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Yao Wei Lu, PhD

Assistant Professor of Medicine

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Email yaoweilu@usc.edu
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Awards

  • American Heart Association (AHA) Second Century Early Faculty Independence Award, 2023

Publications

  • Trbp inhibits cardiac fibrosis through TGF-β pathway mediated crosstalk between cardiomyocytes and fibroblasts. Clin Sci (Lond). 2025 Feb 19.. View in PubMed
  • Endothelial FOXM1 and Dab2 promote diabetic wound healing. JCI Insight. 2025 Jan 23; 10(2).. View in PubMed
  • Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders. Mol Metab. 2025 Jan; 91:102065.. View in PubMed
  • Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy. Circ Res. 2024 Jul 19; 135(3):434-449.. View in PubMed
  • The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation. J Clin Invest. 2024 May 14; 134(13).. View in PubMed
  • Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration. Circulation. 2023 12 05; 148(23):1887-1906.. View in PubMed
  • mt-Ty 5’tiRNA regulates skeletal muscle cell proliferation and differentiation. Cell Prolif. 2023 Aug; 56(8):e13416.. View in PubMed
  • INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10. Circulation. 2023 07 04; 148(1):47-67.. View in PubMed
  • PCBP1 regulates alternative splicing of AARS2 in congenital cardiomyopathy. bioRxiv. 2023 May 18.. View in PubMed
  • A defect in mitochondrial protein translation influences mitonuclear communication in the heart. Nat Commun. 2023 03 22; 14(1):1595.. View in PubMed
  • Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. Cardiovasc Res. 2023 03 17; 119(1):221-235.. View in PubMed
  • Sox17 mediates adult arterial endothelial cell adaptation to hemodynamics. Biomaterials. 2023 02; 293:121946.. View in PubMed
  • INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10. bioRxiv. 2023 Jan 09.. View in PubMed
  • Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression. Circ Res. 2023 01 06; 132(1):e22-e42.. View in PubMed
  • Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction. Clin Sci (Lond). 2022 11 30; 136(21):1537-1554.. View in PubMed
  • Set7 Deletion Prevents Glucose Intolerance and Improves the Recovery of Cardiac Function After Ischemia and Reperfusion in Obese Female Mice. Cell Physiol Biochem. 2022 Jun 30; 56(3):293-309.. View in PubMed
  • The Role of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease. Cells. 2022 06 03; 11(11).. View in PubMed
  • Cardiac CIP protein regulates dystrophic cardiomyopathy. Mol Ther. 2022 02 02; 30(2):898-914.. View in PubMed
  • Diabetes and Its Cardiovascular Complications: Comprehensive Network and Systematic Analyses. Front Cardiovasc Med. 2022; 9:841928.. View in PubMed
  • MEF2 (Myocyte Enhancer Factor 2) Is Essential for Endothelial Homeostasis and the Atheroprotective Gene Expression Program. Arterioscler Thromb Vasc Biol. 2021 03; 41(3):1105-1123.. View in PubMed
  • Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction. Circulation. 2020 12; 142(22):2196-2199.. View in PubMed
  • Deletion of miRNA-22 Induces Cardiac Hypertrophy in Females but Attenuates Obesogenic Diet-Mediated Metabolic Disorders. Cell Physiol Biochem. 2020 Dec 01; 54(6):1199-1217.. View in PubMed
  • Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart. Nat Commun. 2020 09 16; 11(1):4666.. View in PubMed
  • Transcriptional control of a novel long noncoding RNA Mymsl in smooth muscle cells by a single Cis-element and its initial functional characterization in vessels. J Mol Cell Cardiol. 2020 01; 138:147-157.. View in PubMed
  • Cell chirality regulates intercellular junctions and endothelial permeability. Sci Adv. 2018 10; 4(10):eaat2111.. View in PubMed
  • Transforming growth factor β1 suppresses proinflammatory gene program independent of its regulation on vascular smooth muscle differentiation and autophagy. Cell Signal. 2018 Oct; 50:160-170.. View in PubMed
  • Non-coding RNA in Ischemic and Non-ischemic Cardiomyopathy. Curr Cardiol Rep. 2018 09 26; 20(11):115.. View in PubMed
  • Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic Lamina. Arterioscler Thromb Vasc Biol. 2017 07; 37(7):1380-1390.. View in PubMed
  • Selective expression of TSPAN2 in vascular smooth muscle is independently regulated by TGF-β1/SMAD and myocardin/serum response factor. FASEB J. 2017 06; 31(6):2576-2591.. View in PubMed
  • MEF2 transcription factors are key regulators of sprouting angiogenesis. Genes Dev. 2016 Oct 15; 30(20):2297-2309.. View in PubMed
  • Venous Endothelial Marker COUP-TFII Regulates the Distinct Pathologic Potentials of Adult Arteries and Veins. Sci Rep. 2015 Nov 05; 5:16193.. View in PubMed
  • Insulin-like growth factor-1 receptor activation prevents high glucose-induced mitochondrial dysfunction, cytochrome-c release and apoptosis. Biochem Biophys Res Commun. 2009 Jun 26; 384(2):259-64.. View in PubMed
  • MicroRNA-221 regulates high glucose-induced endothelial dysfunction. Biochem Biophys Res Commun. 2009 Mar 27; 381(1):81-3.. View in PubMed

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