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Charles Liu, MD, PhD
Professor of Clinical Neurological Surgery
Director, USC Neurorestoration Center
Neurological Surgery
GNH 3300 Health Sciences Campus Los Angeles
+1 323 226 7421


Dr. Liu completed his undergraduate education in Chemical Engineering at the University of Michigan, Ann Arbor, and went on to receive his PhD in Chemical/Biomedical Engineering at Rice University. He then attended the Yale University School of Medicine, receiving his MD degree. He trained in neurosurgery at the University of Southern California Affiliated Hospitals.

He is presently professor of neurosurgery and neurology and holds the Apuzzo Professorship for Advanced Neurosurgery. He is also Director of the USC Center for Neurorestoration, which functions to bring scientific advances in the laboratory and engineers new tools to restore function to the injured and diseased nervous system. He also serves as the Surgical Director of the USC Comprehensive Epilepsy Program, one of the premier and highest volume surgical epilepsy programs in the world.

He has received numerous research awards and made a large number of visitorships/invited lectures throughout the world. He also serves as Associate Editor of the journal, WORLD NEUROSURGERY. He is a principal neurosurgical consultant for the NCAA USC Trojans Athletics Department. In addition, he serves on the Executive Committee of the Congress of Neurological Surgeons. At Rancho los Amigos, Dr. Liu is Chair of the Department of Neurosurgery and is developing cutting-edge programs in restorative neurosurgery, collaborating with scientists at Caltech and USC, among others.


Castle Connolly Medical Ltd. : Top Doctor, 2015

Castle Connolly Medical Ltd: Top Doctor, 2011


. Proprioceptive and cutaneous sensations in humans elicited by intracortical microstimulation Elife. 2018 Apr 10; 7. View in: PubMed

. Preventable complications in epilepsy admissions: The "July effect" Epilepsy Res. 2017 Nov; 137:101-106. View in: PubMed

. The Weekend Effect on Morbidity and Mortality Among Pediatric Epilepsy AdmissionsPediatr Neurol. 2017 Sep; 74:24-31. e1. View in: PubMed

. Potentially preventable complications in epilepsy admissions: The "weekend effect" Epilepsy Behav. 2017 05; 70(Pt A):50-56. View in: PubMed

. Interplay between Cortical Spreading Depolarization and Seizures Stereotact Funct Neurosurg. 2017; 95(1):1-5. View in: PubMed

. Atypical central neurocytoma with metastatic craniospinal dissemination: a case report Clin Imaging. 2016 Nov - Dec; 40(6):1108-1111. View in: PubMed

. Introduction: Neurorestoration: re-animating the CNS Neurosurg Focus. 2016 May; 40(5):E1. View in: PubMed

. Cortical spreading depolarization: Pathophysiology, implications, and future directions J Clin Neurosci. 2016 Feb; 24:22-7. View in: PubMed

. Rational Approach to Understanding and Preventing Sports-Related Traumatic Brain Injuries World Neurosurg. 2015 Dec; 84(6):1556-7. View in: PubMed

. Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder Trauma Mon. 2015 Nov; 20(4):e27360. View in: PubMed

. The importance of preoperative diagnosis of blister aneurysms J Clin Neurosci. 2015 Sep; 22(9):1408-12. View in: PubMed

. A Single-Center Experience with the NeuroPace RNS System: A Review of Techniques and Potential Problems World Neurosurg. 2015 Sep; 84(3):719-26. View in: PubMed

. The Congress of Neurological Surgeons International Division 2014 Neurosurgery. 2015 Aug; 62 Suppl 1:79-80. View in: PubMed

. An in vitro seizure model from human hippocampal slices using multi-electrode arrays J Neurosci Methods. 2015 Apr 15; 244:154-63. View in: PubMed

. Neurosurgery: expanding relevance in the evolution of medicine? World Neurosurg. 2014 Dec; 82(6):955-7. View in: PubMed

. Supplementing the neurosurgical virtuoso: evolution of automation from mythology to operating room adjunct World Neurosurg. 2014 May-Jun; 81(5-6):719-29. View in: PubMed

. Recapitulating flesh with silicon and steel: advancements in upper extremity robotic prosthetics World Neurosurg. 2014 May-Jun; 81(5-6):730-41. View in: PubMed

. Computed tomography for clearance of cervical spine injury in the unevaluable patient World Neurosurg. 2013 Sep-Oct; 80(3-4):405-13. View in: PubMed

. Surgery of the mind, mood, and conscious state: an idea in evolution World Neurosurg. 2013 Sep-Oct; 80(3-4):S2-26. View in: PubMed

. A primer on brain-machine interfaces, concepts, and technology: a key element in the future of functional neurorestoration World Neurosurg. 2013 Mar-Apr; 79(3-4):457-71. View in: PubMed

. A Bosphorus submarine passage and the reinvention of neurosurgery World Neurosurg. 2013 Jan; 79(1):40-52. View in: PubMed

. The use of nanoparticles as contrast media in neuroimaging: a statement on toxicity World Neurosurg. 2012 Dec; 78(6):709-11. View in: PubMed

. Quantum computing: a prime modality in neurosurgery's future World Neurosurg. 2012 Nov; 78(5):404-8. View in: PubMed

. Surgery of the mind, mood, and conscious state: an idea in evolution World Neurosurg. 2012 May-Jun; 77(5-6):662-86. View in: PubMed

. The neurosurgeon "Academician" in China World Neurosurg. 2012 Feb; 77(2):219. View in: PubMed

. Spatio-temporal inter-ictal activity recorded from human epileptic hippocampal slices Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:5166-9. View in: PubMed

. Man, mind, and machine: the past and future of virtual reality simulation in neurologic surgery World Neurosurg. 2011 Nov; 76(5):419-30. View in: PubMed

. Thrombospondin-1 modulates the angiogenic phenotype of human cerebral arteriovenous malformation endothelial cells Neurosurgery. 2011 May; 68(5):1342-53; discussion 1353. View in: PubMed

. Cerebral arteriovenous malformations: issues of the interplay between stereotactic radiosurgery and endovascular surgical therapy World Neurosurg. 2011 May-Jun; 75(5-6):638-47. View in: PubMed

. Visualizing the future: enhancing neuroimaging with nanotechnology World Neurosurg. 2011 May-Jun; 75(5-6):626-37; discussion 618-9. View in: PubMed

. The Terra Cotta Army of Qin Shi Huang World Neurosurg. 2011 Mar-Apr; 75(3-4):352-3. View in: PubMed

. The role of stereotactic radiosurgery in the multimodal management of growth hormone-secreting pituitary adenomas Neurosurg Focus. 2010 Oct; 29(4):E11. View in: PubMed

. A radiographic computed tomography-based study to determine the ideal entry point, trajectory, and length for safe fixation using C-2 pars interarticularis screws J Neurosurg Spine. 2010 Jun; 12(6):602-12. View in: PubMed

. From atom to brain: applications of molecular imaging to neurosurgery World Neurosurg. 2010 May; 73(5):477-85. View in: PubMed

. Molecular imaging, part 1: apertures into the landscape of genomic medicine World Neurosurg. 2010 Apr; 73(4):307-16. View in: PubMed

. Postoperative continuous paravertebral anesthetic infusion for pain control in posterior cervical spine surgery: a case-control study Neurosurgery. 2010 Mar; 66(3 Suppl Operative):99-106; discussion 106-7. View in: PubMed

. Biological restoration of central nervous system architecture and function: part 3-stem cell- and cell-based applications and realities in the biological management of central nervous system disorders: traumatic, vascular, and epilepsy disorders Neurosurgery. 2009 Nov; 65(5):831-59; discussion 859. View in: PubMed

. Neurosurgery and quantum dots: part I--state of the art Neurosurgery. 2009 Jun; 64(6):1015-27; discussion 1027-8. View in: PubMed

. The metamorphosis of neurological surgery and the reinvention of the neurosurgeon Neurosurgery. 2009 May; 64(5):788-94; discussion 794-5. View in: PubMed

. Fenestrated aneurysm clips in the surgical management of anterior communicating artery aneurysms: operative techniques and strategyClinical article. Neurosurg Focus. 2009 May; 26(5):E7. View in: PubMed

. The biological restoration of central nervous system architecture and function: part 2-emergence of the realization of adult neurogenesis Neurosurgery. 2009 Apr; 64(4):581-60; discussion 600-1. View in: PubMed

. Aberrant angiogenic characteristics of human brain arteriovenous malformation endothelial cells Neurosurgery. 2009 Jan; 64(1):139-46; discussion 146-8. View in: PubMed

. The biological restoration of central nervous system architecture and function: part 1-foundations and historical landmarks in contemporary stem cell biology Neurosurgery. 2009 Jan; 64(1):15-39; discussion 34. View in: PubMed

. The alchemy of ideas Neurosurgery. 2008 Dec; 63(6):1035-44; discussion 1044. View in: PubMed

. Internal carotid artery aneurysms occurring at the origin of fetal variant posterior cerebral arteries: surgical and endovascular experience Neurosurgery. 2008 Jul; 63(1 Suppl 1):ONS55-61; discussion ONS61-2. View in: PubMed

. Surgery of the mind and mood: a mosaic of issues in time and evolution Neurosurgery. 2008 Jun; 62(6 Suppl 3):921-40. View in: PubMed

. The future of cerebral surgery: a kaleidoscope of opportunities Neurosurgery. 2008 Jun; 62(6 Suppl 3):1555-79; discussion 1579-82. View in: PubMed

. Novel use of an endovascular embolectomy device for retrograde suction decompression-assisted clip ligation of a large paraclinoid aneurysm: technical case report Neurosurgery. 2008 May; 62(5 Suppl 2):ONSE412-3; discussion ONSE413-4. View in: PubMed

. Neurosurgery in the realm of 10(-9), Part 2: applications of nanotechnology to neurosurgery--present and future Neurosurgery. 2008 Feb; 62(2):269-84; discussion 284-5. View in: PubMed

. Neurosurgery in the realm of 10(-9), part 1: stardust and nanotechnology in neuroscience Neurosurgery. 2008 Jan; 62(1):1-20. View in: PubMed

. Alexander NKonovalov: neurosurgeon, leader, mentor. Neurosurgery. 2008 Jan; 62(1):249-53; discussion 253-5. View in: PubMed

. Chained lightning: part III--Emerging technology, novel therapeutic strategies, and new energy modalities for radiosurgery Neurosurgery. 2007 Dec; 61(6):1111-29; discussion 1129-30. View in: PubMed

. Chained lightning, part II: neurosurgical principles, radiosurgical technology, and the manipulation of energy beam delivery Neurosurgery. 2007 Sep; 61(3):433-46; discussion 446. View in: PubMed

. Surgery of the human cerebrum--a collective modernity Neurosurgery. 2007 Jul; 61(1 Suppl):28; discussion 28-31. View in: PubMed

. Chained lightning, part I: Exploitation of energy and radiobiological principles for therapeutic purposes Neurosurgery. 2007 Jul; 61(1):14-27; discussion 27-8. View in: PubMed

. Stereotactic radiosurgery: adjacent tissue injury and response after high-dose single fraction radiation: Part I--Histology, imaging, and molecular events Neurosurgery. 2007 Jan; 60(1):31-44; discussion 44-5. View in: PubMed

. Recognition and management of delayed hyponatremia following transsphenoidal pituitary surgery J Neurosurg. 2007 Jan; 106(1):66-71. View in: PubMed

. Surgery of the mind and mood: a mosaic of issues in time and evolution Neurosurgery. 2006 Oct; 59(4):720-33; discussion 733-9. View in: PubMed

. Toward the emergence of nanoneurosurgery: part III--nanomedicine: targeted nanotherapy, nanosurgery, and progress toward the realization of nanoneurosurgery Neurosurgery. 2006 Jun; 58(6):1009-26; discussion 1009-26. View in: PubMed

. Toward the emergence of nanoneurosurgery: part II--nanomedicine: diagnostics and imaging at the nanoscale level Neurosurgery. 2006 May; 58(5):805-23; discussion 805-23. View in: PubMed

. Vector analysis correlating bullet trajectory to outcome after civilian through-and-through gunshot wound to the head: using imaging cues to predict fatal outcome Neurosurgery. 2005 Oct; 57(4):737-47; discussion 737-47. View in: PubMed

. Toward the emergence of nanoneurosurgery: part I--progress in nanoscience, nanotechnology, and the comprehension of events in the mesoscale realm Neurosurgery. 2005 Oct; 57(4):606-34; discussion 606-34. View in: PubMed

. Cellular signaling in neural stem cells: implications for restorative neurosurgery Neurosurg Focus. 2005 Sep 15; 19(3):E2. View in: PubMed

. Resorbable polylactic acid interbody spacers with vertebral autograft for anterior cervical discectomy and fusion Neurosurgery. 2005 Jul; 57(1):135-40; discussion 135-40. View in: PubMed

. The evolution and future of minimalism in neurological surgery Childs Nerv Syst. 2004 Nov; 20(11-12):783-9. View in: PubMed

. The physics of image formation in the neuroendoscope Childs Nerv Syst. 2004 Nov; 20(11-12):777-82. View in: PubMed

. Reliability of three-dimensional fluoroscopy for detecting pedicle screw violations in the thoracic and lumbar spine Neurosurgery. 2004 May; 54(5):1138-42; discussion 1142-3. View in: PubMed

. Foundations of neurological surgery: the state of the journal and documentation of surgical methods Clin Neurosurg. 2004; 51:67-9. View in: PubMed

. Artificial niches for human adult neural stem cells: possibility for autologous transplantation therapy J Hematother Stem Cell Res. 2003 Dec; 12(6):689-99. View in: PubMed

. Engineering of the extracellular matrix: working toward neural stem cell programming and neurorestoration--concept and progress report Neurosurgery. 2003 May; 52(5):1154-65; discussion 1165-7. View in: PubMed

. The genesis of neurosurgery and the evolution of the neurosurgical operative environment: part I-prehistory to 2003 Neurosurgery. 2003 Jan; 52(1):3-19; discussion 19. View in: PubMed

. The genesis of neurosurgery and the evolution of the neurosurgical operative environment: part II--concepts for future development, 2003 and beyond Neurosurgery. 2003 Jan; 52(1):20-33; discussion 33-5. View in: PubMed

. Clin Neurosurg. 2002; 49:159-87. View in: PubMed

. Honored guest presentation: surgery of the human cerebrum: a collective modernity Clin Neurosurg. 2002; 49:27-89. View in: PubMed

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