Steven L Giannotta, MD

Professor of Neurological Surgery

Associate Medical Director, Office of Integrated Risk Management

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Overview

Steven L. Giannotta M.D. has spent the majority of his Neurosurgical career at USC. He joined the Department of Neurosurgery at USC in 1980 and served as the Chair of the Department from 2004 to 2024. He also served as the Program Director of the Neurological Surgery Residency Training Program from 2004-2023. Dr. Giannotta earned his medical degree and did his residency at University of Michigan.

Dr. Giannotta has gained local and national recognition for his work in cerebrovascular disease of the brain and spinal cord. He has surgically treated over 3000 intracranial aneurysms. In conjunction with his associates Dr. Giannotta has developed a comprehensive approach to the gamut of cerebrovascular conditions. Techniques utilized in this comprehensive program include but are not limited to microsurgical clip ligation for aneurysms, coil embolization for aneurysms, microvascular excision, embolization, stereotactic radiosurgery using the Gamma Knife for arteriovenous malformations, carotid endarterectomy and extracranial to intracranial bypass procedures for cerebrovascular occlusive disease.

Dr. Giannotta also has an interest and special expertise in surgical approaches to the cranial base. He has surgically removed more than 1000 acoustic neuromas and along with several colleagues in otolaryngology has developed a team approach to complex cranial base lesions including acoustic neuromas, meningiomas of the cranial base, complex aneurysms that require cranial base approaches and other benign conditions affecting the base of the brain and skull. Complex conditions may require several modes of therapy including surgical excision, embolization, and stereotactic radiosurgery using the Gamma Knife and Cyberknife.

Since 1992 Dr. Giannotta has developed one of the largest practices for the surgical treatment of trigeminal neuralgia.

He has been involved in many local, national and international committees and organizations including time as the Chair of the American Board of Neurological Surgeons, Secretary of the Committee on Advanced Subspecialty Training (CAST) for the Society of Neurological Surgeons accrediting Neurosurgery fellowship training programs, and Chair of the Residency Review Committee for Neurosurgery at the ACGME.

Publications

  • Active surveillance versus stereotactic radiosurgery for Koos grade I and II vestibular schwannoma in patients aged 60 years or older. J Neurosurg. 2026 Sep 01; 145(3):732-742.. View in PubMed
  • Stereotactic Radiosurgery Versus Observation in Small- and Medium-Sized Vestibular Schwannoma Patients With Normal Hearing: A Retrospective International Multicenter Study. Neurosurgery. 2026 Apr 01; 98(4):887-894.. View in PubMed
  • Corrigendum to Epigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma. J Clin Invest. 2025 08 01; 135(15).. View in PubMed
  • A new era in neurosurgery residency applications: the impact of preference signaling on the neurosurgical match. J Neurosurg. 2025 Oct 01; 143(4):1108-1120.. View in PubMed
  • So, You Want to Be a Chair? Neurosurgery. 2025 Apr 01; 71(Supplement_1):17-22. Giannotta SL . View in PubMed
  • Vestibular Schwannoma Koos Grade I International Study of Active Surveillance Versus Stereotactic Radiosurgery: The VISAS-K1 Study. Neurosurgery. 2025 Jan 01; 96(1):41-49.. View in PubMed
  • Vestibular Schwannoma Koos Grade II International Study of Active Surveillance Versus Stereotactic Radiosurgery: The VISAS-K2 Study. Neurosurgery. 2025 Jan 01; 96(1):50-58.. View in PubMed
  • Vestibular Schwannoma International Study of Active Surveillance Versus Stereotactic Radiosurgery: The VISAS Study. Int J Radiat Oncol Biol Phys. 2024 10 01; 120(2):454-464.. View in PubMed
  • Frailty is a Predictor of Increased Readmissions and Increased Postoperative Complications After Elective Treatment of Unruptured Aneurysms. World Neurosurg. 2024 01; 181:e882-e896.. View in PubMed
  • A Review of Medical and Surgical Options for the Treatment of Facial Pain. Otolaryngol Clin North Am. 2022 Jun; 55(3):607-632.. View in PubMed