Zhilei Shen, PhD

Assistant Professor Of Clinical Radiation Oncology

Lead, Medical Physics Treatment Planning and Information Technology

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Dr. Zhilei (Julie) Shen is an Assistant Professor of Clinical Radiation Oncology-Medical Physics at USC Norris Cancer Hospital and USC + Los Angeles County Medical Center. She joined USC in November 2019.

Dr. Zhilei (Julie) Shen graduated from Southeast University in Nanjing, China with a Bachelor of Engineering degree in Biomedical Engineering. She received her doctorate degree in Biomedical Engineering from Case Western Reserve University, and completed her residency in medical physics at Cleveland Clinic in 2016.

After completing her residency, Dr. Shen became a clinical assistant professor at University of Pittsburgh Medical Center (UPMC) specializing in medical physics. Dr. Shen has presented and published in multiple areas including biomaterials, biomechanics, ultrasound imaging, medical physics, and medical dosimetry. Her research interests include advanced treatment planning, deformable image registration, and image-guided radiation therapy.

Medical Physics Expertise: Treatment Planning, SRS/SBRT, Gamma Knife, IGRT, DIBH, 4DCT, TBI, TSET, HDR, LDR

Languages Spoken: English and Chinese (Mandarin)


  • Hippocampal sparing radiation therapy for brain metastases: treatment techniques and clinical implementation Chin Clin Oncol. 2023 Oct; 12(5):56. . View in PubMed
  • Radiation therapy practice changes in the COVID-19 pandemic era: A pilot study in California J Appl Clin Med Phys. 2022 Nov; 23(11):e13770. . View in PubMed
  • Automatic segmentation of high-risk clinical target volume for tandem-and-ovoids brachytherapy patients using an asymmetric dual-path convolutional neural network Med Phys. 2022 Mar; 49(3):1712-1722. . View in PubMed
  • Surviving Over a Decade With Glioblastoma: A Clinical Course Characterized by Multiple Recurrences, Numerous Salvage Treatments, and Novel Use of Cesium-131 Tiles Cureus. 2021 Nov; 13(11):e19573. . View in PubMed
  • Automatic detection and segmentation of multiple brain metastases on magnetic resonance image using asymmetric UNet architecture Phys Med Biol. 2021 01 13; 66(1):015003. . View in PubMed
  • Technical Note: Characterization of x-ray beam profiles for a fluoroscopic system incorporating copper filtration Med Phys. 2019 Nov; 46(11):4918-4922. . View in PubMed
  • Three IMRT advanced planning tools: A multi-institutional side-by-side comparison J Appl Clin Med Phys. 2019 Aug; 20(8):65-77. . View in PubMed
  • Evaluation of auto-planning in IMRT and VMAT for head and neck cancer J Appl Clin Med Phys. 2019 Jul; 20(7):39-47. . View in PubMed
  • Volumetric-based image guidance is superior to marker-based alignments for stereotactic body radiotherapy of prostate cancer J Appl Clin Med Phys. 2018 Mar; 19(2):198-203. . View in PubMed
  • Percent depth doses and X-ray beam characterizations of a fluoroscopic system incorporating copper filtration Med Phys. 2017 Apr; 44(4):1275-1286. . View in PubMed
  • Dosimetric impact of orthopedic metal artifact reduction (O-MAR) on Spine SBRT patients J Appl Clin Med Phys. 2015 09 08; 16(5):106-116. . View in PubMed
  • Pressure-morphology relationship of a released carpal tunnel J Orthop Res. 2013 Apr; 31(4):616-20. . View in PubMed
  • In vivo study of transverse carpal ligament stiffness using acoustic radiation force impulse (ARFI) imaging PLoS One. 2013; 8(7):e68569. . View in PubMed
  • A digit alignment device for kinematic analysis of the thumb and index finger Gait Posture. 2012 Jul; 36(3):643-5. . View in PubMed
  • Ultrasound assessment of transverse carpal ligament thickness: a validity and reliability study Ultrasound Med Biol. 2012 Jun; 38(6):982-8. . View in PubMed
  • Viscoelastic properties of isolated collagen fibrils Biophys J. 2011 Jun 22; 100(12):3008-15. . View in PubMed
  • In vitro fracture testing of submicron diameter collagen fibril specimens Biophys J. 2010 Sep 22; 99(6):1986-95. . View in PubMed
  • Stress-strain experiments on individual collagen fibrils Biophys J. 2008 Oct; 95(8):3956-63. . View in PubMed
  • Biomechanical interaction between the transverse carpal ligament and the thenar muscles J Appl Physiol (1985). 2013 Jan 15; 114(2):225-9. . View in PubMed