Faculty

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John M. Ringman, MD, MS
Professor of Clinical Neurology
Neurology
CHP 209 1540 Alcazar St. Health Sciences Campus Los Angeles

Publications

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 Sep; 49(9):1373-1384. View in: PubMed

Patient and caregiver reactions to clinical amyloid imaging. Alzheimers Dement. 2017 Aug; 13(8):924-932. View in: PubMed

A novel PSEN1 (S230N) mutation causing early-onset Alzheimer's Disease associated with prosopagnosia, hoarding, and Parkinsonism. Neurosci Lett. 2017 Jul 29; 657:11-15. View in: PubMed

Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial MRI study. Alzheimers Dement. 2017 Jul 22. View in: PubMed

A comparison of theoretical and statistically derived indices for predicting cognitive decline. Alzheimers Dement (Amst). 2017; 6:171-181. View in: PubMed

Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort. Dement Geriatr Cogn Disord. 2017; 44(1-2):1-11. View in: PubMed

Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease. J Alzheimers Dis. 2017; 58(4):1035-1041. View in: PubMed

Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). Lancet Neurol. 2016 Dec; 15(13):1317-1325. View in: PubMed

Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiol Aging. 2016 Nov; 47:201-209. View in: PubMed

BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain. 2016 Oct; 139(Pt 10):2766-2777. View in: PubMed

Are Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease "Separate but Equal"? JAMA Neurol. Are Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease "Separate but Equal"? JAMA Neurol. 2016 Sep 01; 73(9):1060-1. View in: PubMed

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network. Ann Neurol. 2016 Jun; 79(6):929-39. View in: PubMed

Improvement of Dream Enactment Behavior Associated With Levetiracetam Treatment in Dementia With Lewy Bodies. Alzheimer Dis Assoc Disord. 2016 Apr-Jun; 30(2):175-7. View in: PubMed

Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol. 2016 Mar; 75(3):284-90. View in: PubMed

Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group. PLoS One. 2016; 11(3):e0152082. View in: PubMed

Assessing intracranial vascular compliance using dynamic arterial spin labeling. Neuroimage. 2016 Jan 01; 124(Pt A):433-41. View in: PubMed

Critical review of the Appropriate Use Criteria for amyloid imaging: Effect on diagnosis and patient care. Alzheimers Dement (Amst). 2016; 5:15-22. View in: PubMed

Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group. PLoS One. 2016; 11(9):e0163669. View in: PubMed

Daily Activity Abilities in MCI, Alzheimer's Disease, and Healthy Controls. GeroPsych (Bern). 2015 Dec; 28(4):191-200. View in: PubMed

Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia. Cogn Behav Neurol. 2015 Dec; 28(4):188-97. View in: PubMed

A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy. JAMA Neurol. 2015 Apr; 72(4):414-22. View in: PubMed

Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network. Brain. 2015 Apr; 138(Pt 4):1036-45. View in: PubMed

Donepezil treatment in ethnically diverse patients with Alzheimer disease. Am J Geriatr Psychiatry. 2015 Apr; 23(4):384-90. View in: PubMed

Factors associated with the onset and persistence of post-lumbar puncture headache. JAMA Neurol. 2015 Mar; 72(3):325-32. View in: PubMed

Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. View in: PubMed

Conceptualization and assessment of vulnerability in a complex international Alzheimer's research study. Am J Bioeth. 2015; 15(4):87-9. View in: PubMed

Use of the MoCA in Detecting Early Alzheimer's Disease in a Spanish-Speaking Population with Varied Levels of Education. Dement Geriatr Cogn Dis Extra. 2015 Jan-Apr; 5(1):85-95. View in: PubMed

A survey of attitudes toward clinical trials and genetic disclosure in autosomal dominant Alzheimer's disease. Alzheimers Res Ther. 2015; 7(1):50. View in: PubMed

Effect of potent ?-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. View in: PubMed

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. View in: PubMed

Genetic heterogeneity in Alzheimer disease and implications for treatment strategies. Curr Neurol Neurosci Rep. 2014 Nov; 14(11):499. View in: PubMed

Functional connectivity in autosomal dominant and late-onset Alzheimer disease. JAMA Neurol. 2014 Sep; 71(9):1111-22. View in: PubMed

Functional connectivity in autosomal dominant and late-onset Alzheimer disease. JAMA Neurol. 2014 Sep 1; 71(9):1111-22. View in: PubMed

Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 2014 Jul 15; 83(3):253-60. View in: PubMed

Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease. JAMA Neurol. 2014 Jul 01; 71(7):878-83. View in: PubMed

Younger age of dementia diagnosis in a Hispanic population in southern California. Int J Geriatr Psychiatry. 2014 Jun; 29(6):586-93. View in: PubMed

Age effects on cortical thickness in cognitively normal elderly individuals. Dement Geriatr Cogn Dis Extra. 2014 May; 4(2):221-7. View in: PubMed

Reliability of two-dimensional and three-dimensional pseudo-continuous arterial spin labeling perfusion MRI in elderly populations: comparison with 15O-water positron emission tomography. J Magn Reson Imaging. 2014 Apr; 39(4):931-9. View in: PubMed

The "Alzheimer's type" profile of semantic clustering in amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2014 Apr; 20(4):402-12. View in: PubMed

Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Sci Transl Med. 2014 Mar 05; 6(226):226ra30. View in: PubMed

A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman. J Alzheimers Dis. 2014; 40(2):271-5. View in: PubMed

Neuropathologic correlates of trial-related instruments for Alzheimer's disease. Am J Neurodegener Dis. 2014; 3(1):45-9. View in: PubMed

Memory performance and fMRI signal in presymptomatic familial Alzheimer's disease. Hum Brain Mapp. 2013 Dec; 34(12):3308-19. View in: PubMed

Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4502-9. View in: PubMed

Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults. Neuroimage. 2013 Nov 15; 82:146-53. View in: PubMed

The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study. Neurology. 2013 Oct 15; 81(16):1425-33. View in: PubMed

The impact of the availability of prevention studies on the desire to undergo predictive testing in persons at risk for autosomal dominant Alzheimer's disease. Contemp Clin Trials. 2013 Sep; 36(1):256-62. View in: PubMed

Impaired default network functional connectivity in autosomal dominant Alzheimer disease. Neurology. 2013 Aug 20; 81(8):736-44. View in: PubMed

Similar verbal fluency patterns in amnestic mild cognitive impairment and Alzheimer's disease. Arch Clin Neuropsychol. 2013 Aug; 28(5):400-10. View in: PubMed

Complexity and synchronicity of resting state blood oxygenation level-dependent (BOLD) functional MRI in normal aging and cognitive decline. J Magn Reson Imaging. 2013 Jul; 38(1):36-45. View in: PubMed

New genes and new insights from old genes: update on Alzheimer disease. Continuum (Minneap Minn). 2013 Apr; 19(2 Dementia):358-71. View in: PubMed

Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder. J Psychiatr Res. 2013 Apr; 47(4):494-504. View in: PubMed

Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer's disease mutations. J Neurol Neurosurg Psychiatry. 2013 Feb; 84(2):154-62. View in: PubMed

Estimating sample sizes for predementia Alzheimer's trials based on the Alzheimer's Disease Neuroimaging Initiative. Neurobiol Aging. 2013 Jan; 34(1):62-72. View in: PubMed

1a,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-ß phagocytosis and inflammation in Alzheimer's disease patients. J Alzheimers Dis. 2013; 34(1):155-70. View in: PubMed

Agitation and psychosis associated with dementia with lewy bodies exacerbated by modafinil use. Am J Alzheimers Dis Other Demen. 2012 Nov; 27(7):468-73. View in: PubMed

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clin Investig (Lond). 2012 Oct 01; 2(10):975-984. View in: PubMed

Comparison of clinical characteristics between familial and non-familial early onset Alzheimer's disease. J Neurol. 2012 Oct; 259(10):2182-8. View in: PubMed

Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med. 2012 Aug 30; 367(9):795-804. View in: PubMed

Evidence for a role of the rare p. A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet. 2012 Aug 01; 21(15):3500-12. View in: PubMed

Evidence for a role of the rare p. A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet. 2012 Aug 1; 21(15):3500-12. View in: PubMed

Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. View in: PubMed

The exception makes the rule: not all Aß plaques are created equal. Neurology. 2012 Jul 17; 79(3):206-7. View in: PubMed

Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol. 2012 Jul; 69(7):836-41. View in: PubMed

Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype. Arch Neurol. 2012 Jun; 69(6):757-64. View in: PubMed

Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults. J Neurosci. 2012 Apr 25; 32(17):5964-72. View in: PubMed

Increased fMRI signal with age in familial Alzheimer's disease mutation carriers. Neurobiol Aging. 2012 Feb; 33(2):424. e11-21. View in: PubMed

Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers. Dement Geriatr Cogn Dis Extra. 2012 Jan; 2(1):652-7. View in: PubMed

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther. 2012; 4(5):43. View in: PubMed

Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2012; 33(1):1-5. View in: PubMed

Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dement Geriatr Cogn Disord. 2012; 33(4):219-25. View in: PubMed

Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations. Arch Neurol. 2012 Jan; 69(1):96-104. View in: PubMed

Should persons with autosomal dominant AD be included in clinical trials? Alzheimers Res Ther. Should persons with autosomal dominant AD be included in clinical trials? Alzheimers Res Ther. 2011 May 23; 3(3):18. View in: PubMed

Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011 May 04; 31(18):6764-70. View in: PubMed

Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011 May 4; 31(18):6764-70. View in: PubMed

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. View in: PubMed

Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task. Cereb Cortex. 2011 Apr; 21(4):877-83. View in: PubMed

Neuroimaging measures as endophenotypes in Alzheimer's disease. Int J Alzheimers Dis. 2011 Mar 31; 2011:490140. View in: PubMed

Setting the stage for prevention of familial Alzheimer's disease. Lancet Neurol. 2011 Mar; 10(3):200-1. View in: PubMed

Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation. Neurosci Lett. 2011 Jan 10; 487(3):287-92. View in: PubMed

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimers Res Ther. 2011 Jan 06; 3(1):1. View in: PubMed

Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2011; 32(2):118-25. View in: PubMed

An update on the diagnosis and management of dementing conditions. Rev Neurol Dis. 2011; 8(3-4):e68-87. View in: PubMed

Neuroimaging measures as endophenotypes in Alzheimer's disease. Int J Alzheimers Dis. 2011; 2011:490140. View in: PubMed

Propositional density and apolipoprotein E genotype among persons at risk for familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2011; 32(3):188-92. View in: PubMed

The use of profanity during letter fluency tasks in frontotemporal dementia and Alzheimer disease. Cogn Behav Neurol. 2010 Sep; 23(3):159-64. View in: PubMed

Insensitivity of visual assessment of hippocampal atrophy in familial Alzheimer's disease. J Neurol. 2010 May; 257(5):839-42. View in: PubMed

Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease. Mol Neurodegener. 2010 Jan 14; 5:2. View in: PubMed

Mary S. Easton Center of Alzheimer's Disease Research at UCLA: advancing the therapeutic imperative. J Alzheimers Dis. 2010; 19(2):375-88. View in: PubMed

Current concepts of mild cognitive impairment and their applicability to persons at-risk for familial Alzheimer's disease. Curr Alzheimer Res. 2009 Aug; 6(4):341-6. View in: PubMed

Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid. Arch Neurol. 2009 Apr; 66(4):448-57. View in: PubMed

Commentary on "a roadmap for the prevention of dementia II: Leon Thal Symposium 2008. " Prevention trials in persons at risk for dominantly inherited Alzheimer's disease: opportunities and challenges. Alzheimers Dement. 2009 Mar; 5(2):166-71. View in: PubMed

Diagnosing depression in Alzheimer disease with the national institute of mental health provisional criteria. Am J Geriatr Psychiatry. 2008 Jun; 16(6):469-77. View in: PubMed

Myopathy associated with chronic orlistat consumption: a case report. Neuromuscul Disord. 2008 May; 18(5):410-2. View in: PubMed

Mosaicism for trisomy 21 in a patient with young-onset dementia: a case report and brief literature review. Arch Neurol. 2008 Mar; 65(3):412-5. View in: PubMed

Children of persons with Alzheimer disease: what does the future hold? Alzheimer Dis Assoc Disord. Children of persons with Alzheimer disease: what does the future hold? Alzheimer Dis Assoc Disord. 2008 Jan-Mar; 22(1):6-20. View in: PubMed

Increased prevalence of significant recurrent headache in preclinical familial Alzheimer's disease mutation carriers. Dement Geriatr Cogn Disord. 2008; 25(4):380-4. View in: PubMed

The Huntington disease of woody guthrie: another man done gone. Cogn Behav Neurol. 2007 Dec; 20(4):238-43. View in: PubMed

Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12849-54. View in: PubMed

Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations. Brain. 2007 Jul; 130(Pt 7):1767-76. View in: PubMed

An experimental approach to detecting dementia in Down syndrome: a paradigm for Alzheimer's disease. Brain Cogn. 2007 Jun; 64(1):92-103. View in: PubMed

Performance on MMSE sub-items and education level in presenilin-1 mutation carriers without dementia. Int Psychogeriatr. 2007 Apr; 19(2):323-32. View in: PubMed

Serendipitous improvement in the Yips associated with memantine use. Mov Disord. 2007 Mar 15; 22(4):598-9. View in: PubMed

Visualizing language deterioration in progressive aphasias. Neurology. 2006 Nov 28; 67(10):1738-9. View in: PubMed

The A431E mutation in PSEN1 causing familial Alzheimer's disease originating in Jalisco State, Mexico: an additional fifteen families. Neurogenetics. 2006 Nov; 7(4):277-9. View in: PubMed

Donepezil improves cognitive function and reduces decline in activities of daily living in people with severe Alzheimer's disease. Evid Based Ment Health. 2006 Nov; 9(4):104. View in: PubMed

The Thr354Ile substitution in PSEN1:: disease-causing mutation or polymorphism? Neurology. The Thr354Ile substitution in PSEN1:: disease-causing mutation or polymorphism? Neurology. 2006 Jun 27; 66(12):1955-6. View in: PubMed

Family history of dementia in early-onset versus very late-onset Alzheimer's disease. Int J Geriatr Psychiatry. 2006 Jun; 21(6):597-8. View in: PubMed

Current and emerging pharmacological treatment options for dementia. Behav Neurol. 2006; 17(1):5-16. View in: PubMed

What the study of persons at risk for familial Alzheimer's disease can tell us about the earliest stages of the disorder: a review. J Geriatr Psychiatry Neurol. 2005 Dec; 18(4):228-33. View in: PubMed

Earlier Alzheimer onset in Latino persons: ethnic difference vs selection bias. Arch Neurol. 2005 Nov; 62(11):1786-7. View in: PubMed

Carbonic anhydrase inhibitors and amobarbital resistance. Epilepsia. 2005 Aug; 46(8):1333. View in: PubMed

Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2005 Jun; 7(3):221-32; discussion 255-62. View in: PubMed

A potential role of the curry spice curcumin in Alzheimer's disease. Curr Alzheimer Res. 2005 Apr; 2(2):131-6. View in: PubMed

Mitochondrial encephalomyopathy with lactic acidosis and stroke (MELAS). Rev Neurol Dis. 2005; 2(1):30-4. View in: PubMed

Spasmodic dysphonia in a patient with the A to G transition at nucleotide 8344 in mitochondrial DNA. Mov Disord. 2003 Jun; 18(6):716-8. View in: PubMed

The prevalence and correlates of neuropsychiatric symptoms in a population with Parkinson's disease in Mexico. Neuropsychiatry Neuropsychol Behav Neurol. 2002 Jun; 15(2):99-105. View in: PubMed

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