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Yuki Yamaguchi

Assistant Professor of Research Medicine

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Email [email protected]
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Publications

  • Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery. Nat Biomed Eng. 2026 Apr; 10(4):613-629.. View in PubMed
  • Universal off-the-shelf combination immunotherapy using oncolytic viruses to redirect T cell engagers to target solid tumors. J Immunother Cancer. 2025 Aug 11; 13(8).. View in PubMed
  • CD105+ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation. Breast Cancer Res. 2025 May 15; 27(1):81.. View in PubMed
  • Vascularized tumor-on-a-chip to investigate immunosuppression of CAR-T cells. Lab Chip. 2025 May 13; 25(10):2390-2400.. View in PubMed
  • Nonsignaling extracellular spacer regulates tumor antigen selectivity of CAR T cells. Mol Ther Oncol. 2024 Jun 20; 32(2):200789.. View in PubMed
  • Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting. Nat Commun. 2023 08 07; 14(1):4737.. View in PubMed
  • PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages. J Immunother Cancer. 2022 06; 10(6).. View in PubMed
  • Pre-conditioning modifies the TME to enhance solid tumor CAR T cell efficacy and endogenous protective immunity. Mol Ther. 2021 07 07; 29(7):2335-2349.. View in PubMed
  • Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer. Oncoimmunology. 2018; 7(2):e1380764.. View in PubMed
  • Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017 Sep; 49(9):1346-1353.. View in PubMed
  • Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPARγ activation. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2070-5.. View in PubMed
  • Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum. Cell Cycle. 2011 Jun 01; 10(11):1810-20.. View in PubMed
  • Expression and in vivo rescue of human ABCC6 disease-causing mutants in mouse liver. PLoS One. 2011; 6(9):e24738.. View in PubMed

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