17(2):e1009320. . View in PubMed
  • Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis Elife. 2021 01 22; 10. . View in PubMed
  • Mechanical Anisotropy in Two-Dimensional Selenium Atomic Layers Nano Lett. 2021 10 13; 21(19):8043-8050. . View in PubMed
  • Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis Elife. 2021 01 22; 10. . View in PubMed
  • Field-effect at electrical contacts to two-dimensional materials Nano Res. 2021; 14(12):4894-4900. . View in PubMed
  • Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development Development. 2021 01 21; 148(2). . View in PubMed
  • DNA Structure-Stabilized Liquid-Liquid Self-Assembled Ordered Au Nanoparticle Interface for Sensitive Detection of MiRNA 155 Anal Chem. 2021 08 10; 93(31):11019-11024. . View in PubMed
  • Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in CraniosynostosisCell. 2021 01 07; 184(1):243-256. e18. . View in PubMed
  • Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus EMBO Rep. 2021 08 04; 22(8):e51978. . View in PubMed
  • Arid1a regulates cell cycle exit of transit-amplifying cells by inhibiting the Aurka-Cdk1 axis in mouse incisor Development. 2021 04 15; 148(8). . View in PubMed
  • Arid1a-Plagl1-Hh signaling is indispensable for differentiation-associated cell cycle arrest of tooth root progenitors Cell Rep. 2021 04 06; 35(1):108964. . View in PubMed
  • Rational design of Al2O3/2D perovskite heterostructure dielectric for high performance MoS2 phototransistors Nat Commun. 2020 Aug 26; 11(1):4266. . View in PubMed
  • Lattice oxygen activation enabled by high-valence metal sites for enhanced water oxidation Nat Commun. 2020 Aug 13; 11(1):4066. . View in PubMed
  • Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis Sci Adv. 2020 12; 6(51). . View in PubMed
  • Runx2 Regulates Mouse Tooth Root Development Via Activation of WNT Inhibitor NOTUM J Bone Miner Res. 2020 11; 35(11):2252-2264. . View in PubMed
  • Antimicrobial Bioresorbable Mg-Zn-Ca Alloy for Bone Repair in a Comparison Study with Mg-Zn-Sr Alloy and Pure Mg ACS Biomater Sci Eng. 2020 01 13; 6(1):517-538. . View in PubMed
  • Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes Genes Dev. 2020 04 01; 34(7-8):580-597. . View in PubMed
  • 3D Matrix-Arranged AuAg Nanoclusters As Electrochemiluminescence Emitters for Click Chemistry-Driven Signal Switch Bioanalysis Anal Chem. 2020 02 04; 92(3):2566-2572. . View in PubMed
  • FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research Development. 2020 09 21; 147(18). . View in PubMed
  • Gli1+ Periodontium Stem Cells Are Regulated by Osteocytes and Occlusal ForceDev Cell. 2020 09 14; 54(5):639-654. e6. . View in PubMed
  • Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling Cell Rep. 2020 08 11; 32(6):108007. . View in PubMed
  • PRMT1-p53 Pathway Controls Epicardial EMT and Invasion Cell Rep. 2020 06 09; 31(10):107739. . View in PubMed
  • Nonvolatile Control of the Electronic Properties of In2-xCrxO3 Semiconductor Films by Ferroelectric Polarization Charge ACS Appl Mater Interfaces. 2019 Sep 04; 11(35):32449-32459. . View in PubMed
  • Ultralow-voltage all-carbon low-dimensional-material flexible transistors integrated by room-temperature photolithography incorporated filtration Nanoscale. 2019 Aug 15; 11(32):15029-15036. . View in PubMed
  • Stretchable elastic synaptic transistors for neurologically integrated soft engineering systems Sci Adv. 2019 10; 5(10):eaax4961. . View in PubMed
  • Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development PLoS One. 2019; 14(10):e0223879. . View in PubMed
  • Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars Elife. 2019 07 01; 8. . View in PubMed
  • The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation Hum Mol Genet. 2019 05 15; 28(10):1726-1737. . View in PubMed
  • A Pre-clinical Animal Model of Secondary Head and Neck Lymphedema Sci Rep. 2019 12 04; 9(1):18264. . View in PubMed
  • Regulatory mechanisms of jaw bone and tooth development Curr Top Dev Biol. 2019; 133:91-118. . View in PubMed
  • Discovering the forbidden Raman modes at the edges of layered materials Sci Adv. 2018 Dec; 4(12):eaau6252. . View in PubMed
  • Process analysis of anaerobic fermentation of Phragmites australis straw and cow dung exposing to elevated chromium (VI) concentrations J Environ Manage. 2018 Oct 15; 224:414-424. . View in PubMed
  • Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor Cell Stem Cell. 2018 Jul 05; 23(1):147. . View in PubMed
  • Enzyme-free Target Recycling and Double-Output Amplification System for Electrochemiluminescent Assay of Mucin 1 with MoS2 Nanoflowers as Co-reaction Accelerator ACS Appl Mater Interfaces. 2018 May 02; 10(17):14483-14490. . View in PubMed
  • Hemin as electrochemically regenerable co-reaction accelerator for construction of an ultrasensitive PTCA-based electrochemiluminescent aptasensor Biosens Bioelectron. 2018 Feb 15; 100:490-496. . View in PubMed
  • Prmt1 regulates craniofacial bone formation upstream of Msx1 Mech Dev. 2018 08; 152:13-20. . View in PubMed
  • The role of Hedgehog-responsive fibroblasts in facial nerve regeneration Exp Neurol. 2018 05; 303:72-79. . View in PubMed
  • BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair Bone Res. 2018; 6:30. . View in PubMed
  • Modulation of the Reduction Potential of TiO2- x by Fluorination for Efficient and Selective CH4 Generation from CO2 Photoreduction Nano Lett. 2018 06 13; 18(6):3384-3390. . View in PubMed
  • Regulation of Mesenchymal Stem to Transit-Amplifying Cell Transition in the Continuously Growing Mouse Incisor Cell Rep. 2018 06 05; 23(10):3102-3111. . View in PubMed
  • Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion Dev Biol. 2018 09 01; 441(1):191-203. . View in PubMed
  • An efficient electrochemiluminescence amplification strategy via bis-co-reaction accelerator for sensitive detection of laminin to monitor overnutrition associated liver damage Biosens Bioelectron. 2017 Dec 15; 98:317-324. . View in PubMed
  • Ultrahigh mobility and efficient charge injection in monolayer organic thin-film transistors on boron nitride Sci Adv. 2017 09; 3(9):e1701186. . View in PubMed
  • The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development Development. 2017 11 01; 144(21):4037-4045. . View in PubMed
  • The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression Mediators Inflamm. 2017; 2017:4024672. . View in PubMed
  • Topical Fibronectin Improves Wound Healing of Irradiated Skin Sci Rep. 2017 06 20; 7(1):3876. . View in PubMed
  • Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate Hum Mol Genet. 2017 03 01; 26(5):860-872. . View in PubMed
  • Cellular and molecular mechanisms of tooth root development Development. 2017 02 01; 144(3):374-384. . View in PubMed
  • BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice Development. 2017 07 15; 144(14):2560-2569. . View in PubMed
  • Novel electrochemiluminescence of perylene derivative and its application to mercury ion detection based on a dual amplification strategy Biosens Bioelectron. 2016 Dec 15; 86:720-727. . View in PubMed
  • Tuftsin prevents the negative immunoregulation of neuropilin-1highCD4+CD25+Regulatory T cells and improves survival rate in septic mice Oncotarget. 2016 Dec 06; 7(49):81791-81805. . View in PubMed
  • Generation and characterization of tamoxifen-inducible Pax9-CreER knock-in mice using CrispR/Cas9 Genesis. 2016 09; 54(9):490-6. . View in PubMed
  • Perovskite Photovoltachromic Supercapacitor with All-Transparent Electrodes ACS Nano. 2016 06 28; 10(6):5900-8. . View in PubMed
  • Epidemiology, Etiology, and Treatment of Isolated Cleft Palate Front Physiol. 2016; 7:67. . View in PubMed
  • Nonstoichiometric acid-base reaction as reliable synthetic route to highly stable CH3NH3PbI3 perovskite film Nat Commun. 2016 11 15; 7:13503. . View in PubMed
  • The FaceBase Consortium: a comprehensive resource for craniofacial researchers Development. 2016 07 15; 143(14):2677-88. . View in PubMed
  • Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal Development. 2016 11 15; 143(22):4115-4126. . View in PubMed
  • Sutures Possess Strong Regenerative Capacity for Calvarial Bone Injury Stem Cells Dev. 2016 12 01; 25(23):1801-1807. . View in PubMed
  • Direct TEM observations of growth mechanisms of two-dimensional MoS2 flakes Nat Commun. 2016 07 14; 7:12206. . View in PubMed
  • Mediators Inflamm. 2016; 2016:7132158. . View in PubMed
  • Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence Development. 2015 Nov 01; 142(21):3734-45. . View in PubMed
  • An Nfic-hedgehog signaling cascade regulates tooth root development Development. 2015 Oct 01; 142(19):3374-82. . View in PubMed
  • BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth Dev Cell. 2015 Apr 20; 33(2):125-35. . View in PubMed
  • Temporo-spatial requirement of Smad4 in dentin formation Biochem Biophys Res Commun. 2015 Apr 17; 459(4):706-12. . View in PubMed
  • Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development Dev Biol. 2015 Apr 15; 400(2):180-90. . View in PubMed
  • The suture provides a niche for mesenchymal stem cells of craniofacial bones Nat Cell Biol. 2015 Apr; 17(4):386-96. . View in PubMed
  • Enzyme-free electrochemical immunosensor based on host-guest nanonets catalyzing amplification for procalcitonin detection ACS Appl Mater Interfaces. 2015 Feb 25; 7(7):4127-34. . View in PubMed
  • New type of redox nanoprobe: C60-based nanomaterial and its application in electrochemical immunoassay for doping detection Anal Chem. 2015 Feb 03; 87(3):1669-75. . View in PubMed
  • Mandible and Tongue Development Curr Top Dev Biol. 2015; 115:31-58. . View in PubMed
  • A Comprehensive Study of Soft Palate Development in Mice PLoS One. 2015; 10(12):e0145018. . View in PubMed
  • Preface Curr Top Dev Biol. 2015; 115:xix-xxi. . View in PubMed
  • A model for interprofessional health care: lessons learned from craniofacial teams J Calif Dent Assoc. 2014 Sep; 42(9):637-44. . View in PubMed
  • ALK5-mediated transforming growth factor ß signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions Mol Cell Biol. 2014 Aug; 34(16):3120-31. . View in PubMed
  • Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor Cell Stem Cell. 2014 Feb 06; 14(2):160-73. . View in PubMed
  • TGFß regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate Development. 2014 Feb; 141(4):909-17. . View in PubMed
  • Development of highly polymorphic simple sequence repeat markers using genome-wide microsatellite variant analysis in Foxtail millet [Setaria italica (L) P. Beauv]. BMC Genomics. 2014 Jan 28; 15:78. . View in PubMed
  • Ultrasensitive apurinic/apyrimidinic endonuclease 1 immunosensing based on self-enhanced electrochemiluminescence of a Ru(II) complex Anal Chem. 2014 Jan 21; 86(2):1053-60. . View in PubMed
  • Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice Hum Mol Genet. 2014 Jan 01; 23(1):182-93. . View in PubMed
  • Noncanonical transforming growth factor ß (TGFß) signaling in cranial neural crest cells causes tongue muscle developmental defects J Biol Chem. 2013 Oct 11; 288(41):29760-70. . View in PubMed
  • Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells Circ Res. 2013 Sep 27; 113(8):e76-86. . View in PubMed
  • Supersandwich-type electrochemiluminescenct aptasensor based on Ru(phen)3(2+) functionalized hollow gold nanoparticles as signal-amplifying tags Biosens Bioelectron. 2013 Sep 15; 47:524-9. . View in PubMed
  • CTGF mediates Smad-dependent transforming growth factor ß signaling to regulate mesenchymal cell proliferation during palate development Mol Cell Biol. 2013 Sep; 33(17):3482-93. . View in PubMed
  • Molecular diversity and population structure of Chinese green foxtail [Setaria viridis (L) Beauv. ] revealed by microsatellite analysis. J Exp Bot. 2013 Sep; 64(12):3645-56. . View in PubMed
  • Reagentless electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-L-lysine as co-reactant Biosens Bioelectron. 2013 Jul 15; 45:189-94. . View in PubMed
  • Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development J Biol Chem. 2013 Apr 12; 288(15):10440-50. . View in PubMed
  • Identification of candidate downstream targets of TGFß signaling during palate development by genome-wide transcript profiling J Cell Biochem. 2013 Apr; 114(4):796-807. . View in PubMed
  • Smad4-Irf6 genetic interaction and TGFß-mediated IRF6 signaling cascade are crucial for palatal fusion in mice Development. 2013 Mar; 140(6):1220-30. . View in PubMed
  • Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation PLoS One. 2013; 8(4):e61653. . View in PubMed
  • Molecular regulatory mechanism of tooth root development Int J Oral Sci. 2012 Dec; 4(4):177-81. . View in PubMed
  • Genetic diversity and population structure of Chinese foxtail millet [Setaria italica (L) Beauv. ] landraces. G3 (Bethesda). 2012 Jul; 2(7):769-77. . View in PubMed
  • A collaborative approach to advance student research at the University of Southern California J Calif Dent Assoc. 2012 May; 40(5):433-6438-9. . View in PubMed
  • A TGFß-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development Development. 2012 May; 139(9):1640-50. . View in PubMed
  • Modulation of noncanonical TGF-ß signaling prevents cleft palate in Tgfbr2 mutant mice J Clin Invest. 2012 Mar; 122(3):873-85. . View in PubMed
  • Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor ß (TGFß) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis J Biol Chem. 2012 Jan 20; 287(4):2353-63. . View in PubMed
  • Novel electrochemical catalysis as signal amplified strategy for label-free detection of neuron-specific enolase Biosens Bioelectron. 2012 Jan 15; 31(1):399-405. . View in PubMed
  • Roles of BMP signaling pathway in lip and palate development Front Oral Biol. 2012; 16:60-70. . View in PubMed
  • The FaceBase Consortium: a comprehensive program to facilitate craniofacial research Dev Biol. 2011 Jul 15; 355(2):175-82. . View in PubMed
  • Highly conducting gold nanoparticles-graphene nanohybrid films for ultrasensitive detection of carcinoembryonic antigen Talanta. 2011 Jul 15; 85(1):130-5. . View in PubMed
  • Glucose oxidase and ferrocene labels immobilized at Au/TiO2 nanocomposites with high load amount and activity for sensitive immunoelectrochemical measurement of ProGRP biomarker Biosens Bioelectron. 2011 May 15; 26(9):3838-44. . View in PubMed
  • SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis Development. 2011 May; 138(10):1977-89. . View in PubMed
  • Molecular regulatory mechanism of root development J Calif Dent Assoc. 2011 May; 39(5):321-4. . View in PubMed
  • Alk5-mediated transforming growth factor ß signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells Mol Cell Biol. 2011 May; 31(10):2079-89. . View in PubMed
  • Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins Stem Cells. 2010 Nov; 28(11):2027-40. . View in PubMed
  • Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis Dev Biol. 2010 Nov 01; 347(1):109-21. . View in PubMed
  • Msx1 and Dlx5 function synergistically to regulate frontal bone development Genesis. 2010 Nov; 48(11):645-55. . View in PubMed
  • TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis Dev Biol. 2010 May 01; 341(1):186-95. . View in PubMed
  • Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development J Bone Miner Res. 2010 May; 25(5):1167-78. . View in PubMed
  • Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells J Immunol. 2010 Apr 15; 184(8):4295-306. . View in PubMed
  • Towards a molecular understanding of cleft palate Beijing Da Xue Xue Bao Yi Xue Ban. 2010 Feb 18; 42(1):9-13. . View in PubMed
  • Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells J Biol Chem. 2010 Feb 12; 285(7):4975-82. . View in PubMed
  • TGF-ß signalling and tooth development Chin J Dent Res. 2010; 13(1):7-15. . View in PubMed
  • Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice Development. 2009 Dec; 136(24):4225-33. . View in PubMed
  • A highly selective polymeric membrane barium(II) electrode based on a macrocyclic tetrabasic ligand as neutral carrier Anal Bioanal Chem. 2009 Oct; 395(3):855-62. . View in PubMed
  • Fate of HERS during tooth root development Dev Biol. 2009 Oct 01; 334(1):22-30. . View in PubMed
  • Epithelial-specific requirement of FGFR2 signaling during tooth and palate development J Exp Zool B Mol Dev Evol. 2009 Jun 15; 312B(4):343-50. . View in PubMed
  • Molecular characterization of a rice mutator-phenotype derived from an incompatible cross-pollination reveals transgenerational mobilization of multiple transposable elements and extensive epigenetic instability BMC Plant Biol. 2009 May 29; 9:63. . View in PubMed
  • Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development Stem Cells. 2009 Apr; 27(4):866-77. . View in PubMed
  • Emerging opportunities for the next generation of dental implants? Dent Today. 2009 Mar; 28(3):98-9.. View in PubMed
  • Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row Science. 2009 Feb 27; 323(5918):1232-4. . View in PubMed
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