Faculty

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Leslie Ann Saxon, MD
Professor of Medicine (Clinical Scholar)
Executive Director, Center For Body Computing (Cbc)
Medicine
HCC 300N Health Sciences Campus Los Angeles
+1 323 442 6130

Overview

Dr. Leslie Saxon is a professor of clinical medicine (clinical scholar) at the Keck School of Medicine of USC and specializes in the diagnosis and treatment of cardiac arrhythmias and preventing sudden cardiac death. In addition to her work in cardiovascular medicine, Dr. Saxon serves as the executive director of the internationally acclaimed USC Center for Body Computing (CBC) and newly formed USC Virtual Care Clinic (VCC). The CBC is currently a place for all USC schools, including medicine, engineering, business and the cinematic arts, to form interdisciplinary relationships and accelerate the future of fully integrated, “connected” medicine alongside public and private sector partners. She is a well-known authority on the pre-clinical and clinical development and testing of wearable and implanted technology, including networked devices used in medical, wellness and fitness disciplines. With her clinical expertise, she is a valuable strategist in developing device models and software solutions that offer engaging user-feedback based on real-time physiologic data. Her cultivation of critical innovative partnerships to jointly commercialize products within the CBC is essential for furthering and improving the dissemination of medical information, enhancing communication and improving health outcomes. Dr. Saxon has completed over 150 publications in various medical journals, has spoken at various forums, including TEDMED, South by Southwest (SXSW), WIRED Health and CES, and was recently named “Most Tech Friendly Doc” by Rock Health. Known as a digital health guru, Dr. Saxon is frequently interviewed by national media.

Publications

Pulmonary arterial pressure sensing in a patient with left ventricular assist device during ventricular arrhythmia. HeartRhythm Case Rep. 2017 Jul; 3(7):348-351. View in: PubMed

2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry. Heart Rhythm. 2017 Jul; 14(7):e55-e96. View in: PubMed

Outcomes of cardiac resynchronization therapy in patients with intermittent atrial fibrillation or atrial flutter in the COMPANION trial. Heart Rhythm. 2017 Jun; 14(6):858-865. View in: PubMed

Effects of pressure variation and atrial fibrillation on CardioMEMS™ HF measured pulmonary artery diastolic pressure: comparison of device-averaged and visually inspected waveforms. Physiol Meas. 2017 Jun; 38(6):1094-1103. View in: PubMed

2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry. Ann Noninvasive Electrocardiol. 2017 May; 22(3). View in: PubMed

Athletic Performance Monitoring, Pseudo Science and Metaphysics Meet Ethics. Am J Bioeth. 2017 Jan; 17(1):61-62. View in: PubMed

Digital monitoring and care: Virtual medicine. Trends Cardiovasc Med. 2016 Nov; 26(8):722-730. View in: PubMed

Implantable Cardioverter Defibrillator Programming Characteristics, Shocked Rhythms, and Survival Among Patients Under Thirty Years of Age. J Cardiovasc Electrophysiol. 2016 Oct; 27(10):1183-1190. View in: PubMed

Lessons Learned and Insights Gained in the Design, Analysis, and Outcomes of the COMPANION Trial. JACC Heart Fail. 2016 Jul; 4(7):521-535. View in: PubMed

Mobile Health Application Solutions. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e002477. View in: PubMed

Integration of Smartphone Based Monitoring: No Modality is an Island, Entire of Itself. J Cardiovasc Electrophysiol. 2016 Jan; 27(1):58-9. View in: PubMed

Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators. Circ Arrhythm Electrophysiol. 2015 Oct; 8(5):1173-80. View in: PubMed

Utilization trends and clinical outcomes in patients implanted with a single- vs a dual-coil implantable cardioverter-defibrillator lead: Insights from the ALTITUDE Study. Heart Rhythm. 2015 Aug; 12(8):1770-5. View in: PubMed

Remote Monitoring and Outcomes in Pacemaker and Defibrillator Patients: Big Data Saving Lives? J Am Coll Cardiol. Remote Monitoring and Outcomes in Pacemaker and Defibrillator Patients: Big Data Saving Lives? J Am Coll Cardiol. 2015 Jun 23; 65(24):2611-3. View in: PubMed

Rationale and Design of the Left Atrial Pressure Monitoring to Optimize Heart Failure Therapy Study (LAPTOP-HF). J Card Fail. 2015 Jun; 21(6):479-88. View in: PubMed

Wireless Smartphone ECG Enables Large-Scale Screening in Diverse Populations. J Cardiovasc Electrophysiol. 2015 May; 26(5):520-6. View in: PubMed

Incidence of defibrillator shocks after elective generator exchange following uneventful first battery life. J Am Heart Assoc. 2014 Nov 10; 3(6):e001289. View in: PubMed

Performance of an automatic arrhythmia classification algorithm: comparison to the ALTITUDE electrophysiologist panel adjudications. Pacing Clin Electrophysiol. 2014 Jul; 37(7):889-99. View in: PubMed

Subcutaneous implantable cardioverter-defibrillator. Circulation. 2014 Jun 10; 129(23):e644-6. View in: PubMed

Use of remote monitoring of newly implanted cardioverter-defibrillators: insights from the patient related determinants of ICD remote monitoring (PREDICT RM) study. Circulation. 2013 Nov 26; 128(22):2372-83. View in: PubMed

Survival after shock therapy in implantable cardioverter-defibrillator and cardiac resynchronization therapy-defibrillator recipients according to rhythm shocked. The ALTITUDE survival by rhythm study. J Am Coll Cardiol. 2013 Oct 29; 62(18):1674-9. View in: PubMed

The subcutaneous implantable defibrillator: a new technology that raises an existential question for the implantable cardioverter-defibrillator. Circulation. 2013 Aug 27; 128(9):938-40. View in: PubMed

Impact of shock energy and ventricular rhythm on the success of first shock therapy: the ALTITUDE first shock study. Heart Rhythm. 2013 May; 10(5):702-8. View in: PubMed

Ubiquitous wireless ECG recording: a powerful tool physicians should embrace. J Cardiovasc Electrophysiol. 2013 Apr; 24(4):480-3. View in: PubMed

CRT or CRT-D devices? The case for 'high energy' devices. Heart Fail Rev. 2012 Nov; 17(6):777-9. View in: PubMed

2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Europace. 2012 Sep; 14(9):1236-86. View in: PubMed

2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Heart Rhythm. 2012 Sep; 9(9):1524-76. View in: PubMed

Guideline adherence after ST-segment elevation versus non-ST segment elevation myocardial infarction. Circ Cardiovasc Qual Outcomes. 2012 Sep 01; 5(5):654-61. View in: PubMed

Noise, artifact, and oversensing related inappropriate ICD shock evaluation: ALTITUDE noise study. Pacing Clin Electrophysiol. 2012 Jul; 35(7):863-9. View in: PubMed

Spinal cord stimulation: a triple threat therapy? J Cardiovasc Electrophysiol. Spinal cord stimulation: a triple threat therapy? J Cardiovasc Electrophysiol. 2012 May; 23(5):541-2. View in: PubMed

Unoperated congenitally corrected transposition of the great arteries, nonrestrictive ventricular septal defect, and pulmonary stenosis in middle adulthood: do multiple wrongs make a right? World J Pediatr Congenit Heart Surg. 2012 Jan 01; 3(1):123-9. View in: PubMed

Left ventricular versus biventricular for cardiac resynchronization therapy: comparable but not equal. Circulation. 2011 Dec 20; 124(25):2803-4. View in: PubMed

Real world evaluation of dual-zone ICD and CRT-D programming compared to single-zone programming: the ALTITUDE REDUCES study. J Cardiovasc Electrophysiol. 2011 Sep; 22(9):1023-9. View in: PubMed

Cardiac resynchronization therapy and the relationship of percent biventricular pacing to symptoms and survival. Heart Rhythm. 2011 Sep; 8(9):1469-75. View in: PubMed

Implantable cardioverter defibrillator electrogram adjudication for device registries: methodology and observations from ALTITUDE. Pacing Clin Electrophysiol. 2011 Aug; 34(8):1003-12. View in: PubMed

Impact of relaxation training on patient-perceived measures of anxiety, pain, and outcomes after interventional electrophysiology procedures. Pacing Clin Electrophysiol. 2011 Jul; 34(7):821-6. View in: PubMed

Treatment of ventricular tachycardia in patients with heart failure. Curr Cardiol Rep. 2011 Jun; 13(3):203-9. View in: PubMed

Ventricular tachycardia in the era of ventricular assist devices. J Cardiovasc Electrophysiol. 2011 Mar; 22(3):359-63. View in: PubMed

The role of cardiac electrophysiology in myocardial regenerative stem cell therapy. J Cardiovasc Transl Res. 2011 Feb; 4(1):61-5. View in: PubMed

Cardiovascular care and research in the networked era. J Cardiovasc Transl Res. 2011 Feb; 4(1):1-2. View in: PubMed

Direct left atrial pressure monitoring in severe heart failure: long-term sensor performance. J Cardiovasc Transl Res. 2011 Feb; 4(1):3-13. View in: PubMed

Long-term outcome after ICD and CRT implantation and influence of remote device follow-up: the ALTITUDE survival study. Circulation. 2010 Dec 07; 122(23):2359-67. View in: PubMed

Implant wizard. Interview by Gary Baldwin. Health Data Manag. 2010 Jan; 18(1):40. View in: PubMed

Novel use of a vascular plug to anchor an azygous vein ICD lead. J Cardiovasc Electrophysiol. 2010 Jan; 21(1):99-102. View in: PubMed

Complete heart block and preserved LV function: does right ventricular pacing site matter? J Cardiovasc Electrophysiol. Complete heart block and preserved LV function: does right ventricular pacing site matter? J Cardiovasc Electrophysiol. 2009 Aug; 20(8):906-7. View in: PubMed

Influence of left ventricular lead location on outcomes in the COMPANION study. J Cardiovasc Electrophysiol. 2009 Jul; 20(7):764-8. View in: PubMed

Statin use is associated with improved survival in patients with advanced heart failure receiving resynchronization therapy. Congest Heart Fail. 2009 Jul-Aug; 15(4):159-64. View in: PubMed

Shortage of female cardiologists: exploring the issues. Mayo Clin Proc. 2008 Sep; 83(9):1022-5. View in: PubMed

Impact of cardiac resynchronization therapy on exercise performance, functional capacity, and quality of life in systolic heart failure with QRS prolongation: COMPANION trial sub-study. J Card Fail. 2008 Feb; 14(1):9-18. View in: PubMed

Survival after tachyarrhythmic arrest--what are we waiting for? N Engl J Med. Survival after tachyarrhythmic arrest--what are we waiting for? N Engl J Med. 2008 Jan 03; 358(1):77-9. View in: PubMed

Body computing: how networked medical devices can solve problems facing health care today. J Cardiovasc Electrophysiol. 2007 Dec; 18(12):1345-7. View in: PubMed

Influence of diabetes on cardiac resynchronization therapy with or without defibrillator in patients with advanced heart failure. J Card Fail. 2007 Nov; 13(9):769-73. View in: PubMed

The editor's roundtable: Cardiac resynchronization therapy. Am J Cardiol. 2007 Oct 01; 100(7):1145-52. View in: PubMed

Defining response and defining how we measure response to CRT. J Cardiovasc Electrophysiol. 2007 Sep; 18(10):1020-1. View in: PubMed

Taser-induced rapid ventricular myocardial capture demonstrated by pacemaker intracardiac electrograms. J Cardiovasc Electrophysiol. 2007 Aug; 18(8):876-9. View in: PubMed

Remote Active Monitoring in Patients with Heart Failure (RAPID-RF): design and rationale. J Card Fail. 2007 May; 13(4):241-6. View in: PubMed

Does cardiac resynchronization therapy reduce the incidence of atrial fibrillation, and does atrial fibrillation compromise the cardiac resynchronization therapy effect? Heart Rhythm. Does cardiac resynchronization therapy reduce the incidence of atrial fibrillation, and does atrial fibrillation compromise the cardiac resynchronization therapy effect? Heart Rhythm. 2007 Mar; 4(3 Suppl):S31-3. View in: PubMed

Effects of cardiac resynchronization therapy with or without a defibrillator on survival and hospitalizations in patients with New York Heart Association class IV heart failure. Circulation. 2007 Jan 16; 115(2):204-12. View in: PubMed

Predictors of sudden cardiac death and appropriate shock in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Trial. Circulation. 2006 Dec 19; 114(25):2766-72. View in: PubMed

Selection of patients for CRT--prevention or reversal of remodeling as a therapeutic endpoint for CRT. J Cardiovasc Electrophysiol. 2006 Dec; 17(12):1293-4. View in: PubMed

Recommendations from the Heart Rhythm Society Task Force on Device Performance Policies and Guidelines Endorsed by the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) and the International Coalition of Pacing and Electrophysiology Organizations (COPE). Heart Rhythm. 2006 Oct; 3(10):1250-73. View in: PubMed

More is better with cardiac resynchronization therapy--but is it enough? Eur Heart J. More is better with cardiac resynchronization therapy--but is it enough? Eur Heart J. 2006 Aug; 27(16):1891-2. View in: PubMed

Patient selection for primary prevention ICDs--are eps shocking patients into consent? J Card Fail. Patient selection for primary prevention ICDs--are eps shocking patients into consent? J Card Fail. 2006 Aug; 12(6):413-5. View in: PubMed

Results of the multicenter RENEWAL 3 AVT clinical study of cardiac resynchronization defibrillator therapy in patients with paroxysmal atrial fibrillation. J Cardiovasc Electrophysiol. 2006 May; 17(5):520-5. View in: PubMed

Cost effectiveness of cardiac resynchronization therapy in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial. J Am Coll Cardiol. 2005 Dec 20; 46(12):2311-21. View in: PubMed

Septal to posterior wall motion delay fails to predict reverse remodeling or clinical improvement in patients undergoing cardiac resynchronization therapy. J Am Coll Cardiol. 2005 Dec 20; 46(12):2208-14. View in: PubMed

Delayed defibrillation testing after CRT-D implant-weighing competing risks. J Cardiovasc Electrophysiol. 2005 Dec; 16(12):1284-5. View in: PubMed

A comparison of cardiac resynchronization by sequential biventricular pacing and left ventricular pacing to simultaneous biventricular pacing: rationale and design of the DECREASE-HF clinical trial. J Card Fail. 2005 Apr; 11(3):233-9. View in: PubMed

Sudden cardiac death: epidemiology and temporal trends. Rev Cardiovasc Med. 2005; 6 Suppl 2:S12-20. View in: PubMed

Effects of resynchronization therapy on cardiac function in pacemaker patients "upgraded" to biventricular devices. J Cardiovasc Electrophysiol. 2004 Nov; 15(11):1284-9. View in: PubMed

Improvement in heart rate turbulence as a measure of response to beta-blocker therapy for heart failure. J Cardiovasc Electrophysiol. 2004 Jul; 15(7):757-8. View in: PubMed

Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004 May 20; 350(21):2140-50. View in: PubMed

Noninvasive assessment of the biventricular pacing system. Ann Noninvasive Electrocardiol. 2004 Jan; 9(1):58-70. View in: PubMed

Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias. J Am Coll Cardiol. 2003 Oct 15; 42(8):1454-9. View in: PubMed

Usefulness of QRS prolongation in predicting risk of inducible monomorphic ventricular tachycardia in patients referred for electrophysiologic studies. Am J Cardiol. 2003 Oct 01; 92(7):804-9. View in: PubMed

Resynchronization therapy for the treatment of heart failure. Circulation. 2003 Sep 02; 108(9):1044-8. View in: PubMed

NASPE training requirements for cardiac implantable electronic devices: selection, implantation, and follow-up. Pacing Clin Electrophysiol. 2003 Jul; 26(7 Pt 1):1556-62. View in: PubMed

Isolated bundle branch block and left ventricular dysfunction. J Card Fail. 2003 Apr; 9(2):87-92. View in: PubMed

Ventricular resynchronization: a promising therapy for heart failure. Am J Geriatr Cardiol. 2003 Jan-Feb; 12(1):41-8. View in: PubMed

The MIRACLE trial: an electrophysiologist's perspective. J Card Fail. 2002 Aug; 8(4):202-3. View in: PubMed

Heart failure and Implantable Cardioverter Defibrillator (ICD) therapy: Update and perspective on current primary prevention trials. J Card Fail. 2002 Jun; 8(3):161-6. View in: PubMed

Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling. Circulation. 2002 Mar 19; 105(11):1304-10. View in: PubMed

Arrhythmias associated with dilated cardiomyopathy. Card Electrophysiol Rev. 2002 Feb; 6(1-2):18-25. View in: PubMed

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