Alice Marie Stek, MD

Clinical Assistant Professor of Obstetrics and Gynecology (Part-Time)

Image of Alice Marie Stek, MD
Is this your profile? Click to edit

Overview

Dr. Stek completed a residency in Obstetrics and Gynecology and a fellowship in maternal-fetal medicine (MFM). Her research and clinical interests are primarily in the field of HIV in pregnancy and HIV in women. She has been conducting clinical research in these areas since starting her MFM Fellowship. Dr. Stek has been active in the Pediatric AIDS Clinical Trials Group for over 12 years, where she serves on the Perinatal RAC, the Obstetrics Subcommittee and the AACTG Womens Health Committee. She is a member of eight PACTG and AACTG protocol teams and is co-chair and vice-chair of several protocols. She is also a member of the local WIHS team.

Dr. Steks current research, both in the multicenter research organizations and in the MCA Centers own projects, focuses on the use of antiretroviral medications in pregnancy. Dr. Stek, in collaboration with PACTG pharmacologists in Boston, San Diego, and San Francisco, and locally with Dr. Michael Neely and the USC School of Pharmacy, is studying the pharmacokinetics, and safety and efficacy (collaborating with PACTG, AACTG, and MCA internists and pediatricians) of the medications used to prevent perinatal HIV transmission and for maternal health. Together with a pathologist at Baylor University, she is studying placental pathology in women using antiretrovirals during pregnancy. She collaborated with the USC pathology/lo aboratory medicine department and MCA pediatricians in designing and implementing a rapid HIV testing program for women in labor, and is currently evaluating this program with the USC pathology/laboratory medicine department and an MCA epidemiologist. Other collaborative research projects in the PACTG and AACTG include a comprehensive project to collect data on HIV-infected pregnancies, an evaluation of postpartum virologic and immunologic changes, and a trial of a therapeutic HPV vaccine in HIV-positive adolescents. In addition to these research activities, Dr. Stek provides clinical care for MCAs pregnant patients, and teaches at Womens and Childrens Hospital, USC Keck School of Medicine, and occasionally at USC main campus, as well as outside the university both in the local community and outside of Los Angeles.

Publications

  • Pharmacokinetics and Safety of Clofazimine in Women With Rifampicin-resistant Tuberculosis During Pregnancy and the Postpartum Period: Results From IMPAACT P1026s. J Infect Dis. 2026 Jan 17; 233(1):16-26.. View in PubMed
  • Population Pharmacokinetics of Bictegravir During Pregnancy and Postpartum: Role of Adherence in Maintaining Therapeutic Exposure. J Clin Pharmacol. 2026 Jan; 66(1):e70134.. View in PubMed
  • Pharmacokinetics of first-line tuberculosis drugs rifampin, isoniazid, ethambutol, and pyrazinamide during pregnancy and postpartum with and without efavirenz-based antiretroviral treatment: IMPAACT P1026s study. Antimicrob Agents Chemother. 2025 09 03; 69(9):e0005225.. View in PubMed
  • Pharmacokinetics and Safety of Levofloxacin for Treatment of Rifampicin-Resistant Tuberculosis During Pregnancy and the Postpartum Period: Results from IMPAACT P1026s. Clin Pharmacokinet. 2025 Apr; 64(4):619-630.. View in PubMed
  • Pharmacokinetics and Safety of Bictegravir in Pregnant and Postpartum Persons With HIV and Their Infants. J Acquir Immune Defic Syndr. 2025 Mar 01; 98(3):300-307.. View in PubMed
  • Cardiovascular Adaptation in Normal Pregnancy With 2D and 3D Echocardiography, Speckle Tracking, and Radial Artery Tonometry. JACC Adv. 2024 Nov; 3(11):101360.. View in PubMed
  • Pharmacokinetics and Safety of Remdesivir in Pregnant and Nonpregnant Women With COVID-19: Results From IMPAACT 2032. J Infect Dis. 2024 Oct 16; 230(4):878-888.. View in PubMed
  • Pharmacokinetics and safety of first-line tuberculosis drugs rifampin, isoniazid, ethambutol, and pyrazinamide during pregnancy and postpartum: results from IMPAACT P1026s. Antimicrob Agents Chemother. 2023 11 15; 67(11):e0073723.. View in PubMed
  • “We Are Not Different than Others”: A Qualitative Study of the Lived Experience of Hispanic Adolescents and Young Adults Living with Perinatally Acquired HIV. Int J Environ Res Public Health. 2023 02 08; 20(4).. View in PubMed
  • Assessing the efficacy of magnesium oxide and riboflavin as preventative treatment of migraines in pregnancy. Arch Gynecol Obstet. 2023 12; 308(6):1749-1754.. View in PubMed