Yueh-Yun Chi

Professor of Research Pediatrics and Population & Public Health Sciences

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Overview

Dr. Yueh-Yun Chi is the Director of the Biostatistics Core for the Cancer and Blood Disease Institute (CBDI) at Children’s Hospital Los Angeles (CHLA) and Professor of Research Pediatrics and Population and Public Health Sciences at Keck School of Medicine of USC.

Dr. Chi provides leadership for biostatistical support for faculty, trainees, and staff of the CBDI. Under her leadership, the CBDI Biostatistics Core has doubled in size and capacity in 2022. Dr. Chi also provides statistical oversight for the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) and the New Approaches to Neuroblastoma Therapy (NANT) consortia, in which she has been able to refine and improve study design and conduct for existing and new trials. Prior to joining USC/CHLA, she was a faculty member at the University of Florida and served as the lead statistician for the Renal Tumors and Soft Tissue Committees of the Children’s Oncology Group, the world’s largest research organization dedicated exclusively to pediatric cancer research.

Publications

Clinical characteristics and surgical outcomes of vertebral lesions associated with tumor-induced osteomalacia: report of 16 patients and review of the literature Osteoporos Int. 2024 Nov; 35(11):1951-1962. . View in PubMed
Ultra-High Dose Vitamin D in Pediatric Hematopoietic Stem Cell Transplantation: A Nonrandomized Controlled TrialTransplant Cell Ther. 2021 12; 27(12):1001. e1-1001. e9. . View in PubMed
A compact, versatile drug-induced splicing switch system with minimal background expression Cell Rep Methods. 2024 Aug 30; 100842. . View in PubMed
Generation of human induced pluripotent stem cells carrying albumin-sfGFP reporter Stem Cell Res. 2024 Aug 26; 81:103543. . View in PubMed
Optimizing early phase clinical trial washout periods: a report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium J Natl Cancer Inst. 2024 Jul 04. . View in PubMed
A modified glycosylase base editor without predictable DNA off-target effects FEBS Lett. 2024 Jun 30. . View in PubMed
Improvement of TaC9-ABE mediated correction of human SMN2 gene Biotechnol Bioeng. 2024 Jun 24. . View in PubMed
Response to Letter to the Editor From Judit Toke and Miklós Tóth: “Shift in Calcium From Peripheral Bone to Axial Bone After Tumor Resection in Patients With Tumor-Induced Osteomalacia” J Clin Endocrinol Metab. 2024 Jun 17; 109(7):e1558. . View in PubMed
Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment Nat Commun. 2024 Apr 18; 15(1):3258. . View in PubMed
Phase 1 study of high-dose DFMO, celecoxib, cyclophosphamide and topotecan for patients with relapsed neuroblastoma: a New Approaches to Neuroblastoma Therapy trial Br J Cancer. 2024 Mar; 130(5):788-797. . View in PubMed
Nivolumab Plus 5-Azacitidine in Pediatric Relapsed/Refractory Acute Myeloid Leukemia (AML): Phase I/II Trial Results from the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium Cancers (Basel). 2024 Jan 24; 16(3). . View in PubMed
Stability of African swine fever virus genome under different environmental conditions Vet World. 2023 Nov; 16(11):2374-2381. . View in PubMed
Mini-PE, a prime editor with compact Cas9 and truncated reverse transcriptase Mol Ther Nucleic Acids. 2023 Sep 12; 33:890-897. . View in PubMed
TP53 germline pathogenic variant frequency in anaplastic rhabdomyosarcoma: A Children’s Oncology Group report Pediatr Blood Cancer. 2023 May 17; e30413. . View in PubMed
Bcl-xL Promotes the Survival of Motor Neurons Derived from Neural Stem Cells Biology (Basel). 2023 Jan 13; 12(1). . View in PubMed
Influence of Obesity and Changes in Weight or BMI on Incident Fractures in Postmenopausal Women: From Peking Vertebral Fracture Study Calcif Tissue Int. 2023 11; 113(5):483-495. . View in PubMed
Survival outcomes and surgical morbidity based on surgical approach to pulmonary metastasectomy in pediatric, adolescent and young adult patients with osteosarcoma Cancer Med. 2023 10; 12(20):20231-20241. . View in PubMed
Generation of a homozygous RANGRF knockout hiPSC line by CRISPR/Cas9 system Stem Cell Res. 2023 09; 71:103136. . View in PubMed
Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results Nat Med. 2023 05; 29(5):1092-1102. . View in PubMed
Alveolar rhabdomyosarcoma has superior response rates to vinorelbine compared to embryonal rhabdomyosarcoma in patients with relapsed/refractory disease: A meta-analysis Cancer Med. 2023 05; 12(9):10222-10229. . View in PubMed
Shift in Calcium From Peripheral Bone to Axial Bone After Tumor Resection in Patients With Tumor-Induced Osteomalacia J Clin Endocrinol Metab. 2023 10 18; 108(11):e1365-e1373. . View in PubMed
Ultra-High Performance Liquid Chromatography-Mass Spectrometry-based Serum Metabolomics for Early Diagnosis of Refractory Tumor-induced Osteomalacia: A Case-control Study J Clin Endocrinol Metab. 2023 07 14; 108(8):2016-2023. . View in PubMed
Serum Irisin level is associated with fall risk, muscle strength, and cortical porosity in postmenopausal women Front Endocrinol (Lausanne). 2023; 14:1096950. . View in PubMed
The First Compound Heterozygous Mutations of DMP1 Causing Rare Autosomal Recessive Hypophosphatemic Rickets Type 1 J Clin Endocrinol Metab. 2023 03 10; 108(4):791-801. . View in PubMed
Robust genetic model-based SNP-set association test using CauchyGM Bioinformatics. 2023 01 01; 39(1). . View in PubMed
Relationships between sclerostin and morphometric vertebral fractures, bone mineral density, and bone microarchitecture in postmenopausal women Arch Osteoporos. 2023 04 29; 18(1):57. . View in PubMed
Generation of hiPSCs with ABO c767T>C substitution: resulting in splicing variants. Front Genet. 2023; 14:1141756. . View in PubMed
Hyperparathyroidism in a Large Cohort of Chinese Patients With Tumor-induced Osteomalacia J Clin Endocrinol Metab. 2023 04 13; 108(5):1224-1235. . View in PubMed
Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial Clin Cancer Res. 2023 07 05; 29(13):2410-2418. . View in PubMed
Incident vertebral fracture and longitudinal BMD change in Chinese postmenopausal women with early CKD: Peking Vertebral Fracture Study Arch Osteoporos. 2023 09 11; 18(1):116. . View in PubMed
Improved USER cloning for TALE assembly and its application to base editing PLoS One. 2023; 18(8):e0289509. . View in PubMed
Na-Cl Co-transporter (NCC) gene inactivation is associated with improved bone microstructure Osteoporos Int. 2022 Oct; 33(10):2193-2204. . View in PubMed
Kidney Preservation and Wilms Tumor Development in Children with Diffuse Hyperplastic Perilobar Nephroblastomatosis: A Report from the Children’s Oncology Group Study AREN0534 Ann Surg Oncol. 2022 May; 29(5):3252-3261. . View in PubMed
Rising drug cost impacts on cost-effectiveness of 2 chemotherapy regimens for intermediate-risk rhabdomyosarcoma: A report from the Children’s Oncology Group Cancer. 2022 Jan 15; 128(2):317-325. . View in PubMed
Tumor-induced osteomalacia combined with acromegaly: A case report Ann N Y Acad Sci. 2022 11; 1517(1):88-92. . View in PubMed
Survival of pediatric Hodgkin lymphoma patients treated with doxorubicin, bleomycin, vincristine, etoposide, prednisone, and cyclophosphamide (ABVE-PC) versus doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) at a single institution Pediatr Blood Cancer. 2022 05; 69(5):e29601. . View in PubMed
Decitabine and vorinostat with FLAG chemotherapy in pediatric relapsed/refractory AML: Report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium Am J Hematol. 2022 05; 97(5):613-622. . View in PubMed
ASO Video Abstract: Kidney Preservation and Wilms Tumor Development in Children with Diffuse Hyperplastic Perilobar Nephroblastomatosis-A Report from the Children’s Oncology Group Study AREN0534 Ann Surg Oncol. 2022 05; 29(5):3262-3263. . View in PubMed
Bone Impairment in a Large Cohort of Chinese Patients With Tumor-Induced Osteomalacia Assessed by HR-pQCT and TBS J Bone Miner Res. 2022 03; 37(3):454-464. . View in PubMed
Outcomes based on histopathologic response to preoperative chemotherapy in children with bilateral Wilms tumor: A prospective study (COG AREN0534) Cancer. 2022 07 01; 128(13):2493-2503. . View in PubMed
Clinical characteristics and the influence of rs1800470 in patients with Camurati-Engelmann disease Front Endocrinol (Lausanne). 2022; 13:1041061. . View in PubMed
Independent Assessment of the Children’s Hepatic Tumors International Collaboration Risk Stratification for Hepatoblastoma and the Association of Tumor Histological Characteristics With Prognosis JAMA Netw Open. 2022 02 01; 5(2):e2148013. . View in PubMed
Temsirolimus combined with cyclophosphamide and etoposide for pediatric patients with relapsed/refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium trial (TACL 2014-001) Haematologica. 2022 10 01; 107(10):2295-2303. . View in PubMed
Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor Cells. 2022 12 08; 11(24). . View in PubMed
Local Control For High-Grade Nonrhabdomyosarcoma Soft Tissue Sarcoma Assigned to Radiation Therapy on ARST0332: A Report From the Childrens Oncology Group Int J Radiat Oncol Biol Phys. 2021 Jul 01; 110(3):821-830. . View in PubMed
Early Discrimination Between Tumor-Induced Rickets/Osteomalacia and X-Linked Hypophosphatemia in Chinese Children and Adolescents: A Retrospective Case-Control Study J Bone Miner Res. 2021 09; 36(9):1739-1748. . View in PubMed
Alveolar rhabdomyosarcoma with regional nodal involvement: Results of a combined analysis from two cooperative groups Pediatr Blood Cancer. 2021 03; 68(3):e28832. . View in PubMed
Metabolic response as assessed by 18 F-fluorodeoxyglucose positron emission tomography-computed tomography does not predict outcome in patients with intermediate- or high-risk rhabdomyosarcoma: A report from the Children’s Oncology Group Soft Tissue Sarcoma Committee Cancer Med. 2021 02; 10(3):857-866. . View in PubMed
The prognostic significance of anaplasia in childhood rhabdomyosarcoma: A report from the Children’s Oncology Group Eur J Cancer. 2021 01; 143:127-133. . View in PubMed
Survival outcomes of patients with localized FOXO1 fusion-positive rhabdomyosarcoma treated on recent clinical trials: A report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group Cancer. 2021 03 15; 127(6):946-956. . View in PubMed
Haplotype-resolved germline and somatic alterations in renal medullary carcinomas Genome Med. 2021 07 14; 13(1):114. . View in PubMed
Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children’s Oncology Group J Natl Cancer Inst. 2021 07 01; 113(7):875-883. . View in PubMed
Benefit of delayed primary excision in rhabdomyosarcoma: A report from the Children’s Oncology Group Cancer. 2021 01 15; 127(2):275-283. . View in PubMed
Relationships between reproductive hormones and maternal pregnancy physiology in women conceiving with or without in vitro fertilization Am J Physiol Regul Integr Comp Physiol. 2021 09 01; 321(3):R454-R468. . View in PubMed
Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial Lancet Oncol. 2020 08; 21(8):1110-1122. . View in PubMed
Imaging Characteristics of Nephrogenic Rests Versus Small Wilms Tumors: A Report From the Children’s Oncology Group Study AREN03B2 AJR Am J Roentgenol. 2020 05; 214(5):987-994. . View in PubMed
Pediatr Blood Cancer. 2020 05; 67(5):e28243. . View in PubMed
An efficient integrative resampling method for gene-trait association analysis Genet Epidemiol. 2020 03; 44(2):197-207. . View in PubMed
A risk-based treatment strategy for non-rhabdomyosarcoma soft-tissue sarcomas in patients younger than 30 years (ARST0332): a Children’s Oncology Group prospective study Lancet Oncol. 2020 01; 21(1):145-161. . View in PubMed
Activity of Vincristine and Irinotecan in Diffuse Anaplastic Wilms Tumor and Therapy Outcomes of Stage II to IV Disease: Results of the Children’s Oncology Group AREN0321 Study J Clin Oncol. 2020 05 10; 38(14):1558-1568. . View in PubMed
Results of Treatment for Patients With Multicentric or Bilaterally Predisposed Unilateral Wilms Tumor (AREN0534): A report from the Children’s Oncology Group Cancer. 2020 08 01; 126(15):3516-3525. . View in PubMed
A prospective study of pediatric and adolescent renal cell carcinoma: A report from the Children’s Oncology Group AREN0321 study Cancer. 2020 12 01; 126(23):5156-5164. . View in PubMed
Relationship between tumor response at therapy completion and prognosis in patients with Group III rhabdomyosarcoma: A report from the Children’s Oncology Group Int J Cancer. 2020 09 01; 147(5):1419-1426. . View in PubMed
Outcome analysis of stage I epithelial-predominant favorable-histology Wilms tumors: A report from Children’s Oncology Group study AREN03B2 Cancer. 2020 06 15; 126(12):2866-2871. . View in PubMed
Maternal endothelial function, circulating endothelial cells, and endothelial progenitor cells in pregnancies conceived with or without in vitro fertilization Am J Physiol Regul Integr Comp Physiol. 2020 06 01; 318(6):R1091-R1102. . View in PubMed
Reply to DM. Green. J Clin Oncol. 2020 03 01; 38(7):773-774. . View in PubMed
Impact of local control and surgical lymph node evaluation in localized paratesticular rhabdomyosarcoma: A report from the Children’s Oncology Group Soft Tissue Sarcoma Committee Int J Cancer. 2020 12 01; 147(11):3168-3176. . View in PubMed
Tetralithio Metalla-aromatics with Two Independent Perpendicular Dilithio Aromatic Rings Spiro-fused by One Manganese Atom Angew Chem Int Ed Engl. 2019 Jul 08; 58(28):9625-9631. . View in PubMed
Refinement of risk stratification for childhood rhabdomyosarcoma using FOXO1 fusion status in addition to established clinical outcome predictors: A report from the Children’s Oncology Group Cancer Med. 2019 10; 8(14):6437-6448. . View in PubMed
Maternal Cardiovascular Dysregulation During Early Pregnancy After In Vitro Fertilization Cycles in the Absence of a Corpus Luteum Hypertension. 2019 09; 74(3):705-715. . View in PubMed
Treatment of stage I anaplastic Wilms’ tumour: a report from the Children’s Oncology Group AREN0321 study Eur J Cancer. 2019 09; 118:58-66. . View in PubMed
Clinical features and outcomes of young patients with epithelioid sarcoma: an analysis from the Children’s Oncology Group and the European paediatric soft tissue Sarcoma Study Group prospective clinical trials Eur J Cancer. 2019 05; 112:98-106. . View in PubMed
Effect of Mode of Conception on Maternal Serum Relaxin, Creatinine, and Sodium Concentrations in an Infertile Population Reprod Sci. 2019 03; 26(3):412-419. . View in PubMed
Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum Hypertension. 2019 03; 73(3):640-649. . View in PubMed
Outcome of Wilms tumor patients with bone metastasis enrolled on National Wilms Tumor Studies 1-5: A report from the Children’s Oncology Group Pediatr Blood Cancer. 2019 01; 66(1):e27430. . View in PubMed
Impact of cyclophosphamide and etoposide on outcome of clear cell sarcoma of the kidney treated on the National Wilms Tumor Study-5 (NWTS-5) Pediatr Blood Cancer. 2019 01; 66(1):e27450. . View in PubMed
Treatment Approach and Outcomes in Infants With Localized Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children’s Oncology Group Int J Radiat Oncol Biol Phys. 2019 01 01; 103(1):19-27. . View in PubMed
Power and Sample Size for Fixed-Effects Inference in Reversible Linear Mixed Models Am Stat. 2019; 73(4):350-359. . View in PubMed
Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women Am J Physiol Endocrinol Metab. 2019 10 01; 317(4):E677-E685. . View in PubMed
The addition of cixutumumab or temozolomide to intensive multiagent chemotherapy is feasible but does not improve outcome for patients with metastatic rhabdomyosarcoma: A report from the Children’s Oncology Group Cancer. 2019 01 15; 125(2):290-297. . View in PubMed
Augmentation of Therapy for Combined Loss of Heterozygosity 1p and 16q in Favorable Histology Wilms Tumor: A Children’s Oncology Group AREN0532 and AREN0533 Study Report J Clin Oncol. 2019 10 20; 37(30):2769-2777. . View in PubMed
Increased local failure for patients with intermediate-risk rhabdomyosarcoma on ARST0531: A report from the Children’s Oncology Group Cancer. 2019 09 15; 125(18):3242-3248. . View in PubMed
Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms’ tumor JCI Insight. 2019 08 08; 4(15). . View in PubMed
Randomized Phase II Trial of Bevacizumab or Temsirolimus in Combination With Chemotherapy for First Relapse Rhabdomyosarcoma: A Report From the Children’s Oncology Group J Clin Oncol. 2019 11 01; 37(31):2866-2874. . View in PubMed
Wave reflections and global arterial compliance during normal human pregnancy Physiol Rep. 2018 Dec; 6(24):e13947. . View in PubMed
Impact of Surveillance Imaging Modality on Survival After Recurrence in Patients With Favorable-Histology Wilms Tumor: A Report From the Children’s Oncology Group J Clin Oncol. 2018 Oct 18; JCO1800076. . View in PubMed
Reply to DM. Green. J Clin Oncol. 2018 Sep 13; JCO1800659. . View in PubMed
First trimester pregnancy ultrasound findings as a function of method of conception in an infertile population J Assist Reprod Genet. 2018 May; 35(5):863-870. . View in PubMed
Soluble CD14, CD163, and CD27 biomarkers distinguish ART-suppressed youth living with HIV from healthy controls J Leukoc Biol. 2018 04; 103(4):671-680. . View in PubMed
Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children’s Oncology Group AREN0533 Study J Clin Oncol. 2018 06 01; 36(16):1564-1570. . View in PubMed
Addition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk Rhabdomyosarcoma: A Report From the Children’s Oncology Group J Clin Oncol. 2018 09 20; 36(27):2770-2777. . View in PubMed
Undifferentiated Sarcomas in Children Harbor Clinically Relevant Oncogenic Fusions and Gene Copy-Number Alterations: A Report from the Children’s Oncology Group Clin Cancer Res. 2018 08 15; 24(16):3888-3897. . View in PubMed
Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children’s Oncology Group Cancer. 2018 05 01; 124(9):1973-1981. . View in PubMed
Outcome and Prognostic Factors in Stage III Favorable-Histology Wilms Tumor: A Report From the Children’s Oncology Group Study AREN0532 J Clin Oncol. 2018 01 20; 36(3):254-261. . View in PubMed
Internal pilot design for balanced repeated measures Stat Med. 2018 02 10; 37(3):375-389. . View in PubMed
Histology, fusion status, and outcome in metastatic rhabdomyosarcoma: A report from the Children’s Oncology Group Pediatr Blood Cancer. 2017 Dec; 64(12). . View in PubMed
Formation and ligand-based reductive chemistry of bridged bis-alkylidene scandium(iii) complexes Chem Sci. 2017 Oct 01; 8(10):6852-6856. . View in PubMed
45 Gy is not sufficient radiotherapy dose for Group III orbital embryonal rhabdomyosarcoma after less than complete response to 12 weeks of ARST0331 chemotherapy: A report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group Pediatr Blood Cancer. 2017 Sep; 64(9). . View in PubMed
Patterns of chemotherapy-induced toxicities and outcome in children and adolescents with metastatic rhabdomyosarcoma: A report from the Children’s Oncology Group Pediatr Blood Cancer. 2017 Sep; 64(9). . View in PubMed
Outcome of patients with intracranial relapse enrolled on national Wilms Tumor Study Group clinical trials Pediatr Blood Cancer. 2017 Jul; 64(7). . View in PubMed
Spiro Metalla-aromatics of Pd, Pt, and Rh: Synthesis and Characterization J Am Chem Soc. 2017 Apr 12; 139(14):5039-5042. . View in PubMed
Comparison of multiple non-invasive methods of measuring cardiac output during pregnancy reveals marked heterogeneity in the magnitude of cardiac output change between women Physiol Rep. 2017 Apr; 5(8). . View in PubMed
CuOTf-Catalyzed Selective Generation of 2-Aminopyrimidines from Carbodiimides and Diaryliodonium Salts by a Triple C(sp3 )-H Functionalization Chemistry. 2017 Jan 18; 23(4):757-761. . View in PubMed
Surgery alone is sufficient therapy for children and adolescents with low-risk synovial sarcoma: A joint analysis from the European paediatric soft tissue sarcoma Study Group and the Children’s Oncology Group Eur J Cancer. 2017 06; 78:1-6. . View in PubMed
Clinical Outcome and Biological Predictors of Relapse After Nephrectomy Only for Very Low-risk Wilms Tumor: A Report From Children’s Oncology Group AREN0532 Ann Surg. 2017 04; 265(4):835-840. . View in PubMed
Synthesis of Quinoline Derivatives via Cu-Catalyzed Cascade Annulation of Heterocumulenes, Alkynes, and Diaryliodonium Salts Org Lett. 2017 05 19; 19(10):2694-2697. . View in PubMed
Dual Functionalization of White Phosphorus: Formation, Characterization, and Reactivity of Rare-Earth-Metal Cyclo-P3 Complexes Angew Chem Int Ed Engl. 2017 12 11; 56(50):15886-15890. . View in PubMed
Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children’s Oncology Group Clin Cancer Res. 2016 Nov 15; 22(22):5582-5591. . View in PubMed
Collection of pregnancy outcome records following infertility-challenges and possible solutions J Assist Reprod Genet. 2016 Aug; 33(8):993-9. . View in PubMed
A polyethylenimine functionalized porous/hollow nanoworm as a drug delivery system and a bioimaging agent Phys Chem Chem Phys. 2016 Mar 21; 18(11):7820-8. . View in PubMed
Pediatric cystic nephromas: distinctive features and frequent DICER1 mutations Hum Pathol. 2016 Feb; 48:81-7. . View in PubMed
Aromatic Dicupra[10]annulenes J Am Chem Soc. 2016 Jan 13; 138(1):60-3. . View in PubMed
Association of Chromosome 1q Gain With Inferior Survival in Favorable-Histology Wilms Tumor: A Report From the Children’s Oncology Group J Clin Oncol. 2016 09 10; 34(26):3189-94. . View in PubMed
Direct Synthesis of Phospholyl Lithium from White Phosphorus Angew Chem Int Ed Engl. 2016 08 01; 55(32):9187-90. . View in PubMed
Structure and Reaction Chemistry of Magnesium Organocuprates Derived from Magnesiacyclopentadienes and Copper(I) Salts Angew Chem Int Ed Engl. 2016 11 14; 55(47):14762-14765. . View in PubMed
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users Am J Clin Nutr. 2015 Sep; 102(3):616-25. . View in PubMed
Synthesis and Mechanistic Study of Cyclic Oxoguanidines via Zn(OTf)2 -Catalyzed Guanylation/Amidation from Readily Available Amino Acid Esters and Carbodiimides Chemistry. 2015 Jul 13; 21(29):10369-78. . View in PubMed
Frozen blastocyst embryo transfer using a supplemented natural cycle protocol has a similar live birth rate compared to a programmed cycle protocol J Assist Reprod Genet. 2015 Jul; 32(7):1057-62. . View in PubMed
Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors Cancer Cell. 2015 Feb 09; 27(2):286-97. . View in PubMed
Low-dose adefovir dipivoxil may induce Fanconi syndrome: clinical characteristics and long-term follow-up for Chinese patients Antivir Ther. 2015; 20(6):603-11. . View in PubMed
Dysbiosis and alterations in predicted functions of the subgingival microbiome in chronic periodontitis Appl Environ Microbiol. 2015 Jan; 81(2):783-93. . View in PubMed
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes J Nutr. 2015 Jan; 145(1):87-95. . View in PubMed
Oxidant-switchable selective synthesis of 2-aminobenzimidazoles via C-H amination/acetoxylation of guanidines Org Lett. 2014 Dec 19; 16(24):6274-7. . View in PubMed
Substituent-controlled selective synthesis of N-acyl 2-aminothiazoles by intramolecular Zwitterion-mediated C-N bond cleavage J Org Chem. 2014 Nov 21; 79(22):11146-54. . View in PubMed
Vitamin B-6 restriction reduces the production of hydrogen sulfide and its biomarkers by the transsulfuration pathway in cultured human hepatoma cells J Nutr. 2014 Oct; 144(10):1501-8. . View in PubMed
Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells Am J Physiol Endocrinol Metab. 2014 Jul 01; 307(1):E93-101. . View in PubMed
Power calculation for overall hypothesis testing with high-dimensional commensurate outcomes Stat Med. 2014 Feb 28; 33(5):812-27. . View in PubMed
Cleavage of the C=N bond in carbodiimides via release of high ring strain: a new strategy for the selective synthesis of 2-aminoaryl alkynyl imines Chemistry. 2014 Feb 24; 20(9):2463-8. . View in PubMed
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women J Nutr. 2013 Nov; 143(11):1719-27. . View in PubMed
Mechanistic study on the cleavage and reorganization of C(sp3)-H and C=N bonds in carbodiimides: synthesis of 1,2-dihydrothiopyrimidines and 2,3-dihydropyrimidinthiones through four-component coupling Chemistry. 2013 Aug 05; 19(32):10643-54. . View in PubMed
Confidence regions for repeated measures ANOVA power curves based on estimated covariance BMC Med Res Methodol. 2013 Apr 15; 13:57. . View in PubMed
Number and function of bone-marrow derived angiogenic cells and coronary flow reserve in women without obstructive coronary artery disease: a substudy of the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE) PLoS One. 2013; 8(12):e81595. . View in PubMed
Two-Step Hypothesis Testing When the Number of Variables Exceeds the Sample Size Commun Stat Simul Comput. 2013; 42(5):1113-1125. . View in PubMed
Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects PLoS One. 2013; 8(6):e63544. . View in PubMed
Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women J Nutr. 2012 Oct; 142(10):1791-7. . View in PubMed
Novel mutations of CYP27B1 gene lead to reduced activity of 1a-hydroxylase in Chinese patients Bone. 2012 Sep; 51(3):563-9. . View in PubMed
Bayesian influence measures for joint models for longitudinal and survival data Biometrics. 2012 Sep; 68(3):954-64. . View in PubMed
Global hypothesis testing for high-dimensional repeated measures? outcomes. Stat Med. 2012 Apr 13; 31(8):724-42.. View in PubMed
Regioselective ring expansion of 2,4-diiminoazetidines via cleavage of C-N and C(sp3)-H bonds: efficient construction of 2,3-dihydropyrimidinesulfonamides J Am Chem Soc. 2012 Feb 15; 134(6):2926-9. . View in PubMed
Repeat radiosurgery for intracranial arteriovenous malformations Neurosurgery. 2012 Jan; 70(1):150-4; discussion 154. . View in PubMed
Radiographic response of brain metastasis after linear accelerator radiosurgery Stereotact Funct Neurosurg. 2012; 90(2):69-78. . View in PubMed
Incidence of ventricular shunt placement for hydrocephalus with clipping versus coiling for ruptured and unruptured cerebral aneurysms in the Nationwide Inpatient Sample database: 2002 to 2007 World Neurosurg. 2011 Dec; 76(6):548-54. . View in PubMed
Incidence of seizures or epilepsy after clipping or coiling of ruptured and unruptured cerebral aneurysms in the nationwide inpatient sample database: 2002-2007 Neurosurgery. 2011 Sep; 69(3):644-50; discussion 650. . View in PubMed
Stent-associated flow remodeling causes further occlusion of incompletely coiled aneurysms Neurosurgery. 2011 Sep; 69(3):598-603; discussion 603-4. . View in PubMed
Linear accelerator radiosurgery for nonvestibular schwannomas Neurosurgery. 2011 Apr; 68(4):974-84; discussion 984. . View in PubMed
Effect of weekend compared with weekday stroke admission on thrombolytic use, in-hospital mortality, discharge disposition, hospital charges, and length of stay in the Nationwide Inpatient Sample Database, 2002 to 2007 Stroke. 2010 Oct; 41(10):2323-8. . View in PubMed
Relationship between higher rates of adverse events in deep brain stimulation using standardized prospective recording and patient outcomes Neurosurg Focus. 2010 Aug; 29(2):E4. . View in PubMed
Timing of aneurysm surgery: the International Cooperative Study revisited in the era of endovascular coiling J Neurointerv Surg. 2010 Jun; 2(2):131-4. . View in PubMed
Identification and preliminary characterization of ubiquitin C terminal hydrolase 1 (UCHL1) as a biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage J Neurosci Res. 2010 May 15; 88(7):1475-84. . View in PubMed
Length of stay and total hospital charges of clipping versus coiling for ruptured and unruptured adult cerebral aneurysms in the Nationwide Inpatient Sample database 2002 to 2006 Stroke. 2010 Feb; 41(2):337-42. . View in PubMed
Using scientifically and statistically sufficient statistics in comparing image segmentations Stat Interface. 2010 Jan 01; 3(1):91-101. . View in PubMed
Validation of the radiosurgery-based arteriovenous malformation score in a large linear accelerator radiosurgery experience J Neurosurg. 2009 Oct; 111(4):832-9. . View in PubMed
Rapid fabrication of custom patient biopsy guides J Appl Clin Med Phys. 2009 Sep 02; 10(4):260-272. . View in PubMed
The linkage between pediatric quality of life and health conditions: establishing clinically meaningful cutoff scores for the PedsQL Value Health. 2009 Jul-Aug; 12(5):773-81. . View in PubMed
Factors associated with aspirin resistance in patients premedicated with aspirin and clopidogrel for endovascular neurosurgery Neurosurgery. 2009 May; 64(5):890-5; discussion 895-6. . View in PubMed
The effect of coiling versus clipping of ruptured and unruptured cerebral aneurysms on length of stay, hospital cost, hospital reimbursement, and surgeon reimbursement at the university of Florida Neurosurgery. 2009 Apr; 64(4):614-9; discussion 619-21. . View in PubMed
Linear accelerator radiosurgery for cavernous sinus meningiomas Stereotact Funct Neurosurg. 2009; 87(2):120-7. . View in PubMed
Lower incidence of reoperation with longer shunt survival with adult ventriculoperitoneal shunts placed for hemorrhage-related hydrocephalus Neurosurgery. 2008 Jul; 63(1):70-4; discussion 74-5. . View in PubMed
Conjugal Alzheimer disease: risk in children when both parents have Alzheimer disease Arch Neurol. 2008 Mar; 65(3):373-8. . View in PubMed
A new class of mixture models for differential gene expression in DNA microarray data J Stat Plan Inference. 2008 Feb 01; 138(2):387-404. . View in PubMed
The need for reorientation toward cost-effective prediction: comments on ‘Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond’ by Pencina et al, Statistics in Medicine (DOI: 10. 1002/sim. 2929). Stat Med. 2008 Jan 30; 27(2):182-4. . View in PubMed
Bayesian hierarchical modeling for time course microarray experiments Biometrics. 2007 Jun; 63(2):496-504. . View in PubMed
Joint models for multivariate longitudinal and multivariate survival data Biometrics. 2006 Jun; 62(2):432-45. . View in PubMed
Comparison of human and automatic segmentations of kidneys from CT images Int J Radiat Oncol Biol Phys. 2005 Mar 01; 61(3):954-60. . View in PubMed
Symptom patterns and subgrouping of schizophrenic patients: significance of negative symptoms assessed on admission Schizophr Res. 2002 Jul 01; 56(1-2):105-19. . View in PubMed

Yueh-Yun Chi

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