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Hittu Matta, PhD

Associate Professor Of Research Medicine

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Phone +1 323 865 3950
Email [email protected]
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Overview

Dr. Matta earned her Master’s and PhD in Microbiology followed by a fellowship at The Hamon Center for Therapeutic and Oncology Research, University of Texas Southwestern Medical Center.

Dr. Matta’s research interests include KSHV-associated malignancies and drug development.

Publications

  • p97 Inhibition Synergistically Enhances Hypomethylating Therapy through Targeting of PLK1 in Acute Myeloid Leukemia. Cancer Res Commun. 2026 06 01; 6(6):1509-1521.. View in PubMed
  • A novel thermostable beetle luciferase based cytotoxicity assay. Sci Rep. 2021 05 11; 11(1):10002.. View in PubMed
  • Narciclasine, an isocarbostyril alkaloid, has preferential activity against primary effusion lymphoma. Sci Rep. 2020 03 31; 10(1):5712.. View in PubMed
  • A Fast and Sensitive Luciferase-based Assay for Antibody Engineering and Design of Chimeric Antigen Receptors. Sci Rep. 2020 02 11; 10(1):2318.. View in PubMed
  • A novel luciferase-based assay for the detection of Chimeric Antigen Receptors. Sci Rep. 2019 02 13; 9(1):1957.. View in PubMed
  • Development and characterization of a novel luciferase based cytotoxicity assay. Sci Rep. 2018 01 09; 8(1):199.. View in PubMed
  • Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Oncogene. 2016 Apr 07; 35(14):1797-810.. View in PubMed
  • NEMO is essential for Kaposi’s sarcoma-associated herpesvirus-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death, and its N-terminal 251 residues are sufficient for this process. J Virol. 2014 Jun; 88(11):6345-54.. View in PubMed
  • A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-κB. Clin Cancer Res. 2013 Sep 15; 19(18):5016-26.. View in PubMed
  • Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors. Oncogene. 2014 May 29; 33(22):2928-37.. View in PubMed

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