Mitchell E. Gross, MD, PhD

Associate Professor of Clinical Medicine

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Overview

Dr. Gross is research director of the USC Norris Westside Cancer Center and the Center for Applied Molecular Medicine. His overall research interest focuses on applying modern techniques relating to the study of genes and proteins (genomics and proteomics) on the clinical problems faced in treating patients with prostate cancer. A particular interest relates to the androgen receptor and relating proteins and pathways as key driving forces behind the development and treatment of prostate cancer. As a medical oncologist, his clinical activities are focused on therapeutic clinical trials incorporating both molecularly targeted and conventional therapies to the care of patients with prostate cancer. He serves as primary investigator on many multi-center phase 1 and 2 clinical trials

Dr. Gross has earned degrees from the University of California, San Diego (B.A.), Baylor College of Medicine in Houston (M.D.), and the University of California, Los Angeles (Ph.D. Molecular Biology). He completed a residency in internal medicine and a fellowship in hematology and medical oncology at the UCLA Center for the Health Sciences.

Awards

  • Phi Beta Kappa, 1989
  • UCSD/Revelle College Academic: Leadership Award, 1990
  • Alpha Omega Alpha, 1994
  • Hewlett Packard Award for Excellence in Internal Medicine, 1994
  • Specialty Training Advanced Research Fellowship, 1997
     – 2002
  • Amgen Fellowship Research Award, 1999
  • Rhone Phoulenc Rorer Travel Award, 1999
  • AACR-AFLAC Scholar in Training Award,, 2001
  • Donna and Jesse Garber Award, 2006

Research Funding

  • Selective Cancer Treatment Based on High Frequency Ultrasonic Beam
    NIH · R21EB022932 · Sep 16, 2016 – Jul 31, 2018 · Role: Co-Principal Investigator
  • Role of PIASy in Androgen Signaling and Prostate Cancer
    NIH · K08DK064379 · Aug 21, 2002 – Jun 30, 2007 · Role: Principal Investigator

Publications

  • EphB4-ephrin-B2 are targets in castration resistant prostate cancer. Br J Cancer. 2025 May; 132(8):679-689.. View in PubMed
  • MRI Detection of Lymph Node Metastasis through Molecular Targeting of C-C Chemokine Receptor Type 2 and Monocyte Hitchhiking. ACS Nano. 2024 01 23; 18(3):2091-2104.. View in PubMed
  • Cell State and Cell Type: Deconvoluting Circulating Tumor Cell Populations in Liquid Biopsies by Multi-Omics. Cancers (Basel). 2023 Aug 03; 15(15).. View in PubMed
  • Synthesis and anti-cancer potential of potent peripheral MAOA inhibitors designed to limit blood:brain penetration. Bioorg Med Chem. 2023 09 07; 92:117425.. View in PubMed
  • Immune biomarkers associated with COVID-19 disease severity in an urban, hospitalized population. Pract Lab Med. 2023 Aug; 36:e00323.. View in PubMed
  • In Vivo Non-Thermal, Selective Cancer Treatment With High-Frequency Medium-Intensity Focused Ultrasound. IEEE Access. 2021; 9:122051-122066.. View in PubMed
  • Effect of Periodized Resistance Training on Skeletal Muscle During Androgen Deprivation Therapy for Prostate Cancer: A Pilot Randomized Trial. Integr Cancer Ther. 2021 Jan-Dec; 20:15347354211035442.. View in PubMed
  • CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation. J Control Release. 2021 01 10; 329:614-623.. View in PubMed
  • Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer. Prostate Cancer Prostatic Dis. 2021 03; 24(1):61-68.. View in PubMed
  • Monitoring dynamic cytotoxic chemotherapy response in castration-resistant prostate cancer using plasma cell-free DNA (cfDNA). BMC Res Notes. 2019 May 15; 12(1):275.. View in PubMed